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Heart Disease and Cardiovascular System

Discussion in 'Why Do You Medicate?' started by momofthegoons, Oct 20, 2017.

  1. momofthegoons

    momofthegoons Nurse Ratched Staff Member

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    Microdosing Cannabis For Heart Disease And Cardiovascular Health
    by DanaSmith on Thursday Mar 23, 2017

    MICRODOSING CANNABIS FOR CARDIOVASCULAR DISEASE


    Cardiovascular problems are a leading cause of death, and have even claimed more lives than cancer. Heart attacks can strike suddenly and without warning, although most heart problems can be avoided by preventing atherosclerosis.

    Atherosclerosis is a heart condition characterized by the hardening and narrowing of the arteries. This occurs from the accumulation of fat on the blood vessel’s inner cell lining, called the endothelium. When fat builds up this in turn leads to an inflammatory response from the immune system which will cause even more damage to the arteries. Atherosclerosis is a very common contributing factor to life-threatening heart conditions including strokes and heart attacks.

    The exact cause of atherosclerosis isn’t known although smoking cigarettes, high blood pressure, high glucose levels, and high cholesterol levels contribute to one’s risk. Changing one’s diet and getting regular exercise is effective in preventing or slowing down the progression of atherosclerosis although patients still commonly seek out medication such as blood thinners and statins, which are used to lower cholesterol levels. Blood thinners may be life-saving but they are not without side effects such as prolonged bleeding, bleeding gums, nosebleeds, bloody urine or feces, and unusually heavy menstruation.

    However, cannabis can be a safer, natural alternative.

    How Cannabis Can Help

    The cardiovascular system has several cannabinoid receptors, which leads experts to think that cannabis can play a major role in keeping the heart healthy. We now have significant evidence that tells us that cannabinoids found in cannabis can help prevent atherosclerosis. Cannabinoids are critical for regulating the immune system and acting as an anti-inflammatoryagent. Inflammation is a major aspect of atherosclerosis, and cannabinoid use may slow down the progression of this heart disease.


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    In a 2005 study, scientists revealed that taking low doses of THC orally was effective in inhibiting progression of atherosclerosis in the mice subjects. They found that 1mg/kg of THC administered daily yielded the most significant improvements; and this amount of THC is much lower than what is needed to produce a psychoactive buzz. The study also concluded that the THC worked to decrease the inflammatory response in the immune system and was critical in supporting the anti-inflammatory benefits for heart disease.

    Another common factor that increases one’s risk for atherosclerosis is endothelial dysfunction, which is also affected by the presence of cannabinoids. Research shows that activating the CB2 receptors is beneficial in reducing the number of endothelial-related issues such as health problems caused by high glucose diets including fat accumulation in both human and animal models of atherosclerosis.

    Additionally, other studies also show that cannabinoids are effective in protecting against ischemia-reperfusion injury, which is caused by inflammation when blood supply is returned to oxygen-deprived tissue. This commonly occurs after a patient suffers from brain trauma or a stroke, which leads experts to think that medical cannabis can be beneficial for patients who are recovering from these conditions.

    However, some studies suggests that patients who are already sick with cardiovascular conditions may benefit more from using strains that are high in CBD instead of THC. This is because while CB1 and CB2 receptors are present throughout the cardiovascular system, activating these receptors might actually aggravate atherosclerosis especially in patients who are already in poor health. This is because THC activates CB1 receptors in the brain that can contribute to increased pulse rate and blood pressure, which can increase the risk for heart attack and stroke especially if cannabis is consumed through smoking because this impairs blood oxygen supply for the heart.

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    Cardiac patients are better off avoiding strains that are high in THC and can benefit from using CBD strains instead to prevent and treat atherosclerosis.

    More research on the use of cannabis for treating and preventing heart conditions is needed, although it’s clear that traditional methods of consuming cannabis may not be the best way to benefit from the plant’s medicinal properties. More doctors are prescribing edibles and vaporizers as a safer and healthier way to consume cannabis especially for patients who are already sick.

    Studies also show that various cannabinoids have their own effects on atherosclerosis; THC will act on CB1 and CB2 receptors while CBD is thought to act on CB2 receptors only.
     
  2. Kellya86

    Kellya86 Herb Gardener.....

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    This is something I'm very interested in..
    My family has a generic defect of some sort, excessive plaque deposits and narrowing of the ateries have led to most of the men in my family not living very long....
    My brother recently (few years actually now) had a heart attack at the age of 33... and my dad is clogged beyond repair now.. he is 59...
    Luckily I seem to be ok.... I wonder why...:weed:
     
    BD9, GreenHopper and momofthegoons like this.
  3. momofthegoons

    momofthegoons Nurse Ratched Staff Member

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    Major New Study Says Cannabis Reduces Risk Of Stroke


    Cannabis may reduce stroke by bringing more oxygen into the brain, this breakthrough human study suggests.

