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Meds 700 Medicinal Uses for Cannabis sorted by Disease

momofthegoons

Vapor Accessory Addict
Staff member
This thread is a listing of all of the medicinal uses for cannabis sorted by disease (in 2012). There are also informational links regarding cannabis. While this is an older article, it has a lot of great information. The Glossary is at at the end. This first post is the latest introduction and pages 1 - 4. Prior year's introductions are at the end of the article.

Granny Storm Crow's MMJ Reference List- January 2012

Well, here I am again, staring at this blank screen, trying to figure out what to say so you will share the information I have gathered. ―Once the medical facts about cannabis become known, the need for legalization becomes obvious!‖ How many times have I said that? I need YOU to educate those around you. I can‘t do it alone!

At times, it seems so futile- this never-ending battle against ignorance about cannabis. But I can‘t give up - this simple herb has some amazing uses and people need to know what it can do.

Cannabis should be treated like any other medicinal herb, because that‘s what it is, just an herbal medicine with a rather pleasant side effect- you feel ―high‖. Unlike common aspirin, cannabis never kills by overdose. Compared to some pharmaceutical drugs‘ side effects, the ―cotton-mouth‖, ―red eye‖, ―munchies‖ and ―feeling a just bit too good‖ from using cannabis seems so trivial!

As Americans, we should be free to exercise our right to choose the type of medicines that we take. Anyone exhibiting the first signs of Alzheimer‘s should be able to choose between Aricept, Marinol, or natural cannabis to slow the deposit of mind-clogging amyloid plaque.

“When tested at double the concentration of THC, Aricept blocked plaque formation only 22% as well as THC, and Cognex blocked plaque formation only 7% as well as THC.” (Marijuana May Slow Alzheimer's - WebMD, 2006)

Marinol is just a capsule of a pure synthetic THC dissolved in sesame oil. It will work, but some people find that it causes anxiety because it lacks CBD (cannabidiol) to balance the THC high.

Natural cannabis has CBD and other cannabinoids in it, which act in a different way to slow the progress of Alzheimer‘s. (―Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer‘s disease‖ - Molecular Pharmacology, 2011) I know which I would logically choose, but in 2/3s of the US, and everywhere by federal law, that choice is forbidden to us. Our government has banned our best choice!

Then there are thousands facing the severe nausea of chemotherapy- will they be able to keep an anti- nausea pill down long enough for it to work? Wouldn‘t it be simpler to inhale some cannabis vapor, or smoke, and get almost instantaneous relief? In 16 states, you can!

And the pain from cancer? “Medical Marijuana a Success in Israel‖ – “More than two-thirds of cancer patients who were prescribed medical marijuana to combat pain are reportedly satisfied with the treatment” Are we less free than the Israelis? They are free to get legal, prescribed cannabis for cancer pain- are you? Our neighbor, Canada, has legal medical cannabis, and their government grows cannabis for patients! And surprise! The US has 4 federally legal MMJ patients and grows for them. The program is closed. No new patients allowed! Why? And why is cannabis research, all but banned in the US? This prohibitionist foolishness has to end!

2012 is supposed to be a time of change, an ―interesting‖ year. It is time for us to demand a change in the laws on cannabis! We must keep telling the truth, keep presenting the facts to our friends and our families. The facts are there in PubMed- cannabis IS medicine! Our government lies to us about cannabis! And folks- “If the truth won’t do, then something is wrong!”


1

It Is Time for Marijuana to Be Reclassified as Something Other Than a Schedule I Drug! (2005) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1681626&tool=pmcentrez

ACEA/ ARACHIDONYL-2'-CHLOROETHYLAMIDE - synthetic, CB1 agonist

The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU- 210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice. (abst – 2002) http://www.ncbi.nlm.nih.gov/pubmed/12095655

In vivo effects of CB1 receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain of healthy and ethanol-treated rats. (full – 2006) http://www.if-pan.krakow.pl/pjp/pdf/2006/6_876.pdf

Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock- induced seizure model. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16930590

Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. (full - 2007) http://jpet.aspetjournals.org/content/322/3/1144.long

Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17870135

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells (full - 2008) http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block

Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation. (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585399/?tool=pubmed

Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees. (full – 2008) http://onlinelibrary.wiley.com/doi/10.1002/art.23156/full

Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha- mediated ceramide de novo synthesis in colon cancer cells. (full – 2008) http://clincancerres.aacrjournals.org/content/14/23/7691.long

Endogenous cannabinoids induce fever through the activation of CB1 receptors. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765314/?tool=pubmed


2

The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats. (full – 2009) http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02098.x/full

Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19223154

Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19827302

Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19751793

Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19150453

Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation (abst - 2010) http://www.nature.com/npp/journal/vaop/ncurrent/full/npp2010214a.html

Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21764086

L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21928146

Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22079489

Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by Aβ neurotoxicity. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22172925

Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21937980

Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22233683


3

ACHILLES TENDINOSIS

Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169627/?tool=pubmed

ACNE


The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757311/?tool=pubmed

Endocannabinoid signaling and epidermal differentiation. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21628127


ADD/ ADHD

ADHD by Ryan P (anecdotal - no date)

http://www.rxmarijuana.com/shared_comments/ADHD4.htm

Marijuana and ADD Therapeutic uses of Medical Marijuana in the treatment of ADD (no date) http://www.onlinepot.org/medical/add&mmj.htm

Barba Jacob and the history of marihuana (abst – 1986)

http://www.ncbi.nlm.nih.gov/pubmed/3296662

How Cannabis Compares to other treatments (no date - 2008)

http://dcsafeaccess.org/medical/how-cannabis-compares-to-other-treatments/

Recipe For Trouble (anecdotal/ news - 2002 )

http://www.cbsnews.com/stories/2002/03/05/48hours/main503022.shtml

Association between cannabinoid receptor gene (CNR1) and childhood attention deficit/hyperactivity disorder in Spanish male alcoholic patients (full - 2003) http://www.nature.com/mp/journal/v8/n5/full/4001278a.html

Cannabinoids effective in animal model of hyperactivity disorder (abst - 2003)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=162#4

Cannabis 'Scrips to Calm Kids? (news - 2004)

http://www.foxnews.com/story/0,2933,117541,00.html


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Pages 5 - 9

Fitness to drive in spite (because) of THC (abst - 2007)

http://www.unboundmedicine.com/medline/ebm/record/17879702/abstract/[Fitness_to_drive_in_spite_ _because__of_THC%5D

Science: THC normalized impaired psychomotor performance and mood in a patient with hyperactivity disorder (news - 2007) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=254

Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685476/?tool=pubmed

Cannabis Improves Symptoms of ADHD (full - 2008)

http://www.cannabis-med.org/english/journal/en_2008_01_1.pdf

Cannabis use and adult ADHD symptoms. (abst - 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18242878

Autism, ADD, ADHD and Marijuana Therapy (news - 2008)

http://www.entheology.org/edoto/anmviewer.asp?a=319

Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications (abst – 2009) http://pharmgkb.org/pmid/19897083

Why I Give My 9-year-old Pot (anecdotal/news - 2009)

http://www.doublex.com/section/health-science/why-i-give-my-9-year-old-pot

Why I Give My 9-Year-Old Pot, Part II (news/anecdotal - 2009)

http://www.doublex.com/section/health-science/why-i-give-my-9-year-old-pot-part-ii
Why I Give My 9-Year-Old Pot, Part 3 (news - 2010) http://www.slate.com/id/2251174/

Science: Cannabis effective in the treatment of TOURETTE Syndrome and attention deficit hyperactivity disorder (ADHD) (news – 2010)
http://www.cannabis- med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=323&search_pattern=tourette#2

Loss of striatal cannabinoid CB1 receptor function in attention-deficit / hyperactivity disorder mice with point-mutation of the dopamine transporter. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22034972

Why I Give My Autistic Son Pot, Part 4 (news – 2011)

http://www.slate.com/id/2294072/?from=rss


5

ADDICTION

An Abstinence Syndrome Following Chronic Administration of Delta-9- terahydrocannabinol in Rhesus Monkeys. (abst – 1980) http://www.ncbi.nlm.nih.gov/pubmed/6255508

Abuse potential of dronabinol (Marinol). (abst – 1998)

http://www.ncbi.nlm.nih.gov/pubmed/9692381

Relative Addictiveness of Various Substances (full - 1990)

http://www.ukcia.org/research/addictiv.htm

Genetic differences in delta 9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains. (abst – 1996) http://www.ncbi.nlm.nih.gov/pubmed/8649214

Anandamide, an Endogenous Cannabinoid, Has a Very Low Physical Dependence Potential (full - 1998) http://jpet.aspetjournals.org/content/287/2/598.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= cannabinoid&searchid=1&FIRSTINDEX=480&resourcetype=HWCIT

Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect. (abst – 2001) http://www.ncbi.nlm.nih.gov/pubmed/11359533

Chronic Morphine Modulates the Contents of the Endocannabinoid, 2-Arachidonoyl Glycerol, in Rat Brain (full - 2003) http://www.nature.com/npp/journal/v28/n6/full/1300117a.html

Does Cannabis Use Predict Poor Outcome for Heroin-dependent Patients on Maintenance Treatment? Past Findings and More Evidence Against. (abst – 2003) http://medical-journals.healia.com/doc/12603227/Does-cannabis-use-predict-poor-outcome-for-heroin- dependent-patients-on-maintenance-treatment-Past-findings-and-more-evidence-against

Cannabis Abuse is Not a Risk Factor for Treatment Outcome in Methadone Maintenance Treatment: a 1-year Prospective Study in an Israeli Clinic. (abst – 2004) http://www.ncbi.nlm.nih.gov/pubmed/14731193

Alcohol Consumption Moderates the Link Between Cannabis Use and Cannabis Dependence in an Internet Survey. (abst – 2005) http://psycnet.apa.org/journals/adb/19/2/212/

Confirming alcohol-moderated links between cannabis use and dependence in a national sample (abst – 2006) http://www.sciencedirect.com/science/article/pii/S0306460305002959


6

Long term marijuana users seeking medical cannabis in California (2001–2007): demographics, social characteristics, patterns of cannabis and other drug use of 4117 applicants (full - 2007) http://www.harmreductionjournal.com/content/4/1/16

Lack of behavioral sensitization after repeated exposure to THC in mice and comparison to methamphetamine (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637562/?tool=pubmed

Merck Manual - Marijuana (Cannabis) (excerpt - 2008)

http://www.merckmanuals.com/professional/sec23/ch352/ch352i.html?qt=marijuana&alt=sh


Study of 4000 indicates marijuana discourages use of hard drugs.

http://www.csdp.org/publicservice/medicalmj08.htm

Calling B.S. on the Idea of 'Marijuana Addiction' (news – 2008)

http://www.alternet.org/drugs/80408/?page=entire

When Your Kid Smokes Pot (news – 2008)

http://mensnewsdaily.com/2010/08/08/when-your-kid-smokes-pot/

(news – 2008)


Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats (full - 2009) http://www.nature.com/npp/journal/v34/n11/full/npp200970a.html

The Surprising Effect Of Marijuana On Morphine Dependence (news - 2009)

http://www.redorbit.com/news/health/1716066/the_surprising_effect_of_marijuana_on_morphine_depende nce/

Active Ingredient In Cannabis Eliminates Morphine Dependence In Rats (news - 2009)

http://www.sciencedaily.com/releases/2009/07/090706090440.htm

Four percent of adults worldwide using cannabis (news – 2009)

http://www.independent.co.uk/life-s...health-news/four-percent-of-adults-worldwide- using-cannabis-1804190.html

Medical marijuana users in substance abuse treatment. (full – 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848643/?tool=pubmed

Teen Pot Smoking Won't Lead to Other Drugs as Adults (news - 2010)

http://www.webmd.com/parenting/news/20100902/teen-pot-smoking-wont-lead-to-other-drugs-as-adults

Aerobic Exercise Training Reduces Cannabis Craving and Use in Non-Treatment Seeking Cannabis-Dependent Adults (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050879/?tool=pmcentrez

Abuse potential and psychoactive effects of δ-9-tetrahydrocannabinol and cannabidiol

oromucosal spray (Sativex), a new cannabinoid medicine. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21542664


7

Dronabinol for the treatment of cannabis dependence: a randomized, double-blind, placebo-controlled trial. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21310551/abstract/Dronabinol_for_the_treatment_ of_cannabis_dependence:_a_randomized_double_blind_placebo_controlled_trial_

The genetic basis of the endocannabinoid system and drug addiction in humans (abst – 2011) http://jop.sagepub.com/content/early/2011/09/20/0269881111416689

Exercise can reduce cannabis use in persons who don't want to stop (news – 2011)

http://www.news-medical.net/news/20110304/Exercise-can-reduce-cannabis-use-in-persons-who-dont- want-to-stop.aspx

Medical marijuana laws in 50 states: Investigating the relationship between state legalization of medical marijuana and marijuana use, abuse and dependence. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22099393

2-AG / 2-ARACHIDONOYLGLYCEROL - endocannabinoid, CB1 & CB 2 agonist 2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

(abst – 1995) http://www.sciencedirect.com/science/article/pii/S0006291X85724370

A Second Endogenous Cannabinoid That Modulates Long-term Potentiation.
(abst – 1997) http://medical-journals.healia.com/doc/9285589/A-second-endogenous-cannabinoid-that-modulates-long- term-potentiation

Brain Chemicals Mimic Marijuana (news - 1997)

http://www.ukcia.org/research/anandami.php

2-Arachidonoyl-glycerol as an "endocannabinoid": limelight for a formerly neglected metabolite. (abst - 1998) http://www.ncbi.nlm.nih.gov/pubmed/9526090

Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor (full – 1999) http://www.jbc.org/content/274/5/2794.long

Endocannabinoids control spasticity in a multiple sclerosis model (full - 2000)

http://www.fasebj.org/cgi/reprint/00- 0399fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&sear chid=1&FIRSTINDEX=10&sortspec=relevance&resourcetype=HWCIT

Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2

cannabinoid receptor: antagonism by anandamide. (full – 2000)

http://molpharm.aspetjournals.org/content/57/5/1045.long


8

Endocannabinoids and Vascular Function (full - 2000)

http://jpet.aspetjournals.org/content/294/1/27.long

Cardiovascular effects of endocannabinoids--the plot thickens. (abst - 2000)

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=10785543&dopt=abstrac tplus

Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes. (full – 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572991/?tool=pubmed

Endogenous cannabinoids mediate hypotension after experimental myocardial infarction (full - 2001) http://content.onlinejacc.org/cgi/content/full/38/7/2048?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT

Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors (full - 2001) http://jpet.aspetjournals.org/content/299/3/951.full

Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation (full - 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572987/?tool=pmcentrez

2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor (full - 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC31108/

An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. (abst - 2001) http://www.ncbi.nlm.nih.gov/pubmed/11586361

Sourcing the Code: Searching for the Evolutionary Origins of Cannabinoid Receptors, Vanilloid Receptors, and Anandamide (full – 2002) http://www.cannabis-med.org/data/pdf/2002-01-3.pdf

Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2- AG) in immune cells (full - 2002) http://www.fasebj.org/cgi/content/full/15/12/2171?maxtoshow=&hits=10&RESULTFORMAT=&fulltext= cannabis&andorexactfulltext=and&searchid=1&FIRSTINDEX=10&sortspec=relevance&resourcetype=H WCIT

The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids. (full – 2002) http://jpet.aspetjournals.org/content/300/1/34.long

Comparison of the enzymatic stability and intraocular pressure effects of 2-

arachidonylglycerol and noladin ether, a novel putative endocannabinoid. (full – 2002)

http://www.iovs.org/content/43/10/3216.full


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Pages 10 - 14

Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. (full – 2002) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573386/?tool=pubmed

Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine. (abst – 2002) http://www.ncbi.nlm.nih.gov/pubmed/12393235

Endocannabinoids protect the rat isolated heart against ischaemia (full - 2003)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573907/?tool=pmcentrez

Chronic Morphine Modulates the Contents of the Endocannabinoid, 2-Arachidonoyl Glycerol, in Rat Brain (full - 2003) http://www.nature.com/npp/journal/v28/n6/full/1300117a.html

Role of Endogenous Cannabinoids in Synaptic Signaling (full - 2003)

http://physrev.physiology.org/cgi/content/full/83/3/1017?maxtoshow=&hits=80&RESULTFORMAT=&ful ltext=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy (full - 2003) http://jpet.aspetjournals.org/content/307/1/129.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

Manipulation of the endocannabinoid system by a general anaesthetic. (full – 2003)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573927/?tool=pubmed

Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/12447606

Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/12914975

The endocannabinoid system: a general view and latest additions (full - 2004)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574255/?tool=pmcentrez

New perspectives in the studies on endocannabinoid and cannabis: 2- arachidonoylglycerol as a possible novel mediator of inflammation (full - 2004) http://www.jstage.jst.go.jp/article/jphs/96/4/367/_pdf

2-Arachidonoylglycerol A Novel Inhibitor of Androgen-Independent Prostate Cancer Cell Invasion (full - 2004) http://cancerres.aacrjournals.org/c...8826?ijkey=951f5f9d238bdf059cf30ee2be3a5a31aa f2b094

The endocannabinoid-CB receptor system: Importance for development and in pediatric disease. (abst - 2004) http://www.ncbi.nlm.nih.gov/pubmed/15159678


10

A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells (full – 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450257/

Analgesia through endogenous cannabinoids (full - 2005)

http://www.cmaj.ca/cgi/content/full/173/4/357?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=end ocannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=date&resourcetype=HW CIT

CB1 cannabinoid receptor-mediated modulation of food intake in mice (full - 2005)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576140/?tool=pmcentrez

Effects of cannabinoids on colonic muscle contractility and tension in guinea pigs. (full – 2005) http://www.jstage.jst.go.jp/article/jnms/72/1/72_43/_article

The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. (abst - 2005) http://lib.bioinfo.pl/pmid:16364651

Finding of endocannabinoids in human eye tissues: implications for glaucoma. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/15823551

Body's Own Marijuana-Like Compounds Are Crucial For Stress-Induced Pain Relief (news - 2005) http://www.sciencedaily.com/releases/2005/06/050628064435.htm

Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and ß-Pancreatic Cells and in Obesity and Hyperglycemia (full - 2006) http://jcem.endojournals.org/cgi/content/full/91/8/3171?ijkey=83a68cef202eafe129332eda53eee8eb613499 82

Endocannabinoids, feeding and suckling – from our perspective (full – 2006)

http://www.nature.com/ijo/journal/v30/n1s/full/0803274a.html

Not Too Excited? Thank Your Endocannabinoids (full - 2006)

http://www.sciencedirect.com/science/article/pii/S0896627306005927

Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458883/?tool=pmcentrez

Weight Control in Individuals With Diabetes (full - 2006)

http://care.diabetesjournals.org/content/29/12/2749.full?maxtoshow=&hits=80&RESULTFORMAT=&full text=cannabis&searchid=1&FIRSTINDEX=2000&resourcetype=HWCIT

A new strategy to block tumor growth by inhibiting endocannabinoid inactivation. (full – 2006) http://www.fasebj.org/content/early/2004/10/02/fj.04-1754fje.long

Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2-

Arachidonoylglycerol in Oxazolone-Induced Contact Dermatitis in Mice (full – 2006)

http://www.jimmunol.org/content/177/12/8796.full


11

Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16506408

Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2- arachidonoylglycerol. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16949718

Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16310817

Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16678907

The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16364651

The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis (full - 2007) http://www.jbc.org/content/282/33/23892.full

Endocannabinoids and the haematological system (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190025/?tool=pmcentrez

Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755791/?tool=pmcentrez

Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565646/?tool=pubmed

Opposing Actions of Endocannabinoids on Cholangiocarcinoma Growth : RECRUITMENT OF Fas AND Fas LIGAND TO LIPID RAFTS (full – 2007) http://www.jbc.org/content/282/17/13098.full

Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus.
(full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042935/?tool=pubmed

Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228252/?tool=pmcentrez

Identification of Endocannabinoids and Related Compounds in Human Fat Cells (full - 2007) http://www.nature.com/oby/journal/v15/n4/full/oby2007100a.html

Endocannabinoids block status epilepticus in cultured hippocampal neurons (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2617750/?tool=pmcentrez


12

Chronologically overlapping occurrences of nicotine-induced anxiety- and depression- related behavioral symptoms: effects of anxiolytic and cannabinoid drugs (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075518/?tool=pubmed

