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Meds Cannabis and Healing

Discussion in 'Why Do You Medicate?' started by momofthegoons, May 12, 2017.

  1. momofthegoons

    momofthegoons Vapor Accessory Addict Staff Member

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    New research shows cannabis heals broken bones and prevents rejection of transplanted organs

    by Justin Gardner, Intellihub

    The medical uses of cannabis and its derivatives are continuing to be discovered at an astonishing rate. This is despite the fact that U.S. government clings to an absurd, baseless classification of cannabis as a Schedule I drug, which severely limits research and scientific advancement.

    We can add bone fractures and organ transplants to the diverse list of conditions that medicinal cannabis can treat.

    A study performed by Tel Aviv University and Hebrew University researchers finds that the non-psychotropic component cannabinoid cannabidiol (CBD) helps heal bone fractures. They administered the compound to rats with mid-femoral fractures and found that it “markedly enhanced the healing process of the femora after just eight weeks.”

    The team had found in earlier research that our bodies’ cannabinoid receptors stimulate bone formation and inhibit bone loss. It was a natural progression to test how this can be utilized to aid bone healing.

    “The clinical potential of cannabinoid-related compounds is simply undeniable at this point,” said Dr. Gabet. “While there is still a lot of work to be done to develop appropriate therapies, it is clear that it is possible to detach a clinical therapy objective from the psychoactivity of cannabis. CBD, the principal agent in our study, is primarily anti-inflammatory and has no psychoactivity.”

    Back in the U.S., researchers at the University of South Carolina School of Medicine discovered another new field of cannabis treatment. They found that tetrahydrocannabinol (THC), the active ingredient in cannabis, can delay the rejection of incompatible organs.

    The research performed in mice provides clear justification for its testing in clinical trials. If THC can be used to prevent organ rejection, as the authors suggest is possible, it can literally save lives. Again, the work focuses on cannabinoid receptors.

    “More and more research is identifying potential beneficial effects of substances contained in marijuana, but a major challenge has been identifying the molecular pathways involved,” said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. “These new studies point to important roles for the cannabinoid receptors as targets that might be exploited using approaches that refine how we think about substances derived from marijuana.”

    Scientists around the world are resuming the exploration of medical cannabis that was interrupted in the 1930s and ‘40s by irrational government prohibitions. We are only just discovering its usefulness in treating epilepsy, Parkinson’s disease, cancer and multiple sclerosis.

    For centuries, cannabis was used as a medical remedy. The tools of modern medicine are now allowing extraordinary insights into this plant and the powerful capabilities of cannabinoid receptors.

    Despite the amazing benefits of this plant, in police state USA, police officers will kill you for it - and they will call it "justice."



     
    Last edited: Aug 14, 2017
    Madri-Gal, BD9, Shredder and 2 others like this.
  2. momofthegoons

    momofthegoons Vapor Accessory Addict Staff Member

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    Does cannabis aid in trauma recovery?

    Two new studies find cannabis users survive hospitalization more often, and show improved brain-oxygen uptake


    [​IMG]
    At some point in the past you may have heard people describe cannabis as ‘heady’, and according to new research they may have been more spot-on than they knew. A study published earlier this year in the medical journal Neuropsychopharmacology found a direct correlation between THC blood content and the brain’s ability to harvest oxygen from its blood supply, as well as the rate at which oxygen is metabolized by the brain.

    The study, conducted at the Center for BrainHealth at the University of Texas at Dallas, analyzed brain blood oxygenation and metabolism in 175 participants—101 nonusers and 74 regular users, the latter of which had used cannabis at least 5,000 times in their lifetimes, and at least once every day in the 60 days that preceded the study. After a 72-hour period without consuming cannabis, participants were scanned with magnetic resonance imaging, and THC metabolite levels were measured using urinalysis.

    Led by Dr. Francesca Filbey, director of Cognitive Neuroscience Research in Addictive Disorders at the Center for BrainHealth, the study sought to understand the possible neurophysiological mechanisms that may drive cognitive changes associated with long-term cannabis use.

