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Meds 700 Medicinal Uses for Cannabis sorted by Disease

Pages 601 - 605

SPICE various synthetic cannabinoid mixtures - also see the HU and JWH and CP series
Withdrawal Phenomena and Dependence Syndrome After the Consumption of "Spice

Gold" (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719097/?tool=pmcentrez Spice: a never ending story? (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19589652

Pharmacological properties and dependence liabilities of synthetic cannabinoids
(abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20681249/abstract/[Pharmacological_propertie s_and_dependence_liabilities_of_synthetic_cannabinoids%5D_

Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20117892

Spice drugs as a new trend: mode of action, identification and legislation. (abst – 2010)

http://www.ncbi.nlm.nih.gov/pubmed/20566335

Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20857386

Inhaled Incense "K2" May Cause Heart Damage (news – 2010)

http://drwes.blogspot.com/2010/08/inhaled-incense-k2-may-cause-heart.html

Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse? (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139381/?tool=pubmed

Beyond THC: The New Generation of Cannabinoid Designer Drugs. (full – 2011)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187647/?tool=pubmed

Investigating a not-so-natural high. (full – 2011)

http://pubs.acs.org/doi/full/10.1021/ac900564u

Convulsions Associated with the Use of a Synthetic Cannabinoid Product. (full – 2011)

http://www.springerlink.com/content/9651q2672027n38g/fulltext.html

Liquid chromatography-tandem mass spectrometry analysis of urine specimens for K2 (JWH-018) metabolites. (full – 2011)
http://docstore.ingenta.com/cgi- bin/ds_deliver/1/u/d/ISIS/66605491.1/pres/jat/2011/00000035/00000007/art00013/33697C59B13F9CFB13 26169859E74280D392B0112D.pdf?link=http://www.ingentaconnect.com/error/delivery&format=pdf

Psychosis Associated With Synthetic Cannabinoid Agonists: A Case Series (letter – 2011) http://ajp.psychiatryonline.org/cgi/content/full/168/10/1119

The "new" marijuana. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21325097
601

The impact of changes in UK classification of the synthetic cannabinoid receptor agonists in 'Spice'. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21482092

Severe toxicity following synthetic cannabinoid ingestion. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21970775

The emergence and analysis of synthetic cannabinoids. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21337724

Use of high-resolution accurate mass spectrometry to detect reported and previously unreported cannabinomimetics in "herbal high" products. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/20529459

"Spice" girls: synthetic cannabinoid intoxication. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21167669

Three cases of "spice" exposure. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21740143

"Legal highs" - new players in the old drama. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21711229

Comparison of "herbal highs" composition. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21318244

Synthetic cannabinoid use: a case series of adolescents. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21939863

Myocardial Infarction Associated With Use of the Synthetic Cannabinoid K2. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22065271

Cytotoxicity of synthetic cannabinoids found in "Spice" products: the role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21907772/abstract/Cytotoxicity_of_synthetic_cann abinoids_found_in_%22Spice%22_products:_the_role_of_cannabinoid_receptors_and_the_caspase_cascad e_in_the_NG_108_15_cell_line_

High-performance sport, marijuana, and cannabimimetics. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/22080902

Effects of synthetic cannabinoids on electroencephalogram power spectra in rats.
(abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21640532/abstract/Effects_of_synthetic_cannabino ids_on_electroencephalogram_power_spectra_in_rats_

Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?
(abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21441120/abstract/Marijuana_based_drugs:_innov ative_therapeutics_or_designer_drugs_of_abuse
602

Detection of synthetic cannabinoids in herbal incense products. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21741374

'Fake Marijuana' May Trigger Heart Trouble in Teens (news – 2011)

http://health.yahoo.net/news/s/hsn/fakemarijuanamaytriggerhearttroubleinteens

Chemicals Used in "Spice" and "K2" Type Products Now Under Federal Control and Regulation (news – 2011) http://www.justice.gov/dea/pubs/pressrel/pr030111.html

A survey study to characterize use of Spice products (synthetic cannabinoids). (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21835562

'Hammer Head' 'incense' blamed for seizure of youth in Le Roy (news – 2012)

http://thebatavian.com/howard-owens/hammer-head-incense-blamed-seizure-youth-le-roy/29983

SPINAL CORD INJURY

The perceived effects of marijuana on spinal cord injured males.

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=138

Marihuana as a therapeutic agent for muscle spasm or spasticity.

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=53

Cannabis effect on spasticity in spinal cord injury. (abst - 1982)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=113

The effect of delta-9-THC on human spasticity. (abst - 1986)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=154

(abst - 1974) (abst - 1980)

Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial. (abst - 1990) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=160

Treatment of spasticity in spinal cord injury with dronabinol, a tetrahydrocannabinol derivative. (abst - 1995) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=112

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients. (abst - 1996) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=12

Involvement of Dynorphin B in the Antinociceptive Effects of the Cannabinoid CP55,940 in the Spinal Cord (full - 1997) http://jpet.aspetjournals.org/content/281/2/730.full

Cannabis and cannabinoids: pharmacology and rationale for clinical use (abst – 1999)

http://pharmgkb.org/pmid/10575283
603

Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo. (full – 2001) http://jn.physiology.org/content/86/6/3061.long

Clinical investigation of delta-9-tetrahydrocannabinol (THC) as an alternative therapy for overactive bladders in spinal cord injury (SCI) patients. (abst - 2001) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=102

The treatment of spasticity with D9-tetrahydrocannabinol (D9-THC) in patients with spinal cord injury (abst - 2003) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=79

Therapeutic potential of cannabinoids in CNS disease. (abst - 2003)

http://www.ncbi.nlm.nih.gov/pubmed/12617697

Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861843/?tool=pmcentrez

Effects of a Cannabinoid Agonist on Spinal Nociceptive Neurons in a Rodent Model of Neuropathic Pain (full - 2006) http://jn.physiology.org/cgi/content/full/96/6/2984

The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury. (abst - 2006) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=166

Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury. (full – 2008) http://jpet.aspetjournals.org/content/326/1/12.long

Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743245/?tool=pmcentrez

The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function (full – 2009) http://content.karger.com/produktedb/produkte.asp?DOI=000201556&typ=pdf

Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826109/?tool=pubmed

Effect of dronabinol on central neuropathic pain after spinal cord injury: a pilot study. (abst – 2010) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=313
(abst - 2004) Treatments for Chronic Pain in Persons With Spinal Cord Injury: A Survey Study

Are oral cannabinoids safe and effective in refractory neuropathic pain?

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=143
(full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1864800/?tool=pmcentrez
604

Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20920894

The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20156559

A randomized, double-blinded, crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20434606

Cannabinoid Agonists Inhibit Neuropathic Pain Induced by Brachial Plexus Avulsion in Mice by Affecting Glial Cells and MAP Kinases. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172222/?tool=pubmed

Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21354467

Targetting CB1 Cannabinoid Receptor for Neuroprotetion in Spinal Cord Injury
(abst – 2011) http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/lb422?maxtoshow=&hits=80& RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype =HWCIT

Spinal Cord Injuries Induce Changes of CB1 Cannabinoid Receptor and C-C Chemokine Expression in Brain Areas Underlying Circuitry of Chronic Pain Conditions.
(abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21265596/abstract/Spinal_Cord_Injuries_Induce_ Changes_of_CB1_Cannabinoid_Receptor_and_C_C_Chemokine_Expression_in_Brain_Areas_Underlying _Circuitry_of_Chronic_Pain_Conditions_

Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21970496

Activation of spinal and supraspinal cannabinoid-1 receptors leads to antinociception in a rat model of neuropathic spinal cord injury pain. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21813113

Cannabidiol-treated Rats Exhibited Higher Motor Score After Cryogenic Spinal Cord Injury. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21915768

Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22210507
605
 
Pages 606 - 610

SPLEEN


Molecular characterization of a peripheral receptor for cannabinoids (abst – 1993)

http://pharmgkb.org/pmid/7689702

A Cyclooxygenase Metabolite of Anandamide Causes Inhibition of Interleukin-2 Secretion in Murine Splenocytes (full – 2004) http://jpet.aspetjournals.org/content/311/2/683.full

Regulatory effect of cannabinoid receptor agonist on chemokine-induced lymphocyte chemotaxis. (full – 2011) http://www.jstage.jst.go.jp/article/bpb/34/7/1090/_pdf

Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21875957

STEM CELLS

Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919431/?tool=pubmed

CB2 cannabinoid receptors promote mouse neural stem cell proliferation. (abst – 2007)

http://www.ncbi.nlm.nih.gov/pubmed/17328768

Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20826813

Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21063029

Pleiotropic effects of prostaglandin E(2) in hematopoiesis; prostaglandin E(2) and other eicosanoids regulate hematopoietic stem and progenitor cell function. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21722751

Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21063029

Scientists Meet to Discuss Cannabinoids and Stem Cells (news – 2011)

http://www.examiner.com/medical-mar.../scientists-meet-to-discuss-cannabinoids-and- stem-cells#ixzz1RmgEd9oq
606

STRESS
- also see ANXIETY, POST TRAUMATIC STRESS DISORDER
Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats

(abst – 2000) http://www.springerlink.com/content/w3jc8rk16k9p92fl/

Synergistic Interactions between Cannabinoids and Environmental Stress in the Activation of the Central Amygdala (full - 2005) http://www.nature.com/npp/journal/v30/n3/full/1300535a.html

Body's Own Marijuana-Like Compounds Are Crucial For Stress-Induced Pain Relief (news - 2005) http://www.sciencedaily.com/releases/2005/06/050628064435.htm

Endocannabinoids -- The Brain's Cannabis -- Demonstrate Novel Modes Of Action To Stress (news - 2005) http://www.sciencedaily.com/releases/2005/07/050720065810.htm

Endocannabinoids Mediate the Effects of Acute Stress and Corticosterone on Sex Behavior (full – 2007) http://endo.endojournals.org/content/148/2/493.full

Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685476/?tool=pubmed

Endocannabinoids: Stress, Anxiety, and Fear (full - 2009)

http://neuro.psychiatryonline.org/cgi/content/full/21/2/iv?maxtoshow=&hits=80&RESULTFORMAT=&fu lltext=cannabis&searchid=1&FIRSTINDEX=1120&resourcetype=HWCIT

Cannabinoid Receptor Activation in the Basolateral Amygdala Blocks the Effects of Stress on the Conditioning and Extinction of Inhibitory Avoidance (full - 2009) http://www.jneurosci.org/cgi/content/full/29/36/11078?maxtoshow=&hits=10&RESULTFORMAT=&fullt ext=Dr.+Irit+Akirav+&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

Effects of {Delta}9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress. (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19406854/abstract/Effects_of_{Delta}9_tet rahydrocannabinol_on_reward_and_anxiety_in_rats_exposed_to_chronic_unpredictable_stress_

Endogenous cannabinoid signaling is essential for stress adaptation (full - 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889099/?tool=pmcentrez

Motion Sickness, Stress and the Endocannabinoid System (full - 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873996/?tool=pmcentrez

Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic

Unpredictable Stress (abst - 2010)

http://www.nature.com/npp/journal/vaop/ncurrent/abs/npp201099a.html
607

Endocannabinoids and the cardiovascular response to stress. (abst - 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21708837

Cannabinoid receptor expression and phosphorylation are differentially regulated between male and female cerebellum and brain stem after repeated stress: Implication for PTSD and drug abuse. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21600961

Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21884761

Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21771609

Cannabinoids Prevent the Development of Behavioral and Endocrine Alterations in a Rat Model of Intense Stress. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21918506

STORAGE

The stability of cannabis and its preparations on storage. (abst – 1976)

http://www.ncbi.nlm.nih.gov/pubmed/6643

The decomposition of acidic and neutral cannabinoids in organic solvents. (abst – 1977)

http://www.ncbi.nlm.nih.gov/pubmed/17692

Constituents of Cannabis sativa L. XIII: Stability of dosage form prepared by impregnating synthetic (--)-delta 9-trans-tetrahydrocannabinol on placebo Cannabis plant material. (abst – 1978) http://www.ncbi.nlm.nih.gov/pubmed/660481

Stability of Cannabis sativa L. samples and their extracts, on prolonged storage in Delhi. (full – 1978) http://www.lycaeum.org/leda/docs/16647.shtml?ID=16647

Stability of Cannabinoids in Dried Samples of Cannabis Dating from Around 1896-1905. (abst – 1990) http://medical-journals.healia.com/doc/2314109/Stability-of-cannabinoids-in-dried- samples-of-cannabis-dating-from-around-1896-1905

STROKE

The inhibitory effects of cannabinoids, the active constituents of Cannabis sativa L. on

human and rabbit platelet aggregation. (abst - 1989)

http://www.ncbi.nlm.nih.gov/pubmed/2575149
608

HU-211, a Novel Noncompetitive N-Methyl-D-Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat (full - 1995) http://stroke.ahajournals.org/cgi/content/full/26/12/2313

Marijuana chemical tapped to fight strokes ? (news - 1998)

http://findarticles.com/p/articles/mi_m1200/is_n2_v154/ai_20973037/?tag=content;col1

Dope hope for stroke victims (news - 1998)

http://news.bbc.co.uk/2/hi/science/nature/126181.stm

Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures (full - 1999) http://www.jneurosci.org/cgi/content/full/19/8/2987?maxtoshow=&hits=80&RESULTFORMAT=&fulltext =cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype =HWCIT

Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia. (abst – 1999) http://www.ncbi.nlm.nih.gov/pubmed/10202976

Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice (full - 2002)

http://www.jneurosci.org/cgi/content/full/22/22/9771?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabinoid&searchid=1&FIRSTINDEX=80&resourcetype=HWCIT#Top

Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210. (full - 2003) http://stroke.ahajournals.org/cgi/reprint/34/8/2000

US Patent 6630507 - Cannabinoids as antioxidants and neuroprotectants (full - 2003)

http://www.patentstorm.us/patents/6630507/fulltext.html

Post-ischemic Treatment with Cannabidiol Prevents Electroencephalographic Flattening, Hyperlocomotion and Neuronal Injury in Gerbils. (abst – 2003) http://www.sciencedirect.com/science/article/pii/S030439400300569X

Therapeutic potential of cannabinoids in CNS disease. (abst - 2003)

http://www.ncbi.nlm.nih.gov/pubmed/12617697

Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. (abst – 2004) http://www.ncbi.nlm.nih.gov/pubmed/15640760

Cannabidiol Prevents Cerebral Infarction Via a Serotonergic 5-Hydroxytryptamine1A Receptor–Dependent Mechanism (full - 2005) http://stroke.ahajournals.org/cgi/content/full/36/5/1071

Medical marijuana: study shows that THC slows atherosclerosis (news - 2005)

http://thenexthurrah.typepad.com/the_next_hurrah/2005/04/medical_marijua.html
609

Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16864698

The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis (full - 2007) http://www.jbc.org/content/282/33/23892.full

Cannabinoid CB2 receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637559/?tool=pmcentrez

Δ9-Tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189998/?tool=pmcentrez

Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. (full - 2007) http://www3.interscience.wiley.com/cgi-bin/fulltext/118484119/HTMLSTART

Delta(9)-tetrahydrocannabinol (Delta(9)-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. (abst - 2007) http://www.unboundmedicine.com/medline/ebm/record/17289082/abstract/Delta_9__tetrahydrocannabinol __Delta_9__THC__prevents_cerebral_infarction_via_hypothalamic_independent_hypothermia

The endocannabinoid system and neurogenesis in health and disease. (abst - 2007)

http://www.ncbi.nlm.nih.gov/pubmed/17404371

Role of cannabinoids and endocannabinoids in cerebral ischemia (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581413/?tool=pmcentrez

Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury (full - 2008) http://science.iowamedicalmarijuana.org/pdfs/neuro/Zhang 2008.pdf

Cannabinoid receptors in acute and chronic complications of atherosclerosis (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219535/?tool=pmcentrez

Endocannabinoids and cannabinoid receptors in ischaemia–reperfusion injury and preconditioning (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219536/?tool=pmcentrez

Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18634812

Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia. (abst – 2008) http://www.ncbi.nlm.nih.gov/pubmed/18823959.
610
 
Pages 611 - 615

Modulation of cannabinoid receptor activation as a neuroprotective strategy for EAE and stroke. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855650/?tool=pubmed

Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high- mobility group box1-inhibiting mechanism. (full – 2009) http://www.jstage.jst.go.jp/article/bpb/32/9/1538/_pdf

Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death. (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19087195

CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury. (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19332079

Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke (full – 2010) http://www.mdpi.com/1424-8247/3/7/2197/pdf

Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment. (full – 2010) http://www.fasebj.org/content/24/3/788.long

The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20875047

The cannabinoid WIN55212-2 promotes neural repair after neonatal hypoxia-ischemia. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/21115947

The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic- ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. (abst – 2010)

http://www.unboundmedicine.com/medline/ebm/record/19900555/abstract/The_neuroprotective_effect_of_ cannabidiol_in_an_in_vitro_model_of_newborn_hypoxic_ischemic_brain_damage_in_mice_is_mediated_ by_CB_2__and_adenosine_receptors_

Targeting the Endocannabinod System to Limit Myocardial and Cerebral Ischemic and Reperfusion Injury. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21470162/abstract/Targeting_the_Endocannabinod _System_to_Limit_Myocardial_and_Cerebral_Ischemic_and_Reperfusion_Injury_

Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia- ischemia in newborn pigs. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21654550

Residual effects of focal brain ischaemia upon cannabinoid CB(1) receptor density and functionality in female rats. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21145311

Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain

damage in middle cerebral artery occluded rats and non-human primates. (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22119394
611

Cannabinoid type 2 receptor activation downregulates stroke-induced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22020035

The Cannabinoid WIN 55212-2 Mitigates Apoptosis and Mitochondrial Dysfunction After Hypoxia Ischemia. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21909954

TAK SERIES – synthetic cannabinoids
TAK-875 - Takeda moves potential first-in-class diabetes drug into phase III (news – 2011)

http://www.inpharm.com/news/166980/takeda-diabetes-tak-875-phase-iii

TAK-937- synthetic CB1 & CB2 agonist

Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22119394

TASTE - also see APPETITE STIMULANT

Overeating, Alcohol and Sucrose Consumption Decrease in Cb1 Receptor Deleted Mice. (abst – 2004) http://medical-journals.healia.com/doc/12770700/Overeating-alcohol-and-sucrose-consumption-decrease- in-CB1-receptor-deleted-mice

AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1615836/?tool=pmcentrez

Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. (full – 2007) http://www.nature.com/npp/journal/v32/n11/full/1301376a.html

Endocannabinoids selectively enhance sweet taste (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818929/?tool=pmcentrez

Enhanced Sweet Taste: Endocannabinoids Act Directly on Tongue Taste Receptors (news - 2009) http://www.sciencedaily.com/releases/2009/12/091222104920.htm
612

Chemicals in pot stimulate tongue receptors to taste sweetness. (news - 2009)

http://www.thefreelibrary.com/Chemicals+in+pot+stimulate+tongue+receptors+to+taste+sweetness.- a0215089160

Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors. (full – 2010) http://www.jstage.jst.go.jp/article/endocrj/57/6/467/_pdf

Reciprocal modulation of sweet taste by leptin and endocannabinoids. (abst – 2010)

http://www.ncbi.nlm.nih.gov/pubmed/20865375

Endocannabinoid Modulation Of Tongue Sweet Taste Receptors May Help Control Feeding Behavior (news – 2010) http://www.medicalnewstoday.com/releases/174683.php

Sweet taste and (AAT)12 repeat in the cannabinoid receptor gene in obese females (letter – 2011) http://www.jstage.jst.go.jp/article/endocrj/58/4/323/_pdf