2-AG + 2 new players = forecast for therapeutic advances. (full – 2007)

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VRP-4RFCCVN- 4&_user=10&_coverDate=12%2F26%2F2007&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway& _sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9ee f728e35c89b5764ef2d27c0cdffe9&searchtype=a

CB2 receptors in the brain: role in central immune function (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219530/?tool=pmcentrez

Opposing Actions of Endocannabinoids on Cholangiocarcinoma Growth (full - 2007)

http://www.jbc.org/content/282/17/13098.full

Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pál Pacher (interview - 2007) http://www.jleukbio.org/cgi/content/full/82/6/1390?maxtoshow=&hits=80&RESULTFORMAT=&fulltext =cannabinoid&searchid=1&FIRSTINDEX=880&resourcetype=HWCIT

Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17419758

The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17706636

The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. (full - 2008) http://www.fasebj.org/cgi/content/full/22/1/285

Cannabinoids Inhibit HIV-1 Gp120-Mediated Insults in Brain Microvascular Endothelial Cells (full - 2008) http://www.jimmunol.org/cgi/content/full/181/9/6406?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

Endocannabinoid 2-Arachidonoylglycerol Protects Neurons by Limiting COX-2 Elevation (full – 2008) http://www.jbc.org/content/283/33/22601.full

Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats (full - 2008) http://www.jneurosci.org/cgi/content/full/28/39/9702?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabinoid&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

Cannabinoid receptors and the regulation of bone mass (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219540/?tool=pmcentrez


13

Pharmacological Inhibition of CB1 Cannabinoid Receptor Protects Against Doxorubicin- Induced Cardiotoxicity (full - 2008) http://content.onlinejacc.org/cgi/content/full/50/6/528

Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet (full - 2008) http://www.nature.com/oby/journal/v16/n3/full/oby2007106a.html

Endocannabinoids and the Control of Energy Homeostasis (full – 2008)

http://www.jbc.org/content/283/48/33021.full?sid=931583b1-e797-43e0-8296-7fd75bb49403

The influence of mast cell mediators on migration of SW756 cervical carcinoma cells. (full – 2008) http://www.jstage.jst.go.jp/article/jphs/106/2/106_208/_article

Endocannabinoids and nutrition. (full – 2008)

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2826.2008.01687.x/pdf

Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon. (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755791/?tool=pubmed

Mechanisms for Recycling and Biosynthesis of Endogenous Cannabinoids Anandamide and 2-Arachidonylglycerol (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581634/?tool=pmcentrez

Dysregulation of the endocannabinoid system in obesity. (abst – 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18426509

Understanding the effects of endogenous cannabinoids (news - 2008)

http://arstechnica.com/science/news/2008/11/understanding-the-effects-of-endogenous-cannabinoids.ars

Marijuana-Inspired Painkiller? New Chemical Pathway Discovered (news - 2008)

http://www.sciencedaily.com/releases/2008/11/081123150249.htm

Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791688/?tool=pmcentrez

Endocannabinoids and Their Receptors as Targets for Obesity Therapy (full - 2009)

http://endo.endojournals.org/cgi/content/full/150/6/2531#top

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19502530

Circulating endocannabinoid concentrations during orthostatic stress (abst – 2009)

www.ncbi.nlm.nih.gov/pubmed/19756829

The endocannabinoid 2-arachidonoylglycerol promotes sperm developement through activation of cannabinoid-2 receptors (abst – 2009) http://www.cannabis-med.org/index.php?tpl=cannabinoids&id=238&lng=en&red=cannabinoidslist

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Pages 15 - 19

Cannabinoid Receptors as Target for Treatment of Osteoporosis: A Tale of Two Therapies (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001217/?tool=pubmed

Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients (full - 2010) http://www.lipidworld.com/content/9/1/43

Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871782/?tool=pubmed

Endogenous cannabinoid signaling is essential for stress adaptation

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889099/?tool=pmcentrez

Endocannabinoid signalling: has it got rhythm? (full – 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931554/?tool=pubmed

(full - 2010)

The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. (full – 2010) http://www.jneurosci.org/content/30/26/8965.long

The endocannabinoid system as a target for the treatment of neurodegenerative disease (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931550/?tool=pubmed

The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20156559

The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20875047

Painkilling System in Brain: Too Much of a Good Thing? (news - 2010)

http://www.sciencedaily.com/releases/2010/08/100824151036.htm

Anti-proliferative Effect of a Putative Endocannabinoid, 2-Arachidonylglyceryl Ether in Prostate Carcinoma Cells (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039283/?tool=pmcentrez

The endocannabinoid system and cancer: therapeutic implication (full – 2011)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01327.x/full

Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders? (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20512266/abstract/[Pharmacological_exploitat ion_of_the_endocannabinoid_system:_new_perspectives_for_the_treatment_of_depression_and_anxiety_d isorders%5D_

15

Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19840245

Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933347/?tool=pubmed

Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048484/?tool=pubmed

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2‐arachidonoylglycerol signalling through cannabinoid receptors (full – 2011)

http://onlinelibrary.wiley.com/doi/10.1111/j.1748-1716.2011.02280.x/full

Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. (full – 2011) http://www.jbc.org/content/early/2011/06/10/jbc.M110.202853.long

Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21810593

The Endogenous Cannabinoid 2-Arachidonoylglycerol Is Intravenously Self- Administered by Squirrel Monkeys (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21562266/abstract/The_Endogenous_Cannabinoid _2_Arachidonoylglycerol_Is_Intravenously_Self_Administered_by_Squirrel_Monkeys_

Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21551239/abstract/Increasing_endogenous_2_arac hidonoylglycerol_levels_counteracts_colitis_and_related_systemic_inflammation_

Administration of 2-arachidonoylglycerol ameliorates both acute and chronic Experimental Autoimmune Encephalomyelitis (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21406188/abstract/Administration_of_2_arachidon oylglycerol_ameliorates_both_acute_and_chronic_Experimental_Autoimmune_Encephalomyelitis_

Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21256197/abstract/Endocannabinoid_2_arachidono ylglycerol_protects_neurons_against_%CE%B2_amyloid_insults_

Alteration of the Endocannabinoid System In Mouse Brain During Prion Disease. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21195746/abstract/Alteration_of_the_Endocannabi noid_System_In_Mouse_Brain_During_Prion_Disease_

Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21875957

16

The major central endocannabinoid directly acts at GABA(A) receptors. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/22025726

2-Arachidonoylglycerol (2-AG) Induces Corneal Epithelial Cell Migration via Cannabinoid CB1 Receptors (abst – 2011) http://abstracts.iovs.org/cgi/content/abstract/52/6/1995?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT

Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21109417

Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/20817042/abstract/Increment_of_hypothalamic_2_ arachidonoylglycerol_induces_the_preference_for_a_high_fat_diet_via_activation_of_cannabinoid_1_rece ptors_

Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in bombesin- induced activation of central adrenomedullary outflow in rats. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21371452

Endocannabinoid CB1 receptors modulate visual output from the thalamus. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21773721

Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21995886

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21145341/abstract/Inhibition_of_endocannabinoid _catabolic_enzymes_elicits_anxiolytic_like_effects_in_the_marble_burying_assay_

New metabolic pathway for controlling brain inflammation (news – 2011)

http://www.news-medical.net/news/20111021/New-metabolic-pathway-for-controlling-brain- inflammation.aspx

Cannabinoid Receptor Type 1 (CB1) Activation Inhibits Small GTPase RhoA Activity and Regulates Motility of Prostate Carcinoma Cells. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22087025

2-AGE/ 2-ARACHIDONYL GLYCERYL ETHER/ NOLADIN ETHER

endocannabinoid, CB 1 & 2 agonist

2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor (full - 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC31108/

17

Comparison of the enzymatic stability and intraocular pressure effects of 2- arachidonylglycerol and noladin ether, a novel putative endocannabinoid. (full – 2002) http://www.iovs.org/content/43/10/3216.full

Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide. (abst – 2002) http://www.ncbi.nlm.nih.gov/pubmed/12384227

Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/14584958

The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors. (full – 2005) http://jpet.aspetjournals.org/content/314/2/868.long

Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/15763177

Noladin ether acts on trabecular meshwork cannabinoid (CB1) receptors to enhance aqueous humor outflow facility. (full – 2006) http://www.iovs.org/content/47/5/1999.long

2-Arachidonylglyceryl ether and abnormal cannabidiol-induced vascular smooth muscle relaxation in rabbit pulmonary arteries via receptor-pertussis toxin sensitive G proteins- ERK1/2 signaling. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17292352

Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. (full – 2010) http://www.jneurosci.org/content/30/18/6273.long

Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol. (full – 2011) http://onlinelibrary.wiley.com/doi/10.1002/biof.131/full

Anti-proliferative Effect of a Putative Endocannabinoid, 2-Arachidonylglyceryl Ether in Prostate Carcinoma Cells (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039283/?tool=pmcentrez

AGING /USE BY SENIORS

Changes in cannabinoid receptor binding and mRNA levels in several
brain regions of aged rats (full - 1998) http://www.ncbi.nlm.nih.gov/pubmed/9748581

18

The Peripheral Cannabinoid Receptor CB2 and CD40 Are Novel Biological Markers

That Predict Outcome in Diffuse Large B-Cell Lymphoma of Elderly Patients.

(abst - 2004)

http://abstracts.hematologylibrary.org/cgi/content/abstract/104/11/3256?maxtoshow=&hits=80&RESULTF ORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=800&resourcetype=HWCIT

Using Marijuana in Adulthood: the Experience of a Sample of Users in Oklahoma City. (abst – 2005) http://medical-journals.healia.com/doc/16537332/Using-marijuana-in-adulthood-the-experience-of-a- sample-of-users-in-Oklahoma-City

Pass the Doobie, pops (news - 2005)

http://www.thefreelibrary.com/Pass+the+doobie,+pops.-a0131273013

Projecting drug use among aging baby boomers in 2020. (abst – 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16275134

Inflammation and aging: can endocannabinoids help? (full - 2008)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2408719&tool=pmcentrez

Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586121/?tool=pmcentrez

Cannabinoids Attenuate the Effects of Aging Upon Neuroinflammation and Neurogenesis. (abst - 2008) http://www.cannabisscience.com/research-a-development/anti-aging.html

CN BC: Expert Testifies Cannabis Helps Slow Aging (news - 2008)

http://www.mapinc.org/drugnews/v08/n458/a05.html

Could Marijuana Substance Help Prevent Or Delay Memory Impairment In The Aging Brain? (news - 2008) http://www.sciencedaily.com/releases/2008/11/081119120141.htm

Marijuana may be good for the aging brain (news - 2008)

http://www.news-medical.net/news/2008/11/19/43212.aspx

Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011092/?tool=pubmed

The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/21069097

The Management of Chronic Pruritus in the Elderly (full – 2010)

http://www.skintherapyletter.com/2010/15.8/2.html

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but

increases food intake and obesity with age. (abst – 2010)

http://www.springerlink.com/content/g037q1lh40l15161/

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Pages 20 - 24

Older Adults' Pot Use Up (news - 2010)

http://www.mapinc.org/drugnews/v10/n138/a02.html?1189

Marijuana Use By Seniors Goes Up As Boomers Age

http://www.mapinc.org/drugnews/v10/n136/a01.html?1189

Pot Breaks the Age Barrier (news - 2010)

http://www.mapinc.org/drugnews/v10/n233/a01.html?1190

(news - 2010)

Marijuana use among older adults in the U.S.A.: user characteristics, patterns of use, and implications for intervention (abst – 2011) http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8259427&fulltextType=RA&f ileId=S1041610210002176

Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1(-/-) mice. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/20724033

Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging (full– 2011)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131310/?tool=pubmed

Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [(18)F]MK-9470 PET. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/18077184

125 Year Old Woman Claimed Smoking Cannabis Everyday Was Her Secret to Long Life (news – 2011) http://www.hanf-info.ch/info/en/125-Year-Old-Woman-Claimed-Smoking.html

Endocannabinoid Signaling In Dietary Restriction And Lifespan Extension (news – 2011) http://www.medicalnewstoday.com/releases/225007.php

Bodyguard for the Brain: Researchers Identify Mechanism That Seems to Protect Brain from Aging (news – 2011) http://www.sciencedaily.com/releases/2011/07/110712093856.htm

Pot smoking not tied to middle-age mental decline (news – 2012)

http://www.mnn.com/health/fitness-w...smoking-not-tied-to-middle-age-mental-decline

AIDS – see HIV

20

AJULEMIC ACID/ IP-751/ HU-239 - synthetic analog of Δ8-THC-11-oic acid

The Role of Cannabis and Cannabinoids in Pain Management (full – 2002)

http://www.humanhemphealth.ca/Russo-AAPM_chapter.pdf

Marijuana-Derived Compound Targets Pain, Inflammation (news - 2002)

http://www.sciencedaily.com/releases/2002/08/020822071026.htm

Ajulemic Acid (IP-751): Synthesis, Proof of Principle, Toxicity Studies, and Clinical Trials (full - 2004) http://www.aapsj.org/view.asp?art=aapsj070115

Ajulemic acid: A novel cannabinoid produces analgesia without a ―high‖ (abst - 2004)

http://www.ncbi.nlm.nih.gov/pubmed/15240185?dopt=Abstract

Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials (full - 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751505/?tool=pubmed

Marijuana-Derived Drug Suppresses Bladder Overactivity And Irritation In Animal Models (news - 2005) http://www.sciencedaily.com/releases/2005/09/050906080225.htmhttp://www.sciencedaily.com/releases/2 005/09/050906080225.htm

Cannabimimetic Properties of Ajulemic Acid (full - 2006)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633725/?tool=pmcentrez

Marijuana-Derived Drug Suppresses Bladder Pain In Animal Models

http://www.sciencedaily.com/releases/2006/05/060521103039.htm

Cannabimimetic Properties of Ajulemic Acid (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633725/

(news - 2006)

In humans, ajulemic acid has a more favorable side-effect profile than THC for the treatment of chronic neuropathic pain (full - 2007) http://www.cannabis-med.org/english/journal/en_2007_01_1.pdf

Letter: Preclinical assessment of abuse liability of ajulemic acid (letter - 2007)

http://www.cannabis-med.org/english/journal/en_2007_01_2.pdf

Suppression of fibroblast metalloproteinases by ajulemic acid, a nonpsychoactive cannabinoid acid. (abst - 2007) http://www.ncbi.nlm.nih.gov/pubmed/16927387

Effects of IP-751, ajulemic acid, on bladder overactivity induced by bladder irritation in rats. (abst - 2007) http://www.ncbi.nlm.nih.gov/pubmed/17656248

Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/17786950

21

Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid. (abst - 2008) http://www.ncbi.nlm.nih.gov/sites/pubmed

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664885/?tool=pmcentrez

Cannabinoids as novel anti-inflammatory drugs. (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/?tool=pubmed

Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4 (full - 2009) http://www.fasebj.org/cgi/content/full/23/5/1503?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=c annabis&searchid=1&FIRSTINDEX=2400&resourcetype=HWCIT

ALCOHOLISM /ALCOHOL

Facts on Cannabis and Alcohol (article – no date)

http://www.saferchoice.org/content/view/24/53/#longterm

Alcohol and marijuana: comparison of use and abuse in regular marijuana users. (abst – 1984) http://www.ncbi.nlm.nih.gov/pubmed/6332109

Interaction of cannabidiol and alcohol in humans. (abst – 1979)

http://www.ncbi.nlm.nih.gov/pubmed/120541

Effect of Alcohol and Marihuana on Tobacco Smoking. (abst – 1980)

http://www.ncbi.nlm.nih.gov/pubmed/7353341

Concordant alcohol and marihuana use in women. (abst – 1986)

http://www.ncbi.nlm.nih.gov/pubmed/3741616

Alcohol use, marihuana smoking, and sexual activity in women. (abst – 1988)

http://www.ncbi.nlm.nih.gov/pubmed/3355664

Marihuana attenuates the rise in plasma ethanol levels in human subjects. (abst – 1992) http://www.ncbi.nlm.nih.gov/pubmed/1326277

Effects of Alcohol Pretreatment on Human Marijuana Self-administration. (abst – 1994)

http://medical-journals.healia.com/doc/7862844/Effects-of-alcohol-pretreatment-on-human-marijuana- self-administration

Alcohol and marijuana: effects on epilepsy and use by patients with epilepsy. (abst – 2001) http://www.ncbi.nlm.nih.gov/pubmed/11737161

22

Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. (abst – 2002) http://www.ncbi.nlm.nih.gov/pubmed/11841893

Cannabis as a Substitute for Alcohol (full - 2003)

http://ccrmg.org/journal/03sum/substitutealcohol.html

Association between cannabinoid receptor gene (CNR1) and childhood attention deficit/hyperactivity disorder in Spanish male alcoholic patients (full - 2003) http://www.nature.com/mp/journal/v8/n5/full/4001278a.html

Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice (full - 2003) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298783/?tool=pmcentrez

Cannabinoid Cb1 Receptor Knockout Mice Exhibit Markedly Reduced Voluntary Alcohol Consumption and Lack Alcohol-induced Dopamine Release in the Nucleus Accumbens. (abst – 2003)

http://medical-journals.healia.com/doc/12562514/Cannabinoid-CB1-receptor-knockout-mice-exhibit- markedly-reduced-voluntary-alcohol-consumption-and-lack-alcohol-induced-dopamine-release-in-the- nucleus-accumbens

Overeating, Alcohol and Sucrose Consumption Decrease in Cb1 Receptor Deleted Mice. (abst – 2004) http://medical-journals.healia.com/doc/12770700/Overeating-alcohol-and-sucrose-consumption-decrease- in-CB1-receptor-deleted-mice

Comparison of Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol- Induced Neurotoxicity (full - 2005) http://jpet.aspetjournals.org/content/314/2/780.full

Ethanol Induces Higher Bec in Cb1 Cannabinoid Receptor Knockout Mice While Decreasing Ethanol Preference. (full – 2005) http://alcalc.oxfordjournals.org/content/40/1/54.long

Alcohol Consumption Moderates the Link Between Cannabis Use and Cannabis Dependence in an Internet Survey. (abst – 2005) http://psycnet.apa.org/journals/adb/19/2/212/

Role of cannabinoid receptors in alcohol abuse (news - 2005)

http://www.medicalnewstoday.com/articles/30338.php

Effects of Alcohol and Combined Marijuana and Alcohol Use During Adolescence on Hippocampal Volume and Asymmetry (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821342/?tool=pubmed

In vivo effects of CB1 receptor ligands on lipid peroxidation and antioxidant defense

systems in the rat brain of healthy and ethanol-treated rats. (full – 2006)

http://www.if-pan.krakow.pl/pjp/pdf/2006/6_876.pdf

23

Confirming alcohol-moderated links between cannabis use and dependence in a national sample (abst – 2006) http://www.sciencedirect.com/science/article/pii/S0306460305002959

The endocannabinoid signaling system: a potential target for next-generation therapeutics for alcoholism (full - 2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1975858

Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans (abst – 2007) http://pharmgkb.org/pmid/17189959

Report: Marijuana Less Harmful than Alcohol or Tobacco (news - 2008)

http://www.jointogether.org/news/headlines/inthenews/2008/report-marijuana-less.html

Cannabis reverses brain damage from alcohol (news - 2008)

http://medicalcannabisawareness.myblogsite.com/entry36.html#body

Cannabis as a substitute for alcohol and other drugs. (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795734/?tool=pmcentrez

Daily marijuana users with past alcohol problems increase alcohol consumption during marijuana abstinence. (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19783385/full_citation/Daily_marijuana_users_wit h_past_alcohol_problems_increase_alcohol_consumption_during_marijuana_abstinence_

White Matter Integrity in Adolescents with Histories of Marijuana Use and Binge Drinking. (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19631736/abstract/White_Matter_Integrity_in_Ad olescents_with_Histories_of_Marijuana_Use_and_Binge_Drinking_

Maternal Marijuana use not Associated with Psychotic Symptoms , but Alcohol is (news - 2009) http://ohiopatientsnetwork.org/index.php?option=com_content&view=article&id=85:marijuana-not- associated-with-psychotic-symptoms-but-alcohol-is&catid=3:newsflash

Cannabis as a substitute for heavy alcohol usage? (news - 2009)

http://www.news-medical.net/news/20091201/Cannabis-as-a-substitute-for-heavy-alcohol-usage.aspx

Influence of ethanol on cannabinoid pharmacokinetic parameters in chronic users (full - 2010) http://www.springerlink.com/content/511171841x1u1521/fulltext.html

Learning and memory performances in adolescent users of alcohol and marijuana: interactive effects. (full – 2010) http://www.thefreelibrary.com/Learning+and+memory+performances+in+adolescent+users+of+alcohol+an d...-a0241277101

The Endocannabinoid System Tonically Regulates Inhibitory Transmission and

Depresses the Effect of Ethanol in Central Amygdala (abst - 2010)

http://www.nature.com/npp/journal/v35/n9/abs/npp201070a.html

24
 
Pages 25 - 30

11-nor-Delta9-tetrahydrocannabinol-9-carboxylic acid ethyl ester (THC-COOEt): unsuccessful search for a marker of combined cannabis and alcohol consumption.