    What they found was that participants with a history of cannabis use showed increased blood flow within the brain, higher rates of oxygen extraction from that blood, and higher cerebral metabolic rates for oxygen than in non-using participants. This could indicate that THC helps the brain dilate existing blood vessels, or that it aids in the development of additional circulatory pathways.

    The study’s authors are careful to emphasize that these correlations don’t necessarily establish a causal link between cannabis and the observed changes. But this increase in oxygen uptake could be one of the reasons cannabis users have higher rates of surviving intensive care hospitalization, as observed by another recent study conducted at the University of Arizona.

    In an ahead-of-print data summary, the research team at U of A has announced their findings from a nine year study that analyzed adult trauma patients admitted into the Arizona State Trauma Registry over a five year period. The study found a strong correlation between patients who screened positive for cannabis and decreased mortality rates compared to ICU patients who screened negative for cannabis.

    The Arizona study focused on 2,678 patients—1,339 cannabis-positive and 1,339 cannabis-negative, matched for age, severity of injury, and length of stay in hospital or ICU. The study found that overall, “patients with a positive marijuana screen had a lower mortality rate (5.3 percent versus 8.9 percent) compared to patients with a negative marijuana screen.”

    The authors also noted that among patients who received mechanical ventilation, the cannabis-positive group experienced a mortality rate that was less than half that of the cannabis-negative group, at 7.3 percent versus 16.1 percent.

    These new findings also serve to bolster previous research, such as the 2014 study conducted at UCLA linking cannabis-positive patients with an increased survival rate among brain injury hospitalizations.

    While the data presented in these studies is compelling, the authors of all three studies cited in this article call for further research into the physiological effects of regular cannabis use.


     
  3. momofthegoons

    momofthegoons Vapor Accessory Addict Staff Member

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    Scientist Reveal What Cannabis Does to Your Bones
    By Dr. Fateh Malik October 4, 2017

    A study was published by The Journal of Bone and Mineral Research, conducted by researchers from Tel Aviv University and Hebrew University. This study showed that a chemical in marijuana, known as cannabinoid cannabidiol (CBD), strengthens bones and accelerates the healing of fractures, without causing any psychotropic effects.
    The researcher Yankel Gabet explained:

    “WE FOUND THAT CBD ALONE MAKES BONES STRONGER DURING HEALING, ENHANCING THE MATURATION OF THE COLLAGENOUS MATRIX, WHICH PROVIDES THE BASIS FOR NEW MINERALIZATION OF BONE TISSUE. AFTER BEING TREATED WITH CBD, THE HEALED BONE WILL BE HARDER TO BREAK IN THE FUTURE.”

    The team of experts inflicted mild femoral fractures on rats, and then gave an injection of CBD to some of them, while others received CBD plus tetrahydrocannabinol (THC, the ingredient that causes the marijuana high). They analyzed the healing between them and the rats that had not received any marijuana chemicals. Their conclusion was that rats injected with CBD experienced the same effects, regardless of the addition of THC.

    Gabet added:

    “WE FOUND CBD ALONE TO BE SUFFICIENTLY EFFECTIVE IN ENHANCING FRACTURE HEALING. OTHER STUDIES HAVE ALSO SHOWN CBD TO BE A SAFE AGENT, WHICH LEADS US TO BELIEVE WE SHOULD CONTINUE THIS LINE OF STUDY IN CLINICAL TRIALS TO ASSESS ITS USEFULNESS IN IMPROVING HUMAN FRACTURE HEALING.”

    The same team previously found that the body contains receptors which respond to cannabinoid compounds, and they are not confined to the brain. This study showed that the skeleton has cannabinoid receptors which trigger bone formation and prevent bone loss, and the second study just confirmed this.

    Gabet said:

    “WE ONLY RESPOND TO CANNABIS BECAUSE WE ARE BUILT WITH INTRINSIC COMPOUNDS AND RECEPTORS THAT CAN ALSO BE ACTIVATED BY COMPOUNDS IN THE CANNABIS PLANT.”