Ingredient in cannabis restores taste for cancer patients (news – 2011)

http://news.yahoo.com/s/afp/20110222/hl_afp/healthdiseasecancerdrugscannabisfood

Cannabis Ingredient Can Help Cancer Patients Regain Their Appetites and Sense of Taste, Study Finds (news – 2011) http://www.sciencedaily.com/releases/2011/02/110222192830.htm

TAXONOMY/ GENETICS OF CANNABIS

Cannabinoid Phenotypes in Cannabis sativa (abst - 1973)

http://www.nature.com/nature/journal/v245/n5421/abs/245147a0.html

Cannabinoid patterns in seedlings of Cannabis sativa L. and their use in the determination of chemical race. (abst – 1977) http://www.ncbi.nlm.nih.gov/pubmed/19599

Cannabinoid level in the leaves as a tool for the early discrimination of cannabis chemiovariants (abst - 1984) http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6W-4C3C6JF- 5&_user=10&_origUdi=B6TH7-42WPSNF- 37&_fmt=high&_coverDate=01%2F31%2F1984&_rdoc=1&_orig=article&_acct=C000050221&_version =1&_urlVersion=0&_userid=10&md5=26ab3ca7038dff6b314c88d4b81f04bd

Identification of a New Chemotype in Cannabis sativa: Cannabigerol - Dominant Plants, Biogenetic and Agronomic Prospects (abst – 1987) https://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-962705

Histochemical detection of hemp trichomes and their correlation with the THC content. (abst - 1988) http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=2855383&dopt=abstract plus
613

A Male-associated Dna Sequence in a Dioecious Plant, Cannabis Sativa L. (abst – 1995)

http://medical-journals.healia.com/doc/8589931/A-male-associated-DNA-sequence-in-a-dioecious-plant- Cannabis-sativa-L

Boys and Girls Come Out to Play: The Molecular Biology of Dioecious Plants
(full - 2000) http://aob.oxfordjournals.org/cgi/reprint/86/2/211?maxtoshow=&hits=80&RESU`LTFORMAT=&fulltext= cannabis&searchid=1&FIRSTINDEX=1440&resourcetype=HWCIT

Variations of D9-THC content in single plants of hemp varieties (full - 2000)

http://www.ukcia.org/research/VariationOfTHCContent.pdf

THC (TETRAHYDROCANNABINOL) ACCUMULATION IN GLANDS OF CANNABIS (CANNABACEAE) (full - 2001) http://www.hempreport.com/issues/17/malbody17.html

The inheritance of chemical phenotype in Cannabis sativa L. (full - 2002)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462421/pdf/12586720.pdf

An overview of DNA methods for the identification and individualization of marijuana. (full - 2003) http://www.cmj.hr/2003/44/3/12808725.pdf

The Gene Controlling Marijuana Psychoactivity : MOLECULAR CLONING AND HETEROLOGOUS EXPRESSION OF Δ1-TETRAHYDROCANNABINOLIC ACID SYNTHASE FROM CANNABIS SATIVA L. (full - 2004) http://www.jbc.org/content/279/38/39767.full

A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae) (full – 2004) http://www.amjbot.org/content/91/6/966.full

The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Delta1-tetrahydrocannabinolic acid synthase from Cannabis sativa L. (full – 2004) http://www.jbc.org/content/279/38/39767.long

A chemotaxonomic analysis of terpenoid variation in Cannabis (abst - 2004)

http://www.ncbi.nlm.nih.gov/pubmed/21653452

RAPD markers encoding retrotransposable elements are linked to the male sex in Cannabis sativa L. (full – 2005)
http://www.ncbi.nlm.nih.gov/pubmed/16391699

Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity,

is secreted into the storage cavity of the glandular trichomes. (abst – 2005)

http://www.ncbi.nlm.nih.gov/pubmed/16024552
614

DNA polymorphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in ―drug- type‖ and ―fiber-type‖ Cannabis sativa L. (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16143478

History of Cannabis and Its Preparations in Saga, Science and Sobriquet (full - 2007)

http://www3.interscience.wiley.com/cgi-bin/fulltext/115806128/PDFSTART

Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17544411

Phytochemical and genetic analyses of ancient cannabis from Central Asia (full - 2008)

http://jxb.oxfordjournals.org/cgi/content/full/59/15/4171

DNA polymorphism detection of Cannabis using amplified fragment length polymorphism (abst - 2008) http://www.unboundmedicine.com/medline/ebm/record/18979914/abstract/[DNA_polymorphism_dete ction_of_Cannabis_using_amplified_fragment_length_polymorphism%5D

Genetic individualization of Cannabis sativa by a short tandem repeat multiplex system (abst - 2008) http://www.unboundmedicine.com/medline/ebm/record/19066867/abstract/Genetic_individualization_of_C annabis_sativa_by_a_short_tandem_repeat_multiplex_system_

Identification of candidate genes affecting Δ9-tetrahydrocannabinol biosynthesis in Cannabis sativa (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736886/?tool=pmcentrez

US Patent Application 20090324797 - MODULATING PLANT OIL LEVELS (full – 2009) http://www.patentstorm.us/applications/20090324797/fulltext.html

Assessment of Cannabinoids Content in Micropropagated Plants of Cannabis sativa and Their Comparison with Conventionally Propagated Plants and Mother Plant during Developmental Stages of Growth. (abst - 2009) http://marijuana.researchtoday.net/archive/6/12/2685.htm

Assessment of the Genetic Stability of Micropropagated Plants of Cannabis sativa by ISSR Markers. (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19637112/abstract/Assessment_of_the_Genetic_St ability_of_Micropropagated_Plants_of_Cannabis_sativa_by_ISSR_Markers_

Hemp And Marijuana: Genes Producing THC, Active Ingredient In Cannabis Plant, Identified (news - 2009) http://www.sciencedaily.com/releases/2009/09/090915113538.htm

Genes producing tetrahydrocannabinol in marijuana identified (news - 2009)

http://www.news-medical.net/news/20090916/Genes-producing-tetrahydrocannabinol-in-marijuana- identified.aspx
615
 
Pages 616 - 620

Characteristics of Cannabis sativa L.: seed morphology, germination and growth characteristics, and distinction from Hibiscus cannabinus L (full - 2010) http://www.jstage.jst.go.jp/article/yakushi/130/2/130_237/_article

In silicio expression analysis of PKS genes isolated from Cannabis sativa L. (full – 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036156/?tool=pubmed

Genetic Identification of Female Cannabis sativa Plants at Early Developmental Stage (abst - 2010) https://www.thieme-c onnect.de/DOI/DOI?10.1055/s-0030-1249978

The results of an experimental indoor hydroponic Cannabis growing study, using the 'Screen of Green' (ScrOG) method-Yield, tetrahydrocannabinol (THC) and DNA analysis. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20462712

Metabolic fingerprinting of Cannabis sativa L., cannabinoids and terpenoids for chemotaxonomic and drug standardization purposes. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/21040939

A real-time PCR assay for the relative quantification of the tetrahydrocannabinolic acid (THCA) synthase gene in herbal Cannabis samples (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/22093702/abstract/A_real_time_PCR_assay_for_t he_relative_quantification_of_the_tetrahydrocannabinolic_acid__THCA__synthase_gene_in_herbal_Cann abis_samples_

Assessment of the genetic stability of micropropagated plants of Cannabis sativa by ISSR markers. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19637112

The draft genome and transcriptome of Cannabis sativa. (full - 2011)

http://genomebiology.com/content/pdf/gb-2011-12-10-r102.pdf

Characteristics of cannabinoids composition of Cannabis plants grown in Northern Thailand and its forensic application. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21636228

Investigations into the Hypothesis of Transgenic Cannabis (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/22211569

Medicinal Genomics Sequences the Cannabis Genome to Assemble the Largest Known Gene Collection of this Therapeutic Plant. (news – 2011) http://www.thefreelibrary.com/Medicinal+Genomics+Sequences+the+Cannabis+Genome+to+Assemble+th e...-a0264585240

Cannabis Sequencing Study Explores Differences Between Marijuana, Hemp Producing Plants (news – 2011)

http://www.genomeweb.com/sequencing/cannabis-sequencing-study-explores-differences-between- marijuana-hemp-producing
616

TEA AS MEDICINE


Concentration of Marijuana Metabolites in the Urine After Ingestion of Hemp Seed Tea. (abst - 1999) http://medical-journals.healia.com/doc/10390703/Concentration-of-marijuana-metabolites-in-the-urine- after-ingestion-of-hemp-seed-tea

Cuppa Gives A Better 'ooh' (news - 2006)

http://www.thehempire.com/index.php/cannabis/news/cuppa_gives_a_better_ooh

Cannabis tea revisited: A systematic evaluation (abst - 2007)

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=1760492 6&ordinalpos=24&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

TEETH /DENTISTRY

HEMP AS A MEDICAMENT : Therapeutic results in stomatology (full - 1955)

http://www.greenpassion.org/showthread.php?t=25133

Emotional response to intravenous delta9tetrahydrocannabinol during oral surgery. (abst – 1976) http://www.ncbi.nlm.nih.gov/pubmed/1062533

A study of the effect of delta 9-tetrahydrocannabinol (delta 9-THC) on mammalian salivary flow. (abst - 1978) http://jpet.aspetjournals.org/content/206/3/567.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabis&searchid=1&FIRSTINDEX=2560&resourcetype=HWCIT

Illicit drugs for toothache (letter - 2002)

http://www.nature.com/bdj/journal/v192/n3/full/4801311a.html

Inhibition of Salivary Secretion by Activation of Cannabinoid Receptors (full - 2006)

http://ebm.rsmjournals.com/cgi/content/full/231/8/1421?maxtoshow=&hits=80&RESULTFORMAT=&full text=cannabinoid&searchid=1&FIRSTINDEX=880&resourcetype=HWCIT

Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16406050

Comments on a home remedy for Abcessed Tooth. (forum - 2007)

http://www.myhomeremedies.com/remedy.cgi?remedyid=4638

Activation of CB2 cannabinoid receptors: a novel therapeutic strategy to accelerate

osseointegration of dental implants. (abst - 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19027245
617

Cannabis use and destructive periodontal diseases among adolescents (abst - 2009)

http://www.unboundmedicine.com/medline/ebm/record/19236530/abstract/Cannabis_use_and_destructive_ periodontal_diseases_among_adolescents_

Cannabis relieves Toothache pain? (anecdotal - 2009)

http://www.freshherbguru.com/2009/07/cannabis-relieves-toothache-pain.html

Involvement of the endocannabinoid system in periodontal healing. (abst - 2010)

http://www.ncbi.nlm.nih.gov/pubmed/20233580

Behavioral effects of pulp exposure in mice lacking cannabinoid receptor 2. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22152627

THC/ TETRAHYDROCANNABINOL CB1 & 2 agonist

STUDIES ON THE PHARMACOLOGY AND ACUTE TOXICITY OF COMPOUNDS WITH MARIHUANA ACTIVITY (abst - 1946) http://jpet.aspetjournals.org/content/88/2/154.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=marihuana&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

Chemical basis of hashish activity. (abst - 1970)

http://www.ncbi.nlm.nih.gov/pubmed/4987683

Some actions of delta-1 tetrahydrocannabinol and cannabidiol at cholinergic junctions. (full – 1971) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1703324/pdf/brjpharm00552-0217.pdf

Activity of Dgr8-and Dgr9-Tetrahydrocannabinol and Related Compounds in the Mouse (abst - 1971) http://www.sciencemag.org/cgi/content/abstract/172/3979/165?maxtoshow=&hits=80&RESULTFORMAT =&fulltext=marihuana&searchid=1&FIRSTINDEX=2240&resourcetype=HWCIT

A metabolic interaction in vivo between cannabidiol and Δ1-tetrahydrocannabinol (full - 1972) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1666148/?tool=pubmed

Water-soluble derivatives of 1 -tetrahydrocannabinol. (abst- 1972)

http://www.ncbi.nlm.nih.gov/pubmed/5043146

Effect of Biogenic Amines and Cannabinoids on Bacterial Chemotaxis

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC246374/?page=1

Effects of marihuana in laboratory animals and in man (full - 1974)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1776629&tool=pmcentrez

(full - 1973)
618

A pilot study of orally administered Δ1-trans-tetrahydrocannabinol in the management of patients undergoing radiotherapy for carcinoma of the bronchus (full - 1974) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402430/?tool=pmcentrez&page=1

Smoked marijuana and oral delta-9-THC on specific airway conductance in asthmatic subjects (full - 1974) http://www.ukcia.org/research/SmokedAndOralInAsthmatic.php

Acute effects of smoked marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects. (abst - 1974) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=67

Intravenous delta9-Tetrahydrocannabinol: Effects of ventilatory control and cardiovascular dynamics. (full - 1975) http://journals.lww.com/anesthesiology/pages/articleviewer.aspx?year=1975&issue=06000&article=00008 &type=abstract

Interactions in man of delta-9-tetrahydrocannabinol. II. Cannabinol and cannabidiol. (abst – 1975) http://www.ncbi.nlm.nih.gov/pubmed/1097148

Effects of smoked marijuana in experimentally induced asthma. (abst - 1975)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=57

Absence of interaction between delta9-tetrahydrocannabinol (delta-THC) and cannabidiol (CBD) in aggression, muscle control and body temperature experiments in mice.
(abst – 1975) http://www.ncbi.nlm.nih.gov/pubmed/1171491

The influence of delta9-tetrahydrocannabinol, cannabinol and cannabidiol on tissue oxygen consumption. (abst – 1975) http://www.ncbi.nlm.nih.gov/pubmed/1197914

Analgesic effect of delta-9-tetrahydrocannabinol. (abst - 1975)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=16

The analgesic properties of delta-9-tetrahydrocannabinol and codeine. (abst - 1975)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=17

Antibacterial activity of delta9-tetrahydrocannabinol and cannabidiol. (abst - 1976)

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=1085130&dopt=abstract plus

Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol of asthmatic patients. (full - 1976) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC470501/?tool=pubmed

In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas. (abst - 1977) http://www.ncbi.nlm.nih.gov/pubmed/616322
619

Bronchial effects of aerosolized delta 9-tetrahydrocannabinol in healthy and asthmatic subjects. (abst - 1977)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=109

Delta-9-Tetrahydrocannibinol as an Antiemetic in Cancer Patients Receiving High-Dose Methotrexate (full - 1979) http://www.medmjscience.org/Pages/science/chang.html

Cannabinoids. II. Cardiovascular Effects (full - 1980)

http://jpet.aspetjournals.org/content/214/1/131.full.pdf+html?ijkey=e751d405c4b7e494c235b602119e4f9b 8c62c04d&keytype2=tf_ipsecsha

Plasma delta-9-tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking (abst - 1980) http://www.nature.com/clpt/journal/v28/n3/abs/clpt1980181a.html

Marihuana as a therapeutic agent for muscle spasm or spasticity. (abst - 1980)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=53

Sedative activity of cannabis in relation to its delta'-trans-tetrahydrocannabinol and cannabidiol content. (full -1981) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2071638/?tool=pmcentrez

Activity of cannabis in relation to its delta'-trans-tetrahydro-cannabinol content.
(full - 1981) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2071597/?tool=pmcentrez&page=1

The seed and the soil: effect of dosage, personality and starting state on the response to delta 9 tetrahydrocannabinol in man. (full – 1981) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401962/?tool=pubmed

The cardiovascular and autonomic effects of repeated administration of delta-9- tetrahydrocannabinol to rhesus monkeys. (abst – 1981) http://www.ncbi.nlm.nih.gov/pubmed/6257883

Comparison of effects of marihuana cigarettes of three different potencies (full - 1982)

http://www.nature.com/clpt/journal/v31/n5/pdf/clpt198286a.pdf

Ocular Effects of Topical Administration of {Delta}9-Tetrahydrocannabinol in Man (full - 1982)
http://archopht.ama- assn.org/cgi/reprint/100/2/265?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searc hid=1&FIRSTINDEX=2960&resourcetype=HWCIT

Multiple-Drop Study of Topically Applied 1% {Delta}9-Tetrahydrocannabinol in Human Eyes (full - 1983)
http://archopht.ama- assn.org/cgi/reprint/101/4/591?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabis&searchid= 1&FIRSTINDEX=2800&resourcetype=HWCIT
620
 
Pages 621 - 625

Neurobehavioral actions of cannabichromene and interactions with delta 9- tetrahydrocannabinol. (abst - 1983) http://www.ncbi.nlm.nih.gov/pubmed/6301931

Respiratory and cardiovascular depressant effects of nabilone, N-methyllevonantradol and delta 9-tetrahydrocannabinol in anesthetized cats. (abst - 1983) http://jpet.aspetjournals.org/content/227/2/508.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=marihuana&searchid=1&FIRSTINDEX=1920&resourcetype=HWCIT

Allergenic properties of naturally occurring cannabinoids. (abst - 1983)

http://www.ncbi.nlm.nih.gov/pubmed/6620158

Acute Effects of Natural and Synthetic Cannabis Compounds on Prolactin Levels in Human Males. (abst – 1984) http://www.ncbi.nlm.nih.gov/pubmed/6320226

Intraocular pressure, ocular toxicity and neurotoxicity after administration of delta 9- tetrahydrocannabinol or cannabichromene. (abst – 1984) http://www.ncbi.nlm.nih.gov/pubmed/6323206

Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. (abst – 1984) http://www.ncbi.nlm.nih.gov/pubmed/6098513

Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds (abst – 1984) http://www.ncbi.nlm.nih.gov/pubmed/6090851

The quasi-morphine withdrawal syndrome: effect of cannabinol, cannabidiol and tetrahydrocannabinol. (abst - 1985) http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=2994117&dopt=abstract plus

Antiemetic efficacy of levonantradol compared to delta-9-tetrahydrocannabinol for chemotherapy-induced nausea and vomiting. (abst – 1985) http://www.ncbi.nlm.nih.gov/pubmed/2981616

The effect of delta-9-THC on human spasticity. (abst - 1986)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=154

Oral vs. Inhaled Cannabinoids for Nausea/Vomiting from Cancer Chemotherapy (full - 1988) http://www.medmjscience.org/Pages/science/pierson.html

The inhibitory effects of cannabinoids, the active constituents of Cannabis sativa L. on human and rabbit platelet aggregation. (abst - 1989) http://www.ncbi.nlm.nih.gov/pubmed/2575149

Marijuana Smoking: Factors That Influence the Bioavailability of Tetrahydrocannabinol (full - 1990) http://www.ukcia.org/research/FactorsThatInfluenceBioavailability.pdf

A comparison of the ocular and central effects of delta 9-tetrahydrocannabinol and cannabigerol. (abst - 1990) http://www.ncbi.nlm.nih.gov/pubmed/1965836
621

Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial. (abst - 1990)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=10

Chronic Exposure to Delta 9-tetrahydrocannabinol Fails to Irreversibly Alter Brain Cannabinoid Receptors. (abst - 1991) http://medical-journals.healia.com/...posure-to-delta-9-tetrahydrocannabinol-fails- to-irreversibly-alter-brain-cannabinoid-receptors

Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism. (full - 1992) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1907498/?tool=pmcentrez&page=1

Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide. (full - 1993) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175863/?tool=pmcentrez&page=1

Effects of delta 9-THC on marijuana smoking, dose choice, and verbal report of drug liking. (full - 1994) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1334408/?tool=pubmed

Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice.
(abst - 1994) http://jpet.aspetjournals.org/content/268/3/1381.abstract?maxtoshow=&hits=80&RESULTFORMAT=&ful ltext=marihuana&searchid=1&FIRSTINDEX=1840&resourcetype=HWCIT

Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin (abst - 1995) http://ajpheart.physiology.org/cgi/content/abstract/269/6/H1859?maxtoshow=&hits=80&RESULTFORMA T=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=2320&resourcetype=HWCIT

NTP Technical Report on the Toxicology and Carcinogenesis Studies of 1-Trans-Delta9- Tetrahyrdocannabinol (CAS No. 1972-08-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (full - 1996) http://www.druglibrary.org/Schaffer/hemp/Trans-Delta Report.pdf

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity : a pilot study with 2 patients. (abst - 1996) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=12

Toxicity and Carcinogenicity of {Delta}9-Tetrahydrocannabinol in Fischer Rats and B6C3F1 Mice (abst - 1996) http://toxsci.oxfordjournals.org/cgi/content/abstract/30/1/109?maxtoshow=&hits=80&RESULTFORMAT= &fulltext=marihuana&searchid=1&FIRSTINDEX=240&resourcetype=HWCIT

Genetic differences in delta 9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains. (abst – 1996) http://www.ncbi.nlm.nih.gov/pubmed/8649214
622

The perceived effects of smoked cannabis on patients with multiple sclerosis. (abst - 1997) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=13

Study: THC Not Cancer-Causing (news - 1997) http://www.ukcia.org/research/cancer.php

Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants (full - 1998) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=20965&tool=pmcentrez

Cerebellar activity and disturbed time sense after THC. (abst - 1998)

http://www.ncbi.nlm.nih.gov/pubmed/9666122

Treatment of Tourette's Syndrome With Delta-9-Tetrahydrocannabinol

http://ajp.psychiatryonline.org/cgi/content/full/156/3/495

Cannabis and cannabinoids: pharmacology and rationale for clinical use

http://pharmgkb.org/pmid/10575283

Cannabis: Discrimination of "Internal Bliss"? (abst – 1999)

(letter - 1999) (abst – 1999)
http://medical-journals.healia.com/doc/10515300/Cannabis-discrimination-of-internal-bliss

Advantages of polypharmaceutical herbal cannabis compared to single ingredient, synthetic tetrahydrocannabinol (full - 2000)

http://www.cannabis-science.com/papers/cannabis terpenes.pdf

Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. (full - 2000) http://depts.washington.edu/stellalb/images/Nature2000.pdf

Cannabinoids might reduce spasticity in multiple sclerosis (full - 2000)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1117698/?tool=pmcentrez

Variations of D9-THC content in single plants of hemp varieties (full - 2000)

http://www.ukcia.org/research/VariationOfTHCContent.pdf

GC-MS analysis of the total delta9-THC content of both drug- and fiber-type cannabis seeds. (abst – 2000) http://www.ncbi.nlm.nih.gov/pubmed/11110027

Cannabinoids in clinical practice. (abst - 2000)

http://www.ncbi.nlm.nih.gov/pubmed/11152013

Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A. (full – 2001) http://www.nature.com/npp/journal/v24/n2/full/1395605a.html

Tetrahydrocannabinol for treatment of chronic pain (abst - 2001)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=147
623

Neuroprotection by Delta 9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity (abst - 2001) http://www.jneurosci.org/cgi/content/abstract/21/17/6475?maxtoshow=&hits=10&RESULTFORMAT=&f ulltext=cannabis&andorexactfulltext=and&searchid=1&FIRSTINDEX=70&sortspec=relevance&resourcet ype=HWCIT

Clinical investigation of delta-9-tetrahydrocannabinol (THC) as an alternative therapy for overactive bladders in spinal cord injury (SCI) patients. (abst - 2001) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=102

Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease (full - 2002) http://bloodjournal.hematologylibra...ll/100/2/627?ijkey=eb71d6d7a06f311440761cfac6 a7d081bcc2771d

The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids. (full – 2002) http://jpet.aspetjournals.org/content/300/1/34.long

Cannabinoids and multiple sclerosis. (abst - 2002)

http://www.ncbi.nlm.nih.gov/pubmed/12182963

Cannabinoids in the treatment of pain and spasticity in multiple sclerosis. (abst - 2002)

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=12137404&dopt=abstrac tplus

Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN (full - 2003) http://www.jleukbio.org/cgi/content/full/75/3/453?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT

The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy (full - 2003) http://jpet.aspetjournals.org/content/307/1/129.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

Treatment of Tourette Syndrome with Delta-9-Tetrahydrocannabinol (Delta9-THC): No Influence on Neuropsychological Performance (full - 2003) http://www.nature.com/npp/journal/v28/n2/abs/1300047a.html

Inhibition of tumor angiogenesis by cannabinoids (full - 2003)

http://www.fasebj.org/cgi/reprint/02- 0795fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&sear chid=1&FIRSTINDEX=20&sortspec=relevance&resourcetype=HWCIT

Effects of THC on Behavioral Measures of Impulsivity in Humans (full - 2003)

http://www.nature.com/npp/journal/v28/n7/full/1300176a.html
Cannabis and the brain. (full - 2003) http://brain.oxfordjournals.org/cgi/content/full/126/6/1252
624

Cannabinoids: Potential Anticancer Agents (full - 2003)

http://americanmarijuana.org/Guzman-Cancer.pdf

The treatment of spasticity with D9-THC) in patients with spinal cord injury (abst - 2003)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=79

Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/12447606

Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial. (abst - 2003) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=146#1

Cannabis use for chronic non-cancer pain: results of a prospective survey.

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=91

Cannabis can help MS sufferers (news - 2003)

http://www.newscientist.com/article/dn4356-cannabis-can-help-ms-sufferers.html

(abst - 2003)

Differential Effects of THC or CBD-rich Cannabis Extracts on Working Memory in Rats (full - 2004) http://www.ukcia.org/research/THCCBDWorkingMemory.pdf

Cannabinoids: Defending the Epileptic Brain (full - 2004)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176332/?tool=pmcentrez

Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ̳N of 1‘ studies (full - 2004) http://www.ukcia.org/research/InitialExperiencesChronicPain.pdf

The good and the bad effects of (−) trans-delta-9-tetrahydrocannabinol (Δ9-THC) on humans (abst - 2004) http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCS-4CSG2C4- 2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlV ersion=0&_userid=10&md5=99df29b0ce94c395c01f5aad8825d28b

Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels following weight loss. (abst – 2004) http://www.ncbi.nlm.nih.gov/pubmed/15099912

Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early- morning behavior in young adults. (abst - 2004) http://www.ncbi.nlm.nih.gov/pubmed/15118485?dopt=Abstract

THC in marijuana may block the spread of forms of cancer causing herpes viruses (news - 2004) http://www.news-medical.net/news/2004/09/22/4990.aspx

Cannabis truly helps multiple sclerosis sufferers (news - 2004)

http://www.newscientist.com/article/dn6387-cannabis-truly-helps-multiple-sclerosis-sufferers.html
625
 
Pages 626 - 630

Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice (full - 2005) http://www.nature.com/nature/journal/v434/n7034/full/nature03389.html

Synergistic Interactions between Cannabinoids and Environmental Stress in the Activation of the Central Amygdala (full - 2005) http://www.nature.com/npp/journal/v30/n3/full/1300535a.html

Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death (full - 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1824211/?tool=pmcentrez

The effects of Δ9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide (full - 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576168/?tool=pmcentrez

Cannabis may help keep arteries clear (news - 2005)

http://www.newscientist.com/article/mg18624956.000

Medical marijuana: study shows that THC slows atherosclerosis

http://thenexthurrah.typepad.com/the_next_hurrah/2005/04/medical_marijua.html

Science: THC slows development of atherosclerosis in animal study

(news - 2005) (news - 2005)
http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=190#1

Cannabis Spray for Bipolar (news - 2005)

http://www.prohealth.com/me-cfs/blog/boardDetail.cfm?id=565511

Chemicals in Cannabis may help mentally ill (news - 2005)

http://www.news-medical.net/news/2005/06/06/10716.aspx

A tale of two cannabinoids:The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. (full - 2006) http://mcforadhd.free.fr/Russo_Tale_of_Two_Cannabinoids_Med_Hypoth_2006.pdf

Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In- Cachexia-Study-Group (full - 2006) http://jco.ascopubs.org/content/24/21/3394.long

A Molecular Link between the Active Component of Marijuana and Alzheimer‘s

Disease Pathology (full - 2006)

http://www.ukcia.org/research/AlzheimersDiseasePathology.pdf

(news - 2005) New Synthetic Delta-9-THC Inhaler Offers Safe, Rapid Delivery , Phase I Study

THC effective in appetite and weight loss in severe lung disease (COPD)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=191#2 (news - 2005) http://www.medicalnewstoday.com/articles/22937.php
626

{Delta}9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer Cells through Cdc2 Regulation (full - 2006) http://cancerres.aacrjournals.org/cgi/content/full/66/13/6615

Δ9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria (full - 2006) http://mcr.aacrjournals.org/content/4/8/549.full

Further Characterization of the Time-Dependent Vascular Effects of Δ9- Tetrahydrocannabinol (full - 2006) http://jpet.aspetjournals.org/content/317/1/428.full

Cannabinoids and the Endocannabinoid System (full - 2006)

http://www.cannabis-med.org/english/journal/en_2006_01_2.pdf

The Cannabinoid Cb1 Receptor Antagonist Rimonabant Attenuates the Hypotensive Effect of Smoked Marijuana in Male Smokers. (full – 2006) http://www.ahjonline.com/article/S0002-8703(05)01013-6/fulltext

Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia. (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16997463?dopt=Abstract

Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16834825

A pilot clinical study of Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. (abst - 2006) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=193

Delta(9)-Tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
(abst - 2006) http://www.unboundmedicine.com/medline/ebm/record/17140550/abstract/Delta_9__Tetrahydrocannabino l_protects_hippocampal_neurons_from_excitotoxicity

The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16458258

The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury. (abst - 2006) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=166

An Experimental Study of Catechol-O-Methyltransferase Val(158)Met Moderation of Delta-9-Tetrahydrocannabinol-Induced Effects on Psychosis and Cognition
(abst - 2006)

http://www.unboundmedicine.com/medline/ebm/record/16936704/abstract/An_Experimental_Study_of_Ca techol_O_Methyltransferase_Val_158_Met_Moderation_of_Delta_9_Tetrahydrocannabinol_Induced_Effe cts_on_Psychosis_and_Cognition
627

Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16506408

THC and prochlorperazine effective in reducing vomiting in women following breast surgery (news - 2006) http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=219#1

THC inhibits primary marker of Alzheimer's disease (news - 2006)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=225#3

Cannabis destroys cancer cells (news - 2006) http://www.news- medical.net/news/2006/03/01/16340.aspx

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9- tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/?tool=pubmed&itool=EntrezSystem2.PEntrez.Pub med.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.Pubmed_DiscoveryDbLinks&ordinalpos=1

Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771679/?tool=pubmed

Opioid Antagonism of Cannabinoid Effects: Differences between Marijuana Smokers and Nonmarijuana Smokers (full - 2007) http://www.nature.com/npp/journal/v32/n6/full/1301243a.html

The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo. (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189766/?tool=pubmed

Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083705/?tool=pubmed

CB2 receptors in the brain: role in central immune function (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219530/?tool=pmcentrez

Δ9-Tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189998/?tool=pmcentrez

Low dose combination of morphine and Δ9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040345/

On the pharmacological properties of Delta9-tetrahydrocannabinol (THC). (abst - 2007) http://www.ncbi.nlm.nih.gov/pubmed/17712813
628

The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat involves the CB(2) cannabinoid receptor. (abst - 2007) http://www.unboundmedicine.com/medline/ebm/record/17588560/abstract/The_antinociceptive_effect_of_ Delta9_tetrahydrocannabinol_in_the_arthritic_rat_involves_the_CB_2__cannabinoid_receptor

THC improves appetite and reverses weight loss in AIDS patients (abst - 2007)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=189

Repeated Treatment with Cannabidiol but Not Delta9-tetrahydrocannabinol Has a Neuroprotective Effect Without the Development of Tolerance (abst - 2007) http://medical-journals.healia.com/doc/17320118/Repeated-treatment-with-cannabidiol-but-not-Delta9- tetrahydrocannabinol-has-a-neuroprotective-effect-without-the-development-of-tolerance

Synergy between Delta(9)-tetrahydrocannabinol and morphine in the arthritic rat (abst - 2007)

http://www.unboundmedicine.com/medline/ebm/record/17498686/abstract/Synergy_between_Delta_9__tet rahydrocannabinol_and_morphine_in_the_arthritic_rat

The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. (abst - 2007) http://www.ncbi.nlm.nih.gov/pubmed/17583570

Delta(9)-tetrahydrocannabinol (Delta(9)-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. (abst - 2007) http://www.unboundmedicine.com/medline/ebm/record/17289082/abstract/Delta_9__tetrahydrocannabinol __Delta_9__THC__prevents_cerebral_infarction_via_hypothalamic_independent_hypothermia

Symptomatic treatment of multiple sclerosis using cannabinoids: recent advances. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17868014

Medicinal chemistry endeavors around the phytocannabinoids. (abst - 2007)

http://www.ncbi.nlm.nih.gov/pubmed/17712816

Effects of a Selective Cannabinoid Agonist and Antagonist on Body Temperature in Rats (abst - 2007) http://www.fasebj.org/cgi/content/meeting_abstract/21/5/A409?maxtoshow=&hits=80&RESULTFORMA T=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=800&resourcetype=HWCIT

Pot's Active Ingredient Halts Lung Cancer Growth, Study Says (news - 2007)

http://www.illinoisnorml.org/content/view/529/27/

Cannabis can reduce Allergic Skin Reactions, latest research shows (news - 2007)

http://www.healthjockey.com/2007/06/08/cannabis-can-reduce-allergic-skin-reactions-latest-research- shows/

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-

tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
629

Δ9-Tetrahydrocannabinol Content of Commercially Available Hemp Products
(full - 2008) https://secure.manitobaharvest.com/images/uploads/pages/File/thc_study_jat_2008.pdf

Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Δ9-tetrahydrocannabinol (full - 2008) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2279017

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells (full - 2008) http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block

Cannabinoids in the management of difficult to treat pain (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/?tool=pmcentrez

Cannabinoid receptors in acute and chronic complications of atherosclerosis (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219535/?tool=pmcentrez

Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. (full - 2008)

http://www.cannabisasmedicine.com/story/antibacterial-cannabinoids-cannabis-sativa- structure%E2%88%92activity-study

Delta-9-tetrahydrocannabinol pharmacokinetics (abst - 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18847571

High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18615640

Effect of intrapulmonary tetrahydrocannabinol administration in humans. (abst - 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18515447

Science: THC reduces reflux of acid from the stomach (news – 2008)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=285#1

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697695/?tool=pubmed

Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. (full - 2009) http://www.nature.com/npp/journal/v34/n3/full/npp2008138a.html

Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells (full – 2009) http://www.jbc.org/content/285/3/1616.full?sid=43211ca4-a4aa-4182-a554-d15e2835e288
630
 
Pages 631 - 635

Hydroxylation and Further Oxidation of Δ9-Tetrahydrocannabinol by Alkane-Degrading Bacteria (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786519/?tool=pmcentrez

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664885/?tool=pubmed

Evaluation of Prevalent Phytocannabinoids in the Acetic Acid Model of Visceral Nociception (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765124/?tool=pubmed

Tetrahydrocannabinol (Delta 9-THC) Treatment in Chronic Central Neuropathic Pain and Fibromyalgia Patients: Results of a Multicenter Survey (full - 2009) http://www.hindawi.com/journals/arp/2009/827290.html

Actions of delta-9-tetrahydrocannabinol in cannabis (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731700/?tool=pmcentrez

Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma (full - 2009) http://mct.aacrjournals.org/content/8/7/1838.full

TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action. (full – 2009)

http://www.landesbioscience.com/journals/autophagy/SalazarAUTO5-7.pdf

Cannabinoid action induces autophagymediated cell death through stimulation of ER stress in human glioma cells. (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19425170/abstract/

Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users. (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/18719045?ordinalpos=44&itool=EntrezSystem2.PEntrez.Pubmed.Pu bmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Modulation of effective connectivity during emotional processing by Delta9- tetrahydrocannabinol and cannabidiol. (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19775500?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pub med_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Opposite Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology. (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19924114/full_citation/Opposite_Effects_of_Delta _9_Tetrahydrocannabinol_and_Cannabidiol_on_Human_Brain_Function_and_Psychopathology_

Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)- tetrahydrocannabinol in rats. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19393686

Active cannabis chemicals halt prostate cancer cell growth (news - 2009)

http://www.news-medical.net/news/20090908/Active-cannabis-chemicals-halt-prostate-cancer-cell- growth.aspx
631

Marijuana Chemicals Ease MS Symptoms, Review Confirms (news - 2009)

http://www.drugfree.org/uncategorized/marijuana-chemicals-ease-ms

THC initiates brain cancer cells to destroy themselves (news - 2009)

http://www.worldhealth.net/news/thc_initiates_brain_cancer_cells_to_dest/

Active Component Of Marijuana Has Anti-Cancer Effects, Study Suggests (news - 2009) http://www.sciencedaily.com/releases/2009/04/090401181217.htm

Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898685/?tool=pmcentrez

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917429/?tool=pmcentrez

Smoked cannabis for chronic neuropathic pain: a randomized controlled trial (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950205/?tool=pmcentrez

Therapeutical use of the cannabinoids in psychiatry (full – 2010)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516- 44462010000500009&lng=en&nrm=iso&tlng=en

Effect of (-)-Delta(9)-tetrahydrocannabinoid on the hepatic redox state of mice. (full – 2010)
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100- 879X2010007500015&lng=en&nrm=iso&tlng=en

The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931570/?tool=pubmed

Antidepressant-like effect of Delta(9)-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/?tool=pubmed

Cannabinoids Inhibit Cellular Respiration of Human Oral Cancer Cells (full - 2010)

http://content.karger.com/produktedb/produkte.asp?DOI=000312686&typ=pdf

Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20417220/abstract/Delta9_tetrahydrocannabinol_is _a_full_agonist_at_CB1_receptors_on_GABA_neuron_axon_terminals_in_the_hippocampus_

Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/19896326
632

Modulation of Adipocyte Biology by Δ9-Tetrahydrocannabinol (abst - 2010)

http://www.nature.com/oby/journal/vaop/ncurrent/abs/oby2010100a.html

The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti- invasion activity at low concentration and apoptosis induction at high concentration. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19916793

Exposure to a high-fat diet decreases sensitivity to Δ9-tetrahydrocannabinol-induced motor effects in female rats (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20850461

Chronic cannabinoid administration lowers viral replication in lymph nodes of SIV infected Rhesus macaques (abst - 2010) http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/752.6?maxtoshow=&hits=80& RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=720&resourcetype=HWCIT

Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20884951

THC Prevents MDMA Neurotoxicity in Mice. (abst - 2010)

http://www.ncbi.nlm.nih.gov/pubmed/20174577

Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20118579

Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology (abst - 2010) http://www.nature.com/npp/journal/v35/n3/full/npp2009184a.html

A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/19785914/abstract/A_behavioural_comparison_of_ acute_and_chronic_Delta9_tetrahydrocannabinol_and_cannabidiol_in_C57BL/6JArc_mice_

Disposition of Cannabichromene, Cannabidiol, and Δ9-Tetrahydrocannabinol and its Metabolites in Mouse Brain following Marijuana Inhalation Determined by High- Performance Liquid Chromatography-Tandem Mass Spectrometry (abst - 2010) http://www.ingentaconnect.com/content/pres/jat/2010/00000034/00000008/art00012

Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20884951

Oral Delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in

an adolescent by increasing intracortical inhibition: a case report. (abst - 2010)

http://www.ncbi.nlm.nih.gov/pubmed/20520294
633

Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ9-tetrahydrocannabinol (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20619971

Regulation of nausea and vomiting by cannabinoids (abst - 2010)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476- 5381.2010.01176.x/abstract;jsessionid=56CED9CE51B025C161AA2E821BEC94ED.d01t01

Tocolytic Effect of Δ9-Tetrahydrocannabinol in Mice Model of Lipopolysaccharide— Induced Preterm Delivery: Role of Nitric Oxide (abst - 2010) http://rsx.sagepub.com/content/17/4/391.abstract

Key ingredient staves off marijuana memory loss (news - 2010)

http://www.nature.com/news/2010/101001/full/news.2010.508.html?s=news_rss

Marijuana May Extend Life Expectancy Of Lou Gehrig's Disease Patients, Study Says (news - 2010) http://www.norml.org/index.cfm?Group_ID=8191

THC Keeps Monkeys Alive in AIDS Research Model (news - 2010)

http://cannabination.com/2010/10/23/thc-keeps-monkeys-alive-in-aids-research-model/

Science: Cannabis effective in the treatment of TOURETTE Syndrome and attention deficit hyperactivity disorder (ADHD) (news – 2010)
http://www.cannabis- med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=323&search_pattern=tourette#2

Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa (full – 2011) http://www.jstage.jst.go.jp/article/bpb/34/5/774/_pdf

Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial

(full – 2011) http://annonc.oxfordjournals.org/content/early/2011/02/11/annonc.mdq727.full Cannabinoid Neuroimmune Modulation of SIV Disease. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21830069

Tolerance to chronic delta-9-tetrahydrocannabinol (Δ9-THC) in rhesus macaques infected with simian immunodeficiency virus. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21463073/abstract/Tolerance_to_chronic_delta_9_ tetrahydrocannabinol__%CE%94%E2%81%B9_THC__in_rhesus_macaques_infected_with_simian_immu nodeficiency_virus_

Cannabidiol potentiates Δ(9)-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats.
(abst - 2011) http://www.ncbi.nlm.nih.gov/pubmed/21667074

Prospects for cannabinoid therapies in basal ganglia disorders. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21545415
634

Combined effects of THC and caffeine on working memory in rats. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21699509

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. (abst - 2011) http://www.ncbi.nlm.nih.gov/pubmed/21749363

Δ(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21645556/abstract/Δ_9__THC_and_WIN5 5212_2_affect_brain_tissue_levels_of_excitatory_amino_acids_in_a_phenotype__compound__dose__and _region_specific_manner_

The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21449917/abstract/The_fatty_acid_amide_hydrolas e_inhibitor_URB_597:_interactions_with_anandamide_in_rhesus_monkeys_

Effects of synthetic cannabinoids on electroencephalogram power spectra in rats.
(abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21640532/abstract/Effects_of_synthetic_cannabino ids_on_electroencephalogram_power_spectra_in_rats_

THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis. (abst - 2011) http://www.unboundmedicine.com/medline/ebm/record/21456949/abstract/THC_and_CBD_oromucosal_s pray__Sativex%C2%AE__in_the_management_of_spasticity_associated_with_multiple_sclerosis_

Plasma cannabinoid pharmacokinetics following controlled oral delta9- tetrahydrocannabinol and oromucosal cannabis extract administration (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21078841/abstract/Plasma_cannabinoid_pharmaco kinetics_following_controlled_oral_delta9_tetrahydrocannabinol_and_oromucosal_cannabis_extract_admi nistration_

Pharmacokinetics of a combination of Δ9-tetrahydro-cannabinol and celecoxib in a porcine model of hemorrhagic shock. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21341278/abstract/Pharmacokinetics_of_a_combin ation_of_%CE%949_tetrahydro_cannabinol_and_celecoxib_in_a_porcine_model_of_hemorrhagic_shock_

Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ(9) -tetrahydrocannabinol in BV-2 microglial cells (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21542829/abstract/Differential_transcriptional_pro files_mediated_by_exposure_to_the_cannabinoids_cannabidiol_and_%CE%94_9___tetrahydrocannabinol _in_BV_2_microglial_cells_

Pre- and post-conditioning treatment with an ultra-low dose of Δ9-tetrahydrocannabinol (THC) protects against pentylenetetrazole (PTZ)-induced cognitive damage.
(abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21315768
635
 
Pages 636 - 640

Heterogeneity in the composition of marijuana seized in California. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21288662/abstract/Heterogeneity_in_the_composit ion_of_marijuana_seized_in_California_

Modulation of Auditory and Visual Processing by Delta-9-Tetrahydrocannabinol and Cannabidiol: an fMRI Study. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21412224

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21175579/abstract/Effects_of_cannabinoids_and_c annabinoid_enriched_Cannabis_extracts_on_TRP_channels_and_endocannabinoid_metabolic_enzymes_

Ingredient in cannabis restores taste for cancer patients (news – 2011)

http://news.yahoo.com/s/afp/20110222/hl_afp/healthdiseasecancerdrugscannabisfood

Marijuana Compound Treats Multiple Health Issues (news – 2011)

http://www.foxnews.com/health/2010/03/10/cannabis-deficient/

Another Study Confirms Anti-Cancer Effects of THC and CBD (news – 2011)

http://www.examiner.com/medical-mar...a/another-study-confirms-anti-cancer-effects- of-thc-and-cbd-1

THC ACID/ THCA - non-psychoactive precursor of THC

The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Delta1-tetrahydrocannabinolic acid synthase from Cannabis sativa L. (full – 2004) http://www.jbc.org/content/279/38/39767.long

Crystallization of Δ1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa (full - 2005) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1952348&tool=pmcentrez

Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor coupled pathways. (abst - 2006)
http://www.ncbi.nlm.nih.gov/pubmed/16504929

THC inhibits primary marker of Alzheimer's disease (news - 2006)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=225#3

Identification and Characterization of Cannabinoids That Induce Cell Death through Mitochondrial Permeability Transition in Cannabis Leaf Cells (full – 2007) http://www.jbc.org/content/282/28/20739.full?sid=a5db98db-ff96-4187-8790-57097bbe15c1

Production of THC acid by the biosynthetic enzyme secreted from transgenic Pichia pastoris. (abst - 2007) http://marijuana.researchtoday.net/archive/4/8/1331.htm
636

Cannabinoids act as necrosis-inducing factors in Cannabis sativa (full - 2008)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2634471&tool=pmcentrez

Evaluation of Prevalent Phytocannabinoids in the Acetic Acid Model of Visceral Nociception (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765124/?tool=pubmed

A real-time PCR assay for the relative quantification of the tetrahydrocannabinolic acid (THCA) synthase gene in herbal Cannabis samples (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/22093702/abstract/A_real_time_PCR_assay_for_t he_relative_quantification_of_the_tetrahydrocannabinolic_acid__THCA__synthase_gene_in_herbal_Cann abis_samples_

Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa (full – 2011) http://www.jstage.jst.go.jp/article/bpb/34/5/774/_pdf

Immunochemical approach using monoclonal antibody against Δ(9)- tetrahydrocannabinolic acid (THCA) to discern cannabis plants and to investigate new drug candidates. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21143135/abstract/Immunochemical_approach_usi ng_monoclonal_antibody_against_%CE%94_9__tetrahydrocannabinolic_acid__THCA__to_discern_canna bis_plants_and_to_investigate_new_drug_candidates_

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21175579/abstract/Effects_of_cannabinoids_and_c annabinoid_enriched_Cannabis_extracts_on_TRP_channels_and_endocannabinoid_metabolic_enzymes_

TETRAHYDROCANNABINOL-HEMISUCCINATE / THC-HS

US Patent 5389375 - Stable suppository formulations effecting bioavailability of Ɗ9 -thc (full - 1995) http://www.patentstorm.us/patents/5389375/fulltext.html

US Patent 5508037 - Stable suppository formulations effecting bioavailability of Ɗ9 - THC (full - 1996) http://www.patentstorm.us/patents/5508037/fulltext.html

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients. (abst - 1996) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=12

Chemical Stabilization of a Delta9-Tetrahydrocannabinol Prodrug in Polymeric Matrix

Systems Produced by a Hot-melt Method: Role of Microenvironment pH (full - 2006)

http://www.aapspharmscitech.org/view.asp?art=pt070371
637

Preparation and characterization of inclusion complexes of a hemisuccinate ester prodrug of delta9-tetrahydrocannabinol with modified beta-cyclodextrins. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20333489/abstract/Preparation_and_characterizatio n_of_inclusion_complexes_of_a_hemisuccinate_ester_prodrug_of_delta9_tetrahydrocannabinol_with_mod ified_beta_cyclodextrins_

Effect of ion pairing on in vitro transcorneal permeability of a Δ(9) -tetrahydrocannabinol prodrug: Potential in glaucoma therapy. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21989812/abstract/Effect_of_ion_pairing_on_in_vi tro_transcorneal_permeability_of_a_%CE%94_9___tetrahydrocannabinol_prodrug:_Potential_in_glaucom a_therapy_

TETRAHYDROCANNABIVARIN/ THCV phytocannabinoid, CB1 & CB2 antagonist Cannabivarin and Tetrahydrocannabivarin, Two New Constituents of Hashish

(abst - 1971) http://www.nature.com/nature/journal/v232/n5312/abs/232579a0.html

Delta9-tetrahydrocannabivarin as a marker for the ingestion of marijuana versus Marinol: results of a clinical study (abst - 2001) http://www.unboundmedicine.com/medline/ebm/record/11599601/abstract/

Plant cannabinoids: a neglected pharmacological treasure trove (full - 2005)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1751232&tool=pmcentrez

Evidence that the plant cannabinoid Δ9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist (full - 2005) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751228/?tool=pubmed

The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo. (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189766/?tool=pubmed

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9- tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/

Non-psychotropic plant cannabinoids:new therapeutic opportunities from an ancient herb (full - 2009 )

http://cannabisinternational.org/info/Non-Psychoactive-Cannabinoids.pdf

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties

in fasted and non-fasted mice (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697695/?tool=pubmed
638

Delta9-tetrahydrocannabivarin testing may not have the sensitivity to detect marijuana use among individuals ingesting dronabinol. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815025/?tool=pubmed

The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931567/?tool=pubmed

Delta-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20196794

Anticonvulsant effects of GWP42006 in vitro and in vivo in rat (abst - 2010)

http://www.physoc.org/custom2/publications/proceedings/archive/article.asp?ID=Proc Physiol Soc %2019C117

Symptom-relieving and neuroprotective effects of the phytocannabinoid D(9) -THCV in animal models of Parkinson's disease (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21323909/abstract/Symptom_relieving_and_neuro protective_effects_of_the_phytocannabinoid_D_9___THCV_in_animal_models_of_Parkinson%27s_disea se_

Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ(9)-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive- compulsive behaviour. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21796370

Δ(8) -Tetrahydrocannabivarin protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress and inflammatory response involving CB(2) receptors. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21470208/abstract/Δ_8___Tetrahydrocann abivarin_protects_against_hepatic_ischemia/reperfusion_injury_by_attenuating_oxidative_stress_and_infla mmatory_response_involving_CB_2__receptors_

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21175579/abstract/Effects_of_cannabinoids_and_c annabinoid_enriched_Cannabis_extracts_on_TRP_channels_and_endocannabinoid_metabolic_enzymes_

CB(1) -independent mechanisms of Δ(9) -THCV, AM251 and SR141716 (rimonabant). (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21740450

Phytocannabinoids as novel therapeutic agents in CNS disorders

http://www.ncbi.nlm.nih.gov/pubmed/21924288

Cannabis could help treat epilepsy (news – 2011)

http://www.newkerala.com/news/world/fullnews-186693.html

Cannabis could be used to treat epilepsy (news – 2011)

(abst – 2011)
http://www.telegraph.co.uk/science/...Cannabis-could-be-used-to-treat-epilepsy.html
639

New research provides hope for those with epilepsy (news - 2011)

http://medicalxpress.com/news/2011-04-epilepsy.html

TIME PERCEPTION

Cannabis, atropine, and temporal information processing.

http://www.ncbi.nlm.nih.gov/pubmed/6100128

Cerebellar activity and disturbed time sense after THC.

http://www.ncbi.nlm.nih.gov/pubmed/9666122

(abst - 1984) (abst – 1998)

Cannabinoid modulation of time estimation in the rat. (abst – 2001)

http://www.ncbi.nlm.nih.gov/pubmed/11256448

Marijuana Alters the Human Cerebellar Clock. (abst – 2003)

http://medical-journals.healia.com/doc/12821798/Marijuana-alters-the-human-cerebellar-clock

Effects of marijuana on temporal discriminations in humans. (abst – 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16495725

Cannabinoid Modulation of Time Estimation in the Rat. (full – 2001)

http://content.apa.org/pubmed/bne/115/1/243

TINNITUS - also see HEARING
Drug treatments for subjective tinnitus: serendipitous discovery versus rational drug

design. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/16044667 Doctor's diary: cannabis as medicine - the dilemma (news - 2005)

http://www.safeaccessnow.org/article.php?id=1752

Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension : a case report (abst + 1st page - 2006) http://www.liebertonline.com/doi/abs/10.1089/jop.2006.22.68

Cannabinoid receptor down-regulation in the ventral cochlear nucleus in a salicylate model of tinnitus. (abst - 2007) http://www.ncbi.nlm.nih.gov/pubmed/17376618
640
 
Pages 641 - 645

The effects of the synthetic cannabinoid receptor agonists, WIN55,212-2 and CP55,940, on salicylate-induced tinnitus in rats. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20630477

Patterns of use, sequence of onsets and correlates of tobacco and cannabis

http://www.sciencedirect.com/science/article/pii/S0306460311002152

TOBACCO VS CANNABIS

So, you thought it was the tar that caused cancer... (news - no date)

http://www.ukcia.org/research/cancer2.php

Effect of Alcohol and Marihuana on Tobacco Smoking. (abst – 1980)

http://www.ncbi.nlm.nih.gov/pubmed/7353341

Marijuana v.s. Tobacco smoke compositions (list - 1988)

http://www.ukcia.org/research/smoke-contents.php

(abst – 2011)
Tobacco and marijuana use on offspring growth from birth through 3 years of age.
(abst - 1992) http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=1488035 &ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Marijuana Less Harmful to Lungs than Cigarettes (news - 1994)

http://www.ukcia.org/research/lungs.php

Prenatal tobacco and marijuana use among adolescents: effects on offspring gestational age, growth, and morphology. (abst – 1995)
http://www.ncbi.nlm.nih.gov/pubmed/7724314

High anxieties - What the WHO doesn't want you to know about cannabis
(news - 1998) http://www.newscientist.com/article/mg15721220.200-high-anxieties--what-the-who-doesnt-want-you-to- know-about-cannabis.html

Behavioural and biochemical evidence for interactions between Δ9-tetrahydrocannabinol and nicotine (full - 2002) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573143/?tool=pmcentrez

Tobacco and Cannabis Smoking Cessation Can Lead to Intoxication with Clozapine or Olanzapine. (abst – 2002)

http://medical-journals.healia.com/doc/11981356/Tobacco-and-cannabis-smoking-cessation-can-lead-to- intoxication-with-clozapine-or-olanzapine
641

Comparing cannabis with tobacco—again Link between cannabis and mortality is still not established (full - 2003) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC196384/?tool=pmcentrez

̳You can‘t go without a fag . . . you need it for your hash‘—a qualitative exploration of smoking, cannabis and young people (full - 2004) http://www.ukcia.org/research/YouCantGoWithoutAFag.pdf

Delta9-tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice. (abst - 2004) http://www.ncbi.nlm.nih.gov/pubmed/15548217?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pub med_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Cannabis and tobacco smoke are not equally carcinogenic (full - 2005)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1277837

Cigars-for-blunts: choice of tobacco products by blunt smokers. (abst – 2005)

http://www.ncbi.nlm.nih.gov/pubmed/16537327

Smoking Marijuana Does Not Cause Lung Cancer (news - 2005)

http://www.mapinc.org/drugnews/v05/n1065/a03.html

Cancer Risk from Tobacco Greater than Marijuana Smoking, Researcher Says (news - 2005)
http://www.drugfree.org/join-together/drugs/cancer-risk-from-tobacco-than

Cannabis Smoke Is Less Likely To Cause Cancer Than Tobacco Smoke (news - 2005) http://www.sciencedaily.com/releases/2005/10/051019003339.htm

Aluminum in Tobacco and Cannabis and Smoking-Related Disease (abst - 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16490479

Explicit and Implicit Effects of Anti-marijuana and Anti-tobacco Tv Advertisements. (abst – 2006) http://www.sciencedirect.com/science/article/pii/S0306460306000955

Marijuana Improves Fertility in Tobacco Smokers (news - 2006)

http://news.softpedia.com/news/Marijuana-Improves-Fertility-in-Tobacco-Smokers-41535.shtml

Marijuana-like Chemical Can Restore Sperm Function Lost to Tobacco Abuse (news - 2006) http://www.rxpgnews.com/specialtopics/article_5093.shtml

Some go without a cigarette: characteristics of cannabis users who have never smoked tobacco. (full - 2007) http://archpedi.ama-assn.org/cgi/content/full/161/11/1042

Chronologically overlapping occurrences of nicotine-induced anxiety- and depression-

related behavioral symptoms: effects of anxiolytic and cannabinoid drugs (full - 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075518/?tool=pubmed
642

A Comparison of Mainstream and Sidestream Marijuana and Tobacco Cigarette Smoke Produced under Two Machine Smoking Conditions (full - 2007) http://www.ukcia.org/research/ComparisonOfSmoke.pdf

Progression from marijuana use to daily smoking and nicotine dependence in a national sample of U.S. adolescents (abst - 2007) http://www.erowid.org/references/refs_view.php?ID=6951

Cannabis use when it's legal (abst - 2007) http://www.ncbi.nlm.nih.gov/pubmed/17097818 Are Cigarettes More of a Drag on Teens than Marijuana? (news - 2007)

http://www.scientificamerican.com/article.cfm?id=are-cigarettes-more-of-a

Cannabinoid Receptor 1 Gene Association With Nicotine Dependence (full - 2008)

http://archpsyc.ama- assn.org/cgi/content/full/65/7/816?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&se archid=1&FIRSTINDEX=0&resourcetype=HWCIT

Hypothesizing that marijuana smokers are at a significantly lower risk of carcinogenicity

relative to tobacco-non-marijuana smokers: evidenced based on statistical reevaluation of

current literature. (full - 2008)

http://www.thefreelibrary.com/Hypothesizing+that+marijuana+smokers+are+at+a+significantly+lower...- a0196052086

Inhibition of anandamide hydrolysis by URB597 reverses abuse-related behavioral and neurochemical effects of nicotine in rats. (abst – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663803/?tool=pubmed

Cannabis-based Drugs can help you quit Smoking (news - 2008)

http://www.healthjockey.com/2008/03/11/cannabis-based-drugs-can-help-you-quit-smoking/

Report: Marijuana Less Harmful than Alcohol or Tobacco (news - 2008)
http://www.drugfree.org/join-together/other/report-marijuana-less

Curing Addiction With Cannabis Medicines? (news - 2008)

http://www.sciencedaily.com/releases/2008/03/080307110348.htm

Cannabis Smoke and Cancer: Assessing the Risk (news - 2008)

http://www.norml.org/index.cfm?Group_ID=6891

Characteristics of Adolescents Who Use Cannabis But Not Tobacco

http://forum.grasscity.com/showthread.php?p=11734799#post11734799

(news - 2008)
Effects of the cannabinoid CB1 receptor antagonist AM 251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats. (full - 2009) http://www.if-pan.krakow.pl/pjp/pdf/2009/2_304.pdf