(abst – 2010)

http://www.unboundmedicine.com/medline/ebm/record/20074877/abstract/11_nor_Delta9_tetrahydrocanna binol_9_carboxylic_acid_ethyl_ester__THC_COOEt_:_unsuccessful_search_for_a_marker_of_combined_ cannabis_and_alcohol_consumption_

Role of the endocannabinoid system in alcoholic liver disease. (abst – 2010)

http://www.ncbi.nlm.nih.gov/pubmed/21525760

The effects of cannabis and alcohol on simulated arterial driving: Influences of driving experience and task demand. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20380913/abstract/The_effects_of_cannabis_and_a lcohol_on_simulated_arterial_driving:_Influences_of_driving_experience_and_task_demand_

Study shows direct cellular interaction between endocannabinoids and alcohol in the brain (news - 2010) http://www.news-medical.net/news/20100513/Study-shows-direct-cellular-interaction-between- endocannabinoids-and-alcohol-in-the-brain.aspx

Marijuana To Control Alcohol Abuse (news - 2010)

http://psychcentral.com/news/2009/12/01/marijuana-to-control-alcohol-abuse/9863.html

Marijuana May Offset Alcohol-Induced Cognitive Impairment Among Teens (news – 2010) http://www.norml.org/index.cfm?Group_ID=8378

Study Overturns Decade-Old Findings in Neurobiology: Research Suggests Potential Target for Drugs to Combat Alcohol Addiction (news - 2010) http://www.sciencedaily.com/releases/2010/05/100512151549.htm

Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers (abst - 2011) http://www.ncbi.nlm.nih.gov/pubmed/21110996

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating kupffer cell polarization in mice. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21735467

Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21886913

Popular intoxicants: what lessons can be learned from the last 40 years of alcohol and cannabis regulation? (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21926420

Racial differences in trajectories of heavy drinking and regular marijuana use from ages 13 to 24 among African-American and White males. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21908109

Some features of teenage beer alcoholism combined with hashish addiction (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21322145

25

Influence of ethanol on cannabinoid pharmacokinetic parameters in chronic users. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21116612

Rural adolescent alcohol, tobacco, and illicit drug use: a comparison of students in victoria, australia, and washington state, United States. (abst – 2011) http://marijuana.researchtoday.net/archive/8/10/4782.htm

Latest Studies Imply That Cannabinoids Are Protective Against Alcohol-Induced Brain Damage (news – 2011) http://networkedblogs.com/mFuuX

Why Medical Marijuana Laws Reduce Traffic Deaths (news - 2011)

http://healthland.time.com/2011/12/02/why-medical-marijuana-laws-reduce-traffic-deaths/

Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004984/?tool=pubmed

Tolerance to cannabinoid-induced behaviors in mice treated chronically with ethanol. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21701813

ALLERGIES AND CANNABIS

Marijuana smoking and fungal sensitization. (abst - 1983)

http://www.ncbi.nlm.nih.gov/pubmed/6833678

Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/12835895

Pot Chemical May Curb Inflammation (news – 2007)

http://www.webmd.com/allergies/news/20070607/pot-chemical-may-curb-inflammation

Cannabis helps treat allergic reactions (news - 2007)

http://www.safeaccessnow.org/article.php?id=4768

Constituents Of Hashish And Marijuana May Help To Fight Inflammation And Allergies (news - 2007) http://www.sciencedaily.com/releases/2007/06/070607171120.htm

Marijuana Might Help Cure Allergic Contact Dermatitis (a.k.a. Poison Ivy) (news - 2007) http://www.healthcentral.com/skin-cancer/c/83/12569/cure-aka-ivy/1/

Cannabis for allergic contact dermatitis (news - 2007)

http://www.news-medical.net/news/2007/08/17/28901.aspx

26

Constituents Of Hashish And Marijuana May Help To Fight Inflammation And Allergies (news - 2007) http://www.sciencedaily.com/releases/2007/06/070607171120.htm

Cannabis can reduce Allergic Skin Reactions, latest research shows (news - 2007)

http://www.healthjockey.com/2007/06/08/cannabis-can-reduce-allergic-skin-reactions-latest-research- shows/

Allergic Skin Disease Could Be Treated With Substance Found In Cannabis (news – 2007) http://www.medicalnewstoday.com/releases/79889.php

Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid System
(full - 2008)
http://pediatrics.aappublications.org/cgi/reprint/122/Supplement_4/S200- a?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=1120 &resourcetype=HWCIT

Hemp: A replacement for common food allergens? (news - 2009)

http://www.examiner.com/x-20151-Manchester-Gluten-Free-Examiner~y2009m8d25-Hemp--A- replacement-for-common-food-allergens

Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/21042286

Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: Role of CB(1)/CB(2) receptors. (abst - 2010) http://www.unboundmedicine.com/medline/ebm/record/21056512/abstract/Beneficial_effects_of_cannabin oids__CB__in_a_murine_model_of_allergen_induced_airway_inflammation:_Role_of_CB_1_/CB_2__rec eptors_

Protective role of palmitoylethanolamide in contact allergic dermatitis. (abst – 2010)

http://www.ncbi.nlm.nih.gov/pubmed/19909294

The cannabinoid receptor agonist WIN 55,212-2 inhibits antigen-induced plasma extravasation in guinea pig airways. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20150748

Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21601500

ALLERGIES TO CANNABIS

Allergy to Marihuana (abst - 1971)

http://www.annals.org/content/75/4/571.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=ca nnabis&searchid=1&FIRSTINDEX=1920&resourcetype=HWCIT

27

Occupational immediate type allergy to hemp pollen and hashish (abst – 1980)

http://www.ncbi.nlm.nih.gov/pubmed/6447587

Allergic Skin Test Reactivity to Marijuana in the Southwest (full - 1983)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1010828&tool=pmcentrez

Allergenic properties of naturally occurring cannabinoids. (abst - 1983)

http://www.ncbi.nlm.nih.gov/pubmed/6620158

Cannabis (hemp) positive skin tests and respiratory symptoms (abst - 2000)

http://www.ncbi.nlm.nih.gov/pubmed/11030280

Allergic rhinoconjunctivitis caused by Cannabis sativa pollen (full - 2007)

http://www.jiaci.org/issues/vol18issue1/13-17.pdf

Cannabaceae Pollen in the Atmosphere of Brianza, Northen Italy. (abst – 2007)

http://medical-journals.healia.com/doc/17375735/Cannabaceae-pollen-in-the-atmosphere-of-Brianza- Northen-Italy

Sensitization and Allergy to Cannabis sativa Leaves in a Population of Tomato Sensitized Patients. (abst - 2008) http://marijuana.researchtoday.net/archive/5/2/1629.htm

Allergic hypersensitivity to cannabis in patients with allergy and illicit drug users.
(full – 2011) http://www.elsevier.es/sites/default/files/elsevier/eop/S0301-0546(10)00287-9.pdf

IgE-Mediated Hypersensitivity Reactions to Cannabis in Laboratory Personnel. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21832832

ALS / AMYOTROPHIC LATERAL SCLEROSIS

Marijuana in the management of amyotrophic lateral sclerosis (abst - 2001)

http://ajh.sagepub.com/cgi/content/abstract/18/4/264?maxtoshow=&hits=80&RESULTFORMAT=&fulltex t=cannabis&searchid=1&FIRSTINDEX=1200&resourcetype=HWCIT

Survey of cannabis use in patients with amyotrophic lateral sclerosis. (abst - 2004)

http://ajh.sagepub.com/cgi/content/abstract/21/2/95?maxtoshow=&hits=80&RESULTFORMAT=&fulltext =cannabinoid&searchid=1&FIRSTINDEX=2000&resourcetype=HWCIT

Delayed disease progression in ALS mice by treatment with a cannabinoid. (abst - 2004)

http://www.ncbi.nlm.nih.gov/pubmed/15204022?dopt=Abstract

Cannabis' Potential Exciting Researchers in Treatment of ALS, Parkinson's Disease -

URB597 (news - 2004)

http://www.illinoisnorml.org/index2.php?option=com_content&do_pdf=1&id=104

28

Cannabis Relieves Lou Gehrigs Symptoms - New Study (news - 2004)

http://www.rense.com/general51/lou.htm

Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival. (abst - 2005) http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1618356 0

Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice (full - 2006) http://www.fasebj.org/cgi/content/full/20/7/1003

AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16781706

The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819701/?tool=pmcentrez

The endocannabinoid system in targeting inflammatory neurodegenerative diseases
(full - 2007) http://medicalcannabis.com/images/pdf09/indications/neurodegenerative/centonze_et_al_2007_inflammato ry_neuro.pdf

Cannabinoids and neuroprotection in motor-related disorders. (abst - 2007)

http://www.ncbi.nlm.nih.gov/pubmed/18220777

The (Endo)Cannabinoid System in Multiple Sclerosis and Amyotrophic Lateral Sclerosis (abst – 2007) http://medical-journals.healia.com/...cannabinoid-system-in-multiple-sclerosis-and- amyotrophic-lateral-sclerosis

The endocannabinoid system in amyotrophic lateral sclerosis. (abst – 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18781981

Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18279310

Role of CB2 receptors in neuroprotective effects of cannabinoids. (abst - 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18291574

Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects (full - 2009)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768535/?tool=pmcentrez

Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750822/?tool=pmcentrez

29

Cannabinoids and neurodegenerative diseases. (abst - 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19839933

Cannabis and Amyotrophic Lateral Sclerosis: Hypothetical and Practical Applications, and a Call for Clinical Trials. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20439484

The endocannabinoid system in the inflammatory and neurodegenerative processes of multiple sclerosis and of amyotrophic lateral sclerosis. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20353778

Abnormal sensitivity of cannabinoid CB1 receptors in the striatum of mice with experimental amyotrophic lateral sclerosis. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19452308

The endocannabinoid system in gp120-mediated insults and HIV-associated dementia. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20353779

Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: a randomised, double-blind crossover trial. (abst – 2010) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=291

Marijuana May Extend Life Expectancy Of Lou Gehrig's Disease Patients, Study Says (news - 2010) http://www.norml.org/index.cfm?Group_ID=8191

ALZHEIMER'S DISEASE

Marijuana reduces memory impairment (news - no date)

http://www.healthnewstrack.com/health-news-811.html

Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. (abst - 1997) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=59

Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide. (abst – 2002) http://www.ncbi.nlm.nih.gov/pubmed/12384227

US Patent 6630507 - Cannabinoids as antioxidants and neuroprotectants (full - 2003)

http://www.patentstorm.us/patents/6630507.html

Cannabinoid CB2 Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains (full – 2003)

http://www.jneurosci.org/content/23/35/11136.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= cannabinoid&searchid=1&FIRSTINDEX=80&resourcetype=HWCIT

30
 
Pages 31 - 35

Safety and efficacy of Dronabinol in the treatment of agitation in patients with Alzheimer‘s disease with anorexia (abst - 2003) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=61

Open-label study of Dronabinol in the treatment of refractory agitation in Alzheimer‘s disease : a pilot study (abst - 2003) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=92

Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on β-amyloid-induced toxicity in PC12 cells (full - 2004) http://www3.interscience.wiley.com/cgi-bin/fulltext/118757302/HTMLSTART

Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. (full – 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266095/?tool=pubmed

Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation (full - 2005) http://www.jneuroinflammation.com/content/2/1/29

Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation (full - 2005) http://www.jneurosci.org/cgi/content/full/25/8/1904

Avoidance of Abeta[(25-35)] / (H(2)O(2)) -induced apoptosis in lymphocytes by the cannabinoid agonists CP55,940 and JWH-015 via receptor-independent and PI3K- dependent mechanisms: role of NF-kappaB and p53. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/17017986

Phosphorylated amyloid-beta: the toxic intermediate in alzheimer's disease neurodegeneration. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/15709490

Cannabinoid control of motor function at the basal ganglia.

http://www.ncbi.nlm.nih.gov/pubmed/16596785

Marijuana Ingredient May Stall Decline From Alzheimer's

http://www.sciencedaily.com/releases/2005/02/050224111638.htm

Marijuana Slows Alzheimer's Decline (news - 2005)

http://www.mapinc.org/drugnews/v05/n307/a10.html

Marijuana May Block Alzheimer's (news - 2005)

http://news.bbc.co.uk/2/hi/health/4286435.stm

Marijuana Ingredient May Help Alzheimer's (news - 2005)

(abst – 2005) (news - 2005)

http://www.webmd.com/alzheimers/news/20050223/marijuana-ingredient-may-help-alzheimers

Cannabinoids reduce the progression of Alzheimer's disease in animals (news - 2005)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=187#1

31

Pass the Doobie, pops (news - 2005)

http://www.thefreelibrary.com/Pass+the+doobie,+pops.-a0131273013

The Cannabinoid CB2 Receptor as a Target for Inflammation-Dependent Neurodegeneration (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435344/?tool=pmcentrez

A Molecular Link between the Active Component of Marijuana and Alzheimer‘s Disease Pathology (full - 2006) http://www.ukcia.org/research/AlzheimersDiseasePathology.pdf

Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia
(full - 2006) http://science.iowamedicalmarijuana.org/pdfs/neuro/Walther 2006.pdf

Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16732431

Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF- kappaB involvement. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16490313

The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16389547

CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16837132

Marijuana Compound Efficient Against Alzheimer's Disease
(news – 2006) http://news.softpedia.com/news/Marijuana-Compound-Efficient-against-Alzheimer-s-Disease-37410.shtml

THC inhibits primary marker of Alzheimer's disease (news - 2006)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=225#3

Marijuana's Active Ingredient May Slow Progression Of Alzheimer's Disease (news - 2006) http://www.sciencedaily.com/releases/2006/10/061009031544.htm

Marijuana may help stave off Alzheimer‘s (news - 2006)

http://www.msnbc.msn.com/id/15145917/

Marijuana May Slow Alzheimer's (news - 2006)

http://www.webmd.com/alzheimers/news/20061006/marijuana-may-slow-alzheimers

Pot-Like Compound May Slow Alzheimer's (news - 2006)

http://www.webmd.com/alzheimers/news/20061019/pot-like-compound-may-slow-alzheimers

32

Latest Buzz: Marijuana May Slow Progression Of Alzheimer's Disease (news - 2006)

http://www.sciencedaily.com/releases/2006/10/061018151055.htm

Alzheimer's disease; taking the edge off with cannabinoids? (full - 2007)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17828287

Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression (full - 2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2189818&tool=pmcentrez

Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. (full - 2007) http://jpet.aspetjournals.org/content/322/3/1144.long

Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation (full - 2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1852513&tool=pmcentrez

The endocannabinoid system in targeting inflammatory neurodegenerative diseases
(full - 2007) http://medicalcannabis.com/images/pdf09/indications/neurodegenerative/centonze_et_al_2007_inflammato ry_neuro.pdf

Cannabinoid CB2 receptors in human brain inflammation (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219537/

Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586121/?tool=pmcentrez

Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750822/?tool=pmcentrez

Inflammation and aging: can endocannabinoids help? (full - 2008)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2408719&tool=pmcentrez

Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids. (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579926/?tool=pubmed

Role of CB2 receptors in neuroprotective effects of cannabinoids. (abst - 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18291574

The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18781980

Scientists are High on Idea that Cannabis Reduces Memory Impairment (news - 2008)

http://www.physorg.com/news146320102.html

33

Israeli Research Shows Cannabidiol May Slow Alzheimer's Disease (news - 2008)

http://www.israelnationalnews.com/News/News.aspx/125564

Marijuana may be good for the aging brain (news - 2008)

http://www.news-medical.net/news/2008/11/19/43212.aspx

Alzheimer's sufferers may benefit from cannabis compound

http://www.news-medical.net/news/2008/03/11/36068.aspx

Cannabis 'could stop dementia in its tracks' (news - 2008)

(news - 2008)

http://www.dailymail.co.uk/health/article-1087544/Cannabis-stop-dementia-tracks.html

Could Marijuana Substance Help Prevent Or Delay Memory Impairment In The Aging Brain? (news - 2008) http://www.sciencedaily.com/releases/2008/11/081119120141.htm

Attacking Alzheimer's with Red Wine and Marijuana (news - 2008)

http://www.alternet.org/story/110806/

Can cannabis offer hope for Alzheimer's? (news - 2008)

http://findarticles.com/p/articles/mi_8002/is_2008_March_11/ai_n38819766/?tag=content;col1

Cannabis-derived medicines may help Alzheimer's (news - 2008)

http://www.news-medical.net/news/2008/03/10/36024.aspx

Pot joins the fight against Alzheimer's, memory loss (news - 2008)

http://www.scientificamerican.com/blog/60-second-science/post.cfm?id=pot-joins-the-fight-against- alzheim-2008-11-19

Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768535/?tool=pmcentrez

Cannabidiol: a promising drug for neurodegenerative disorders? (full - 2009)

http://onlinelibrary.wiley.com/doi/10.1111/j.1755-5949.2008.00065.x/full

The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages. (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19505450?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa nel.Pubmed_RVDocSum&ordinalpos=18

New neuron production can be increased in the hippocampus of aged rats following cannabinoid treatment (abst – 2009) http://www.scribd.com/doc/49274316/smokeWeedErryDay

Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011092/?tool=pubmed

Cannabinoids and Dementia: A Review of Clinical and Preclinical Data (full – 2010)

http://www.mdpi.com/1424-8247/3/8/2689/pdf

34

The development of cannabinoid CBII receptor agonists for the treatment of central neuropathies. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20236042/abstract/The_development_of_cannabin oid_CBII_receptor_agonists_for_the_treatment_of_central_neuropathies_

Endocannabinoids Prevent β-Amyloid-mediated Lysosomal Destabilization in Cultured Neurons (abst – 2010) http://www.jbc.org/content/285/49/38543.abstract

The endocannabinoid system in gp120-mediated insults and HIV-associated dementia. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20353779

The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20875047

Marijuana could prevent Alzheimer's (news - 2010)

http://www.thelantern.com/mobile/2.1345/marijuana-could-prevent-alzheimer-s-1.72932

Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers' disease (full – 2011) http://molpharm.aspetjournals.org/content/early/2011/02/24/mol.111.071290.long

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230631/?tool=pubmed

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21238581

An amyloid β(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21546126/abstract/An_amyloid_β_42__d ependent_deficit_in_anandamide_mobilization_is_associated_with_cognitive_dysfunction_in_Alzheimer% 27s_disease_

Molecular reorganization of endocannabinoid signalling in Alzheimer's disease.
(abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21459826/abstract/Molecular_reorganization_of_e ndocannabinoid_signalling_in_Alzheimer%27s_disease_

Palmitoylethanolamide counteracts reactive astrogliosis induced by beta-amyloid peptide. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21255263

The role of phytochemicals in the treatment and prevention of dementia. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21639405/abstract/The_role_of_phytochemicals_i n_the_treatment_and_prevention_of_dementia_

Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1(-/-) mice. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/20724033

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Pages 36 - 40

Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21034788

The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21331775

Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21256197/abstract/Endocannabinoid_2_arachidono ylglycerol_protects_neurons_against_%CE%B2_amyloid_insults_

New metabolic pathway for controlling brain inflammation (news – 2011)

http://www.news-medical.net/news/20111021/New-metabolic-pathway-for-controlling-brain- inflammation.aspx

Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by Aβ neurotoxicity. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22172925

Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22233683

Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. (abst – 2012 ) http://www.ncbi.nlm.nih.gov/pubmed/22233683

AM-251 – synthetic, GPR 55 agonist, CB1 antagonist/ inverse agonist

Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors (full - 2001) http://jpet.aspetjournals.org/content/299/3/951.full

Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats (full - 2002) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573379/?tool=pmcentrez

CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction (full - 2003) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573770/?tool=pmcentrez

Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery (full - 2003) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573773/?tool=pmcentrez

36

Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN (full - 2003) http://www.jleukbio.org/cgi/content/full/75/3/453?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT

Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats (full - 2004) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575196/?tool=pmcentrez

Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(_)-Methanandamide- Induced Apoptotic Death of Human Neuroglioma Cells (full - 2004) http://science.iowamedicalmarijuana.org/pdfs/cancer/Hinz 2004.pdf

The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis. (full - 2005) http://www.jstage.jst.go.jp/article/tjem/207/2/207_99/_article

Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus (abst – 2005) http://www.sciencedirect.com/science/article/pii/S0028390805001668

Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808496/?tool=pmcentrez

AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1615836/?tool=pmcentrez

Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861843/?tool=pmcentrez

Inhibition of Salivary Secretion by Activation of Cannabinoid Receptors (full - 2006)

http://ebm.rsmjournals.com/cgi/content/full/231/8/1421?maxtoshow=&hits=80&RESULTFORMAT=&full text=cannabinoid&searchid=1&FIRSTINDEX=880&resourcetype=HWCIT

Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor- independent mechanism. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16500647

Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190006/?tool=pmcentrez

CANNABINOID-INDUCED HYPERPHAGIA: CORRELATION WITH INHIBITION OF PROOPIOMELANOCORTIN NEURONS? (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720321/?tool=pmcentrez

Cannabinoid action in the olfactory epithelium (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1815290/?tool=pmcentrez

37

Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17870135

Cannabinoids Inhibit HIV-1 Gp120-Mediated Insults in Brain Microvascular Endothelial Cells (full - 2008) http://www.jimmunol.org/cgi/content/full/181/9/6406?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells (full - 2008) http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block

Loss of cannabinoid receptor 1 accelerates intestinal tumor growth (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561258/?tool=pubmed

Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697765/?tool=pmcentrez

Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats (full - 2008) http://www.jneurosci.org/cgi/content/full/28/39/9702?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabinoid&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

Feeding induced by cannabinoids is mediated independently of the melanocortin system. (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386290/?tool=pubmed

High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18615640

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697695/?tool=pubmed

Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660732/?tool=pmcentrez

Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739820/?tool=pubmed

Endocannabinoids prevent lysosomal membrane destabilisation evoked by treatment with β-amyloid in cultured rat cortical neurons (abst – 2009) http://www.physoc.org/custom2/publications/proceedings/archive/article.asp?ID=Proc Physiol Soc %2015C9

38

The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats. (full – 2009) http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02098.x/full

Cannabinoids and neurodegenerative diseases. (abst - 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19839933

Effects of the cannabinoid CB1 receptor antagonist AM 251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats. (full - 2009) http://www.if-pan.krakow.pl/pjp/pdf/2009/2_304.pdf

Regulation of the Hypothalamic-Pituitary-Adrenal Axis Circadian Rhythm by Endocannabinoids Is Sexually Diergic (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964781/?tool=pmcentrez

Cannabinoids excite circadian clock neurons. (full – 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927117/?tool=pubmed

Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898685/?tool=pubmed

Spinal and peripheral analgesic effects of the CB cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931557/?tool=pubmed

The Endocannabinoid System Tonically Regulates Inhibitory Transmission and Depresses the Effect of Ethanol in Central Amygdala (abst - 2010) http://www.nature.com/npp/journal/v35/n9/abs/npp201070a.html

Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19800340

Pharmacological characterization of GPR55, a putative cannabinoid receptor.
(abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20298715/abstract/Pharmacological_characterizati on_of_GPR55_a_putative_cannabinoid_receptor_

Cannabidiol (CBD) as an Anti-Arrhythmic – the Role of the CB1 Receptors
(news – 2010) http://cannabisclinicians.org/2011/...nti-arrhythmic-the-role-of-the-cb1-receptors/

AM251, cannabinoids receptors ligand, improves recognition memory in rats. (full – 2011) http://www.if-pan.krakow.pl/pjp/pdf/2011/3_670.pdf

Cannabinoids prevent the development of behavioral and endocrine alterations in a rat

model of intense stress. (full – 2011)

http://www.nature.com/npp/journal/v37/n2/full/npp2011204a.html

39

α-Tocopherol and α-tocopheryl phosphate interact with the cannabinoid system in the rodent hippocampus. (abst - 2011) http://www.ncbi.nlm.nih.gov/pubmed/21843633

Cannabidiol as an anti-arrhythmic, the role of the CB1 receptors. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/22116907/abstract/17_Cannabidiol_as_an_anti_arr hythmic_the_role_of_the_CB1_receptors_

CB(1) -independent mechanisms of Δ(9) -THCV, AM251 and SR141716 (rimonabant). (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21740450

Endocannabinoid CB1 receptors modulate visual output from the thalamus. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21773721

Cannabinoid Receptor Type 1 (CB1) Activation Inhibits Small GTPase RhoA Activity and Regulates Motility of Prostate Carcinoma Cells. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22087025

The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/20888328/abstract/The_effects_of_cannabinoid_dr ugs_on_abnormal_involuntary_movements_in_dyskinetic_and_non_dyskinetic_6_hydroxydopamine_lesio ned_rats_

Pot and Pumpkin Pie: Endocannabinoid System Enhanced by Vitamin E (news – 2011)

http://www.examiner.com/medical-marijuana-in-philadelphia/pot-and-pumpkin-pie-endocannabinoid- system-enhanced-by-vitamin-e

Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21937980

The cannabinoid receptor CB1 inverse agonist AM251 potentiates the anxiogenic activity of urocortin I in the basolateral amygdala. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21736884

AM- 281 - synthetic, CB1 antagonist and inverse agonist
Design and Synthesis of the CB1 Selective Cannabinoid Antagonist AM281: A Potential

Human SPECT Ligand (full – 1999) http://www.aapsj.org/view.asp?art=ps010204

Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal

carotid artery blood flow and mortality in septic shock in rats (full – 2005)

http://bja.oxfordjournals.org/content/94/5/563.full

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Pages 41 - 45

CARDIOVASCULAR Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality in septic shock in rats (abst – 2005) http://academic.research.microsoft.com/Paper/11905213

Effects of AM281, a cannabinoid antagonist, on circulatory deterioration and cytokine production in an endotoxin shock model: comparison with norepinephrine. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/17072693

Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype (full – 2010) http://ajpgi.physiology.org/content/299/1/G63.full?sid=fc6948f0-78cf-405c-981b-afaa05ee417c

Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930808/?tool=pubmed

AM-404 – synthetic, CB1 agonist

Synergistic Interactions between Cannabinoids and Environmental Stress in the Activation of the Central Amygdala (full - 2005) http://www.nature.com/npp/journal/v30/n3/full/1300535a.html

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear (full - 2005) http://www.nature.com/npp/journal/v30/n3/full/1300655a.html

Anxiolytic-like properties of the anandamide transport inhibitor AM404. (abst – 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16541083

Δ9-Tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189998/?tool=pmcentrez

Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21767554

The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats
(abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21557729/abstract/The_anandamide_transport_inh ibitor_AM404_reduces_the_rewarding_effects_of_nicotine_and_nicotine_induced_dopamine_elevations_i n_the_nucleus_accumbens_shell_in_rats_

41

The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats.
(abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21557729

AM-630 - synthetic, CB2 antagonist

Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN (full - 2003) http://www.jleukbio.org/cgi/content/full/75/3/453?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT

Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861843/?tool=pmcentrez

Inhibition of Salivary Secretion by Activation of Cannabinoid Receptors (full - 2006)

http://ebm.rsmjournals.com/cgi/content/full/231/8/1421?maxtoshow=&hits=80&RESULTFORMAT=&full text=cannabinoid&searchid=1&FIRSTINDEX=880&resourcetype=HWCIT

Regulation of Bone Mass, Osteoclast Function, and Ovariectomy-Induced Bone Loss by the Type 2 Cannabinoid Receptor (full - 2008) http://endo.endojournals.org/cgi/content/full/149/11/5619?maxtoshow=&hits=80&RESULTFORMAT=&f ulltext=cannabinoid&searchid=1&FIRSTINDEX=240&resourcetype=HWCIT

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells (full - 2008) http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block

Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688760/?tool=pubmed

A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands.
(abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19768813

Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930808/?tool=pubmed

Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(-/-) mice by

attenuating the activation of T cells and promoting their apoptosis. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/22119709

42

AM -678 - see JWH -100

AM-694 – synthetic, CB1 & CB2 agonist
Beyond THC: The New Generation of Cannabinoid Designer Drugs. (full – 2011)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187647/?tool=pubmed

The impact of changes in UK classification of the synthetic cannabinoid receptor agonists in 'Spice'. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21482092

AM-1241 - synthetic, CB 2 agonist

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS (full - 2003) http://www.pnas.org/content/100/18/10529.full

New Compound That Acts On Peripheral Receptors May Be Promising Treatment For Some Nerve Pain (news - 2003) http://www.sciencedaily.com/releases/2003/08/030812073750.htm

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids (full - 2005) http://www.pnas.org/content/102/8/3093.full

Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. (abst - 2005) http://www.ncbi.nlm.nih.gov/pubmed/16316653

In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor? (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013801/?tool=pubmed

AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16781706

The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819701/?tool=pmcentrez

Peripheral Cannabinoids Attenuate Carcinoma Induced Nociception in Mice (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771220/

43

Selective Activation of Cannabinoid CB2 Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats (full - 2008) http://jpet.aspetjournals.org/content/327/2/584.full#content-block

The endocannabinoid system in amyotrophic lateral sclerosis. (abst - 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18781981

Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis. (full - 2009) http://onlinelibrary.wiley.com/doi/10.1002/ibd.20960/full

Spinal and peripheral analgesic effects of the CB cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931557/?tool=pubmed

A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20176037

Cannabinoids attenuate cancer pain and proliferation in a mouse model. (abst - 2010)

http://www.ncbi.nlm.nih.gov/pubmed/21094209

Self-medication of a cannabinoid CB(2) agonist in an animal model of neuropathic pain. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21550725/abstract/Self_medication_of_a_cannabin oid_CB_2__agonist_in_an_animal_model_of_neuropathic_pain_

Regulation of hematopoietic stem cell trafficking and mobilization by the endocannabinoid system. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22074629

Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21063029

Antinociceptive effects induced through the stimulation of spinal cannabinoid type 2 receptors in chronically inflamed mice (abst - 2011) http://www.unboundmedicine.com/medline/ebm/record/21771590/abstract/Antinociceptive_effects_induce d_through_the_stimulation_of_spinal_cannabinoid_type_2_receptors_in_chronically_inflamed_mice_

AM-1346 - synthetic, CB1 agonist
Synthetic Cannabinoid May Aid Fertility In Smokers (news - 2006)

http://www.medicalnewstoday.com/articles/58063.php

Marijuana-like Chemical Can Restore Sperm Function Lost to Tobacco Abuse (news - 2006) http://www.rxpgnews.com/specialtopics/article_5093.shtml

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Cannabis-based boost for smokers' suffering sperm (news - 2006)

http://www.newscientist.com/article/dn10362-cannabisbased-boost-for-smokers-suffering-sperm.html

Scientist Discovers New Molecule to Treat Chronic Pain (news - 2008)

http://www.physorg.com/news137778721.html

AM-1710 – synthetic, CB2 agonist

Pharmacological characterization of AM1710, a putative cannabinoid CB(2) agonist from the cannabilactone class: Antinociception without central nervous system side-effects. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21382397/abstract/Pharmacological_characterizati on_of_AM1710_a_putative_cannabinoid_CB_2__agonist_from_the_cannabilactone_class:_Antinociceptio n_without_central_nervous_system_side_effects_

AM -2233 – synthetic, CB1 agonist

F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16438957

Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[125/131I]AM2233.
(abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16715483

Another nail in coffin of synthetic cannabis (news – 2011)

http://tvnz.co.nz/national-news/another-nail-in-coffin-synthetic-cannabis-4666168?ref=rss

AM- 4054 - synthetic, CB1 agonist

Behavioral Profile of the Novel Cannabinoid Agonist AM4054 (thesis - 2006)

http://digitalcommons.uconn.edu/cgi/viewcontent.cgi?article=1016&context=srhonors_theses&sei- redir=1#search=%22am-4054%20%2Bcannabinoid%22

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Effects of a Selective Cannabinoid Agonist and Antagonist on Body Temperature in Rats (abst - 2007) http://www.fasebj.org/cgi/content/meeting_abstract/21/5/A409?maxtoshow=&hits=80&RESULTFORMA T=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=800&resourcetype=HWCIT

AM- 4113 – synthetic, CB1 antagonist

Effects of a Selective Cannabinoid Agonist and Antagonist on Body Temperature in Rats (abst - 2007) http://www.fasebj.org/cgi/content/meeting_abstract/21/5/A409?maxtoshow=&hits=80&RESULTFORMA T=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=800&resourcetype=HWCIT

The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21056053

AM 6545 – synthetic, CB1 antagonist

Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes? (full – 2010) http://www.jci.org/articles/view/44...ext]=&search[article_text]=cannabinoid&search[a uthors_text]=&search[fpage]=&search[title_text]=&search[volume]=

AMOTIVATIONAL SYNDROME

Marihuana Use and Psychosocial Adaptation (abst - 1974)

http://archpsyc.ama- assn.org/cgi/content/abstract/31/5/713?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=marihuana& searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

Ganja in Jamaica (book – 1976) http://www.cifas.us/cannabis/PDFs/OCRGanjainJamaica.pdf

Operant acquisition of marihuana in man. (abst - 1976)

http://jpet.aspetjournals.org/content/198/1/42.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=marihuana&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

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Marihuana use. Biologic and behavioral aspects. (abst – 1976)

http://www.ncbi.nlm.nih.gov/pubmed/981073

Cannabis amotivational syndrome and personality trait absorption: A review and reconceptualization (full - 1994) http://www.ukcia.org/research/PersonalityTraitAbsorption.php

Debunking the Amotivational Syndrome (news - 1995)

http://www.drugscience.org/Petition/C3F.html

Lifetime Prevalence of "Amotivational Syndrome" (full – 2005)

http://www.addictioninfo.org/articles/262/1/Lifetime-Prevalence-of-Amotivational-Syndrome/Page1.html

Cannabis, motivation, and life satisfaction in an internet sample (full - 2006)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435998/?tool=pmcentrez

Debunking "Amotivational Syndrome" (news - 2006)

http://www.mapinc.org/drugnews/v06/n400/a06.html

Cannabis Use Not Linked To So-Called "Amotivational Syndrome"

http://norml.org/index.cfm?Group_ID=6824

ANANDAMIDE / AEA – endocannabinoid, CB 1 & 2 agonist

(news - 2006)

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor. (abst – 1992) http://medical-journals.healia.com/...-structure-of-a-brain-constituent-that-binds- to-the-cannabinoid-receptor

Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide. (full - 1993) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175863/?tool=pmcentrez&page=1

Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction (full - 1993) http://www.pnas.org/content/90/16/7656.full.pdf+html

Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes (full - 1994) http://www.pnas.org/content/91/14/6698.full.pdf+html

Formation and inactivation of endogenous cannabinoid anandamide in central neurons. (letter – 1994) http://www.nature.com/nature/journal/v372/n6507/abs/372686a0.html

Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization. (full – 1995) http://www.jbc.org/content/270/11/6030.long

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Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin (abst - 1995) http://ajpheart.physiology.org/cgi/content/abstract/269/6/H1859?maxtoshow=&hits=80&RESULTFORMA T=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=2320&resourcetype=HWCIT

Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. (full – 1997) http://www.jneurosci.org/content/17/4/1226.long

Cannabinoid-Induced Hypotension and Bradycardia in Rats Is Mediated by CB1-Like Cannabinoid Receptors (full - 1997) http://jpet.aspetjournals.org/content/281/3/1030.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext =cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT

Patent 5631297 - Anandamides useful for the treatment of intraocular hypertension, ophthalmic compositions containing the same and methods of use of the same
(full – 1997) http://www.patentstorm.us/patents/5631297/fulltext.html

Anandamide : The molecule of extreme pleasure (report– 1997)

http://www.chm.bris.ac.uk/motm/anandamide/ananh.htm
Brain Chemicals Mimic Marijuana (news - 1997) http://www.ukcia.org/research/anandami.php

Anandamide, an Endogenous Cannabinoid, Has a Very Low Physical Dependence Potential (full - 1998) http://jpet.aspetjournals.org/content/287/2/598.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= cannabinoid&searchid=1&FIRSTINDEX=480&resourcetype=HWCIT

The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation (full - 1998) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC20983/

Trick or treat from food endocannabinoids? (abst – 1998)

http://www.nature.com/nature/journal/v396/n6712/full/396636a0.html
Doped skin (news - 1998) http://www.newscientist.com/article/mg15921434.700-doped-skin.html

Pain modulation by release of the endogenous cannabinoid anandamide (full - 1999)

http://www.pnas.org/content/96/21/12198.full

Cannabis: Discrimination of "Internal Bliss"? (abst – 1999)

http://medical-journals.healia.com/doc/10515300/Cannabis-discrimination-of-internal-bliss

Brain Releases Marijuana-Like Substance In Response To Pain, Study Finds (news - 1999) http://www.sciencedaily.com/releases/1999/10/991013074947.htm

UC Irvine Researchers Demonstrate How Marijuana-Like Chemicals Work In The Brain (news - 1999) http://www.sciencedaily.com/releases/1999/03/990323050735.htm

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Why your brain is primed for a high (news - 1999)

http://www.newscientist.com/article/mg16121792.000-why-your-brain-is-primed-for-a-high.html

Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors (full - 2000)

http://www.jbc.org/content/275/41/31938.full

Endocannabinoids and Vascular Function (full - 2000)

http://jpet.aspetjournals.org/content/294/1/27.long

Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation (full - 2000) http://endo.endojournals.org/cgi/content/full/141/1/118

Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human (full - 2000) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571997/?tool=pmcentrez

Cardiovascular effects of endocannabinoids--the plot thickens. (abst - 2000)

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=10785543&dopt=abstrac tplus

Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice. (abst – 2000) http://www.ncbi.nlm.nih.gov/pubmed/10762668

Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets.
(full – 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC33480/?tool=pubmed

Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation (full - 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572987/?tool=pmcentrez

Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors (full - 2001) http://jpet.aspetjournals.org/content/299/3/951.full

Exogenous anandamide protects rat brain against acute neuronal injury in vivo. (full – 2001) http://www.jneurosci.org/content/21/22/8765.long

Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats (full - 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573067/?tool=pmcentrez

Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells (full - 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222054/pdf/11485574.pdf/?tool=pmcentrez

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Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries (full - 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573021/?tool=pmcentrez

Endogenous cannabinoids mediate hypotension after experimental myocardial infarction (full - 2001) http://content.onlinejacc.org/cgi/content/full/38/7/2048?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT

Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints (full - 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572613/?tool=pmcentrez

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase (full - 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC55427/?tool=pubmed

Leptin-regulated endocannabinoids are involved in maintaining food intake (letter – 2001) http://www.nature.com/nature/journal/v410/n6830/full/410822a0.html

Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of CB(1) and CB(2) receptors. (abst - 2001) http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=11427912&dopt=abstrac tplus

The Central Cannabinoid Receptor Inactivation Suppresses Endocrine Reproductive Functions. (abst – 2001) http://medical-journals.healia.com/doc/11394887/The-central-cannabinoid-receptor-inactivation- suppresses-endocrine-reproductive-functions

Quantification of anandamide content in animal cells and tissues: the normalization makes the difference (full - 2002) http://www.lipidworld.com/content/1/1/4

Sourcing the Code: Searching for the Evolutionary Origins of Cannabinoid Receptors, Vanilloid Receptors, and Anandamide (full – 2002) http://www.cannabis-med.org/data/pdf/2002-01-3.pdf

Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation (full – 2002) http://bloodjournal.hematologylibrary.org/content/100/12/4040.full

Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease (full - 2002) http://bloodjournal.hematologylibra...ll/100/2/627?ijkey=eb71d6d7a06f311440761cfac6 a7d081bcc2771d

A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding (full - 2002) http://www.jneurosci.org/cgi/content/abstract/22/21/9612?ijkey=328b5e83d7be9297b9483d22e0d6319fa0a 862e8&keytype2=tf_ipsecsha