    This study is just a part of all research dedicated to the medical benefits of marijuana compounds, and new findings might stimulate researchers to analyze the positive effects of marijuana in the treatment of osteoporosis or other bone diseases.

    Gabet added:

    “THE CLINICAL POTENTIAL OF CANNABINOID-RELATED COMPOUNDS IS SIMPLY UNDENIABLE AT THIS POINT. WHILE THERE IS STILL A LOT OF WORK TO BE DONE TO DEVELOP APPROPRIATE THERAPIES, IT IS CLEAR THAT IT IS POSSIBLE TO DETACH A CLINICAL THERAPY OBJECTIVE FROM THE PSYCHOACTIVITY OF CANNABIS. CBD, THE PRINCIPAL AGENT IN OUR STUDY, IS PRIMARILY ANTI-INFLAMMATORY AND HAS NO PSYCHOACTIVITY.”

    The medical properties of marijuana are numerous, and it is primarily used to boost appetite in the case of AIDS, to lower the side-effects of chemotherapy, and to soothe chronic pain. Numerous studies claim that it can regulate blood sugar, decelerate the HIV progression, and treat multiple sclerosis and Parkinson’s disease.

    Researchers have shown that CBD suppresses seizures, inhibits the metastasis of many aggressive cancers, and destroys leukemia cells.

    The journal Neuropsychopharmacology published a 2013 study which discovered that CBD is as effective as one antipsychotic drug, which is commonly used in the treatment of schizophrenia and paranoia but causes no side-effects. Other studies have also found that CBD can be used as a safe antipsychotic.

    Marijuana is still technically illegal under U.S. federal law, but 17 U.S. states allow the use of CBD for research or for limited medical functions. Plus, the laws of 23 other countries permit the medical use of marijuana.

    Marijuana is still classified as having “no currently accepted medical use” by the federal government. What might be a change in this approach is the recent decision of the FDA to approve the use of CBD extracts an experimental treatment for the Dravet syndrome, a rare form of childhood epilepsy.

    Sources:
    http://www.scienceworldreport.com
    http://www.business-standard.com
    http://www.dnaindia.com
    http://www.huffingtonpost.com
    http://www.timesofisrael.com
    http://blog.norml.org
    Credit: http://www.naturalnews.com
     
    Madri-Gal and BD9 like this.
  4. momofthegoons

    momofthegoons Vapor Accessory Addict Staff Member

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    I thought this might be of interest to a couple of our members who are about to have surgery or have injuries (including myself lol)... @CarolKing @Shredder @BD9 ....

    Scientist Reveal What Cannabis Does to Your Bones…

    A study was published by The Journal of Bone and Mineral Research, conducted by researchers from Tel Aviv University and Hebrew University. This study showed that a chemical in marijuana, known as cannabinoid cannabidiol (CBD), strengthens bones and accelerates the healing of fractures, without causing any psychotropic effects.
    The researcher Yankel Gabet explained:

    “WE FOUND THAT CBD ALONE MAKES BONES STRONGER DURING HEALING, ENHANCING THE MATURATION OF THE COLLAGENOUS MATRIX, WHICH PROVIDES THE BASIS FOR NEW MINERALIZATION OF BONE TISSUE. AFTER BEING TREATED WITH CBD, THE HEALED BONE WILL BE HARDER TO BREAK IN THE FUTURE.”

    The team of experts inflicted mild femoral fractures on rats, and then gave an injection of CBD to some of them, while others received CBD plus tetrahydrocannabinol (THC, the ingredient that causes the marijuana high). They analyzed the healing between them and the rats that had not received any marijuana chemicals. Their conclusion was that rats injected with CBD experienced the same effects, regardless of the addition of THC.

    Gabet added:

    “WE FOUND CBD ALONE TO BE SUFFICIENTLY EFFECTIVE IN ENHANCING FRACTURE HEALING. OTHER STUDIES HAVE ALSO SHOWN CBD TO BE A SAFE AGENT, WHICH LEADS US TO BELIEVE WE SHOULD CONTINUE THIS LINE OF STUDY IN CLINICAL TRIALS TO ASSESS ITS USEFULNESS IN IMPROVING HUMAN FRACTURE HEALING.”