Comparison of subjective, pharmacokinetic, and physiological effects of marijuana

smoked as joints and blunts. (abst - 2009)

http://www.unboundmedicine.com/medline/ebm/record/19443132/abstract/
643

A comparison of drug use and dependence between blunt smokers and other cannabis users (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19212929/abstract/A_comparison_of_drug_use_an d_dependence_between_blunt_smokers_and_other_cannabis_users_

Cannabis and tobacco use: where are the boundaries? A qualitative study on cannabis consumption modes among adolescents. (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19515745/full_citation/Cannabis_and_tobacco_use :_where_are_the_boundaries_A_qualitative_study_on_cannabis_consumption_modes_among_adolescents _

Uni-Morbid and Co-Occurring Marijuana and Tobacco Use: Examination of Concurrent Associations with Negative Mood States (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861285/?tool=pubmed

Effects of cannabis on lung function: a population-based cohort study. (full - 2010)

http://erj.ersjournals.com/content/35/1/42.long

Disposition of smoked cannabis with high Delta(9)-tetrahydrocannabinol content: A kinetic model. (abst – 2010)

http://www.unboundmedicine.com/medline/ebm/record/20450927/abstract/Disposition_of_smoked_cannab is_with_high_Delta_9__tetrahydrocannabinol_content:_A_kinetic_model_

Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227620/?tool=pubmed

Adding Tobacco to Cannabis--Its Frequency and Likely Implications. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21454910

The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats
(abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21557729/abstract/The_anandamide_transport_inh ibitor_AM404_reduces_the_rewarding_effects_of_nicotine_and_nicotine_induced_dopamine_elevations_i n_the_nucleus_accumbens_shell_in_rats_

Rural adolescent alcohol, tobacco, and illicit drug use: a comparison of students in victoria, australia, and washington state, United States. (abst – 2011) http://marijuana.researchtoday.net/archive/8/10/4782.htm

The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats.
(abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21557729

Why doesn‘t marijuana cause cancer? (news – 2011)

http://www.examiner.com/drug-policy-in-reno/why-doesn-t-marijuana-cause-cancer

Patterns of blunt use among rural young adult african-american men. (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22176848
644

Marijuana Smoke Not as Damaging as Tobacco, Says Study (news - 2012)

http://news.yahoo.com/marijuana-smoke-not-damaging-tobacco-says-study-204709671--abc-news.html

TOLERANCE

Lack of tolerance to 9 -tetrahydrocannabinol in chimpanzees (abst - 1973)

http://www.ncbi.nlm.nih.gov/pubmed/4705343

Long-Term Use of Marihuana and the Development of Tolerance or Sensitivity to{Delta}9Tetrahydrocannabinol (abst -1974)
http://archpsyc.ama- assn.org/cgi/content/abstract/31/1/89?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid &searchid=1&FIRSTINDEX=3040&resourcetype=HWCIT

Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide. (full - 1993) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175863/?tool=pmcentrez&page=1

A Molecular Basis of Analgesic Tolerance to Cannabinoids (full - 2007)

http://www.jneurosci.org/cgi/content/full/27/15/4165?maxtoshow=&hits=10&RESULTFORMAT=&fullte xt=cannabis&andorexactfulltext=and&searchid=1&FIRSTINDEX=20&sortspec=relevance&resourcetype= HWCIT

Repeated Treatment with Cannabidiol but Not Delta9-tetrahydrocannabinol Has a Neuroprotective Effect Without the Development of Tolerance (abst - 2007) http://medical-journals.healia.com/doc/17320118/Repeated-treatment-with-cannabidiol-but-not-Delta9- tetrahydrocannabinol-has-a-neuroprotective-effect-without-the-development-of-tolerance

Blunted Psychotomimetic and Amnestic Effects of Δ-9-Tetrahydrocannabinol in Frequent Users of Cannabis (full – 2008) http://www.nature.com/npp/journal/v33/n10/full/1301643a.html

Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757117/?tool=pubmed

Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study. (abst – 2010) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=316

Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the beta- lactam antibiotic, ceftriaxone, in mice. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21536061/abstract/Role_of_GLT_1_transporter_ac tivation_in_prevention_of_cannabinoid_tolerance_by_the_beta_lactam_antibiotic_ceftriaxone_in_mice_
645
 
Pages 646 - 650

Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21975580/abstract/Neurophysiological_functionin g_of_occasional_and_heavy_cannabis_users_during_THC_intoxication_

Tolerance to chronic delta-9-tetrahydrocannabinol (Δ9-THC) in rhesus macaques infected with simian immunodeficiency virus. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21463073/abstract/Tolerance_to_chronic_delta_9_ tetrahydrocannabinol__%CE%94%E2%81%B9_THC__in_rhesus_macaques_infected_with_simian_immu nodeficiency_virus_

Chronic Δ9-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and cross-tolerance among cannabinoids. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21091643/abstract/Chronic_%CE%94%E2%81%B 9_tetrahydrocannabinol_treatment_in_rhesus_monkeys:_differential_tolerance_and_cross_tolerance_amon g_cannabinoids_

The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/20701826/abstract/The_schizophrenia_susceptibilit y_gene_neuregulin_1_modulates_tolerance_to_the_effects_of_cannabinoids_

TOURETTE'S SYNDROME

MARIJUANA AND TOURETTE'S SYNDROME (letter - 1988)

http://www.druglibrary.org/schaffer/hemp/medical/mjtouret.htm

Effective treatment of Tourette‘s syndrome with marijuana. (abst - 1993)

http://www.cannabis- med.org/studies/ww_en_db_study_show.php?s_id=255&&search_pattern=INTERACTION

Gilles de la Tourette syndrome, influence of nicotine, alcohol, and marijuana on the clinical symptoms (abst - 1997) http://cel.isiknowledge.com/InboundService.do?product=CEL&action=retrieve&SrcApp=Highwire&UT=0 00071008700009&SID=2FbKfcabFdA3KGAbH1L&Init=Yes&SrcAuth=Highwire&mode=FullRecord&c ustomersID=Highwire

Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome. (abst - 1998) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=100

Cannabis in movement disorders. (abst - 1999)

http://www.ncbi.nlm.nih.gov/pubmed/10627163

Treatment of Tourette's Syndrome With Delta-9-Tetrahydrocannabinol

http://ajp.psychiatryonline.org/cgi/content/full/156/3/495

(letter - 1999)
646

Science: THC in TOURETTE-Syndrome (news - 1999)

http://www.cannabis- med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=58&search_pattern=tourette#1

Science/Germany: Clinical study on THC in TOURETTE's syndrome (news – 2000)

http://www.cannabis- med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=70&search_pattern=tourette#1

Combined Treatment of Tourette Syndrome with Delta-9-THC and Dopamine Receptor Antagonists (full – 2002) http://www.cannabis-med.org/data/pdf/2002-03-04-9.pdf

Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol (THC): a randomized crossover trial. (abst - 2002) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=99

Science: THC effective in TOURETTE-Syndrome (news - 2002)

http://www.cannabis- med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=114&search_pattern=tourette#1

Treatment of Tourette Syndrome with Delta-9-Tetrahydrocannabinol (Delta9-THC): No Influence on Neuropsychological Performance (full - 2003) http://www.nature.com/npp/journal/v28/n2/abs/1300047a.html

Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial. (abst - 2003)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=98

Cannabinoids reduce symptoms of Tourette's syndrome. (abst - 2003)

http://www.ncbi.nlm.nih.gov/pubmed/14521482?dopt=Abstract&holding=f1000,f1000m,isrctn

Science: THC effective in TOURETTE syndrome in a 6-week trial (news - 2003)

http://www.cannabis- med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=146&search_pattern=tourette#1

Tourette syndrome is not caused by mutations in the central cannabinoid receptor (CNR1) gene. (abst - 2004) http://www.ncbi.nlm.nih.gov/pubmed/15108190

Cannabinoids for Tourette's Syndrome. (abst - 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19821373

Oral Delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20520294

Science: Cannabis effective in the treatment of TOURETTE Syndrome and attention deficit hyperactivity disorder (ADHD) (news – 2010)
http://www.cannabis- med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=323&search_pattern=tourette#2
647

A New Use for Medical Marijuana? (news - 2010) http://consults.blogs.nytimes.com/ Cannabinoids improve driving ability in a Tourette's patient. (news – 2011)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=350

TRICHOTILLOMANIA compulsive hair pulling – also see OBSESSIVE-COMPULSIVE DISORDER

Dronabinol, a cannabinoid agonist, reduces hair pulling in trichotillomania: a pilot study. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21590520/abstract/Dronabinol_a_cannabinoid_ago nist_reduces_hair_pulling_in_trichotillomania:_a_pilot_study_

Science: THC effective in trichotillomania symptoms in a pilot study (news – 2011)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=348

TUBERCULOSIS

HEMP AS A MEDICAMENT : Importance of hemp seeds in the tuberculosis therapy (Forum thread- full- 1955) (EDEZYME. recipe) http://www.greenpassion.org/showthread.php?p=306753#post306753

A cluster of tuberculosis associated with use of a marijuana water pipe.

http://www.ncbi.nlm.nih.gov/pubmed/12971670

Tuberculosis Outbreak in Marijuana Users, Seattle, Washington, 2004

http://www.cdc.gov/ncidod/eid/vol12no07/05-1436.htm

Pot is good for you? Marijuana fights the superbugs (news - 2008)

(abst - 2003) (full - 2004)
http://www.scientificamerican.com/b...ost.cfm?id=whoa-the-stuff-in-pot-kills-germs- 2008-08-27&sc=rss

ULCERATIVE COLITIS - see COLITIS and also BOWEL DISORDERS
648

URB - 597 / KDS-4103
- slows cannabinoid destruction

Marijuana's Distant Relative May Be The Next Prozac; Chemical Reduces Anxiety Using Novel Nerve System In Body (news - 2002) http://www.sciencedaily.com/releases/2002/12/021202071928.htm

Cannabis' Potential Exciting Researchers in Treatment of ALS, Parkinson's Disease - URB597 (news - 2004) http://www.illinoisnorml.org/index2.php?option=com_content&do_pdf=1&id=104

Antidepressant-like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis. (full – 2005) http://www.pnas.org/content/102/51/18620.long

Parkinsons' Helped By Marijuana-Lke Chemicals In Brain (news – 2007)

http://www.medicalnewstoday.com/releases/62616.php

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751298/?tool=pmcentrez

Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB1 and TRPV1 receptors (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128772/?tool=pmcentrez

The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis (full - 2007) http://www.jbc.org/content/282/33/23892.full

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'- carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. (full - 2007) http://jpet.aspetjournals.org/content/322/1/236.long

Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17511970

Marijuana Against Parkinson? (news – 2007)

http://news.softpedia.com/news/Marijuana-Against-Parkinson-46701.shtml

Marijuana-Like Brain Chemicals Work As Antidepressant (news - 2007)

http://www.sciencedaily.com/releases/2007/11/071105120556.htm

Enhancing Activity Of Marijuana-Like Chemicals In Brain Helps Treat Parkinson's

Symptoms In Mice (news - 2007)

http://www.sciencedaily.com/releases/2007/02/070207171915.htm
649

Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697765/?tool=pmcentrez

The FAAH inhibitor URB-597 ameliorates cannabinoid withdrawal in mice
(abst - 2008) http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/711.6?maxtoshow=&hits=80& RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=720&resourcetype=HWCIT

Inhibition of anandamide hydrolysis by URB597 reverses abuse-related behavioral and neurochemical effects of nicotine in rats. (abst – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663803/?tool=pubmed

Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors. (abst – 2008) http://www.ncbi.nlm.nih.gov/pubmed/18493729

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. (abst - 2009) http://www.ncbi.nlm.nih.gov/pubmed/19502530

Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas. (abst – 2009) http://www.sciencedirect.com/science/article/pii/S0006899308030588

Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. (full – 2011)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227620/?tool=pubmed

Behavioral sequelae following acute diisopropylfluorophosphate intoxication in rats: comparative effects of atropine and cannabinomimetics. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854260/?tool=pubmed

Regulation of nausea and vomiting by cannabinoids (abst - 2010)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476- 5381.2010.01176.x/abstract;jsessionid=56CED9CE51B025C161AA2E821BEC94ED.d01t01

Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis. (abst – 2010)

http://www.unboundmedicine.com/medline/ebm/record/21185649/abstract/Local_application_of_the_endo cannabinoid_hydrolysis_inhibitor_URB597_reduces_nociception_in_spontaneous_and_chemically_induce d_models_of_osteoarthritis_

Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20600638/abstract/Behavioural_and_molecular_co nsequences_of_chronic_cannabinoid_treatment_in_Huntington%27s_disease_transgenic_mice_
650
 
Pages 651 - 655

Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203169/?tool=pubmed

Administration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in rats. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136458/?tool=pubmed

Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21767554

L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21928146

Regulation of nausea and vomiting by cannabinoids . (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21175589/abstract/Regulation_of_nausea_and_vo miting_by_cannabinoids_

URB - 754 -slows cannabinoid destruction
The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor

Proliferation and Neurogenesis (full - 2007) http://www.jbc.org/content/282/33/23892.full

URB - 973 - slows cannabinoid destruction
Compound boosts marijuana-like chemical in the body to relieve pain at injury site

(news - 2010) http://www.eurekalert.org/pub_releases/2010-09/uoc--cbm092010.php

VAPORIZERS - see METHODS OF USE- VAPORIZERS
651

VETERINARY USE/ ANIMALS


THE RELATIVE ACTIVITY OF VARIOUS PURIFIED PRODUCTS OBTAINED FROM AMERICAN GROWN HASHISH (abst - 1938) http://jpet.aspetjournals.org/content/62/2/239.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabis&searchid=1&FIRSTINDEX=640&resourcetype=HWCIT

Disposition and bioavailability of various formulations of tetrahydrocannabinol in the rhesus monkey. (abst – 1985) http://www.ncbi.nlm.nih.gov/pubmed/2985774

A species comparison of the toxicity of nabilone, a new synthetic cannabinoid. (abst – 1987) http://www.ncbi.nlm.nih.gov/pubmed/2888699

Species specificity in the metabolism of nabilone. Relationship between toxicity and metabolic routes. (abst - 1987) http://www.ncbi.nlm.nih.gov/pubmed/3037806

Pharmacokinetics of cannabidiol in dogs. (abst - 1988)

http://dmd.aspetjournals.org/content/16/3/469.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabis&searchid=1&FIRSTINDEX=800&resourcetype=HWCIT

In vitro metabolism of cannabichromene in seven common laboratory animals. (abst – 1990) http://www.ncbi.nlm.nih.gov/pubmed/1981514

In vitro metabolism of delta-11-tetrahydrocannabinol in the mouse, rat, guinea pig, rabbit, hamster, gerbil and cat. (abst – 1990) http://www.ncbi.nlm.nih.gov/pubmed/2253656

In vitro metabolism of cannabigerol in several mammalian species. (abst – 1990)

http://www.ncbi.nlm.nih.gov/pubmed/2224182

Behavioral effects of cannabinoid agents in animals. (abst – 1999)

http://www.ncbi.nlm.nih.gov/pubmed/10803637

Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: possible role in the feeding response. (abst – 1999) http://www.ncbi.nlm.nih.gov/pubmed/10392859

Two hundred and thirteen cases of marijuana toxicoses in dogs. (abst – 2002)

http://www.ncbi.nlm.nih.gov/pubmed?term=Caroline W. Donaldson

The effect of feeding hemp seed meal to laying hens. (abst – 2005)

http://www.ncbi.nlm.nih.gov/pubmed/15957445

Evaluation of a Human On-site Urine Multidrug Test for Emergency Use With Dogs (abst - 2009) http://www.jaaha.org/cgi/content/abstract/45/2/59?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= cannabis&searchid=1&FIRSTINDEX=3200&resourcetype=HWCIT
652

Influence of Feed Supplementation with Cannabis Sativa on Quality of Broilers Carcass (full - 2010) http://www.pvj.com.pk/pdf-files/30_1/34-38.pdf

The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. (full – 2010) http://www.jneurosci.org/content/30/26/8965.long

Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/19800340

Scientific Opinion on the safety of hemp (Cannabis genus) for use as animal feed (full – 2011) http://www.hanf-info.ch/info/en/IMG/pdf/EIHA-11-05-31_EIHA-Statement_on_THC_in_feed.pdf

Dietary hempseed meal intake increases body growth and shortens the larval stage via the upregulation of cell growth and sterol levels in Drosophila melanogaster. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20652493

Vets use hemp seed oil on animals with cancer (news - 2010)

http://www.examiner.com/x-33448-LA-County-Environmental-News-Examiner~y2010m3d22-Vets-use- hemp-seed-oil-on-animals-with-cancer

Michel Rouyer, French Farmer, Fined After Feeding Ducks Marijuana (news - 2010)

http://www.huffingtonpost.com/2010/11/22/michel-rouyer-french-farm_n_786973.html#comments

Cannabidiol decreases body weight gain in rats: Involvement of CB2 receptors. (abst - 2011) http://marijuana.researchtoday.net/archive/8/1/3517.htm

Cannabis intoxication in three Green iguanas (Iguana iguana). (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21265851

Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21601500

Identification of cannabinoid type 1 receptor in dog hair follicles. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21414652/abstract/Identification_of_cannabinoid_t ype_1_receptor_in_dog_hair_follicles_

Pot patch for your pooch developed in Seattle lab (news – 2011)

http://www.king5.com/news/local/A-pot-patch-for-your-pooch-126363118.html

Vets see more dogs snarfing humans‘ medical pot (news – 2011)

http://www.durangoherald.com/article/20111218/NEWS01/712189903/Vets-see-more-dogs-snarfing- humans%E2%80%99-medical-pot
653

VISION
- also see GLAUCOMA

CONJUGATE DEVIATION OF THE EYES AFTER Cannabis indica INTOXICATION* (full - 1964) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=505931&tool=pmcentrez

Delta 9-tetrahydrocannabinol: elevation of absolute visual thresholds of rabbits. (abst – 1979) http://www.ncbi.nlm.nih.gov/pubmed/482306

Physiologic observations in a controlled clinical trial of the antiemetic effectiveness of 5, 10, and 15 mg of delta 9-tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications. (abst - 1981) http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=88

Ocular Effects of Topical Administration of {Delta}9-Tetrahydrocannabinol in Man (full - 1982)
http://archopht.ama- assn.org/cgi/reprint/100/2/265?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searc hid=1&FIRSTINDEX=2960&resourcetype=HWCIT

Mydriasis induced by tetrahydrocannabinol (THC) in rats (full - 1982)

http://www.iovs.org/cgi/reprint/22/3/408?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=marihuan a&searchid=1&FIRSTINDEX=640&resourcetype=HWCIT

Intraocular pressure, ocular toxicity and neurotoxicity after administration of delta 9- tetrahydrocannabinol or cannabichromene. (abst – 1984) http://www.ncbi.nlm.nih.gov/pubmed/6323206

Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. (abst – 1984) http://www.ncbi.nlm.nih.gov/pubmed/6098513

Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol. (abst – 1984) http://www.ncbi.nlm.nih.gov/pubmed/6499952

Persistent visual changes following hashish consumption. (full - 1993)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC513962/?page=1

HU-211, a nonpsychotropic cannabinoid, produces short- and long-term neuroprotection after optic nerve axotomy. (abst – 1996) http://www.ncbi.nlm.nih.gov/pubmed/8714863