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Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. (full – 2002) http://www.jneurosci.org/content/22/16/6900.long

Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism. (abst - 2002) http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=12428277&dopt=abstrac tplus

Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide. (abst – 2002) http://www.ncbi.nlm.nih.gov/pubmed/12384227

Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine. (abst – 2002) http://www.ncbi.nlm.nih.gov/pubmed/12393235

Role of Endogenous Cannabinoids in Synaptic Signaling (full - 2003)

http://physrev.physiology.org/cgi/content/full/83/3/1017?maxtoshow=&hits=80&RESULTFORMAT=&ful ltext=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon (full – 2003) http://ajpgi.physiology.org/content/286/1/G110.full?sid=fc6948f0-78cf-405c-981b-afaa05ee417c

CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction (full - 2003) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573770/?tool=pmcentrez

A new endothelial target for cannabinoids. (full -2003)

http://molpharm.aspetjournals.org/content/63/3/469.long

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis (full - 2003) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166293/

Endocannabinoids protect the rat isolated heart against ischaemia (full - 2003)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573907/?tool=pmcentrez
Cannabis and the brain. (full - 2003) http://brain.oxfordjournals.org/cgi/content/full/126/6/1252

Chronic Morphine Modulates the Contents of the Endocannabinoid, 2-Arachidonoyl Glycerol, in Rat Brain (full - 2003) http://www.nature.com/npp/journal/v28/n6/full/1300117a.html

Manipulation of the endocannabinoid system by a general anaesthetic. (full – 2003)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573927/?tool=pubmed

Cannabinoids inhibit neurodegeneration in models of multiple sclerosis (full - 2003)

http://brain.oxfordjournals.org/cgi/content/full/126/10/2191?ijkey=c7c6bfd158b85c98cb1a190d5ca261455 2989ba0

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Therapeutic potential of cannabinoids in CNS disease. (abst - 2003)

http://www.ncbi.nlm.nih.gov/pubmed/12617697

Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production. (abst - 2003) http://www.ncbi.nlm.nih.gov/pubmed/12746841?dopt=Abstract

Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/12948856

Therapeutic potential of cannabinoids in CNS disease. (abst - 2003)

http://www.ncbi.nlm.nih.gov/pubmed/12617697

Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/12447606

An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice. (abst - 2003) http://www.ncbi.nlm.nih.gov/pubmed/12949722

Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study. (abst - 2003) http://www.ncbi.nlm.nih.gov/pubmed/14746372?dopt=Abstract

The endocannabinoid system: a general view and latest additions (full - 2004)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574255/?tool=pmcentrez

Endocannabinoids: Getting the message across (full - 2004)

http://www.pnas.org/content/101/23/8512.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=can nabis&searchid=1&FIRSTINDEX=2880&resourcetype=HWCIT

Endocannabinoids and Their Implications for Epilepsy (full - 2004)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1176361&tool=pmcentrez

Anandamide Is Able to Inhibit Trigeminal Neurons Using an in Vivo Model of Trigeminovascular-Mediated Nociception (full - 2004) http://jpet.aspetjournals.org/content/309/1/56.full

The complexities of the cardiovascular actions of cannabinoids (full - 2004)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574918/?tool=pmcentrez

Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(_)-Methanandamide- Induced Apoptotic Death of Human Neuroglioma Cells (full - 2004) http://science.iowamedicalmarijuana.org/pdfs/cancer/Hinz 2004.pdf

Involvement of cannabinoid receptors in gut motility and visceral perception (full - 2004) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574910/?tool=pmcentrez

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Plasma Levels of the Endocannabinoid Anandamide in Women—A Potential Role in Pregnancy Maintenance and Labor? (full - 2004) http://jcem.endojournals.org/cgi/content/full/89/11/5482?ijkey=5e8ec5690352ba9f6b990355b2ed69b1d2e5 8a5b

Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1 (full - 2004) http://science.iowamedicalmarijuana.org/pdfs/cancer/Contassot 2004.pdf

A Cyclooxygenase Metabolite of Anandamide Causes Inhibition of Interleukin-2 Secretion in Murine Splenocytes (full – 2004) http://jpet.aspetjournals.org/content/311/2/683.full

Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. (abst - 2004) http://www.ncbi.nlm.nih.gov/pubmed/16574988

How our brains fend off madness, we produce a cannabis like substance

http://www.medicalnewstoday.com/releases/12516.php

Cardiovascular Pharmacology of Cannabinoids (full - 2005)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228270/?tool=pmcentrez

The cardiovascular actions of anandamide: more targets? (full - 2005)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576182/?tool=pmcentrez

(news – 2004)

Cannabinoids promote hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects (full - 2005) http://www.jci.org/cgi/content/full/115/11/3104

Antidepressant-like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis. (full – 2005) http://www.pnas.org/content/102/51/18620.long

Blood pressure regulation by endocannabinoids and their receptors (full - 2005)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225528/?tool=pmcentrez

The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2 (full - 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774787/?tool=pmcentrez

The effects of Δ9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide (full - 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576168/?tool=pmcentrez

Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia–reperfusion

by a novel cannabinoid mechanism (full - 2005)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751211/?tool=pmcentrez

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Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity (full - 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087161/?tool=pmcentrez

Antidepressant-like activity by blockade of anandamide hydrolysis (full - 2005)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16352709

Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa. (full – 2005) http://www.nature.com/npp/journal/v30/n6/full/1300695a.html

Analgesia through endogenous cannabinoids (full - 2005)

http://www.cmaj.ca/cgi/content/full/173/4/357?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=end ocannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=date&resourcetype=HW CIT

Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus (abst – 2005) http://www.sciencedirect.com/science/article/pii/S0028390805001668

Anandamide Induced Anti-Convulsion in an In Vitro Model of Epilepsy (abst - 2005)

http://www.kau.edu.sa/centers/spc/jkau/Doc/Med/12/Mada.pdf

Influence of Anandamide, the Endogenous Agonist of Cannabinoid Receptors on the Circulatory System (abst - 2005) http://medical-journals.healia.com/doc/15928605/Influence-of-anandamide-the-endogenous-agonist-of- cannabinoid-receptors-on-the-circulatory-system

Finding of endocannabinoids in human eye tissues: implications for glaucoma. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/15823551

A biosynthetic pathway for anandamide (full - 2006)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557387/

Activation of G-proteins in brain by endogenous and exogenous cannabinoids. (full – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16584117

Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and ß-Pancreatic Cells and in Obesity and Hyperglycemia (full - 2006) http://jcem.endojournals.org/cgi/content/full/91/8/3171?ijkey=83a68cef202eafe129332eda53eee8eb613499 82

Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P (full – 2006) http://gut.bmj.com/content/55/7/946.full

Endocannabinoids, feeding and suckling – from our perspective (full – 2006)

http://www.nature.com/ijo/journal/v30/n1s/full/0803274a.html

Stage-variations of anandamide hydrolase activity in the mouse uterus during the natural oestrus cycle ( full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440866/?tool=pubmed

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Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice (full - 2006) http://www.fasebj.org/cgi/content/full/20/7/1003

Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. (full – 2006) http://www.fasebj.org/content/early/2006/03/01/fj.05-4943fje.long

Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458883/?tool=pmcentrez

Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor- mediated excitotoxic damage (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751782/?tool=pmcentrez

Inhibition of Salivary Secretion by Activation of Cannabinoid Receptors (full - 2006)

http://ebm.rsmjournals.com/cgi/content/full/231/8/1421?maxtoshow=&hits=80&RESULTFORMAT=&full text=cannabinoid&searchid=1&FIRSTINDEX=880&resourcetype=HWCIT

Not Too Excited? Thank Your Endocannabinoids (full - 2006)

http://www.sciencedirect.com/science/article/pii/S0896627306005927

Effect of N-arachidonoyl-(2-methyl-4-hydroxyphenyl) amine (VDM11), an anandamide transporter inhibitor, on capsaicin-induced cough in mice (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448189/?tool=pmcentrez

Effects of general anesthesia on anandamide blood levels in humans. (full – 2006)

http://journals.lww.com/anesthesiology/Fulltext/2006/02000/Effects_of_General_Anesthesia_on_Anandam ide_Blood.12.aspx

Cannabinoids and the Endocannabinoid System (full - 2006)

http://www.cannabis-med.org/english/journal/en_2006_01_2.pdf

Is there a temperature-dependent uptake of anandamide into cells? ( full – 2006)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1629410/

A new strategy to block tumor growth by inhibiting endocannabinoid inactivation. (full – 2006) http://www.fasebj.org/content/early/2004/10/02/fj.04-1754fje.long

The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. (abst – 2006) www.ncbi.nlm.nih.gov/pubmed/16387640

Local interactions between anandamide, an endocannabinoid, and ibuprofen, a

nonsteroidal anti-inflammatory drug, in acute and inflammatory pain (abst - 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16480822

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Pages 56 - 60

Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16506408

Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome. (abst - 2006) http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=17369898&dopt=abstrac tplus

Anandamide inhibits adhesion and migration of breast cancer cells. (abst - 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16343481?dopt=Abstract

Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16899063

Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2- arachidonoylglycerol. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16949718

Anxiolytic-like properties of the anandamide transport inhibitor AM404. (abst – 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16541083

Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16732431

UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16006105

Metabolism of Anandamide an Endogenous Cannabinoid (chart – 2006)

http://pid.nci.nih.gov/search/pathway_landing.shtml?source=BioCarta Imported&what=graphic&jpg=o n&ppage=1&pathway_id=cb1rpathway

Anandamide Regulates Keratinocyte Differentiation by Inducing DNA Methylation in a CB1 Receptor-dependent Manner (full – 2007) http://www.jbc.org/content/283/10/6005.full

Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228252/?tool=pmcentrez

Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190014/?tool=pubmed

Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system

via CB2 receptors. (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083705/?tool=pubmed

56

Anandamide Regulates Keratinocyte Differentiation by Inducing DNA Methylation in a CB1 Receptor-dependent Manner (full – 2007) http://www.jbc.org/content/283/10/6005.full?sid=931583b1-e797-43e0-8296-7fd75bb49403#sec-4

Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB1 and TRPV1 receptors (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128772/?tool=pmcentrez

Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. (full – 2007) http://www.nature.com/npp/journal/v32/n11/full/1301376a.html

Identification of Endocannabinoids and Related Compounds in Human Fat Cells (full - 2007) http://www.nature.com/oby/journal/v15/n4/full/oby2007100a.html

Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190006/?tool=pmcentrez

Endocannabinoids and the haematological system (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190025/?tool=pmcentrez

Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190007/?tool=pubmed

The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis (full - 2007) http://www.jbc.org/content/282/33/23892.full

Chronologically overlapping occurrences of nicotine-induced anxiety- and depression- related behavioral symptoms: effects of anxiolytic and cannabinoid drugs (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075518/?tool=pubmed

Involvement of the Endocannabinoid System in Retinal Damage after High Intraocular Pressure–Induced Ischemia in Rats (full - 2007) http://www.iovs.org/cgi/content/full/48/7/2997?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=can nabis&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT

Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation (full – 2007) http://ajpgi.physiology.org/content/294/2/G506.full

Opposing Actions of Endocannabinoids on Cholangiocarcinoma Growth (full - 2007) http://www.jbc.org/content/282/17/13098.full

Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pál Pacher (interview - 2007) http://www.jleukbio.org/cgi/content/full/82/6/1390?maxtoshow=&hits=80&RESULTFORMAT=&fulltext =cannabinoid&searchid=1&FIRSTINDEX=880&resourcetype=HWCIT

57

Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor- suppressor efficacy. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17192847

The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17706636

Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients
(abst - 2007) http://www.unboundmedicine.com/medline/ebm/record/17566707/abstract/Anandamide_levels_in_cerebro spinal_fluid_of_first_episode_schizophrenic_patients:_Impact_of_cannabis_use

Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17511970

Marijuana-Like Brain Chemicals Work As Antidepressant (news - 2007)

http://www.sciencedaily.com/releases/2007/11/071105120556.htm

Role seen for cannabis in helping to alleviate allergic skin disease (news - 2007)

http://www.physorg.com/news106487623.html

CB1 Cannabinoid Receptor Inhibition: Promising Approach for Heart Failure? (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669829/?tool=pmcentrez

N-arachidonylethanolamide-Induced Increase in Aqueous Humor Outflow Facility (full - 2008) http://www.iovs.org/cgi/content/full/49/10/4528

Pharmacological Inhibition of CB1 Cannabinoid Receptor Protects Against Doxorubicin- Induced Cardiotoxicity (full - 2008) http://content.onlinejacc.org/cgi/content/full/50/6/528

Modulation of the Endocannabinoid System in Cardiovascular Disease (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568884/?tool=pmcentrez

Cannabinoid receptors and the regulation of bone mass (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219540/?tool=pmcentrez

Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697765/?tool=pmcentrez

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells (full - 2008) http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block

Ulcerative colitis in AKR mice is attenuated by intraperitoneally administered

anandamide. (full – 2008)

http://www.jpp.krakow.pl/journal/archive/12_08/pdf/673_12_08_article.pdf

58

Endocannabinoids and the Control of Energy Homeostasis (full – 2008)

http://www.jbc.org/content/283/48/33021.full?sid=931583b1-e797-43e0-8296-7fd75bb49403

The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604798/?tool=pmcentrez

The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. (full – 2008) http://erc.endocrinology-journals.org/cgi/content/full/15/4/965

Role of cannabinoids and endocannabinoids in cerebral ischemia (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581413/?tool=pmcentrez

Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet (full - 2008) http://www.nature.com/oby/journal/v16/n3/full/oby2007106a.html

Endocannabinoids and nutrition. (full – 2008)

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2826.2008.01687.x/pdf

Role of endocannabinoids and their analogues in obesity and eating disorders. (abst – 2008) http://www.ncbi.nlm.nih.gov/pubmed/19011363

Mechanisms for Recycling and Biosynthesis of Endogenous Cannabinoids Anandamide and 2-Arachidonylglycerol (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581634/?tool=pmcentrez

Inhibition of anandamide hydrolysis by URB597 reverses abuse-related behavioral and neurochemical effects of nicotine in rats. (abst – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663803/?tool=pubmed

The endocannabinoid system: emotion, learning and addiction. (abst - 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18422832

Anandamide and neutrophil function in patients with fibromyalgia. (abst - 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18395993

Understanding the effects of endogenous cannabinoids (news - 2008)

http://arstechnica.com/science/news/2008/11/understanding-the-effects-of-endogenous-cannabinoids.ars

Marijuana-Inspired Painkiller? New Chemical Pathway Discovered (news - 2008)

http://www.sciencedaily.com/releases/2008/11/081123150249.htm

Endocannabinoids and the Heart (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728560/?tool=pmcentrez

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664885/?tool=pmcentrez

(full - 2009)

59

Localisation and Function of the Endocannabinoid System in the Human Ovary (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640464/?tool=pmcentrez

Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791688/?tool=pmcentrez

Endogenous cannabinoids induce fever through the activation of CB1 receptors. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765314/?tool=pubmed

Biomarkers of Endocannabinoid System Activation in Severe Obesity (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808340/?tool=pubmed

Endocannabinoids and Their Receptors as Targets for Obesity Therapy (full - 2009)

http://endo.endojournals.org/cgi/content/full/150/6/2531#top

The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction. (full - 2009)

http://www.reproduction-online.org/cgi/content/full/137/3/403

Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739820/?tool=pubmed

The Endocannabinoid Anandamide: From Immunomodulation to Neuroprotection. Implications for Multiple Sclerosis (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19647114

Characterization of the Endocannabinoid System in Human Neuronal Cells and Proteomic Analysis of Anandamide-induced Apoptosis (full – 2009) http://www.jbc.org/content/284/43/29413.full

Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19659925

Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19394652

Circulating endocannabinoid concentrations during orthostatic stress (abst – 2009)

www.ncbi.nlm.nih.gov/pubmed/19756829

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19502530

Endocannabinoids prevent lysosomal membrane destabilisation evoked by treatment with β-amyloid in cultured rat cortical neurons (abst – 2009) http://www.physoc.org/custom2/publications/proceedings/archive/article.asp?ID=Proc Physiol Soc %2015C9

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Pages 61 - 65

A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19189054/abstract/A_metabolically_stable_analog ue_of_anandamide_Met_F_AEA_inhibits_human_thyroid_carcinoma_cell_lines_by_activation_of_apopto sis_

Is GPR55 an anandamide receptor? (abst - 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19647110

Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872061/?tool=pubmed

Cannabinoid Receptors as Target for Treatment of Osteoporosis: A Tale of Two Therapies (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001217/?tool=pubmed

Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871782/?tool=pubmed

Endogenous cannabinoid signaling is essential for stress adaptation

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889099/?tool=pmcentrez

Endocannabinoids and Schizophrenia (full – 2010)

http://www.mdpi.com/1424-8247/3/10/3101/pdf

(full - 2010)

Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients (full - 2010) http://www.lipidworld.com/content/9/1/43

The endocannabinoid system as a target for the treatment of neurodegenerative disease (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931550/?tool=pubmed

Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. (full – 2010) http://www.jneurosci.org/content/30/18/6273.long

Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227620/?tool=pubmed

The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. (abst, link to PDF - 2010) http://www.spandidos-publications.com/ijo/37/1/187

Effects of anandamide on polyamine levels and cell growth in human colon cancer cells (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20682986

61

Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19840245

Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. (abst – 2010)

http://www.unboundmedicine.com/medline/ebm/record/19847654/abstract/Non_CB1_non_CB2_receptors _for_endocannabinoids_plant_cannabinoids_and_synthetic_cannabimimetics:_focus_on_G_protein_couple d_receptors_and_transient_receptor_potential_channels_

The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20875047

Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders? (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20512266/abstract/[Pharmacological_exploitat ion_of_the_endocannabinoid_system:_new_perspectives_for_the_treatment_of_depression_and_anxiety_d isorders%5D_

Anandamide extends platelets survival through CB(1)-dependent Akt signaling. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19936621

Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20718749/abstract/Interaction_between_anandami de_and_sphingosine_1_phosphate_in_mediating_vasorelaxation_in_rat_coronary_artery_

Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19800340

Compound boosts marijuana-like chemical in the body to relieve pain at injury site (news - 2010) http://www.eurekalert.org/pub_releases/2010-09/uoc--cbm092010.php

Chocolate: The Good, the Bad and the Angry (news - 2010)

http://www.psychologytoday.com/blog/your-brain-food/201011/chocolate-the-good-the-bad-and-the-angry

Painkilling System in Brain: Too Much of a Good Thing? (news - 2010)

http://www.sciencedaily.com/releases/2010/08/100824151036.htm

Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. (full – 2011) http://www.jbc.org/content/early/2011/06/10/jbc.M110.202853.long

Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors. (full – 2011)
http://www.jneuroinflammation.com/content/pdf/1742-2094-8-102.pdf

62

Endocannabinoid system in cardiovascular disorders - new pharmacotherapeutic opportunities (full – 2011)

http://www.jpbsonline.org/article.asp?issn=0975- 7406;year=2011;volume=3;issue=3;spage=350;epage=360;aulast=Cunha

The endocannabinoid system and cancer: therapeutic implication (full – 2011)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01327.x/full

Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203169/?tool=pubmed

Anandamide-loaded nanoparticles: preparation and characterization. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21425945

Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver (abst – 2011) http://www.pnas.org/content/108/15/6323.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT

Cannabinoid applications in glaucoma. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21414525/abstract/Cannabinoid_applications_in_g laucoma_

An amyloid β(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21546126/abstract/An_amyloid_β_42__d ependent_deficit_in_anandamide_mobilization_is_associated_with_cognitive_dysfunction_in_Alzheimer% 27s_disease_

Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21432910/abstract/Arachidonoyl_ethanolamide__ AEA__induced_apoptosis_is_mediated_by_J_series_prostaglandins_and_is_enhanced_by_fatty_acid_ami de_hydrolase__FAAH__blockade_

Intracellular Cannabinoid Type 1 (CB1) Receptors Are Activated by Anandamide (abst – 2011) http://www.jbc.org/content/286/33/29166.abstract?sid=2c3b88ec-b6e6-4245-a171-2e24c17b5e8b

Inhibition of cannabinoid metabolic enzymes reduces NSAID-induced gastric pathology (abst – 2011) http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/807.1?maxtoshow=&hits=80& RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype =HWCIT

Abnormal anandamide metabolism in celiac disease. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/22209002

