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Research Clnical and Scientific Studies on how Cannabis Affects Cancer

momofthegoons

Vapor Accessory Addict
Staff member
There Are Now 100 Scientific Studies on How Cannabis Affects Cancer

A
manda Froehlich,
True Activist
Waking Times Media

Despite the fact that countless individuals have used cannabis oil to heal their afflictions, the U.S. Cancer Institute lists cannabis as a ‘cure’ for cancer on its website, and a multitude of veterans credit the herb with helping them ditch opioids and alleviate symptoms of PTSD, the marijuana plant remains classified as a Schedule I drug in the United States.

In fact, in most countries around the world, use of the herb and its components for medicinal and recreational purposes remains to be illegal. This continues, regardless of the fact that 0 people die from using the herb each year. In contrast, 30,722 die from alcohol poisoning and 38,329 from abusing pharmaceuticals annually (according to 2014 data).

Some activists, such as Rick Simpson, have suggested that the plant is still illegal in the U.S. on a Federal level because of its multitude of uses. A part of the plant known as hemp can be used for clothing, food, and industrial purposes, and components of the ‘flower’ known as marijuana can inspire creativity, free-thinking and, of course, contribute to healing.

It is an injustice that individuals are refused access to the herb considering it is 100% natural and has been cultivated for thousands of years. Additionally, at least 100 studies prove that the plant can combat one of the most frightening modern afflictions: cancer. As 1 in 2 women and 1 in 3 men are predicted to develop cancer in their lifetimes, it is past time the herb lose its stigma and Schedule I status so that citizens worldwide might benefit from its many properties.

FOLLOWING ARE 100 STUDIES PROVING CANNABIS TO BE AN ALL-NATURAL CANCER KILLER:
CANNABIS KILLS TUMOR CELLS

UTERINE, TESTICULAR, AND PANCREATIC CANCERS
BRAIN CANCER
MOUTH AND THROAT CANCER
BREAST CANCER
LUNG CANCER
PROSTATE CANCER
BLOOD CANCER
SKIN CANCER
LIVER CANCER
CANNABIS CANCER CURES (GENERAL)
CANCERS OF THE HEAD AND NECK
CHOLANGIOCARCINOMA CANCER
LEUKEMIA
CANNABIS PARTIALLY/FULLY INDUCED CANCER CELL DEATH
TRANSLOCATION-POSITIVE RHABDOMYOSARCOMA
LYMPHOMA
CANNABIS KILLS CANCER CELLS
MELANOMA
THYROID CARCINOMA
COLON CANCER
INTESTINAL INFLAMMATION AND CANCER
CANNABINOIDS IN HEALTH AND DISEASE
CANNABIS INHIBITS CANCER CELL INVASION
 
Last edited:

Baron23

Well-Known Member
There Are Now 100 Scientific Studies on How Cannabis Affects Cancer

Amanda Froehlich,
True Activist
Waking Times Media

Despite the fact that countless individuals have used cannabis oil to heal their afflictions, the U.S. Cancer Institute lists cannabis as a ‘cure’ for cancer on its website, and a multitude of veterans credit the herb with helping them ditch opioids and alleviate symptoms of PTSD, the marijuana plant remains classified as a Schedule I drug in the United States.

In fact, in most countries around the world, use of the herb and its components for medicinal and recreational purposes remains to be illegal. This continues, regardless of the fact that 0 people die from using the herb each year. In contrast, 30,722 die from alcohol poisoning and 38,329 from abusing pharmaceuticals annually (according to 2014 data).

Some activists, such as Rick Simpson, have suggested that the plant is still illegal in the U.S. on a Federal level because of its multitude of uses. A part of the plant known as hemp can be used for clothing, food, and industrial purposes, and components of the ‘flower’ known as marijuana can inspire creativity, free-thinking and, of course, contribute to healing.

It is an injustice that individuals are refused access to the herb considering it is 100% natural and has been cultivated for thousands of years. Additionally, at least 100 studies prove that the plant can combat one of the most frightening modern afflictions: cancer. As 1 in 2 women and 1 in 3 men are predicted to develop cancer in their lifetimes, it is past time the herb lose its stigma and Schedule I status so that citizens worldwide might benefit from its many properties.