Patent 5631297 - Anandamides useful for the treatment of intraocular hypertension, ophthalmic compositions containing the same and methods of use of the same
(full – 1997) http://www.patentstorm.us/patents/5631297/fulltext.html

Smoking dope restored my sight (news - 1998) http://news.bbc.co.uk/2/hi/health/212301.stm Effects of synthetic delta9-tetrahydrocannabinol on binocular depth inversion of natural

and artificial objects in man. (abst – 1999) http://www.ncbi.nlm.nih.gov/pubmed/10208314 654

Cannabinoids' Role In Retinal Function Described (news - 1999)

http://www.sciencedaily.com/releases/1999/12/991208061213.htm

Different effects of nabilone and cannabidiol on binocular depth inversion in Man. (abst – 2000) http://www.ncbi.nlm.nih.gov/pubmed/10837858

Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d- Aspartate-Induced Retinal Neurotoxicity - Involvement of Peroxynitrite (full - 2003) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892413/?tool=pmcentrez

Dexanabinol (HU-211) has a beneficial effect on axonal sprouting and survival after rat optic nerve crush injury. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/12535983

Cannabis improves night vision: a case study of dark adaptometry and scotopic sensitivity in kif smokers of the Rif mountains of northern Morocco (full - 2004) http://science.iowamedicalmarijuana.org/pdfs/misc/Russo et al. Cannabis Night Vision %20JEP%202004.pdf

Cannabidiol Preserves Retinal Neurons and Reduces Vascular Permeability in Experimental Diabetes (abst - 2004) http://abstracts.iovs.org/cgi/content/abstract/45/5/860?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabinoid&searchid=1&FIRSTINDEX=1760&resourcetype=HWCIT

When spliff gets in your eyes... (news – 2004)

http://www.guardian.co.uk/science/2004/jul/07/sciencenews.research

In-vitro corneal permeation of cannabinoids and their water-soluble phosphate ester prodrugs. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/16105235

Marijuna Cured My Color-Blindness (anecdotal – 2005)

http://mmj.tribe.net/thread/ae2e9a56-f117-4e96-b24d-ae799e956b00

Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592672/?tool=pubmed

Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/17011761

Marijuana Compound May Help Stop Diabetic Retinopathy (news - 2006)

http://www.sciencedaily.com/releases/2006/02/060227184647.htm

Getting Eye On Cannabinoids (news - 2006)

http://www.thehempire.com/index.php/cannabis/news/getting_eye_on_cannabinoids

Endocannabinoids in the retina: From marijuana to neuroprotection. (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584875/?tool=pmcentrez
655
 
Pages 656 - 660

Marijuana compound could prevent eye damage in diabetics (news - 2006)

http://www.thehempire.com/index.php/cannabis/news/marijuana_compound_could_prevent_eye_damage_i n_diabetics

Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592995/?tool=pubmed

Topical WIN55212-2 alleviates intraocular hypertension in rats through a CB1 receptor mediated mechanism of action. (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637200/?tool=pubmed

Mediation of Cannabidiol anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588644/?tool=pmcentrez

Reduction of Congenital Nystagmus in a Patient after Smoking Cannabis. (abst - 2008)

http://www.unboundmedicine.com/medline/ebm/record/18306120/abstract/Reduction_of_Congenital_Nyst agmus_in_a_Patient_after_Smoking_Cannabis_

Assessing changes in pupillary size in Rifian smokers of kif (Cannabis sativa L.). (abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18511011

The role of endocannabinoid system in physiological and pathological processes in the eye (abst - 2008) http://www.unboundmedicine.com/medline/ebm/record/19195174/abstract/[The_role_of_endocannabi noid_system_in_physiological_and_pathological_processes_in_the_eye%5D

Cannabidiol As a Putative Novel Therapy for Diabetic Retinopathy: A Postulated Mechanism of Action as an Entry Point for Biomarker-Guided Clinical Development. (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955420/?tool=pubmed

Presence and regulation of cannabinoid receptors in human retinal pigment epithelial cells. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697670/?tool=pubmed

Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925907/?tool=pubmed

Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20619260

2-Arachidonoylglycerol (2-AG) Induces Corneal Epithelial Cell Migration via Cannabinoid CB1 Receptors (abst – 2011) http://abstracts.iovs.org/cgi/content/abstract/52/6/1995?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT
656

Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/21537423/abstract/Diabetic_retinopathy:_Role_of_ inflammation_and_potential_therapies_for_anti_inflammation_

Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933347/?tool=pubmed

Modulation of Auditory and Visual Processing by Delta-9-Tetrahydrocannabinol and Cannabidiol: an fMRI Study. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21412224

Comparison Of Rat And Human Eyes For The Presence And Distribution Of Cb1 And Cb2 Receptors (abst - 2011) http://abstracts.iovs.org/cgi/content/abstract/52/6/4588?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT

Enhanced solubility, stability, and transcorneal permeability of delta-8- tetrahydrocannabinol in the presence of cyclodextrins.
(abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21637944

Endocannabinoid CB1 receptors modulate visual output from the thalamus. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21773721

Nonpsychotropic Cannabinoids, Abnormal Cannabidiol and Canabigerol-Dimethyl Heptyl, Act at Novel Cannabinoid Receptors to Reduce Intraocular Pressure.
(abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21770780

WILSON'S DISEASE

Cannabis sativa and dystonia secondary to Wilson's disease. (needs free registration) (abst - 2005) http://www.medscape.com/medline/abstract/15390041

WIN 55,212-2 - a synthetic cannabinoid, CB1 agonist
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.

(full - 1992) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC525583/

Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents,

CP 55,940, WIN 55,212-2 and anandamide. (full - 1993)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175863/?tool=pmcentrez&page=1
657

(+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamsters. (abst - 1994) http://www.ncbi.nlm.nih.gov/pubmed/7698178

Cannabinoid Receptor Agonists Protect Cultured Rat Hippocampal Neurons from Excitotoxicity (full - 1998) http://molpharm.aspetjournals.org/content/54/3/459.full

Loss of Cannabinoid Receptor Binding and Messenger Rna Levels and Cannabinoid Agonist-stimulated [35s]guanylyl-5'o-(Thio)-triphosphate Binding in the Basal Ganglia of Aged Rats. (abst - 1998) http://www.ncbi.nlm.nih.gov/pubmed/9578396?dopt=Abstract

Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures (full - 1999) http://www.jneurosci.org/cgi/content/full/19/8/2987?maxtoshow=&hits=80&RESULTFORMAT=&fulltext =cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype =HWCIT

The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats (abst - 1999) http://www.ncbi.nlm.nih.gov/pubmed/10611417

Involvement of Cannabinoid Receptors in the Intraocular Pressure-Lowering Effects of WIN55212-2 (full - 2000) http://jpet.aspetjournals.org/content/292/1/136.long

Cannabinoids might reduce spasticity in multiple sclerosis (full - 2000)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1117698/?tool=pmcentrez

Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human (full - 2000)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571997/?tool=pmcentrez

Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil (full - 2000) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1572019&tool=pmcentrez

Modulation of peristalsis by cannabinoid CB1 ligands in the isolated guinea-pig ileum (full - 2000) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1571902&tool=pmcentrez

Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. (full - 2000) http://depts.washington.edu/stellalb/images/Nature2000.pdf

Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A. (full – 2001) http://www.nature.com/npp/journal/v24/n2/full/1395605a.html

The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat

model of neuropathic pain (full - 2001)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1572814&tool=pmcentrez
658

The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets. (abst - 2001) http://www.ncbi.nlm.nih.gov/pubmed/11388542

The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2 (abst – 2001) http://pharmgkb.org/pmid/11698062

Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice
(full - 2002) http://www.jneurosci.org/cgi/content/full/22/22/9771?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetyp e=HWCIT

CB1 Receptors in the Preoptic Anterior Hypothalamus Regulate WIN 55212-2 [(4,5- Dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H- pyrrolo[3,2,1ij]quinolin-6-one]-Induced Hypothermia (full - 2002) http://jpet.aspetjournals.org/content/301/3/963.full

A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding (full - 2002) http://www.jneurosci.org/cgi/content/abstract/22/21/9612?ijkey=328b5e83d7be9297b9483d22e0d6319fa0a 862e8&keytype2=tf_ipsecsha

Contrasting effects of WIN 55212-2 on motility of the rat bladder and uterus. (full – 2002) http://www.jneurosci.org/content/22/16/7147.long

Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats (full - 2002) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573379/?tool=pmcentrez

The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids. (full – 2002) http://jpet.aspetjournals.org/content/300/1/34.long

Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice
(full - 2002) http://www.jneurosci.org/cgi/content/full/22/22/9771?maxtoshow=&hits=80&RESULTFORMAT=&fullte xt=cannabinoid&searchid=1&FIRSTINDEX=80&resourcetype=HWCIT#Top

Effects of pharmacological manipulations of cannabinoid receptors on severity of dystonia in a genetic model of paroxysmal dyskinesia. (abst - 2002) http://www.ncbi.nlm.nih.gov/pubmed/12421641

Inhibition of tumor angiogenesis by cannabinoids (full - 2003)

http://www.fasebj.org/cgi/reprint/02- 0795fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&sear chid=1&FIRSTINDEX=20&sortspec=relevance&resourcetype=HWCIT
659

Effect of WIN 55212-2, a Cannabinoid Receptor Agonist, on Aqueous Humor Dynamics in Monkeys (full - 2003)
http://archopht.ama- assn.org/cgi/content/full/121/1/87?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=marihuana&sear chid=1&FIRSTINDEX=640&resourcetype=HWCIT

The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy (full - 2003) http://jpet.aspetjournals.org/content/307/1/129.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext= cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212 (full - 2003) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152941/?tool=pmcentrez

Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon (full – 2003) http://ajpgi.physiology.org/content/286/1/G110.full?sid=fc6948f0-78cf-405c-981b-afaa05ee417c

The cannabinoid agonist WIN 55, 212-2 increases nociception threshold in cholestatic rats: implications for the treatment of the pruritus of cholestasis. (abst – 2003) http://www.ncbi.nlm.nih.gov/pubmed/13679241

Cannabinoids: Defending the Epileptic Brain (full - 2004)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176332/?tool=pmcentrez

The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats. (abst – 2004) http://www.ncbi.nlm.nih.gov/pubmed/15519750

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear (full - 2005) http://www.nature.com/npp/journal/v30/n3/full/1300655a.html

Effects of cannabinoids on colonic muscle contractility and tension in guinea pigs. (full – 2005) http://www.jstage.jst.go.jp/article/jnms/72/1/72_43/_article

The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues. (full – 2005) http://www.jstage.jst.go.jp/article/jphs/98/1/77/_pdf

Systemic administration of WIN 55,212-2 increases norepinephrine release in the rat frontal cortex (abst - 2005) http://www.ncbi.nlm.nih.gov/pubmed/15927549

Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma (full - 2006) http://molpharm.aspetjournals.org/content/70/5/1612.full

Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice (full - 2006) http://www.fasebj.org/cgi/content/full/20/7/1003
660
 
Pages 661 -665

Activation of G-proteins in brain by endogenous and exogenous cannabinoids. (full – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16584117

Effects of a Cannabinoid Agonist on Spinal Nociceptive Neurons in a Rodent Model of Neuropathic Pain (full - 2006) http://jn.physiology.org/cgi/content/full/96/6/2984

The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341/?tool=pmcentrez

Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861843/?tool=pmcentrez

Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties

of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and

Status Epilepticus (full - 2006)

http://jpet.aspetjournals.org/content/317/3/1072.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext =cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#ref-list-1

Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest (full - 2006) http://www.jbc.org/content/281/51/39480.full

Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16956707

Cannabinoid receptors as a target for therapy of ovarian cancer (abst - 2006)

http://www.aacrmeetingabstracts.org/cgi/content/abstract/2006/1/1084?maxtoshow=&hits=80&RESULTF ORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT

Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro. (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16536902

The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. (abst - 2006) http://www.ncbi.nlm.nih.gov/pubmed/16458258

Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16864698

Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome. (abst - 2006) http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=17369898&dopt=abstrac tplus

Cannabinoids, in combination with (NSAIDS), produce a synergistic analgesic effect (news - 2006) http://www.norml.org/index.cfm?Group_ID=6819
661

Continuous infusion of the cannabinoid WIN 55,212–2 to the site of a peripheral nerve injury reduces mechanical and cold hypersensitivity (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013951/?tool=pmcentrez

Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861843/?tool=pmcentrez

Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats. (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190028/?tool=pubmed

Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior. (full - 2007) http://www.nature.com/npp/journal/v32/n11/abs/1301365a.html

Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex. (full - 2007) http://www.jneurosci.org/cgi/content/full/27/43/11700

Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852513/?tool=pmcentrez

Antinociceptive Synergy Between the Cannabinoid Receptor Agonist WIN 55,212-2 and Bupivacaine in the Rat Formalin Test (full - 2007)
http://www.anesthesia- analgesia.org/content/104/3/719.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid& searchid=1&FIRSTINDEX=320&resourcetype=HWCIT

Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190006/?tool=pmcentrez

Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771679/?tool=pubmed

CANNABINOID-INDUCED HYPERPHAGIA: CORRELATION WITH INHIBITION OF PROOPIOMELANOCORTIN NEURONS? (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720321/?tool=pmcentrez

Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB1 and TRPV1 receptors (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128772/?tool=pmcentrez

Cannabinoid self-administration in rats: sex differences and the influence of ovarian function (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190022/
662

Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094113/?tool=pmcentrez

Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors. (full - 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189718/?tool=pubmed

Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation (full - 2007) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1852513&tool=pmcentrez

Cannabinoid receptors agonist WIN-55,212-2 inhibits angiogenesis, metastasis and tumor growth of androgen-sensitive prostate cancer cell CWR22R{nu}1 xenograft in athymic nude mice (abst - 2007)

http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2007/1_Annual_Meeting/2195?maxtosh ow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=720&resourcety pe=HWCIT

Additive Effects of Timolol and Cannabinoids on Intraocular Pressure in a Rat Glaucoma Model (abst - 2007) http://abstracts.iovs.org/cgi/content/abstract/48/5/4807?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT

Synthetic form of THC is an effective anti-depressant at low doses (news - 2007)

http://www.news-medical.net/news/2007/10/24/31666.aspx?page=2

Cannabis: Potent Anti-Depressant In Low Doses, Worsens Depression At High Doses (news - 2007) http://www.sciencedaily.com/releases/2007/10/071023183937.htm

Chronic cannabinoid administration in vivo compromises extinction of fear memory. (full - 2008) http://learnmem.cshlp.org/content/15/12/876.long

Topical WIN55212-2 Alleviates Intraocular Hypertension in Rats Through a CB1 Receptor-Mediated Mechanism of Action (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637200/?tool=pmcentrez

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells (full - 2008) http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block

Peripheral Cannabinoids Attenuate Carcinoma Induced Nociception in Mice (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771220/

Acute hypertension reveals depressor and vasodilator effects of cannabinoids in

conscious rats full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697765/?tool=pmcentrez
663

The influence of mast cell mediators on migration of SW756 cervical carcinoma cells. (full – 2008) http://www.jstage.jst.go.jp/article/jphs/106/2/106_208/_article

Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain.

(abst - 2008) http://www.ncbi.nlm.nih.gov/pubmed/18611408

Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma. (abst - 2008) http://www.unboundmedicine.com/medline/ebm/record/18197164/full_citation/Cannabinoid_2_receptor_in duction_by_IL_12_and_its_potential_as_a_therapeutic_target_for_the_treatment_of_anaplastic_thyroid_ca rcinoma_

Cannabinoid receptor agonists inhibit growth and metastasis of breast cancer
(abst - 2008) http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2008/1_Annual_Meeting/4081?maxtosh ow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=480&resourcety pe=HWCIT

Scientists are High on Idea that Cannabis Reduces Memory Impairment (news - 2008)

http://www.physorg.com/news146320102.html

Could Marijuana Substance Help Prevent Or Delay Memory Impairment In The Aging Brain? (news - 2008) http://www.sciencedaily.com/releases/2008/11/081119120141.htm

WIN55,212-2, a Cannabinoid Receptor Agonist, Protects Against Nigrostriatal Cell Loss in the MPTP Mouse Model of Parkinson‘s Disease (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755595/?tool=pmcentrez

Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743245/?tool=pmcentrez

Cannabinoid-1 (CB1) receptors regulate colonic propulsion by acting at motor neurons within the ascending motor pathways in mouse colon (full - 2009) http://ajpgi.physiology.org/cgi/content/full/296/1/G119?maxtoshow=&hits=80&RESULTFORMAT=&full text=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

Cannabinoid Receptor Activation in the Basolateral Amygdala Blocks the Effects of Stress on the Conditioning and Extinction of Inhibitory Avoidance (full - 2009) http://www.jneurosci.org/cgi/content/full/29/36/11078?maxtoshow=&hits=10&RESULTFORMAT=&fullt ext=Dr.+Irit+Akirav+&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human Kaposi‘s sarcoma cells in vitro (full - 2009) http://science.iowamedicalmarijuana.org/pdfs/cancer/Luca et al 2009 19539619.pdf
664

Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660732/?tool=pmcentrez

Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer (full - 2009) http://mct.aacrjournals.org/content/8/11/3117.full

Cannabinoids inhibit fibrogenesis in diffuse systemic sclerosis fibroblasts (full - 2009)

http://rheumatology.oxfordjournals.org/content/48/9/1050.full

Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757117/?tool=pubmed

Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011092/?tool=pubmed

New neuron production can be increased in the hippocampus of aged rats following cannabinoid treatment (abst – 2009) http://www.nature.com/mp/journal/v14/n12/full/mp2009122a.html

Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19385063

Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871782/?tool=pubmed

Cannabinoids excite circadian clock neurons. (full – 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927117/?tool=pubmed

The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis. (full – 2010) http://molpharm.aspetjournals.org/content/77/5/854.long

Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996668/?tool=pubmed

The effect of the activation of cannabinoid receptor on the proliferation and apoptosis of hepatoma HepG2 cells (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20368112

WIN55212-2 ameliorates atherosclerosis associated with suppression of pro-

inflammatory responses in ApoE-knockout mice. (abst – 2010)

http://www.ncbi.nlm.nih.gov/pubmed/20868672
665
 
Pages 666 - 671

The cannabinoid receptor agonist WIN 55,212-2 inhibits antigen-induced plasma extravasation in guinea pig airways. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20150748

Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20375197/abstract/Rimonabant_induced_Delta9_te trahydrocannabinol_withdrawal_in_rhesus_monkeys:_discriminative_stimulus_effects_and_other_withdra wal_signs_

The cannabinoid WIN55212-2 promotes neural repair after neonatal hypoxia-ischemia. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/21115947

The cannabinoid WIN55, 212-2 abrogates dermal fibrosis in scleroderma bleomycin model. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/21177293

Pharmacologically induced hypothermia with cannabinoid receptor agonist WIN55, 212- 2 after cardiopulmonary resuscitation (abst – 2010) http://journals.lww.com/ccmjournal/Abstract/2010/12000/Pharmacologically_induced_hypothermia_with.2 .aspx

The Endocannabinoid System Tonically Regulates Inhibitory Transmission and Depresses the Effect of Ethanol in Central Amygdala (abst - 2010) http://www.nature.com/npp/journal/v35/n9/abs/npp201070a.html

Cannabinoid self-administration attenuates PCP-induced schizophrenia-like symptoms in adult rats. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/19854030

Antiproliferative effects of cannabinoid agonists on deep infiltrating endometriosis. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/21057002

Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20336665

Cannabinoid Receptor Agonist WIN-55,212-2 Protects Differentiated PC12 Cells From Organophosphorus- Induced Apoptosis (abst – 2010) http://ijt.sagepub.com/content/29/2/201.abstract

Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20920894

Chronic Low Doses of a Cannabinoid Causes New Brain Cell Formation (news - 2010)

http://cannabination.com/tag/nih/

WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells. (full – 2011) http://www.nature.com/cddis/journal/v2/n11/full/cddis2011106a.html
666

Cannabinoid Agonists Inhibit Neuropathic Pain Induced by Brachial Plexus Avulsion in Mice by Affecting Glial Cells and MAP Kinases. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172222/?tool=pubmed

Regulatory effect of cannabinoid receptor agonist on chemokine-induced lymphocyte chemotaxis. (full – 2011) http://www.jstage.jst.go.jp/article/bpb/34/7/1090/_pdf

Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress. (full – 2011) http://www.nature.com/npp/journal/v37/n2/full/npp2011204a.html

Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers' disease (full – 2011) http://molpharm.aspetjournals.org/content/early/2011/02/24/mol.111.071290.long

Protective effects of CB1 receptor agonist WIN 55.212-2 in seizure activity in the model of temporal lobe epilepsy (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21469332/abstract/[Protective_effects_of_CB1 _receptor_agonist_WIN_55_212_2_in_seizure_activity_in_the_model_of_temporal_lobe_epilepsy%5D_

Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21238473/abstract/Synthetic_cannabinoid_WIN_5 5212_2_mesylate_enhances_the_protective_action_of_four_classical_antiepileptic_drugs_against_maxima l_electroshock_induced_seizures_in_mice_

The Cannabinoid WIN 55212-2 Mitigates Apoptosis and Mitochondrial Dysfunction After Hypoxia Ischemia. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21909954

Cannabinoid applications in glaucoma. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21414525/abstract/Cannabinoid_applications_in_g laucoma_

Effect of ion pairing on in vitro transcorneal permeability of a Δ(9) -tetrahydrocannabinol prodrug: Potential in glaucoma therapy. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21989812/abstract/Effect_of_ion_pairing_on_in_vi tro_transcorneal_permeability_of_a_%CE%94_9___tetrahydrocannabinol_prodrug:_Potential_in_glaucom a_therapy_

Win 55,212-2 reduces cardiac ischaemia-reperfusion injury in zucker diabetic fatty rats: role of cb2 receptors and cardiac inos/enos expression. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21309057

Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21245146
667

The antimitogenic effect of the cannabinoid receptor agonist WIN55212-2 on human melanoma cells is mediated by the membrane lipid raft. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21807457

Antiproliferative mechanism of a cannabinoid agonist by cell cycle arrest in human gastric cancer cells. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21312237

Effects of Cannabinoid Agonists on Sheep Sphincter of Oddi in vitro. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21921665

Cannabinoids Prevent the Development of Behavioral and Endocrine Alterations in a Rat Model of Intense Stress. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21918506

Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22110202

Δ(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21645556/abstract/Δ_9__THC_and_WIN5 5212_2_affect_brain_tissue_levels_of_excitatory_amino_acids_in_a_phenotype__compound__dose__and _region_specific_manner_

Chronic Δ9-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and cross-tolerance among cannabinoids. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21091643/abstract/Chronic_%CE%94%E2%81%B 9_tetrahydrocannabinol_treatment_in_rhesus_monkeys:_differential_tolerance_and_cross_tolerance_amon g_cannabinoids_

Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22207189

Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22019959

The Cannabinoid WIN 55212-2 Mitigates Apoptosis and Mitochondrial Dysfunction After Hypoxia Ischemia. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21909954

Tolerance to cannabinoid-induced behaviors in mice treated chronically with ethanol. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21701813
668

WITHDRAWAL SYNDROME


An Abstinence Syndrome Following Chronic Administration of Delta-9- terahydrocannabinol in Rhesus Monkeys. (abst – 1980) http://www.ncbi.nlm.nih.gov/pubmed/6255508

Marijuana withdrawal syndrome in a woman. (abst – 1984)

http://www.ncbi.nlm.nih.gov/pubmed/6091465

Merck Manual - Marijuana (Cannabis) (excerpt- 1987)

http://www.ukcia.org/research/merck.htm

Marijuana abstinence effects in marijuana smokers maintained in their home environment. (full – 2001) http://archpsyc.ama-assn.org/cgi/content/full/58/10/917

Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect. (abst – 2001) http://www.ncbi.nlm.nih.gov/pubmed/11359533

The Time Course and Significance of Cannabis Withdrawal. (abst – 2003)

http://medical-journals.healia.com/doc/12943018/The-time-course-and-significance-of-cannabis- withdrawal

Decrease in prostaglandin level is a prerequisite for the expression of cannabinoid withdrawal: a quasi abstinence approach. (abst – 2005) http://www.ncbi.nlm.nih.gov/pubmed/16336946

A Within-Subject Comparison of Withdrawal Symptoms During Abstinence From Cannabis, Tobacco, and Both Substances (full - 2008) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2214670&tool=pmcentrez

Cannabis withdrawal in the United States: results from NESARC. (full - 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777674/?tool=pubmed

Merck Manual - Marijuana (Cannabis) (excerpt - 2008)

http://www.merckmanuals.com/professional/sec23/ch352/ch352i.html?qt=marijuana&alt=sh

The FAAH inhibitor URB-597 ameliorates cannabinoid withdrawal in mice
(abst - 2008) http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/711.6?maxtoshow=&hits=80& RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=720&resourcetype=HWCIT

Pot, Tobacco Withdrawal Equally Rough (news - 2008)

http://www.webmd.com/mental-health/news/20080130/pot-tobacco-withdrawal-equally-rough

Withdrawal Phenomena and Dependence Syndrome After the Consumption of "Spice Gold" (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719097/?tool=pmcentrez
669

Actions of delta-9-tetrahydrocannabinol in cannabis (full - 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731700/?tool=pmcentrez

Cannabis withdrawal severity and short-term course among cannabis-dependent adolescent and young adult inpatients (abst - 2009) http://www.unboundmedicine.com/medline/ebm/record/19783382/abstract/Cannabis_withdrawal_severity_ and_short_term_course_among_cannabis_dependent_adolescent_and_young_adult_inpatients_

Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20375197/abstract/Rimonabant_induced_Delta9_te trahydrocannabinol_withdrawal_in_rhesus_monkeys:_discriminative_stimulus_effects_and_other_withdra wal_signs_

Anxiety-like effects of SR141716-precipitated delta9-tetrahydrocannabinol withdrawal in mice in the elevated plus-maze. (abst – 2010) http://www.unboundmedicine.com/medline/ebm/record/20363293/abstract/Anxiety_like_effects_of_SR141 716_precipitated_delta9_tetrahydrocannabinol_withdrawal_in_mice_in_the_elevated_plus_maze_

Antagonist-elicited cannabis withdrawal in humans. (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21869692

The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys. (abst – 2011) http://www.unboundmedicine.com/medline/ebm/record/21449917/abstract/The_fatty_acid_amide_hydrolas e_inhibitor_URB_597:_interactions_with_anandamide_in_rhesus_monkeys_

WOUNDS/ INJURIES

Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing (abst - 2005) http://www.gastrojournal.org/article/PIIS0016508505009297/abstract

A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management. (full - 2006) http://journals.lww.com/anesthesiology/Fulltext/2006/05000/A_Multicenter_Dose_escalation_Study_of_th e.21.aspx

Cannador: Drug from cannabis plant-extract to reduce surgery pain (news - 2006)

http://www.ecofriend.org/entry/cannador-drug-from-cannabis-plant-extract-to-reduce-surgery-pain/

New frontier for medical cannabis -- topical pot (news - 2007)

http://www.canaseed.com/CannabisNews.aspx?id=138
670

Evidence for a Role of Endocannabinoids, Astrocytes and p38 Phosphorylation in the Resolution of Postoperative Pain (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878341/?tool=pmcentrez

The cannabinoid receptor type 2 is time-dependently expressed during skeletal muscle wound healing in rats (abst - 2010) http://www.ncbi.nlm.nih.gov/sites/pubmed

Endocannabinoid-like N-arachidonoyl serine is a novel pro-angiogenic mediator. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20649563

Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20619260

Involvement of the endocannabinoid system in periodontal healing. (abst - 2010)

http://www.ncbi.nlm.nih.gov/pubmed/20233580

Expression of cannabinoid receptor I during mice skin incised wound healing course (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20967946

Compound boosts marijuana-like chemical in the body to relieve pain at injury site (news - 2010) http://www.eurekalert.org/pub_releases/2010-09/uoc--cbm092010.php

Study: Smoking pot may ease chronic pain (news - 2010)

http://www.cnn.com/2010/HEALTH/08/30/health.pot.reduce.pain/

2-Arachidonoylglycerol (2-AG) Induces Corneal Epithelial Cell Migration via Cannabinoid CB1 Receptors (abst – 2011) http://abstracts.iovs.org/cgi/content/abstract/52/6/1995?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT

YOUNG ADULTS - see CHILDREN/ YOUNG ADULTS

671




 
A few definitions to help you along-

Agonist – a chemical that activates a receptor
Analogue – a synthetic version
Anandamide - A ―messenger chemical‖ made by your body – similar to THC Angiogenesis - making new blood vessels, often to feed a tumor
Antagonist – a chemical that blocks the action of an agonist Anti-nociception- pain relieving
Anxiolytic – calming, anti-anxiety
Apoptosis - a process that leads to the normally programed death of a cell. Autophagy – the cell self-destructs

Beta amyloid plaque / β-amyloid/ Aβ – the stuff that gums up your brain in Alzheimer‘s Bronchodilator – opens up the lungs
Cannabinoids –they activate CB receptors and come from your body, cannabis or labs. Chronic – long term

Downregulation – a decrease in number

Endocannabinoid – a chemical messenger made by your body- anandamide and 2-AG Endocannabinoid System – a system of chemical receptors on and between your cells Endogenous – made in your own body
Epidermal – pertaining to the skin

Hyperalgesia – severe pain

In vivo – in a live animal
In vitro – in a test tube
Ischemia – damage from lack of blood to an area

Ligand - a chemical that binds to a receptor. THC is a ligand of CB1 and CB2 receptors Metastasis – spreading through the body

Neurogenesis – new brain cells are being formed Neuropathic Pain – pain due to nerve injury Neuroprotective – protects nerves and brain cells Nonpsychoactive – won‘t get you high

Phytocannabinoid – a cannabinoid produced by a plant – THC and CBD are examples Receptors - These receive the chemical messages and send them into our cells. Upregulation – increase in number
Vasodilator – expands the blood vessels
 
THE INDEX - January 2012

Introduction............................................................................................. ........................................1
ACEA/ ARACHIDONYL-2'-CHLOROETHYLAMIDE............................................... 2
ACHILLES TENDINOSIS..................................................................................4 ACNE............................................................................................................4
ADD/ ADHD...................................................................................................................................4 ADDICTION.................................................................................................................................6
2-AG /2-ARACHIDONOYLGLYCEROL................................................................8
2-AGE/ 2-ARACHIDONYL GLYCERYL ETHER/ NOLADIN ETHER...........................17
AGING/ USE BY SENIORS ........................................................................................................18
AIDS – see HIV
AJULEMIC ACID.........................................................................................................................21 ALCOHOLISM.............................................................................................................................22
ALLERGIES AND CANNABIS.................................................................................. ..............26
ALLERGIES TO CANNABIS.............................................................................27
ALS / AMYOTROPHIC LATERAL SCLEROSIS......................................................................28
ALZHEIMER'S DISEASE............................................................................................................30
AM- 251.........................................................................................................................................36
AM-281........................................................................................................40
AM-404..........................................................................................................................................41
AM-630..........................................................................................................................................42
AM-694........................................................................................................43
AM-1241........................................................................................................................................43
AM-1346........................................................................................................................................44
AM-1710......................................................................................................45
AM-2233.......................................................................................................45
AM- 4054.......................................................................................................................................45
AM- 4113.......................................................................................................................................46
AM 6545.......................................................................................................46
AMOTIVATIONAL SYNDROME..............................................................................................46 ANANDAMIDE............................................................................................................................47
ANECDOTAL / PERSONAL STORIES......................................................................................65
ANOREXIA NERVOSA - also see APPETITE STIMULANT.............................................................66
ANTI-BACTERIAL PROPERTIES.............................................................................................68
ANTI-FUNGAL PROPERTIES....................................................................................................69
ANTI-INFLAMMATORY PROPERTIES............................................................................. ....69
ANTIMICROBIAL PROPERTIES........................................................................76
ANTIOXIDANT PROPERTIES...................................................................................................77
ANXIOLYTIC EFFECTS.............................................................................................................78
APPETITE STIMULANT.............................................................................................................82
ARACHIDONYL-2'-CHLOROETHYLAMIDE- see ACEA
2-ARACHIDONOYLGLYCEROL- see 2-AG ARTHRITIS...................................................................................................................................90
AS- 1535907..................................................................................................93
AS-1907417...................................................................................................94
ASTHMA.......................................................................................................................................94 ATHEROSCLEROSIS..................................................................................................................95 AUTISM........................................................................................................................................97


BACK PAIN..................................................................................................................................99
BETA-CARYOPHYLENE/ (E)-BCP...........................................................................................99
BIPOLAR DISORDER...............................................................................................................100
BLADDER/ URINARY FUNCTIONS.......................................................................................100 BLEPHAROSPASM...................................................................................................................100 BLOOD........................................................................................................................................100
BLOOD PRESSURE...................................................................................................................103
BONES- see OSTEOPOROSIS
BONE MARROW............................................ .............................................106
BOWEL DISORDERS - also see GERD, COLITIS.........................................................................106
BRAIN CELLS- see NEURONS

BRAIN- PHYSICAL EFFECTS.................................................................................................115
BRAIN TRAUMA.......................................................................................................................117
BREASTFEEDING/ INFANT APPETITE.................................................................................119 BULIMIA.................................................................................................120

CANCER – BASAL CELL CARCINOMA - see CANCER – SKIN

CANCER – BLADDER / URETHRAL.................................................................121
CANCER- BONE........................................................................................................................121
CANCER- BREAST....................................................................................................................122
CANCER- CERVICAL...............................................................................................................125
CANCER- CHEMOTHERAPY- see CHEMOTHERAPY
CANCER- CHOLANGIOCARCINOMA...................................................................................126
CANCER- COLON /COLORECTAL.........................................................................................127
CANCER – ENDOMETRIAL............................................................................129
CANCER- GASTRIC..................................................................................................................129
CANCER- GLIOMA..................................................................................................................130
CANCER- HEAD AND NECK..................................................................................................135
CANCER- KAPOSI'S SARCOMA............................................................................................135
CANCER – KIDNEY.....................................................................................136
CANCER- LEUKEMIA.............................................................................................................136
CANCER – LIVER........................................................................................137
CANCER- LUNG.......................................................................................................................138
CANCER- LYMPHOMA...........................................................................................................141
CANCER- MELANOMA...........................................................................................................142
CANCER - NEUROBLASTOMA..............................................................................................143
CANCER- ORAL........................................................................................................................144
CANCER- OVARIAN.................................................................................................................145
CANCER- PANCREATIC..........................................................................................................145
CANCER- PITUITARY ADENOMA........................................................................................146
CANCER – PNET / PRIMITIVE NEUROECTODERMAL TUMOR.............................146
CANCER- PROSTATE...............................................................................................................146
CANCER - RHABDOMYOSARCOMA....................................................................................148
CANCER- RISK CANNABIS VS TOBACCO..........................................................................149
CANCER- SKIN..........................................................................................................................149
CANCER - SQUAMOUS CELL CARCINOMA......................................................150
CANCER- TESTICULAR...........................................................................................................151
CANCER - THYMOMA.............................................................................................................151
CANCER- THYROID.................................................................................................................151
CANCER- VARIOUS/ UNNAMED...........................................................................................152 CANNABICHROMENE.............................................................................................................159
CANNABIDIOL/ CBD...............................................................................................................160
CANNABIDIOLIC ACID.................................................................................182
CANNABIGEROL / CBG...........................................................................................................182
CANNABINOID HYPEREMESIS SYNDROME....................................................184
CANNABINOID RECEPTORS - see ENDOCANNABINOID SYSTEM, CBRs CANNABINOR.............................................................................................186 CANNADOR...............................................................................................................................186
CARDIOVASCULAR- see HEART DISEASE
CARPAL TUNNEL SYNDROME......................................................................187
CBR- CB 1 RECEPTORS-..........................................................................................................187
CBR – CB 2 RECEPTORS.....................................................................................................205
CBR– GPR 40 RECEPTORS...............................................................................218
CBR – GPR 55/ CB 3 RECEPTORS...........................................................................................219
CBR - GPR109 RECEPTORS.....................................................................................................221
CBR – GPR 119 RECEPTORS...................................................................................................222
CELIAC DISEASE.........................................................................................222
CEREBRAL PALSY.......................................................................................223
CESAMET- see NABILONE
CHEMICAL COMPOSITION....................................................................................................223 CHEMOTHERAPY.....................................................................................................................231
CHILDREN/ YOUNG ADULTS................................................................................................236 CHOLERA...................................................................................................243 CHOLESTEROL...........................................................................................244
CHRONIC FATIGUE SYNDRONE.....................................................................244
COGNATIVE EFFECTS- see IQ COLITUS....................................................................................................244
COPD/ LUNG FUNCTION........................................................................................................246 COUGH.......................................................................................................................................247 COWPOX...................................................................................................248
CP- 47,497...................................................................................................................................248
CP 50,556-1 / LEVONANTRADOL....................................................................250 CP- 55,940...................................................................................................................................251
CROHN'S - see BOWEL DISORDERS
CRUETZFELDT-JACOB DISEASE- see MAD COW DISEASE

CT-3 – also see AJULMIC ACID.......................................................................................................254
CYSTIC FIBROSIS.....................................................................................................................254 CYSTITIS....................................................................................................................................255

DENTISTRY - see TEETH DEPRESSION.............................................................................................................................255 DERMATITIS.............................................................................................................................259
DEXANABINOL - see HU-211 DIABETES..................................................................................................................................261
DOWN‘S SYNDROME...................................................................................267
DRIVING AND CANNABIS......................................................................................................267 DRONABINOL...........................................................................................................................270
DRUG INTERACTIONS- see INTERACTIONS WITH OTHER DRUGS
DRUG TESTING........................................................................................................................274
DRUG TESTING - BLOOD.......................................................................................................277
DRUG TESTING – BREATH TEST....................................................................279
DRUG TESTING - HAIR...........................................................................................................279
DRUG TESTING- OTHER.........................................................................................................281
DRUG TESTING - ORAL..........................................................................................................282
DRUG TESTING - URINE.........................................................................................................283 DYSKINESIA...............................................................................................288 DYSTONIA.................................................................................................................................289

ECZEMA....................................................................................................................................290 EDEMA........................................................................................................................... ........291
EHLERS-DANLOS SYNDROME............................................................................................291
ELMIRIC ACIDS.......................................................................................................................291 ENCEPHALITUS.......................................................................................................................292
ENCEPHALOMYELITIS/ EAE................................................................................................292 ENDOCANNABINOIDS...........................................................................................................293
ENDOCANNABINOID SYSTEM – also see CBRs.....................................................................301 ENDOMETRIOSIS....................................................................................................................319 EPILEPSY...................................................................................................................................319