63

Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21767554

The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21449917/abstract/The_fatty_acid_amide_hydrolas e_inhibitor_URB_597:_interactions_with_anandamide_in_rhesus_monkeys_

Triphasic blood pressure responses to cannabinoids: do we understand the mechanism? (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22022923

Endocannabinoid CB1 receptors modulate visual output from the thalamus. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21773721

Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21995886

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21145341/abstract/Inhibition_of_endocannabinoid _catabolic_enzymes_elicits_anxiolytic_like_effects_in_the_marble_burying_assay_

The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats.
(abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21557729

Marijuana Compound Treats Multiple Health Issues (news – 2011)

http://www.foxnews.com/health/2010/03/10/cannabis-deficient/

Cannabinoid Receptor Type 1 (CB1) Activation Inhibits Small GTPase RhoA Activity and Regulates Motility of Prostate Carcinoma Cells. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22087025

Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21432910

Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22233683

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ANECDOTAL / PERSONAL STORIES

ANECDOTAL ARTICLES (anecdotal - no date)

http://cannabislink.ca/medical/#medanecdotal

ADHD by Ryan P (anecdotal - no date)

http://www.rxmarijuana.com/shared_comments/ADHD4.htm

Lyme Disease by Cynkay Morningstar (anecdotal – no date)

http://rxmarijuana.com/shared_comments/Lyme_Disease.htm

Menière‘s Syndrome by Charlie Ritchie (anecdotal - no date)

http://www.rxmarijuana.com/shared_comments/ritchie.htm

Chemotherapy for Testicular Cancer (anecdotal - no date)

http://www.rxmarihuana.com/shared_comments/testicularchemo.htm

Smoking dope restored my sight (news/anecdotal - 1998)

http://news.bbc.co.uk/2/hi/health/212301.stm

Recipe For Trouble (news/anecdotal - 2002)

http://www.cbsnews.com/stories/2002/03/05/48hours/main503022.shtml

'How cannabis helped me' (news/anecdotal - 2003)

http://news.bbc.co.uk/2/hi/health/3248701.stm

Skin Complaint Man Grew Cannabis (news/ anecdotal- 2004)

http://www.mapinc.org/drugnews/v04.n1222.a09.html

Testimony of Mr. Rene Carlos Guevara to FDA (anecdotal - 2005)

http://www.fda.gov/ohrms/dockets/dockets/05n0479/05N-0479-EC4.htm

Testimony of Terry Jacobs to FDA - why he prefers for medical marijuana to Marinol (news/anecdotal - 2005) http://www.examiner.com/examiner/x-19678-Cannabis-Revolution-Examiner~y2009m11d5-Testimony-of- Terry-Jacobs-to-FDA--why-he-prefers-for-medical-marijuana-to-Marinol

Marijuna Cured My Color-Blindness (anecdotal – 2005)

http://mmj.tribe.net/thread/ae2e9a56-f117-4e96-b24d-ae799e956b00

Cannabis Sativa (Marijuana) for Fibromyalgia (anecdotal - 2007 - 2010)

http://www.fibromyalgia-reviews.com/Drg_Marijuana.cfm

Shared Comments and Observations (anecdotal - 2009)

http://www.rxmarihuana.com/comments_and_observations.htm

Why I Give My 9-year-old Pot (news/ anecdotal - 2009)

http://www.doublex.com/section/health-science/why-i-give-my-9-year-old-pot

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Pages 66 - 70

Why I Give My 9-Year-Old Pot, Part II (news/anecdotal - 2009)

http://www.doublex.com/section/health-science/why-i-give-my-9-year-old-pot-part-ii

Julie Falco brings hope to Multiple Sclerosis patients. Cannabinoids manage pain and promote repair! (news - 2010) http://www.examiner.com/x-19678-Cannabis-Revolution-Examiner~y2010m2d10-Julie-Falco-brings-hope- to-Multiple-Sclerosis-patients-Cannabinoids-manage-pain-and-promote-repair

The Cannabis Closet: Severe Eczema (anecdotal - 2010)

http://andrewsullivan.theatlantic.com/the_daily_dish/2010/05/the-cannabis-closet-severe-eczema.html

Cannabis and PTSD by Michael McKenna (anecdotal - 2010)

http://marijuana-uses.com/cannabis-and-ptsd-by-michael-mckenna/

Steamboat mom sees results from giving autistic son medical marijuana (anecdotal/news - 2010) http://www.steamboatpilot.com/news/2010/oct/31/steamboat-mom-sees-results-giving-autistic-son-med/

Up in smoke: 'Cannabis gave me my life back' (anecdotal – 2010)

http://www.independent.co.uk/life-s...ies/features/up-in-smoke-cannabis-gave-me-my- life-back-2041640.html

Why I Give My 9-Year-Old Pot, Part 3 (news - 2010) http://www.slate.com/id/2251174/ Why I Give My Autistic Son Pot, Part 4 (news – 2011)

http://www.slate.com/id/2294072/?from=rss

Father: Medical marijuana eased pain of my cancer-battling son (anecdotal – 2011)

http://www.komonews.com/news/local/120941429.html

ANOREXIA NERVOSA - also see ―APPETITE STIMULANT‖
Leptin-regulated endocannabinoids are involved in maintaining food intake

(letter – 2001) http://www.nature.com/nature/journal/v410/n6830/full/410822a0.html

Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: differences between restricting and binging/purging subtypes. (abst – 2004) http://www.ncbi.nlm.nih.gov/pubmed/14755457

Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa. (full – 2005) http://www.nature.com/npp/journal/v30/n6/full/1300695a.html

Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects (full – 2008) http://gut.bmj.com/content/57/8/1140.full

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Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa (full - 2008) http://www.capmh.com/content/2/1/33

Role of endocannabinoids and their analogues in obesity and eating disorders. (abst – 2008) http://www.ncbi.nlm.nih.gov/pubmed/19011363

Elevated cannabinoid 1 receptor mRNA is linked to eating disorder related behavior and attitudes in females with eating disorders. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19046818

Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19659925

Activity-based anorexia in C57/BL6 mice: effects of the phytocannabinoid, Delta9- tetrahydrocannabinol (THC) and the anandamide analogue, OMDM-2. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20471226

Molecular mechanisms underlying anorexia nervosa: focus on human gene association studies and systems controlling food intake. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19931559

A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands.
(abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19768813

The genetics of eating disorders. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21243475

Brain Type 1 Cannabinoid Receptor Availability in Patients with Anorexia and Bulimia Nervosa. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21718968

Functional polymorphism in the GPR55 gene is associated with anorexia nervosa. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/20506567

The cannabinoid receptor agonist THC attenuates weight loss in a rodent model of activity-based anorexia. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21412227

Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21109417

Do Deficits in Brain Cannabinoids Contribute to Eating Disorders? (news – 2011) http://www.sciencedaily.com/releases/2011/10/111031115226.htm

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ANTI-BACTERIAL PROPERTIES

HEMP AS A MEDICAMENT : Methods and results of the bacteriological experiments (full - 1955) https://www.greenpassion.org/index.php?/topic/23448-methods-and-results-of-the-bacteriological- experiments/

Antibacterial preparation from hemp (Cannabis sativa) (abst - 1958)

http://chemport.cas.org/cgi- bin/sdcgi?APP=ftslink&action=reflink&origin=ACS&version=1.0&coi=1%3ACAS%3A528%3ADyaG1c XpvVGiug%253D%253D&md5=36fcabac61432cf5e852c26c9bba3cd1

Hemp (Cannabis sativa)-an antibiotic drug. II. Methods and results of bacteriological investigations and preliminary clinical experiences (abst - 1958) http://chemport.cas.org/cgi- bin/sdcgi?APP=ftslink&action=reflink&origin=ACS&version=1.0&coi=1%3ACAS%3A528%3ADyaG1c Xotl2guw%253D%253D&md5=a36c74726c1c02d8a52d1f297d624fc6

Effect of Biogenic Amines and Cannabinoids on Bacterial Chemotaxis (full - 1973)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC246374/?page=1

Antibacterial activity of delta9-tetrahydrocannabinol and cannabidiol. (abst - 1976)

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=1085130&dopt=abstract plus

Biological activity of cannabichromene, its homologs and isomers. (abst - 1981)

http://www.ncbi.nlm.nih.gov/pubmed/7298870

Antiinflammatory and antimicrobial compounds and compositions
United States Patent 4837228 (full - 1989) http://www.freepatentsonline.com/4837228.html

Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.

http://www.cannabisasmedicine.com/story/antibacterial-cannabinoids-cannabis-sativa- structure%E2%88%92activity-study

Cannabinoids kill hospital superbug MRSA (news – 2008)

http://www.worldhealth.net/news/cannabinoids_kill_hospital_superbug_mrsa/

Pot is good for you? Marijuana fights the superbugs (news - 2008)

(full - 2008)

http://www.scientificamerican.com/b...ost.cfm?id=whoa-the-stuff-in-pot-kills-germs- 2008-08-27&sc=rss

Killing bacteria with cannabis (news - 2008)

http://arstechnica.com/journals/science.ars/2008/08/26/killing-bacteria-with-cannabis

New biologically active compounds from cannabis (news - 2008)

http://arstechnica.com/science/news/2009/04/new-biologically-active-compounds-from-cannabis.ars

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A New MRSA Defense (news - 2008)

http://www.technologyreview.com/biomedicine/21366/?a=f

Chemicals in Marijuana May Fight MRSA (news - 2008)

http://www.webmd.com/news/20080904/marijuana-chemicals-may-fight-mrsa

Biologically Active Cannabinoids from High-Potency Cannabis sativa. (abst - 2009)

http://www.unboundmedicine.com/medline/ebm/record/19344127/abstract/Biologically_Active_Cannabino ids_from_High_Potency_Cannabis_sativa_

Characterization and antimicrobial activity of essential oils of industrial hemp varieties (Cannabis sativa L.). (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19969046

Natural plant cannabinoids reduce multi-drug resistant infections (news - 2009)

http://www.news-medical.net/news/2009/04/23/48757.aspx

Cannabis Compounds Reduce Multi-Drug Resistant Infections (news - 2009)

http://www.medicalnewstoday.com/articles/147523.php

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. (abst - 2011) http://www.ncbi.nlm.nih.gov/pubmed/21749363

ANTI-FUNGAL PROPERTIES

Biologically Active Cannabinoids from High-Potency Cannabis sativa.
(abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19344127/abstract/Biologically_Active_Cannabino ids_from_High_Potency_Cannabis_sativa_

ANTI-INFLAMMATORY PROPERTIES

Biological activity of cannabichromene, its homologs and isomers. (abst - 1981)

http://www.ncbi.nlm.nih.gov/pubmed/7298870

Analgesic and antiinflammatory activity of constituents of Cannabis sativa L. (full - 1988) http://www.ukcia.org/research/AnalgesicAndAntiInflammatoryActivityofConstituents.html

Antiinflammatory and antimicrobial compounds and compositions
United States Patent 4837228 (full - 1989) http://www.freepatentsonline.com/4837228.html

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1′,1′-Dimethylheptyl-Δ-8-tetrahydrocannabinol-11-oic Acid: A Novel, Orally Effective Cannabinoid with Analgesic and Anti-inflammatory Properties (full - 1999) http://jpet.aspetjournals.org/content/291/1/31.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= marihuana&searchid=1&FIRSTINDEX=1840&resourcetype=HWCIT

Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat (full - 2002) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1573125&tool=pmcentrez

Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model. (abst - 2003) http://www.ncbi.nlm.nih.gov/pubmed/14644587

New perspectives in the studies on endocannabinoid and cannabis: 2- arachidonoylglycerol as a possible novel mediator of inflammation http://www.jstage.jst.go.jp/article/jphs/96/4/367/_pdf

Cannabinoids and neuroinflammation (full - 2004)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574256/?tool=pmcentrez

(full - 2004)

Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. (full - 2004) http://ajpgi.physiology.org/cgi/content/full/287/1/G7

A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis. (full - 2004) http://onlinelibrary.wiley.com/doi/10.1002/art.20050/full

The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues. (full – 2005) http://www.jstage.jst.go.jp/article/jphs/98/1/77/_pdf

Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation (full - 2005) http://www.jneuroinflammation.com/content/2/1/29

Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials (full - 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751505/?tool=pubmed

Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease. (abst - 2005) http://www.ncbi.nlm.nih.gov/pubmed/15837565?dopt=Abstract

Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/16103691

Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the

Management of Acute and Chronic Pain Episodes (full - 2006)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430692/?tool=pubmed

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Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2- Arachidonoylglycerol in Oxazolone-Induced Contact Dermatitis in Mice (full – 2006) http://www.jimmunol.org/content/177/12/8796.full

The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. (abst – 2006) www.ncbi.nlm.nih.gov/pubmed/16387640

Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pál Pacher (interview - 2007) http://www.jleukbio.org/cgi/content/full/82/6/1390?maxtoshow=&hits=80&RESULTFORMAT=&fulltext =cannabinoid&searchid=1&FIRSTINDEX=880&resourcetype=HWCIT

Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
(full - 2007) http://www.jleukbio.org/cgi/content/full/82/6/1382

Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression (Alzheimer's) (full - 2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2189818&tool=pmcentrez

Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. (full - 2007) http://jpet.aspetjournals.org/content/322/3/1144.long

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro (full - 2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2189767&tool=pmcentrez

Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation (full - 2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1852513&tool=pmcentrez

Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis (full - 2007) http://www.jleukbio.org/cgi/reprint/82/3/532?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=canna binoid&searchid=1&FIRSTINDEX=240&resourcetype=HWCIT

Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190014/?tool=pubmed

The endocannabinoid system in targeting inflammatory neurodegenerative diseases
(full - 2007) http://medicalcannabis.com/images/pdf09/indications/neurodegenerative/centonze_et_al_2007_inflammato ry_neuro.pdf

Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and

neuropathic pain (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219541/?tool=pmcentrez

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Cannabinoids and neuroprotection in motor-related disorders. (abst - 2007)

http://www.ncbi.nlm.nih.gov/pubmed/18220777

Cannabinoids for the treatment of inflammation. (abst - 2007)

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=17520866&dopt=abstrac tplus

A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/12749972

Constituents Of Hashish And Marijuana May Help To Fight Inflammation And Allergies (news - 2007) http://www.sciencedaily.com/releases/2007/06/070607171120.htm

Pot Chemical May Curb Inflammation (news – 2007)

http://www.webmd.com/allergies/news/20070607/pot-chemical-may-curb-inflammation

Endocannabinoids appear to play important role in regulating inflammation (news - 2007) http://www.news-medical.net/news/2007/06/08/26114.aspx

Marijuana Skin Cream? (news - 2007)

http://www.jointogether.org/news/research/summaries/2007/marijuana-skin-cream.html

Anti-inflammatory cannabinoids in diet (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633791/?tool=pmcentrez

Cannabinoid receptors in acute and chronic complications of atherosclerosis (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219535/?tool=pmcentrez

Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats. (full -2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586121/?tool=pubmed

Inflammation and aging: can endocannabinoids help? (full - 2008)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2408719&tool=pmcentrez

Cannabinoid CB2 receptors in human brain inflammation (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219537/

Cannabinoid Modulation of Cutaneous A{delta} Nociceptors During Inflammation (full - 2008) http://jn.physiology.org/cgi/reprint/100/5/2794

Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation. (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585399/?tool=pubmed

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.
(abst - 2008) http://www.unboundmedicine.com/medline/ebm/record/18844286/abstract/Cannabidiol_in_medicine:_a_re view_of_its_therapeutic_potential_in_CNS_disorders_

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Scientists are High on Idea that Cannabis Reduces Memory Impairment (news - 2008)

http://www.physorg.com/news146320102.html

Why Cannabis Stems Inflammation (news - 2008)

http://www.sciencedaily.com/releases/2008/07/080720222549.htm

Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects (full - 2009)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768535/?tool=pmcentrez

Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688760/?tool=pubmed

Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells (full – 2009) http://www.jbc.org/content/285/3/1616.full?sid=43211ca4-a4aa-4182-a554-d15e2835e288

Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4 (full - 2009) http://www.fasebj.org/cgi/content/full/23/5/1503?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=c annabis&searchid=1&FIRSTINDEX=2400&resourcetype=HWCIT

Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750822/?tool=pmcentrez

Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682269/

Cannabinoids as novel anti-inflammatory drugs. (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/?tool=pubmed

The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function (full – 2009) http://content.karger.com/produktedb/produkte.asp?DOI=000201556&typ=pdf

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation
(full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664885/?tool=pmcentrez

Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro- inflammatory cytokines during experimental periodontitis in rats. (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19070683

Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19385063

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How Hemp Seed Oil Can Help Your Arthritis (news – 2009)

http://www.thefreelibrary.com/How+Hemp+Seed+Oil+Can+Help+Your+Arthritis-a01074002477

Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005548/?tool=pubmed

Cannabinoids and Viral Infections (full - 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903762/?tool=pmcentrez

US Patent Application 20100222437 - COMPOSITION CONTAINING NON- PSYCHOTROPIC CANNABINOIDS FOR THE TREATMENT OF INFLAMMATORY DISEASES (full – 2010) http://www.patentstorm.us/applications/20100222437/fulltext.html

The endocannabinoid system as a target for the treatment of neurodegenerative disease (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931550/?tool=pubmed

The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931570/?tool=pubmed

Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20590615

Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation (abst - 2010) http://www.nature.com/npp/journal/vaop/ncurrent/full/npp2010214a.html

WIN55212-2 ameliorates atherosclerosis associated with suppression of pro- inflammatory responses in ApoE-knockout mice. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20868672

Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: Role of CB(1)/CB(2) receptors. (abst - 2010) http://www.unboundmedicine.com/medline/ebm/record/21056512/abstract/Beneficial_effects_of_cannabin oids__CB__in_a_murine_model_of_allergen_induced_airway_inflammation:_Role_of_CB_1_/CB_2__rec eptors_

Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19931394

Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in

the mouse brain: an intravital microscopy study (full – 2011)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034694/?tool=pmcentrez

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Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230631/?tool=pubmed

Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa (full – 2011) http://www.jstage.jst.go.jp/article/bpb/34/5/774/_pdf

Gut feelings about the endocannabinoid system (full – 2011)

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2011.01689.x/full

Local activation of cannabinoid CB1 receptors in the urinary bladder reduces the inflammation-induced sensitization of bladder afferents. (full – 2011) http://www.molecularpain.com/content/pdf/1744-8069-7-31.pdf

The Antinociceptive Effects of JWH-015 in Chronic Inflammatory Pain Are Produced by Nitric Oxide-cGMP-PKG-KATP Pathway Activation Mediated by Opioids. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198780/?tool=pubmed

Cannabinoids and Innate Immunity: Taking a Toll on Neuroinflammation (abst- with link to full – 2011) http://www.tswj.com/2011/230786/abs/

Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21551239/abstract/Increasing_endogenous_2_arac` hidonoylglycerol_levels_counteracts_colitis_and_related_systemic_inflammation_

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21238581

GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils.
(abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21467997/abstract/GPR55_regulates_cannabinoid_ 2_receptor_mediated_responses_in_human_neutrophils_

Immunomodulatory properties of kappa opioids and synthetic cannabinoids in HIV-1 neuropathogenesis. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21850403

Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and cell death (abst – 2011) http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/639.12?maxtoshow=&hits=80 &RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=160&sortspec=date&resourcet ype=HWCIT

Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ(9) -tetrahydrocannabinol in BV-2 microglial cells (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21542829/abstract/Differential_transcriptional_pro files_mediated_by_exposure_to_the_cannabinoids_cannabidiol_and_%CE%94_9___tetrahydrocannabinol _in_BV_2_microglial_cells_

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Pages 76 - 80

Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21362471/abstract/Cannabidiol_protects_against_h epatic_ischemia/reperfusion_injury_by_attenuating_inflammatory_signaling_and_response_oxidative/nitra tive_stress_and_cell_death_

Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21873455

A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21492165/abstract/A_synthetic_cannabinoid_CP55 940_inhibits_lipopolysaccharide_induced_cytokine_mRNA_expression_in_a_cannabinoid_receptor_indep endent_mechanism_in_rat_cerebellar_granule_cells_

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21175579/abstract/Effects_of_cannabinoids_and_c annabinoid_enriched_Cannabis_extracts_on_TRP_channels_and_endocannabinoid_metabolic_enzymes_