FOLLOWING ARE 100 STUDIES PROVING CANNABIS TO BE AN ALL-NATURAL CANCER KILLER:

CANNABIS KILLS TUMOR CELLS

UTERINE, TESTICULAR, AND PANCREATIC CANCERS

BRAIN CANCER

MOUTH AND THROAT CANCER

BREAST CANCER

LUNG CANCER

PROSTATE CANCER

BLOOD CANCER

SKIN CANCER

LIVER CANCER

CANNABIS CANCER CURES (GENERAL)

CANCERS OF THE HEAD AND NECK

CHOLANGIOCARCINOMA CANCER

LEUKEMIA

CANNABIS PARTIALLY/FULLY INDUCED CANCER CELL DEATH

TRANSLOCATION-POSITIVE RHABDOMYOSARCOMA

LYMPHOMA

CANNABIS KILLS CANCER CELLS

MELANOMA

THYROID CARCINOMA

COLON CANCER

INTESTINAL INFLAMMATION AND CANCER

CANNABINOIDS IN HEALTH AND DISEASE

CANNABIS INHIBITS CANCER CELL INVASION

Terrific find. Suggest considering adding this list of links to a sticky "resource" post so we don't lose it.
 

Baron23

Well-Known Member
Not sure if you are suggesting making a resource out of it or adding a sticky. I've added a sticky. :wink:
hehehe...I'm not sure either!! LOL Thanks for the sticky!!
 

momofthegoons

Vapor Accessory Addict
Staff member
I think the author here, Froelich, has those numers and respective genders backasswards!

Perhaps that might be edited, for credibility sake if nothing else?

Ex. Source: http://www.medscape.com/viewarticle/551998


.
That link just leads to a sign in page.....

The link in the quoted part of the article, however, goes to this article in Medicinal News Today, and is from 2015. Perhaps the numbers have changed since then..:idon'tknow:
 

Fat Freddy

Well-Known Member
That link just leads to a sign in page.....

The link in the quoted part of the article, however, goes to this article in Medicinal News Today, and is from 2015. Perhaps the numbers have changed since then..:idon'tknow:

Ahhhh...I suppose because I'm a member of medscape it goes dirctly to the intended article.

Numbers haven't changed.

https://www.cancer.org/cancer/cancer-basics/questions-people-ask-about-cancer.html

"How common is cancer?
About half of all men and one-third of all women in the US will develop cancer during their lifetimes."

https://www.standup2cancer.org/get_involved

.
 
Last edited:

momofthegoons

Vapor Accessory Addict
Staff member
68 Medical Studies About the Anti-Cancer Effects of CANNABINOIDS (2013 – 2017)

Part 1: 100 Medical Studies About the Anti-Cancer Effects of CANNABINOIDS (1975 – 2012)
https://www.facebook.com/notes/cannabis-cures-cancers/100-medical-studies-about-the-anti-cancer-effects-of-cannabinoids-1975-2012/1395955663773651

Part 1 is the OP for this thread.