FAMILIAL MEDITERRANEAN FEVER................................................................................325 FERTILITY................................................................................................................................325
FEVER/ TEMPERATURE CONTROL.....................................................................................327 FIBROMYALGIA......................................................................................................................329
FLU / INFLUENZA....................................................................................................................331
GATEWAY THEORY................................................................................................................331
GENDER-BASED DIFFERENCES...........................................................................................333
GERD/GASTRO-ESOPHAGEAL REFLUX DISEASE............................................................336 GLAUCOMA..............................................................................................................................336 GOUT........................................................................................................341 GRANULOMA.............................................................................................341
GRAVE'S DISEASE...................................................................................................................341
GWP- 42006.................................................................................................342
GYNOCOLOGY AND OBSTETRICS......................................................................................342


HAIR............................................................................................................................................343
HEADACHE- see MIGRAINE
HEARING also see TINNITUS........................................................................................................344
HEART DISEASE/ CARDIOVASCULAR...............................................................................344
HEMORRHAGIC SHOCK................................................................................353 HEPATITIS.................................................................................................................................353
HEREDITARY MULTIPLE EXTOSES................................................................355
HERPES VIRUS..........................................................................................................................355 HEXAHYDROCANNABINOLS................................................................................................356 HICCUPS.....................................................................................................................................356
HISTORICAL STUDIES -PRE 1937..........................................................................................357
HISTORY- ANCIENT USE........................................................................................................360
HISTORY-1937 TO PRESENT..................................................................................................361
HIV / AIDS..................................................................................................................................365 HORMONES...............................................................................................................................369
HPV/ HUMAN PAPILLOMA VIRUS.......................................................................................373
HU-210........................................................................................................................................373
HU-211........................................................................................................................................377
HU-308........................................................................................................................................378
HU-310......................................................................................................379
HU-320........................................................................................................................................379
HU-331........................................................................................................................................379
HU-910......................................................................................................380
HUNTINGTON'S DISEASE......................................................................................................380
HYPEREMESIS - see CANNABINOID HYPEREMESIS SYNDROME HYSTERECTOMY.....................................................................................................................383

IBS - see BOWEL DISORDERS
IDIOPATHIC INTRACRANIAL HYPERTENSION................................................................384 IDRASIL.....................................................................................................384
IMMUNE SYSTEM....................................................................................................................384
INCONTINENCE - see BLADDER OVERACTIVITY

INDICATIONS AND CLINICAL USES....................................................................................387
INFLUENZA-see FLU
INJURIES - see WOUNDS/ INJURIES
INTERACTIONS WITH OTHER DRUGS................................................................................388
31 - IP 751 see AJULEMIC ACID
ISSAC‘S SYNDROME/ ACQUIRED NEUROMYOTONIA.......................................397
IQ/ MEMORY/ COGNATIVE EFFECTS..................................................................................397

JWH-015......................................................................................................................................403
JWH-018......................................................................................................................................405
JWH-073......................................................................................................................................408
JWH-100 / AM -678.......................................................................................409
JWH-133......................................................................................................................................409

KIDNEYS....................................................................................................................................412
KNOCK-OUT MICE....................................... .............................................413

LEGIONAIRES DISEASE................................................................................415 LEISHMANIASIS.......................................................................................................................416
LIVER - NON HEPATITIS.........................................................................................................416
LONG TERM USE EFFECTS....................................................................................................421
LUNG FUNCTION.....................................................................................................................423 LUPUS.........................................................................................................................................424
LYME DISEASE...........................................................................................425

MACULAR DEGENERATION..........................................................................425
MAD COW/ CRUETZFELDT-JACOB DISEASE....................................................................425 MARINOL..................................................................................................................................426
MDA 19......................................................................................................427
MEIGE'S SYNDROME..............................................................................................................428
MEMORY- see IQ
MENIERE'S SYNDROME.........................................................................................................428 MENINGITIS..............................................................................................................................428 MENOPAUSE.............................................................................................................................428
MENTAL DISORDERS - see SCHIZOPHRENIA
METHODS OF USE – BREATH STRIPS............................................................429
METHODS OF USE- CAPSULES........................................................................ ....................430
METHODS OF USE – DECARBOXYLATION......................................................430
METHODS OF USE- E-CIGARETTES..............................................................430
METHODS OF USE- EDIBLES...............................................................................................431
METHODS OF USE- EDIBLES - BEVERAGES....................................................................432
METHODS OF USE- EDIBLES - FOODS.............................................................................433
METHODS OF USE - INHALERS....................................................................434
METHODS OF USE - INJECTION............................................................................................435
METHODS OF USE - NASAL SPRAYS...................................................................................436
METHODS OF USE – RSO / RICK SIMPSON‘S OIL...............................................436
METHODS OF USE - SMOKING.............................................................................................437
METHODS OF USE - SUPPOSITORIES..................................................................................441
METHODS OF USE - TINCTURES..........................................................................................441
METHODS OF USE - TOPICAL OINTMENTS.......................................................................442
METHODS OF USE -TRANSDERMAL PATCH.....................................................................444
METHODS OF USE - VAPORIZERS.......................................................................................444
METHODS OF USE- VARIOUS...............................................................................................446
MIGRAINE/ HEADACHE.........................................................................................................447
MISCELANEOUS STUFF..........................................................................................................448
MORNING SICKNESS..............................................................................................................454
MORTALITY RATES................................................................................................................455
MOTION SICKNESS..................................................................................................................456
MRSA/ METHICILLIN-RESISTANT STAPHLOCOCCUS AUREUS...................................457
MULTIPLE SCLEROSIS/ MS....................................................................................................458
MUSCULAR DYSTROPHY/ MD..............................................................................................469
MUSCLE RELAXANT...............................................................................................................469


NABILONE.................................................................................................................................470
NAIL-PATELLA SYNDROME..........................................................................475 NAUSEA.....................................................................................................................................475
NEURONS/ BRAIN CELLS.......................................................................................................481
NEUROPATHIC PAIN...............................................................................................................487 NEUROPROTECTANT..............................................................................................................492
NIEMANN-PICK DISEASE.......................................................................................................497
NIGHT SWEATS...........................................................................................498
NUTRITION - GENERAL..........................................................................................................498
NUTRITION - HEMP SEED......................................................................................................499
NUTRITION - HEMP SEED OIL...............................................................................................502

O-1602.......................................................................................................504
O-1966.......................................................................................................504 OBESITY.....................................................................................................................................505
OBSESSIVE COMPULSIVE DISORDER.................................................................................510
OMEGA-3/ CB1 CONNECTION ........................................................................511
ORGAN TRANSPLANTS.........................................................................................................512
OSTEOPOROSIS/ BONES........................................................................................................514 OVERDOSES.............................................................................................................................517 OVERVIEWS.............................................................................................................................517


PAIN............................................................................................................................................519 PANCREATITIS.........................................................................................................................527
PERINATAL HYPOXIC-ISCHEMIC INJURY.......................................................528
PARKINSON'S DISEASE..........................................................................................................529
PATENTS RELATED TO CANNABIS.....................................................................................532
PEA – PALMITOYLETHANOLAMIDE...............................................................537 PHARC......................................................................................................538
PHYTOCANNABINOIDS / PLANT EXTRACTS....................................................................539
POISONING – ORGANOPHOSPHATE................................................................544
POISONING – PARAQUAT.............................................................................544
POST-OPERATIVE PAIN..........................................................................................................545
POST TRAUMATIC STRESS DISORDER/ PTSD...................................................................546
PRADER WILLI SYNDROME..........................................................................549
PREGNANCY/ PRENATAL EXPOSURE................................................................................550 PRIONS.......................................................................................................................................555
PROXIMAL MYOTONIC MYOPATHY / PROMM................................................................556
PRURITIS (chronic itch).............................................................................................................556 PSORIASIS.................................................................................................................................558

QUITTING CANNABIS..................................................................................559
QUITTING OTHER DRUGS......................................................................................................560

RADIATION-INDUCED NAUSEA...........................................................................................563
RADIATION SICKNESS.................................................................................564
REFLEX SYMPATHETIC DYSTROPHY............................................................564
RESTLESS LEG SYNDROME..................................................................................................564
RETINITIS PIGMENTOSA..............................................................................565 RIMONABANT..........................................................................................................................565
R(+)-METHANANANDAMIDE.............................................................................................569
RWJ- 400065.............................................................................................................................. 571

SAFETY AS A MEDICINE........................................................................................................571
SAFETY-ADULTERANTS/ CONTAMINANTS......................................................................573
SATIVEX....................................................................................................................................575
SCHIZOPHRENIA/ MENTAL DISORDERS...........................................................................578 SCLERODERMA.......................................................................................................................585
SEPTIC SHOCK.........................................................................................................................586
SICKLE CELL DISEASE...........................................................................................................587 SINUSITIS....................................................................................................................... .........587
SLEEPING SICKNESS/ TRYPANOSOMIASIS......................................................588
SLEEP MODULATION..............................................................................................................588 SMALLPOX.................................................................................................590
SMELL / ODOR DETECTION...........................................................................590
SMOKED CANNABIS AS A MEDICATION...........................................................................591
SOCIAL ADJUSTMENT/ BEHAVIOR.....................................................................................595 SPASTICITY................................................................................................................... .........597 SPICE.........................................................................................................601
SPINAL CORD INJURY............................................................................................................603 SPLEEN......................................................................................................606
STEM CELLS...............................................................................................606 STRESS......................................................................................................607 STORAGE...................................................................................................608 STROKE......................................................................................................................................608


TAK SERIES...............................................................................................612 TASTE.......................................................................................................612
TAXONOMY/ GENETICS OF CANNABIS.............................................................................613
TEA AS MEDICINE...................................................................................................................617
TEETH /DENTISTRY.................................................................................................................617
THC/ TETRAHYDROCANNABINOL......................................................................................618
THC ACID/ THCA......................................................................................................................636 TETRAHYDROCANNABINOL-HEMISUCCINATE / THC-HS............................................637
TETRAHYDROCANNABOVARIN/ THCV.............................................................................638
TIME PERCEPTION.......................................................................................640
TINNITUS- also see HEARING......................................................................................................640
TOBACCO VS CANNABIS.......................................................................................................641 TOLERANCE..............................................................................................................................645
TOURETTE'S SYNDROME......................................................................................................646 TRICHOTILLOMANIA...................................................................................648 TUBERCULOSIS........................................................................................................................648

ULCERATIVE COLITIS- see COLITIS, also BOWEL DISORDERS
URB - 597/ KDS-4103...............................................................................................................649
URB - 754...................................................................................................................................651
URB - 973...................................................................................................................................651

VAPORIZERS - see METHODS OF USE- VAPORIZERS
VETERINARY USE/ ANIMALS...............................................................................................652 VISION........................................................................................................................................654

WILSON'S DISEASE................................................................................................................657
WIN 55,212-2..............................................................................................................................657
WITHDRAWAL SYNDROME..................................................................................................669
WOUNDS/ INJURIES.................................................................................................................670

YOUNG ADULTS - see CHILDREN/YOUNG ADULTS
 
Introduction - July 2011- This year‘s message to all of you is a little different. I am going to be explaining a major scientific discovery- the Omega-3 / CB1 connection, and how it affects your healing with cannabis! But to understand fully this discovery, we need to revisit Biology 101.

Every cell in your body has tiny chemical receptors all over the cell‘s ―skin‖ or cell membrane. These receptors work kind of like an ignition switch- you put the right type of chemical ―key‖ into a receptor and it ―turns on‖ some kind of action. The type 1 cannabinoid receptors (CB1s) are the ones we are interested in looking at. They are found both in the body and the brain.

―Turning on‖ a CB1 receptor with either an endocannabinoid that your body makes, or a phytocannabinoid like THC, can result in many different things occurring. A cancer cell may be ―told‖ to die through a process called apoptosis, it may activate a basic instinct such as nursing, soothe an irritated digestive tract, or simply ease your pain. The CB1 receptors in your brain are the ones to blame, or praise, for the cannabis ―high‖.

Every time a cell divides, whether it is a brain cell, or a body cell, it needs to make new ―skin‖ to grow back to its full size, and that involves making a whole bunch of new receptors.

And this is where the cutting-edge science starts-- to make functional CB1 receptors, you absolutely need Omega-3! In “Nutritional omega-3 deficiency abolishes endocannabinoid- mediated neuronal functions”, the Omega-6-rich ―western diet‖ is implicated in our declining mental and physical health. The ―ideal‖ proportion of Omega-6 to Omega-3 is around 3 to 4 parts Omega-6 to every 1 part Omega-3. Our ―western diet‖ can deliver up to a 50 to 1 ratio!

When no Omega-3 is available, our bodies will ―jury-rig‖ a new receptor with an Omega-6 where there should be an Omega-3. This results in a small, but important chunk, the Gi/o effector protein, not getting attached. As with a machine, the pieces need to be assembled right to work!

A drop in the number of working CB1 receptors is an early clinical sign in Parkinson‘s, colon cancer, Huntington‘s, and heralds a high risk for premature birth. Mice bred to be low in CB1 receptors have more severe heart attacks and strokes. Cancers ravage them. They age and become senile earlier than normal mice. They are used to study neurological conditions and bowel disorders. They often seem depressed. They sound a lot like many modern Americans.

The three most common sources of Omega-3 are fish oil, flax seed oil and hemp seed oil.

Cannabis is an effective and safe herbal medicine, but we need functioning CB1 receptors for it to work its miracles. Virtually every person needs more Omega-3 in their diet, but none as much as the medical users of cannabis! Cannabis heals us using our cannabinoid receptors, and also provides the Omega-3 that we need to make healthy CB receptors, so we can heal. And that is the simple, but scientific truth.

If the truth won‘t do, then something is wrong!


Introduction - July 2010 - This is my third year of sharing "Granny's list" with all of you. Last year, I told you "How this list came about." This year, it's "Why you should be sharing my list!"

From 60 pages, a symbolic celebration of my then 60 years on Earth, my list has grown to an equally symbolic 420 pages of links, in hopeful anticipation of the dawning of medical freedom in other states.

My "Granny's list" contains 100s of studies about cannabis and how can heal- all done in an environment of "strong discouragement" on the part of the US government. How large my collection would be if research into this healing herb had been unrestricted? What would we know if we could have researched during those 70- odd years of prohibition?

As a medicine, cannabis is potentially invaluable- this collection is ample proof of that! From stopping hiccups, to halting breast cancer's terrible spread, cannabis works! But there are still too many "may"s and "might"s when it comes to cannabis. We need more research, which will not, and cannot, happen until cannabis is legalized and rescheduled.

When I began using cannabis medically over 40 years ago, there was no such thing as "medical use"- not even the concept existed! Education has made the difference. Somewhere along the line, every one of the people who have voted to legalize medical use in their state, learned that cannabis was an effective medicine, perhaps from a relative's use, or from a program they saw, or a study they read. They learned the truth.

In a Canadian survey of doctors, a majority admitted that most of what they knew about cannabis came from their patients! They had learned only the "government line" in medical school. That was in Canada, where medical use is federally legal! So how much does your doctor really know about cannabis? My list gives you a way to educate him.

And you shouldn't stop with your doctor. Local city councilmen and commissioners have the power to ban dispensaries through local ordinances. It is easier to educate them before it's an issue. They need the medical facts about cannabis to make logical decisions!

We all know someone who has diabetes, fibro, cancer or MS. They shouldn't have to suffer, physically, financially, or legally, for using a safer-than-aspirin herbal medicine. One they could easily grow if sane cannabis laws were in place. Home-grown cannabis is cheaper and works faster than any pill and the side effects are far more pleasant.

Cannabis, with its remarkable safety record, should be the first medicine tried, not be the medicine of last resort! It is only by educating others, that we can bring cannabis back into mainstream medicine where it belongs. Please share the facts about cannabis with those around you, and back them up with medical studies from my list.

The simple truth is "Cannabis heals". And as my wise old grandfather once said,

"If the truth won't do, then something is wrong!"

Intro - 2008
"If the truth won't do, then something is wrong!"

Those were the furious words of my grandfather to my Mother. I had walked in from joyfully stuffing my face with red raspberries in the garden, straight into "war zone"! My gentle grandfather in a fury, his hand raised! Mom was just beginning to shrink back away from him. They saw me and quickly sent me away. But it was too late, the scene and the words were seared into my 5-year-old brain. That was over 55 years ago, but I still remember it clearly. My grandfather was a minister, one very short step away from God in my 5 year old mind. It was one of those life changing moments. It is still rare for me to tell a lie. I never found out what my Mother's lie was.

As I child, I suffered a traumatic head injury. Another child tried to murder me with a hammer. I was left with frequent migraines. At 19, like many rebellious teens, I tried cannabis. It took about a year for me to make the connection between using cannabis and the absence of my normally frequent migraines. I have used cannabis ever since.

I am an avid reader. While perusing an old book on herbal medicine, I read how the little old ladies of Mexico made and used a cannabis/tequila rub on their arthritic hands. Then I met Joey, an epileptic musician. He told me another interesting fact- when he had pot he could cut his medication in half! On a camping trip years later, I smelled an unmistakable odor. Following my nose, I was totally shocked to find a grandmotherly lady in her 70s puffing away on a delicate oriental pipe. "Parkinson's. And the pot's way cheaper than the pills!" Her nephew kept her well supplied, she said. We had a nice chat about various medical uses of cannabis.

Epilepsy, Parkinson's, arthritis, and my migraines! What else was it good for? Yet every news article on cannabis that I saw, claimed one new horror after another. Men grew breasts and were impotent. Women became sterile or miscarried. It made you crazy and murderous. Made you lazy and do nothing. It caused cancer and heart attacks...What I had learned on my own and from others and what I was being told in the press were so different!

What was the truth? I began researching. I printed the first studies up and kept them in a notebook, just as a personal reference. The notebook quickly filled. I started a Word file of the URLs and on July 30 2007, I posted it. It continues to grow.

Here's some of what I have found. All I've done is copy the URLs, then put them all in some semblance order for everyone to use as a reference. Please feel free to share this list with anyone who could benefit from it.

July 30, 2007

It‘s my 60th birthday! That‘s a pretty big milestone. I‘ve out-lived my beautiful, crazy mother (59 years 11 months) and I‘ve been married and toking for 40 years. So, since 60 rolls around only once, I decided to give you a gift! I though I‘d share my notebook with you. It is a compilation of medical studies, news articles and information on cannabis.

In addition to the obvious use of people who are ill getting information on what might heal them, I hope that many of you will take up a challenge from me. I want this spread around- to your doctor, your politicians, ministers, and anyone who could use the info.

Information does no good if it is hoarded. If you know someone who is ill, copy and paste the part they need, or print up the article, and mail it to them (anonymously, might be a good idea in a lot of cases). Also, send a page or three of a print out of the titles and URLs and a typed message (again anonymously) leading to this post to your doctor. Something simple, like ―Want to know more? Visit here!‖and give the URL.

I‘m hoping that in return for the hours I spent collecting this, you will give me a present in return- mailing this out and telling others. By spreading knowledge to help others, you give them power over their own lives! Knowledge is power! And the truth will set us free (to smoke our pot in peace!) - Storm Crow
 
This is an updated (March/2109), and slightly different, list of the 700 Medical Cannabis studies. This one is provided by Cannabis Activism Now.

700 Medical Cannabis Studies Sorted By Disease
Next time somebody tells you that more ‘studies’ need to be done on cannabis, show them this!
I have SCA= ATAXIA for short.
My cerebellum is shrink!
I did a lot on this planet actually?
I was 50 when I was told by a NEUROLOGIST near where I live.
Begin a surfer of wave’s, golfer, cycling and growing up playing sport’s to a high degree it was hard having to stop sport’s.
I had a “put your EGO in your pocket”!
Thank you for such a wonderful site.
 

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