New metabolic pathway for controlling brain inflammation (news – 2011)

http://www.news-medical.net/news/20111021/New-metabolic-pathway-for-controlling-brain- inflammation.aspx

ANTIMICROBIAL PROPERTIES

Susceptibility of Naegleria fowleri to delta 9-tetrahydrocannabinol. (full - 1979)

http://aac.asm.org/cgi/reprint/16/5/674?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=marihuana &searchid=1&FIRSTINDEX=1040&resourcetype=HWCIT

The trypanocidal effect of Cannabis sativa constituents in experimental animal trypanosomiasis. (African Sleeping Sickness) (abst – 1994) http://www.ncbi.nlm.nih.gov/pubmed/7900270

The effect of fibre hemp (Cannabis sativa L.) on selected soil-borne pathogens (full – 1994) http://druglibrary.org/olsen/hemp/IHA/iha01103.html

Endocannabinoids Inhibit the Growth of Free-Living Amoebae (full – 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897284/?tool=pubmed

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ANTIOXIDANT PROPERTIES

Biological screening of 100 plant extracts for cosmetic use (II): anti-oxidative activity and free radical scavenging activity. (abst - 1997) http://www.unboundmedicine.com/medline/ebm/record/18505484/abstract/Biological_screening_of_100_p lant_extracts_for_cosmetic_use__II_:_anti_oxidative_activity_and_free_radical_scavenging_activity_

Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
(full - 1998) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=20965&tool=pmcentrez

Cannabinoid Antioxidant Protects Brain Cells -- Without the High (news – 1998)

http://hempworld.com/HempPharm/articles/medicalm05.html

Cannabinoids protect cells from oxidative cell death: a receptor-independent mechanism. (full - 2000) http://jpet.aspetjournals.org/content/293/3/807.full

Neuroprotective Antioxidants from Marijuana (abst – 2000)

http://onlinelibrary.wiley.com/doi/10.1111/j.1749- 6632.2000.tb06193.x/abstract;jsessionid=2FC02E954345A713B5843BEE89616F4F.d02t01

US Patent 6630507 - Cannabinoids as antioxidants and neuroprotectants (full - 2003)

http://www.patentstorm.us/patents/6630507.html

Synergistic Interactions between Cannabinoids and Environmental Stress in the Activation of the Central Amygdala (full - 2005) \http://www.nature.com/npp/journal/v30/n3/full/1300535a.html

Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death (full - 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1824211/?tool=pmcentrez

Comparison of Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol- Induced Neurotoxicity (full - 2005) http://jpet.aspetjournals.org/content/314/2/780.full

In vivo effects of CB1 receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain of healthy and ethanol-treated rats. (full – 2006) http://www.if-pan.krakow.pl/pjp/pdf/2006/6_876.pdf

Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. (abst - 2007) http://www.ncbi.nlm.nih.gov/pubmed/17196181

Repeated Treatment with Cannabidiol but Not Delta9-tetrahydrocannabinol Has a Neuroprotective Effect Without the Development of Tolerance (abst - 2007) http://medical-journals.healia.com/doc/17320118/Repeated-treatment-with-cannabidiol-but-not-Delta9- tetrahydrocannabinol-has-a-neuroprotective-effect-without-the-development-of-tolerance

Cannabinoids and neuroprotection in motor-related disorders. (abst - 2007)

http://www.ncbi.nlm.nih.gov/pubmed/18220777

77

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.
(abst - 2008) http://www.unboundmedicine.com/medline/ebm/record/18844286/abstract/Cannabidiol_in_medicine:_a_re view_of_its_therapeutic_potential_in_CNS_disorders_

The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18781980

Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682269/

Effect of (-)-Delta(9)-tetrahydrocannabinoid on the hepatic redox state of mice. (full – 2010)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100- 879X2010007500015&lng=en&nrm=iso&tlng=en

Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20590615

Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034694/?tool=pmcentrez

ANXIOLYTIC EFFECTS (anxiety reducing)
How Cannabis Compares to other treatments (no date - 2008)

http://dcsafeaccess.org/medical/how-cannabis-compares-to-other-treatments/

Sedative activity of cannabis in relation to its delta'-trans-tetrahydrocannabinol and cannabidiol content. (full - 1981) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2071638/?tool=pmcentrez

The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety (abst - 1981)
http://www.cannabis- med.org/studies/ww_en_db_study_show.php?s_id=229&&search_pattern=ANXIOLYTIC.

Single-dose study of nabilone in anxious volunteers. (abst - 1981)

http://www.cannabis- med.org/studies/ww_en_db_study_show.php?s_id=236&&search_pattern=blood,pressure

78

Antianxiety effect of cannabidiol in the elevated plus-maze. (abst – 1990)

http://www.ncbi.nlm.nih.gov/pubmed/1969666

Anxiety with Depression Research Review (full - 2000)

http://www.ukcia.org/research/AnxietyWithDepressionResearchReview.pdf

Therapeutic aspects of cannabis and cannabinoids. (full - 2001)

http://bjp.rcpsych.org/cgi/content/full/178/2/107

Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters. (abst - 2001) http://www.ncbi.nlm.nih.gov/pubmed/11566149

Marijuana's Distant Relative May Be The Next Prozac; Chemical Reduces Anxiety Using Novel Nerve System In Body (news - 2002) http://www.sciencedaily.com/releases/2002/12/021202071928.htm

Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice (abst – 2004)
http://onlinelibrary.wiley.com/doi/10.1111/j.1460- 9568.2004.03293.x/abstract;jsessionid=15C92BB3498FAF0EE40394675E8B1800.d01t01

Marijuana Eyed for Treatment of Anxiety Disorders (news - 2004)

http://www.drugfree.org/join-together/drugs/marijuana-eyed-for-treatment

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects (full - 2005) http://www.jci.org/cgi/content/full/115/11/3104

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear (full - 2005) http://www.nature.com/npp/journal/v30/n3/full/1300655a.html

Cannabidiol as an antipsychotic. A double-blind, controlled clinical trial on cannabidiol vs. amisulpride in acute schizophrenia. (abst - 2005) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=171

High-dose cannabis stimulates growth of brain cells in rats (news – 2005)

http://www.independent.co.uk/life-s...ies/health-news/highdose-cannabis-stimulates- growth-of-brain-cells-in-rats-510869.html

Marijuana might cause new cell growth in the brain (news – 2005)

http://www.newscientist.com/article/dn8155

Endocannabinoids -- The Brain's Cannabis -- Demonstrate Novel Modes Of Action To Stress (news - 2005) http://www.sciencedaily.com/releases/2005/07/050720065810.htm

Cannabinoid CB1 Receptor Mediates Fear Extinction via Habituation-Like Processes (full - 2006) http://www.jneurosci.org/cgi/content/full/26/25/6677?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabinoid&searchid=1&FIRSTINDEX=400&resourcetype=HWCIT

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Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia (full - 2006)

http://science.iowamedicalmarijuana.org/pdfs/neuro/Walther 2006.pdf

Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug (full - 2006)

http://www.scielo.br/scielo.php?pid=S0100-879X2006000400001&script=sci_arttext#Text

Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test. (abst – 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16876926

Anxiolytic-like properties of the anandamide transport inhibitor AM404. (abst – 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16541083

Chronologically overlapping occurrences of nicotine-induced anxiety- and depression- related behavioral symptoms: effects of anxiolytic and cannabinoid drugs (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075518/?tool=pubmed

Modulation of Fear and Anxiety by the Endogenous Cannabinoid System (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789283/?tool=pmcentrez

Cannabinoid Modulation of Amygdala Reactivity to Social Signals of Threat in Humans (full - 2008) http://www.jneurosci.org/cgi/content/full/28/10/2313?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabinoid&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

The association between anxiety and alcohol versus cannabis abuse disorders among adolescents in primary care settings (full - 2008) http://fampra.oxfordjournals.org/cgi/content/full/25/5/321

Endocannabinoids: Stress, Anxiety, and Fear (full - 2009)

http://neuro.psychiatryonline.org/cgi/content/full/21/2/iv?maxtoshow=&hits=80&RESULTFORMAT=&fu lltext=cannabis&searchid=1&FIRSTINDEX=1120&resourcetype=HWCIT

Effects of {Delta}9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress. (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19406854/abstract/Effects_of_{Delta}9_tet rahydrocannabinol_on_reward_and_anxiety_in_rats_exposed_to_chronic_unpredictable_stress_

Modulation of effective connectivity during emotional processing by Delta9- tetrahydrocannabinol and cannabidiol. (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19775500?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pub med_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Opposite Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology. (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19924114/full_citation/Opposite_Effects_of_Delta _9_Tetrahydrocannabinol_and_Cannabidiol_on_Human_Brain_Function_and_Psychopathology_

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Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)- tetrahydrocannabinol in rats. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19393686

Brain CB2 Receptors: Implications for Neuropsychiatric Disorders (full – 2010)

http://www.mdpi.com/1424-8247/3/8/2517/pdf

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20829306

Cannabinoids and anxiety. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/21309120

A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/19785914/abstract/A_behavioural_comparison_of_ acute_and_chronic_Delta9_tetrahydrocannabinol_and_cannabidiol_in_C57BL/6JArc_mice_

Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20457188/abstract/Intra_dorsal_periaqueductal_gr ay_administration_of_cannabidiol_blocks_panic_like_response_by_activating_5_HT1A_receptors_

Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders? (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20512266/abstract/[Pharmacological_exploitat ion_of_the_endocannabinoid_system:_new_perspectives_for_the_treatment_of_depression_and_anxiety_d isorders%5D_

Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress. (full – 2011) http://www.nature.com/npp/journal/v37/n2/full/npp2011204a.html

Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21307846

Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21771609

Cannabinoids and emotionality: a neuroanatomical perspective. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21827834

Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21867717

Anti-Aversive Effects of Cannabidiol on Innate Fear-Induced Behaviors Evoked by an Ethological Model of Panic Attacks Based on a Prey vs the Wild Snake Epicrates cenchria crassus Confrontation Paradigm. (abst - 2011) http://www.ncbi.nlm.nih.gov/pubmed/21918503

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Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. (abst – 2011) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=315

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21145341/abstract/Inhibition_of_endocannabinoid _catabolic_enzymes_elicits_anxiolytic_like_effects_in_the_marble_burying_assay_

Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21937980

APPETITE STIMULANT also see TASTE, OBESITY
Factors influencing the aggressiveness elicited by marihuana in food-deprived rats

(full - 1972) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1666002&tool=pmcentrez Marihuana use. Biologic and behavioral aspects. (abst – 1976)

http://www.ncbi.nlm.nih.gov/pubmed/981073

Anorexia and hyperphagia produced by five pharmacologic classes of hallucinogens. (abst – 1982) http://www.ncbi.nlm.nih.gov/pubmed/6292959

Behavioral analysis of marijuana effects on food intake in humans. (abst - 1986)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=118

Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. (abst - 1988) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=117

Dronabinol enhancement of appetite in cancer patients. (abst - 1990)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=149

Recent clinical experience with dronabinol. (abst - 1991)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=90

Dronabinol stimulates appetite and causes weight gain in HIV patients.

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=20

(abst - 1992)

Dronabinol effects on weight in patients with HIV infection. (abst - 1992)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=45

82

Effect of dronabinol on nutritional status in HIV infection. (abst - 1993)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=150

A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer- associated anorexia. (abst - 1994) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=52

Cannabinoids and appetite stimulation. (abst – 1994)

http://www.ncbi.nlm.nih.gov/pubmed/7816872

Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. (abst - 1995) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=21

The perceived effects of smoked cannabis on patients with multiple sclerosis.
(abst - 1997) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=13

Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease (abst - 1997) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=59

Immunoactive cannabinoids: Therapeutic prospects for marijuana constituents
(full - 2000) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=34030&tool=pmcentrez

Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice. (abst – 2000) http://www.ncbi.nlm.nih.gov/pubmed/10762668

Dietary intake and nutritional status of US adult marijuana users: results from the Third National Health and Nutrition Examination Survey. (full – 2001) http://journals.cambridge.org/action/displayFulltext?type=6&fid=626876&jid=PHN&volumeId=4&issueId =03&aid=562676&bodyId=&membershipNumber=&societyETOCSession=&fulltextType=RA&fileId=S1 368980001000738

Neuroprotection by Delta 9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity (full - 2001) http://www.jneurosci.org/cgi/content/full/21/17/6475?maxtoshow=&hits=10&RESULTFORMAT=&fullte xt=cannabis&andorexactfulltext=and&searchid=1&FIRSTINDEX=50&sortspec=relevance&resourcetype= HWCIT

Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats (full - 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573067/?tool=pmcentrez

Therapeutic Aspects of Cannabis and Cannabinoids (full - 2001)

http://bjp.rcpsych.org/cgi/reprint/178/2/107.pdf

Leptin-regulated endocannabinoids are involved in maintaining food intake (letter – 2001) http://www.nature.com/nature/journal/v410/n6830/full/410822a0.html

Attack of the munchies (news - 2001)

http://www.newscientist.com/article/dn617-attack-of-the-munchies.html

83

Scientists crack 'munchies' mystery (news - 2001)

http://news.bbc.co.uk/2/hi/science/nature/1271718.stm

A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding (full - 2002) http://www.jneurosci.org/cgi/content/abstract/22/21/9612?ijkey=328b5e83d7be9297b9483d22e0d6319fa0a 862e8&keytype2=tf_ipsecsha

Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. (full – 2002) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573386/?tool=pubmed

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis (full - 2003) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166293/

Endogenous cannabinoid system as a modulator of food intake. (full - 2003)

http://www.nature.com/ijo/journal/v27/n3/full/0802250a.html

The cannabinoid system: a role in both the homeostatic and hedonic control of eating? (full – 2003) http://journals.cambridge.org/download.php?file=/BJN/BJN90_04/S000711450300179Xa.pdf &code=62ffe5c7ad41131e6dc05fe2f918880a

Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer‘s disease with anorexia: A retrospective chart review (abst - 2003) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=61

Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/12914975

Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptor. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/12568912

Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/12914975

Endocannabinoids: Getting the message across (full - 2004)

http://www.pnas.org/content/101/23/8512.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=can nabis&searchid=1&FIRSTINDEX=2880&resourcetype=HWCIT

Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels following weight loss. (abst – 2004) http://www.ncbi.nlm.nih.gov/pubmed/15099912

Overeating, Alcohol and Sucrose Consumption Decrease in Cb1 Receptor Deleted Mice. (abst – 2004) http://medical-journals.healia.com/doc/12770700/Overeating-alcohol-and-sucrose-consumption-decrease- in-CB1-receptor-deleted-mice

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Endocannabinoids and food intake: newborn suckling and appetite regulation in adulthood. (full - 2005) http://ebm.rsmjournals.com/cgi/content/full/230/4/225

Food for thought: endocannabinoid modulation of lipogenesis (full - 2005)

http://www.jci.org/articles/view/25076/version/1

Endocannabinoids in the Regulation of Appetite and Body Weight. (abst - 2005)

http://medical-journals.healia.com/doc/16148436/Endocannabinoids-in-the-regulation-of-appetite-and- body-weight

Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus (abst – 2005) http://www.sciencedirect.com/science/article/pii/S0028390805001668

Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/15763177

THC effective in appetite and weight loss in severe lung disease (COPD)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=191#2

Machinery Of The 'Marijuana Munchies' (news - 2005)

http://www.sciencedaily.com/releases/2005/12/051226102503.htm

(news - 2005)

Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In- Cachexia-Study-Group (full - 2006) http://jco.ascopubs.org/content/24/21/3394.long

Effect of a cannabinoid agonist on gastrointestinal transit and postprandial satiation in healthy human subjects: a randomized, placebo-controlled study (abst - 2006) http://cel.isiknowledge.com/InboundService.do?product=CEL&action=retrieve&SrcApp=Highwire&UT=0 00239661000005&SID=2BiIeEJCIN8n7IfjpEB&Init=Yes&SrcAuth=Highwire&mode=FullRecord&custo mersID=Highwire

Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16491428

The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients (abst - 2006) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=177

Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16506408

Dronabinol for supportive therapy in patients with malignant melanoma and liver

metastases (abst - 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=180

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The endogenous cannabinoid system: a new player in the brain-gut-adipose axis (full - 2007) http://www.cannabis-med.org/english/journal/en_2007_02_1.pdf

CANNABINOID-INDUCED HYPERPHAGIA: CORRELATION WITH INHIBITION OF PROOPIOMELANOCORTIN NEURONS? (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720321/?tool=pmcentrez

Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. (full – 2007) http://www.nature.com/npp/journal/v32/n11/full/1301376a.html

Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus.
(full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042935/?tool=pubmed

Dronabinol an effective appetite stimulant? (abst - 2007)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=188

THC improves appetite and reverses weight loss in AIDS patients (abst - 2007)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=189

Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting. (abst - 2007)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=191

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep. (abst - 2007) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=190

Feeding induced by cannabinoids is mediated independently of the melanocortin system. (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386290/?tool=pubmed

Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats (full - 2008) http://www.jneurosci.org/cgi/content/full/28/39/9702?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabinoid&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

Endocannabinoids and the Control of Energy Homeostasis (full – 2008)

http://www.jbc.org/content/283/48/33021.full?sid=931583b1-e797-43e0-8296-7fd75bb49403

The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet. (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275439/?tool=pubmed

ENDOCANNABINOIDS AND THE NEUROCHEMISTRY OF GLUTTONY. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18638022

Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18991890

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Role of endocannabinoids and their analogues in obesity and eating disorders. (abst – 2008) http://www.ncbi.nlm.nih.gov/pubmed/19011363

Endocannabinoids and Their Receptors as Targets for Obesity Therapy (full - 2009)

http://endo.endojournals.org/cgi/content/full/150/6/2531#top

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697695/?tool=pubmed

Endocannabinoids selectively enhance sweet taste (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818929/?tool=pmcentrez

Endogenous cannabinoid signalling and energy balance (abst – 2009)

http://gradworks.umi.com/NR/44/NR44386.html

Cannabinoids and appetite: food craving and food pleasure. (abst – 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19367510

Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19150453

Natural Pot-Like Compound Could Fight Obesity (news - 2009)

http://www.scientificamerican.com/p...=natural-pot-like-compound-could-fig-09-12-29

Enhanced Sweet Taste: Endocannabinoids Act Directly on Tongue Taste Receptors (news - 2009) http://www.sciencedaily.com/releases/2009/12/091222104920.htm

Chemicals in pot stimulate tongue receptors to taste sweetness. (news - 2009)

http://www.thefreelibrary.com/Chemicals+in+pot+stimulate+tongue+receptors+to+taste+sweetness.- a0215089160

The multiple functions of the endocannabinoid system: a focus on the regulation of food intake. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832623/?tool=pubmed

Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype (full – 2010) http://ajpgi.physiology.org/content/299/1/G63.full?sid=fc6948f0-78cf-405c-981b-afaa05ee417c

Cannabis constituents modulate δ9-tetrahydrocannabinol-induced hyperphagia in rats. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20349049

A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands.
(abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19768813

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Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis (abst - 2010) http://www.nature.com/npp/journal/vaop/ncurrent/abs/npp201058a.html

Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19800340

A low-Δ9tetrahydrocannabinol cannabis extract induces hyperphagia in rats. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20975531

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age. (abst – 2010) http://www.springerlink.com/content/g037q1lh40l15161/

Endocannabinoid Modulation Of Tongue Sweet Taste Receptors May Help Control Feeding Behavior (news – 2010) http://www.medicalnewstoday.com/releases/174683.php

Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial
(full – 2011) http://annonc.oxfordjournals.org/content/early/2011/02/11/annonc.mdq727.full

Cannabidiol inhibits the hyperphagia induced by cannabinoid-1 or serotonin-1A receptor agonists. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21238476

Cannabidiol decreases body weight gain in rats: Involvement of CB2 receptors. (abst - 2011) http://marijuana.researchtoday.net/archive/8/1/3517.htm

Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study. (abst – 2010) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=316

Science: Cannabis influences blood levels of appetite hormones in people with HIV (news – 2011)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=363#2

Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21213357

The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21056053

Cannabidiol potentiates Δ(9)-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats.
(abst - 2011) http://www.ncbi.nlm.nih.gov/pubmed/21667074

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Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21109417

Non-Δ9tetrahydrocannabinol phytocannabinoids stimulate feeding in rats. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22157176

Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/20817042/abstract/Increment_of_hypothalamic_2_ arachidonoylglycerol_induces_the_preference_for_a_high_fat_diet_via_activation_of_cannabinoid_1_rece ptors_