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    Up until now, the relationship between cannabis and stroke has been a complicated one. A major study published in early 2017 suggested that cannabis use was associated with an increased risk of stroke and other cardiac problems. The study reviewed over 315,000 hospital discharge records. However, just a few months later, another study calls bunk on the stroke claims. Here’s why science says cannabis reduces the risk of stroke.

    Science says cannabis can reduce risk of stroke
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    Photo credit
    Smoking tobacco is considered a major risk factor for. Now, however, a recent study announced to the press in August 2017 suggests that smoking cannabis is linked with a significant decrease in stroke risk. The research recruited 74 cannabis consumers and 101 non-consumers.

    All of the canna-friendly individuals were well-acquainted with the herb. They had consumed the plant at least 5,000 times in their lives, most often via smoking.

    After getting an MRI, a test that uses magnetic fields to generate images of organs in the body, the researchers found that cannabis consumers had greater global oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2).

    OEF measures the percentage of oxygen removed from the blood and into surrounding tissues. Cerebral metabolic rate refers to the brain’s ability to oxidize glucose (sugar) for energy.

    When the oxygen supply to the brain is cut off, such as in the case of stroke, the brain cannot use glucose for energy and you’ll lose consciousness within five to 10 seconds or so. A few minutes without oxygen causes permanent brain damage as brain functions essentially stop due to lack of energy.

    More oxygen traveling into tissues and the improved ability to use oxygen to make energy would drastically decrease the risk of stroke. As this study suggests, cannabis changes the blood flow of oxygen to the brain.

    The study also found that cannabis consumers had greater blood flow to regions of the brain responsible for learning, the putamen.

    All about blood pressure
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    Photo credit
    Dr. Francesca Filbey, the lead researcher, explains that the effects of cannabis on blood pressure have a huge role to play in its ability to seemingly get more oxygen into the brain. This is important, as high blood pressure is one of the primary risk factors for stroke. She states,

    […] primary psychoactive ingredient present in cannabis -tetrahydrocannabinol (THC) – relaxes arterial walls resulting in lower blood pressure and increased blood flow to tissues.

    Filbey isn’t the only medical researcher to find that cannabis lowers blood pressure. As early as the 1970s, scientists have discovered that psychoactive cannabis lowers blood pressure in humans. Additional research suggests that regular consumers can become tolerant to these effects.

    However, Filbey’s research of consumers who have toked up over 5,000 times suggests that even with this regular consumption, cannabis fans were still more likely to have improvements in the levels of oxygen delivered to organs.

    In the study, consumers were asked to abstain from cannabis for 72 hours prior to the examination. They had also used the herb daily for 60 days prior to the study. Before the examination, they were given urine tests to ensure that they had not consumed cannabis.

    The research was published in the journal Neuropsychopharmacology.
     
    CarolKing, Melting Pot, BD9 and 2 others like this.
  4. BD9

    BD9 Leaf Dawg

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    https://www.etonline.com/kevin-smit...re-massive-heart-attack-saved-his-life-101487

    Smith’s calm demeanor was due, in part, to the joint he’d smoked before his stand-up special, which proceeded the heart attack.

    “I said, ‘Doc, honestly, I just smoked too much weed this morning. That’s what this is,’” Smith said, after being told he was having a heart attack. “I honestly thought I was too high. I’d smoked a bunch of weed that day because I was doing the show and then I smoked a joint right before the show and then I got off stage and all of the sudden I had a heart attack.”

    “He goes, ‘No, quite the opposite. That weed saved your life.’ And I was like, ‘Do tell! Like, what do you mean?’” Smith quipped. “He said, ‘You kept calm. They told you [that] you were having a massive heart attack, and you remained calm the whole time, so that joint saved your life.’”

     
  5. Baron23

    Baron23 Well-Known Member

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    Actually, MJ really helped save my life from an MI also but in a different way. I have had two MI's with stents inserted for each. Then, about two years ago, and right after a hugely successful nuclear stress test (useless things that they are), I noticed that when I vaped I was getting pains between my shoulder blades as my heart rate goes up in the first 15-20 minutes after. MJ was an early warning sign of a 90% blockage in my circumflex artery so I was able to get another stent but avoid another MI and the associated damage.

    I'm very grateful to that early warning sign.
     

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