    The same team previously found that the body contains receptors which respond to cannabinoid compounds, and they are not confined to the brain. This study showed that the skeleton has cannabinoid receptors which trigger bone formation and prevent bone loss, and the second study just confirmed this.

    Gabet said:

    “WE ONLY RESPOND TO CANNABIS BECAUSE WE ARE BUILT WITH INTRINSIC COMPOUNDS AND RECEPTORS THAT CAN ALSO BE ACTIVATED BY COMPOUNDS IN THE CANNABIS PLANT.”

    This study is just a part of all research dedicated to the medical benefits of marijuana compounds, and new findings might stimulate researchers to analyze the positive effects of marijuana in the treatment of osteoporosis or other bone diseases.

    Gabet added:

    “THE CLINICAL POTENTIAL OF CANNABINOID-RELATED COMPOUNDS IS SIMPLY UNDENIABLE AT THIS POINT. WHILE THERE IS STILL A LOT OF WORK TO BE DONE TO DEVELOP APPROPRIATE THERAPIES, IT IS CLEAR THAT IT IS POSSIBLE TO DETACH A CLINICAL THERAPY OBJECTIVE FROM THE PSYCHOACTIVITY OF CANNABIS. CBD, THE PRINCIPAL AGENT IN OUR STUDY, IS PRIMARILY ANTI-INFLAMMATORY AND HAS NO PSYCHOACTIVITY.”

    The medical properties of marijuana are numerous, and it is primarily used to boost appetite in the case of AIDS, to lower the side-effects of chemotherapy, and to soothe chronic pain. Numerous studies claim that it can regulate blood sugar, decelerate the HIV progression, and treat multiple sclerosis and Parkinson’s disease.

    Researchers have shown that CBD suppresses seizures, inhibits the metastasis of many aggressive cancers, and destroys leukemia cells.

    The journal Neuropsychopharmacology published a 2013 study which discovered that CBD is as effective as one antipsychotic drug, which is commonly used in the treatment of schizophrenia and paranoia but causes no side-effects. Other studies have also found that CBD can be used as a safe antipsychotic.

    Marijuana is still technically illegal under U.S. federal law, but 17 U.S. states allow the use of CBD for research or for limited medical functions. Plus, the laws of 23 other countries permit the medical use of marijuana.

    Marijuana is still classified as having “no currently accepted medical use” by the federal government. What might be a change in this approach is the recent decision of the FDA to approve the use of CBD extracts an experimental treatment for the Dravet syndrome, a rare form of childhood epilepsy.

    Sources:
    http://www.scienceworldreport.com
    http://www.business-standard.com
    http://www.dnaindia.com
    http://www.huffingtonpost.com
    http://www.timesofisrael.com
    http://blog.norml.org
    Credit: http://www.naturalnews.com
     
    Madri-Gal and BD9 like this.
  5. momofthegoons

    momofthegoons Vapor Accessory Addict Staff Member

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    Cannabis Is Healing Your Bones And Improving Bone Density

    Healing bones seems like the least likely benefit for medical cannabis, yet here we are.
    The connection between cannabis and bone health isn’t an obvious one. Making the connection between strong bones and medicinal cannabis isn’t necessarily logical. How can a puff from a joint improve density, or heal fractures? But this avenue of cannabis research is well underway, exploring how cannabinoids may increase the density of aging bones, reduce the risk of osteoporosis, and now, healing bones with fractures.

    We already know that the endocannabinoid system controls bone health to some degree. Both the CB1 and CB2 receptors regulate various aspects of bone formation and reabsorption. There is already a basis for the use of cannabis for bone loss related to osteoporosis and other bone density conditions. Now, new research is suggesting how some cannabinoids may help heal fractured bones, at least so much as in rat models.


    [​IMG]

    Updates on Cannabis for Bone Health
    In 2017, the Journal of Bone and Mineral Research published a study out of Jerusalem about the impact of THC and CBD on healing bones. This was a joint project by Dr. Yankel Gabet of the Bone Research Laboratory at the Department of Anatomy and Anthropology at TAU’s Sackler Faculty of Medicine and Prof. Itai Bab of Hebrew University’s Bone Laboratory. They explored how each compound works to heal mid-femur fractures in lab rats.