Cannabinoids in children (abst – 2011)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=295

Ingredient in cannabis restores taste for cancer patients (news – 2011)

http://news.yahoo.com/s/afp/20110222/hl_afp/healthdiseasecancerdrugscannabisfood

Cannabis Ingredient Can Help Cancer Patients Regain Their Appetites and Sense of Taste, Study Finds (news – 2011) http://www.sciencedaily.com/releases/2011/02/110222192830.htm

Study helps explain why fatty foods are complicit in weight gain (news - 2011)

http://www.news-medical.net/news/20110705/Study-helps-explain-why-fatty-foods-are-complicit-in- weight-gain.aspx

Endocannabinoid Signaling In Dietary Restriction And Lifespan Extension (news – 2011) http://www.medicalnewstoday.com/releases/225007.php

Father: Medical marijuana eased pain of my cancer-battling son

http://www.komonews.com/news/local/120941429.html

Smoking marijuana not linked to obesity: study (news – 2011)

http://health.yahoo.net/news/s/nm/us_marijuana_obesity

ARACHIDONYL-2'-CHLOROETHYLAMIDE see ACEA

2-ARACHIDONOYLGLYCEROL see2-AG

(anecdotal – 2011)

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ARTHRITIS

ANTI-EDEMA AND ANALGESIC PROPERTIES OF Δ9- TETRAHYDROCANNABINOL (THC) (abst- 1973) http://jpet.aspetjournals.org/content/186/3/646.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=marihuana&searchid=1&FIRSTINDEX=2160&resourcetype=HWCIT

Analgesic and antiinflammatory activity of constituents of Cannabis sativa L. (full - 1988) http://www.ukcia.org/research/AnalgesicAndAntiInflammatoryActivityofConstituents.html

US Patent 6132762 - Transcutaneous application of marijuana (full - 2000)

http://www.patentstorm.us/patents/6132762/fulltext.html

Immunoactive cannabinoids: Therapeutic prospects for marijuana constituents
(full - 2000) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=34030&tool=pmcentrez

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis (full - 2000) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC16904/?tool=pubmed

Marijuana Extract Helps Arthritis Pain (news - 2000)

http://www.prohealth.com//library/showArticle.cfm?libid=552

Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints (full - 2001) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572613/?tool=pmcentrez

Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model. (abst - 2003) http://www.ncbi.nlm.nih.gov/pubmed/14644587

Cannabis May Suppress Immune System (news - 2003)

http://lupus.webmd.com/news/20030415/cannabis-may-suppress-immune-system

A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis. (full- 2004) http://onlinelibrary.wiley.com/doi/10.1002/art.20050/full

Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials (abst - 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751505/?tool=pmcentrez

Rheumatoid arthritis, Cannabis based medicine eases pain and suppresses disease (news - 2005) http://www.medicalnewstoday.com/articles/33376.php

Cannabis could relieve rheumatoid arthritis pain (news - 2005)

http://www.independent.co.uk/life-style/health-and-families/health-news/cannabis-could-relieve- rheumatoid-arthritis-pain-514536.html

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Cannabis-Based Drug Relieves Arthritis Pain (news - 2005)

http://www.medpagetoday.com/Rheumatology/Arthritis/2097

First study to use a cannabis-based medicine for treating rheumatoid arthritis (news - 2005) http://www.news-medical.net/news/2005/11/09/14393.aspx

Pot-Based Drug Promising for Arthritis (news - 2005)

http://www.webmd.com/rheumatoid-arthritis/news/20051108/pot-based-drug-promising-for-arthritis

Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis (full - 2006) http://rheumatology.oxfordjournals.org/cgi/content/full/45/1/50?maxtoshow=&hitqs=80&RESULTFORM AT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=2240&resourcetype=HWCIT

The use of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis (letter - 2006) http://rheumatology.oxfordjournals.org/cgi/content/full/45/6/781

Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro. (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16536902

The Cannabinergic System as a Target for Anti-inflammatory Therapies (abst - 2006)

http://www.ingentaconnect.com/content/ben/ctmc/2006/00000006/00000013/art00008

SAFETY AND TOLERABILITY OF LONG-TERM TREATMENT WITH A CANNABIS-BASED MEDICINE (SATIVEX) IN PATIENTS WITH RHEUMATOID ARTHRITIS (abst - 2006)

http://eular.bmj.com/cgi/content/abstract/65/Suppl_2/498- a?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=1840 &resourcetype=HWCIT

In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219539/?tool=pmcentrez

Arthritis and pain. Future targets to control osteoarthritis pain. (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206352/?tool=pubmed

INHIBITORY EFFECT OF CANNABINOID AGONISTS ON CYTOKINE PRODUCTION IN HUMAN OSTEOARTRITHIC AND RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES (abst - 2007)

http://eular.bmj.com/cgi/content/abstract/66/Suppl_2/283- b?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=320& resourcetype=HWCIT

Suppression of fibroblast metalloproteinases by ajulemic acid, a nonpsychoactive cannabinoid acid. (abst - 2007) http://www.ncbi.nlm.nih.gov/pubmed/16927387

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The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat involves the CB(2) cannabinoid receptor. (abst - 2007) http://www.unboundmedicine.com/medline/ebm/record/17588560/abstract/The_antinociceptive_effect_of_ Delta9_tetrahydrocannabinol_in_the_arthritic_rat_involves_the_CB_2__cannabinoid_receptor

Synergy between Delta(9)-tetrahydrocannabinol and morphine in the arthritic rat
(abst - 2007) http://www.unboundmedicine.com/medline/ebm/record/17498686/abstract/Synergy_between_Delta_9__tet rahydrocannabinol_and_morphine_in_the_arthritic_rat

Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453762/?tool=pubmed

In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints (full - 2008) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2219539&tool=pmcentrez

Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees. (full – 2008) http://onlinelibrary.wiley.com/doi/10.1002/art.23156/full

CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways. (full – 2008) http://ajpheart.physiology.org/content/294/3/H1145.long

How Cannabis Compares to other treatments (article - 2008)

http://dcsafeaccess.org/medical/how-cannabis-compares-to-other-treatments/

Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid. (abst - 2008) http://www.ncbi.nlm.nih.gov/sites/pubmed

Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/17786950

Anti-inflammatory compound from cannabis found in herbs (news - 2008)

http://www.rsc.org/chemistryworld/News/2008/June/24060801.asp

Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4 (full - 2009) http://www.fasebj.org/cgi/content/full/23/5/1503?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=c annabis&searchid=1&FIRSTINDEX=2400&resourcetype=HWCIT

Cannabinoids as novel anti-inflammatory drugs. (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/?tool=pubmed

How Hemp Seed Oil Can Help Your Arthritis (news – 2009)

http://www.thefreelibrary.com/How+Hemp+Seed+Oil+Can+Help+Your+Arthritis-a01074002477

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Tissue Engineering of Cartilage; Can Cannabinoids Help? (full – 2010)

http://www.mdpi.com/1424-8247/3/9/2970/pdf

Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005548/?tool=pubmed

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132591/?tool=pubmed

Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis. (abst – 2010)

http://www.unboundmedicine.com/medline/ebm/record/21185649/abstract/Local_application_of_the_endo cannabinoid_hydrolysis_inhibitor_URB597_reduces_nociception_in_spontaneous_and_chemically_induce d_models_of_osteoarthritis_

Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20863899

Cannabinoids for Treatment of Chronic Non-Cancer Pain; a Systematic Review of Randomized Trials. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21426373

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21238581

The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21683763

AS- 1535907 synthetic, GPR119 agonist

The role of small molecule GPR119 agonist, AS1535907, in glucose-stimulated insulin secretion and pancreatic β-cell function (full – 2010) http://pubget.com/search?q=authors:"Y Yonetoku"

Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat

perfused pancreas and diabetic db/db mice. (abst – 2010)

http://www.ncbi.nlm.nih.gov/pubmed/20937249

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AS-1907417 synthetic, GPR119 agonist

AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20816753

ASTHMA - also see LUNG FUNCTION

Acute effects of smoked marijuana and oral delta-9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects (full - 1974) http://www.ukcia.org/research/SmokedAndOralInAsthmatic.php

Effects of smoked marijuana in experimentally induced asthma. (full - 1975)

http://www.ukcia.org/research/InducedAsthma/index.php

Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol of asthmatic patients. (full - 1976) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC470501/?tool=pmcentrez&page=1

Bronchial effects of aerosolized delta 9-tetrahydrocannabinol (abst - 1977)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=109

Bronchodilator effect of delta1-tetrahydrocannabinol. (full - 1978)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1429361/

Comparison of bronchial effects of nabilone and terbutaline (abst - 1983)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=43

Acute and subacute bronchial effects of oral cannabinoids. (abst - 1984)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=44

Role of prostaglandins in marihuana-induced bronchodilation. (abst – 1986)

http://www.ncbi.nlm.nih.gov/pubmed/3006196

ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF CONSTITUENTS OF CANNABIS SATIVA L. (full - 1988) http://www.ukcia.org/research/AnalgesicAndAntiInflammatoryActivityofConstituents.html

Cannabis and cannabinoids: pharmacology and rationale for clinical use (abst – 1999)

http://pharmgkb.org/pmid/10575283

Therapeutic aspects of cannabis and cannabinoids. (full - 2001)

http://bjp.rcpsych.org/cgi/content/full/178/2/107

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Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/16103691

New Synthetic Delta-9-THC Inhaler Offers Safe, Rapid Delivery (news - 2005)

http://www.medicalnewstoday.com/articles/22937.php

The Cannabinergic System as a Target for Anti-inflammatory Therapies (abst - 2006)

http://www.ingentaconnect.com/content/ben/ctmc/2006/00000006/00000013/art00008

Cannabinoid CB(2) receptor activation prevents bronchoconstriction and airway oedema in a model of gastro-oesophageal reflux. (abst - 2007) http://www.ncbi.nlm.nih.gov/pubmed/17643417

Cannabinoids as novel anti-inflammatory drugs. (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/?tool=pubmed

Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005548/?tool=pubmed

Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: Role of CB(1)/CB(2) receptors. (abst - 2010) http://www.unboundmedicine.com/medline/ebm/record/21056512/abstract/Beneficial_effects_of_cannabin oids__CB__in_a_murine_model_of_allergen_induced_airway_inflammation:_Role_of_CB_1_/CB_2__rec eptors_

The cannabinoid receptor agonist WIN 55,212-2 inhibits antigen-induced plasma extravasation in guinea pig airways. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20150748

ATHEROSCLEROSIS

Cardiovascular Effects of Cannabis (news - no date)

http://www.idmu.co.uk/canncardio.htm

Cannabinoids impair the formation of cholesteryl ester in cultured human cells. (full – 1981) http://atvb.ahajournals.org/cgi/reprint/1/6/449

Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. (full - 2005) http://www.nature.com/nature/journal/v434/n7034/full/nature03389.html

Cannabis compound tackles blood vessel disease (news - 2005)

http://www.medicalnewstoday.com/articles/22658.php

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Medical marijuana: study shows that THC slows atherosclerosis (news - 2005)

http://thenexthurrah.typepad.com/the_next_hurrah/2005/04/medical_marijua.html

Science: THC slows development of atherosclerosis in animal study (news - 2005)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=190#1
NOT SO DOPEY (news - 2005) http://www.entheology.org/edoto/anmviewer.asp?a=221

Marijuana Chemical Fights Hardened Arteries (news - 2005)

http://www.webmd.com/heart-disease/news/20050406/marijuana-chemical-fights-hardened-arteries

Does Cannabis Hold the Key to Treating Cardiometabolic Disease (full - 2006)

http://www.nature.com/nrcardio/journal/v3/n3/full/ncpcardio0504.html

Cannabinoid receptors in atherosclerosis. (abst – 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16960500

Towards a therapeutic use of selective CB2 cannabinoid receptor ligands for atherosclerosis. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/19804131

The Cannabinergic System as a Target for Anti-inflammatory Therapies (abst - 2006)

http://www.ingentaconnect.com/content/ben/ctmc/2006/00000006/00000013/art00008

Endocannabinoids and the haematological system (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190025/?tool=pmcentrez

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption (full - 2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2228254&tool=pmcentrez

Cannabinoids and cardiovascular disease: the outlook for clinical treatments.
(abst - 2007) http://www.ncbi.nlm.nih.gov/pubmed/17627561?ordinalpos=1&itool=PPMCLayout.PPMCAppController. PPMCArticlePage.PPMCPubmedRA&linkpos=5

Cannabinoid receptors in acute and chronic complications of atherosclerosis (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219535/?tool=pmcentrez

Pleiotropic effects of the CB2 cannabinoid receptor activation on human monocyte migration: implications for atherosclerosis and inflammatory diseases (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267750/?tool=pubmed

CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration

through defined intracellular signaling pathways. (full – 2008)

http://ajpheart.physiology.org/content/294/3/H1145.long

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Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed- enriched diet. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18418423

The emerging role of the endocannabinoid system in cardiovascular disease (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791499/?tool=pmcentrez

Endocannabinoids and the Heart (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728560/?tool=pmcentrez

Cannabidiol-2',6'-Dimethyl Ether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor. (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19406952/abstract/Cannabidiol_2'6'_Dime thyl_Ether_a_Cannabidiol_Derivative_Is_a_Highly_Potent_and_Selective_15_Lipoxygenase_Inhibitor_

Cannabinoids and atherosclerosis. (abst - 2009)

http://www.unboundmedicine.com/medline/ebm/record/19591373/abstract/Cannabinoids_and_atherosclero sis_

US Patent Application 20100158973 - THERAPEUTIC USES OF CANNABIDIOL COMPOUNDS (full – 2010) http://www.patentstorm.us/applications/20100158973/fulltext.html

WIN55212-2 ameliorates atherosclerosis associated with suppression of pro- inflammatory responses in ApoE-knockout mice. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20868672

Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice (full – 2011)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082575/?tool=pubmed

Cannabinoid Receptor 2 Deficiency in Haematopoietic cells Aggravates Early Atherosclerosis in LDL Receptor Deficient Mice. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109635/?tool=pubmed

Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21884703

The effect of dietary hempseed on atherogenesis and contractile function in aortae from hypercholesterolemic rabbits. (abst -2011) http://www.ncbi.nlm.nih.gov/pubmed/21893466

AUTISM

THE SAM PROJECT: James D. (news / anecdotal - 2002)

http://www.letfreedomgrow.com/articles/james_d.htm

Medical marijuana: a valuable treatment for autism? (news / anecdotal - 2003)

http://www.autism.com/ari/editorials/ed_marijuana.htm

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Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16623851

Autism, ADD, ADHD and Marijuana Therapy (news - 2008)

http://www.entheology.org/edoto/anmviewer.asp?a=319

Does marijuana replace pharmaceuticals as a treatment for Autism? (news – 2009)

http://www.examiner.com/special-nee...rg/does-marijuana-replace-pharmaceuticals-as- a-treatment-for-autism

Sam‘s Story: Using Medical Cannabis to Treat Autism Spectrum Disorder (news / anecdotal - 2009) http://www.letfreedomgrow.com/cmu/SamsStory.htm

Mom: Medical marijuana saved son's life (news / anecdotal - 2009)

http://abclocal.go.com/kabc/story?section=news/health&id=6989085

The ultimate herbal remedy: Can cannabis improve autism? (news / anecdotal - 2009)

http://www.independent.co.uk/life-style/health-and-families/features/the-ultimate-herbal-remedy-can- cannabis-improve-autism-1814756.html

Sam's Story: Medical Marijuana and Autism (news / anecdotal - 2009)

http://www.ktla.com/news/landing/ktla-sweeps-sams-story,0,1396115.story

Use of dronabinol (delta-9-THC) in autism: A prospective single-case-study with an early infantile autistic child (full – 2010) http://www.cannabis-med.org/data/pdf/en_2010_04_1.pdf

Can autism be triggered by acetaminophen activation of the endocannabinoid system? (link to full – 2010) http://www.ane.pl/showarticle.php?art=7026

Steamboat mom sees results from giving autistic son medical marijuana
(news/ anecdotal - 2010) http://www.steamboatpilot.com/news/2010/oct/31/steamboat-mom-sees-results-giving-autistic-son-med/

Why I Give My Autistic Son Pot, Part1 (news – 2010)

http://www.doublex.com/section/health-science/why-i-give-my-9-year-old-pot

Why I Give My Autistic Son Pot, Part2 (news – 2010)

http://www.doublex.com/section/health-science/why-i-give-my-9-year-old-pot-part-ii
Why I Give My 9-Year-Old Pot, Part 3 (news - 2010) http://www.slate.com/id/2251174/

Variation in the human Cannabinoid Receptor (CNR1) gene modulates gaze duration for happy faces. (full – 2011) http://www.molecularautism.com/content/pdf/2040-2392-2-10.pdf

Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21886592

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Cannabis Science And The Unconventional Foundation For Autism (UF4A) Partner To Advance Successful Cannabis-Based Autism Treatments (news/info-mercial - 2011) http://www.medicalnewstoday.com/releases/219569.php

Why I Give My Autistic Son Pot, Part 4 (news – 2011)

http://www.slate.com/id/2294072/?from=rss

Wayne Valley alum making a difference in autism research (news – 2011)

http://www.northjersey.com/news/119379944_Wayne_Valley_alum_making_a_difference_in_autism_rese arch.html

BACK PAIN - also see PAIN, SPASTICITY, SPINAL CORD INJURY

BACK PAIN DUE TO DEGENERATED DISC –ANY THERAPEUTIC ROLE OF CANNABIS (abst - 2005)
http://proceedings.jbjs.org.uk/cgi/content/abstract/90-B/SUPP_II/224- d?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=marihuana&searchid=1&FIRSTINDEX=320&re sourcetype=HWCIT

Investigational pharmacology for low back pain (full - 2010) ` http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004649/?tool=pmcentrez

BETA-CARYOPHYLLENE/ (E)-BCP – phytocannabinoid, CB2 agonist Beta-caryophyllene is a dietary cannabinoid (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2449371/?tool=pmcentrez

Anti-inflammatory cannabinoids in diet (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633791/?tool=pmcentrez

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664885/?tool=pmcentrez

(full - 2009)

Screening for Antiviral Activities of Isolated Compounds from Essential Oils
(full - 2009) http://ecam.oxfordjournals.org/cgi/content/full/nep187v1?maxtoshow=&hits=10&RESULTFORMAT=&fu lltext=Beta-caryophyllene+&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2

receptor activation and PPARγ pathway. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21356367

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BIPOLAR DISORDER

The Use of Cannabis as a Mood Stabilizer in Bipolar Disorder: Anecdotal Evidence and the Need for Clinical Research (full - 1998) http://www.ukcia.org/research/TheUseofCannabisasaMoodStabilizerinBipolarDisorder.html

Recipe For Trouble (anecdotal/ news - 2002 )

http://www.cbsnews.com/stories/2002/03/05/48hours/main503022.shtml

Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential. (full - 2005) http://www.ukcia.org/research/CannabinoidsInBipolarAffectiveDisorder.pdf

Cannabis in bipolar (abst - 2005) http://www.pendulum.org/bpnews/archive/001628.html Cannabis Spray for Bipolar (news - 2005)

http://www.prohealth.com/me-cfs/blog/boardDetail.cfm?id=565511

Marijuana Could Provide Mental Health Treatments (news - 2005)

http://www.drugfree.org/join-together/drugs/marijuana-could-provide

Chemicals in Cannabis may help mentally ill (news - 2005)

http://www.news-medical.net/news/2005/06/06/10716.aspx

Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia. (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19891810/full_citation/Opposite_relationships_bet ween_cannabis_use_and_neurocognitive_functioning_in_bipolar_disorder_and_schizophrenia_

The effect of extreme marijuana use on the long-term course of bipolar I illness: a single case study. (abst - 2007)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=247

Genetic association between bipolar disorder and 524A>C (Leu133Ile) polymorphism of CNR2 gene, encoding for CB2 cannabinoid receptor. (abst - 2011) http://www.ncbi.nlm.nih.gov/pubmed/21658778

BLADDER / URINARY FUNCTIONS

Comparative diuretic activity of delta9-tetrahydrocannabinol, cannabidiol, cannabinol

and hydrochlorothiazide in the rat. (abst – 1977)

http://www.ncbi.nlm.nih.gov/pubmed/849066

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