    The Israeli team dosed the rats with a mixture of THC and CBD for eight weeks. They analyzed what is called the “work to failure” rate, which essentially means the amount that the rats could use their injured limb before collapse. They also measured the maximum load on the injured leg. Cannabidiol, a non-intoxicating compound derived from cannabis improved maximum weight as well as the work to failure rate for the duration of the trial. On the flip side, THC had little to no impact over either measure.

    During a post-study autopsy of the lab rats, researchers also uncovered biological and measurable evidence that cannabis healed fractures when compared to a control group. In this study at least, CBD was effective for healing bones over the short term.

    As per Dr. Gabet, “We found that CBD alone makes bones stronger during healing, enhancing the maturation of the collagenous matrix, which provides the basis for new mineralization of bone tissue. After being treated with CBD, the healed bone will be harder to break in the future.”

    Gabet went on to say that their findings warrant further study. Cannabis, and especially CBD, has a low risk of adverse reaction and cannabis more generally is well received by patients. Bone fractures often require opioid prescriptions, and a less addictive alternative is desperately needed.


    [​IMG]

    A Word of Warning for Heavy Cannabis Use
    A relatively recent publication in the American Journal of Medicine uncovered a correlation between heavy cannabis use and low bone mineral density. The authors recruited participants from general practice appointments in the United Kingdom between 2011 and 2013. The researchers categorized participants according to their level of cannabis use. The authors then classified the study participants who consumed cannabis regularly as heavy users.

    The contributors analyzed several biological measurements between each group compared to a control group. These included bone mineral density and fracture history. They also included information that could have an impact on the results of their analysis, like body mass index (BMI), level of physical activity, and dietary calcium intake.

    The research team learned that heavy cannabis users had measurably lower bone mineral density. This was confirmed at three separate locations – the hip, the lower lumbar, and femoral neck. When they evaluated cannabis in comparison to all other influences over bone health (BMI, tobacco use, dietary calcium intake, etc) cannabis consumption still predicted lower density.

    This study opens up a new round of questioning regarding cannabis use and bone health. Is the impact a biphasic effect, where a lower dose improves bone health while a heavy dose is detrimental? Are there differences in cannabinoids or mode of ingestion that influence bone health?

    It’s also worth noting that participants did not consume the cannabis in a controlled setting. Instead, the study relied on self-reported cannabis consumption. Despite this flaw, this paper is an important word of warning to heavy cannabis users. It may be worth speaking to your family doctor to understand your risk to bone density.

    [​IMG]

    Benefits of Cannabis for Fractures
    There are of course many other arguments for healing bones with cannabis beyond the actual fracture. The many cannabinoids in the plant all have therapeutic potential, many of which are useful for post-fracture recovery. Here are a few examples:

    • Pain Management – THC is a medicinally beneficial compound for pain relief. It is already replacing opioid prescriptions for chronic pain in the US and is thought to target neuropathic and inflammatory pain. Both types of pain experienced during fractures.
    • Inflammation – As the body heals, it enters into a state of increased inflammatory response. While necessary during the initial stages of recovery, chronic inflammation does more harm than good. Both CBD and THC may help reduce problematic and painful inflammation near and around the fracture site.
    • Low risk of side effects – Considering the well-known side effects related to opioid use, cannabis is a low-risk alternative. There is a small risk of habit-forming, minimal, and mild side effects but no risk of fatal overdose.
    Healing bones with cannabis isn’t a sure-fire bet (yet), but the evidence is mounting. With a bit more knowledge about how our own endocannabinoid system regulates the formation of bones, cannabis may become another tool in our toolkit for fractures. It’s early enough that you likely won’t hear a doctor advise you to smoke a joint for bone health – we’ll need a few more published peer-reviewed studies before that happens!
     
    Madri-Gal, Helios and arb like this.
  6. arb

    arb Semi shaved ape

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    Wow............
     
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