-------------------------------------------------------------------------------------------
Local Delivery of Cannabinoid-Loaded Microparticles Inhibits Tumor Growth in a Murine Xenograft Model of Glioblastoma Multiforme
PLOS ONE (Public Library of Science) January 2013
Abstract: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054795
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COX-2 and PPAR-γ Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
Molecular Cancer Therapeutics January 2013
FULL TEXT: http://mct.aacrjournals.org/content/12/1/69.full
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Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
British Journal of Pharmacology January 2013
FULL TEXT: http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02027.x/full
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Cannabidiol as potential anticancer drug
British Journal of Clinical Pharmacology February 2013
FULL TEXT: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04298.x/full
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Involvement of PPARγ in the antitumoral action of cannabinoids on hepatocellular carcinoma
Cell Death and Disease May 2, 2013
Abstract: http://www.nature.com/cddis/journal/v4/n5/full/cddis2013141a.html
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The Medical Necessity for Medicinal Cannabis: Prospective, Observational Study Evaluating the Treatment in Cancer Patients on Supportive or Palliative Care
Evidence-based Complementary and Alternative Medicine June 2013
Abstract: http://www.hindawi.com/journals/ecam/2013/510392/
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Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells
Cell Death and Disease June 13, 2013
FULL TEXT:
http://www.nature.com/cddis/journal/v4/n6/fig_tab/cddis2013151f7.html#figure-title
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Structural Requirements for Potent Direct Inhibition of Human Cytochrome P450 1A1 by Cannabidiol: Role of Pentylresorcinol Moiety
J-STAGE: Biological and Pharmaceutical Bulletin: The Pharmaceutical Society of Japan July 2013
Abstract: https://www.jstage.jst.go.jp/article/bpb/36/7/36_b13-00183/_html
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Critical appraisal of the potential use of cannabinoids in cancer management
Cancer Management and Research August 30, 2013
Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770515/?report=classic
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Preparation and characterization of Δ9-tetrahydrocannabinol-loaded biodegradable polymeric microparticles and their antitumoral efficacy on cancer cell lines
Journal of Drug Targeting September 21, 2013
Abstract: http://informahealthcare.com/doi/abs/10.3109/1061186X.2013.809089
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The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action
Biochimica et Biophysica Acta (BBA) (Molecular and Cell Biology of Lipids) October 2013
Abstract: http://www.sciencedirect.com/science/article/pii/S1388198113000851
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Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules
Anticancer Research October 2013
Abstract: http://ar.iiarjournals.org/content/33/10/4373.abstract
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Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
British Journal of Pharmacology October 4, 2013
Abstract: http://onlinelibrary.wiley.com/doi/10.1111/bph.12439/abstract
----------------------------------------------------------------------------------------
Anticancer activity of anandamide in human cutaneous melanoma cells
European Journal of Pharmacology October 15, 2013
Abstract: http://www.sciencedirect.com/science/article/pii/S0014299913006481
-------------------------------------------------------------------------------------------- Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect
PLOS ONE (Public Library of Science) October 21, 2013
Abstract: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0076918
----------------------------------------------------------------------------------------
The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers
International Journal of Endocrinology October 23, 2013
Abstract: http://www.hindawi.com/journals/ije/2013/259676/
----------------------------------------------------------------------------------------
Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation
Case Reports in Oncology November 2013
FULL TEXT: http://www.karger.com/Article/FullText/356446
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Antineoplastic Effect of WIN 55,212-2, a Cannabinoid Agonist, in a Murine Xenograft Model of Gastric Cancer
Chemotherapy December 3, 2013
FULL TEXT: http://www.karger.com/Article/FullText/355666
---------------------------------------------------------------------------------------------
Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death
Cell Death & Disease December 5, 2013
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24309936
--------------------------------------------------------------------------------------------------
Expression and Functional Relevance of Cannabinoid Receptor 1 in Hodgkin Lymphoma
PLOS One (Public Library of Science) December 9, 2013
Abstract:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0081675;jsessionid=DCF33AB8C97C190F617052863FCC061C
-----------------------------------------------------------------------------------------
Cannabinoid Signaling in Glioma Cells
Advances in Experimental Biology and Medicine: Glioma Signaling 2013
Abstract: http://link.springer.com/chapter/10.1007%2F978-94-007-4719-7_11
-------------------------------------------------------------------------------------------
Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
Journal of Neuro-Oncology January 2014
Abstract: http://link.springer.com/article/10.1007/s11060-013-1277-1
--------------------------------------------------------------------------------------------------
Physiological intestinal oxygen modulates the Caco-2 cell model and increases sensitivity to the phytocannabinoid cannabidiol
In Vitro Cellular and Developmental Biology - Animal January 2014
Abstract: http://link.springer.com/article/10.1007/s11626-013-9719-9
-----------------------------------------------------------------------------------------------
Anandamide inhibits breast tumor-induced angiogenesis
Translational Medicine @ UniSa (Official Journal of the Medical School of the University of Salerno) April 8, 2014
FULL TEXT: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140423/
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Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology April 15, 2014
Abstract: http://www.phytomedicinejournal.com/article/S0944-7113(13)00472-8/abstract
----------------------------------------------------------------------------------------------
Cannabinoid CB2 Receptor as a New Phototherapy Target for the Inhibition of Tumor Growth
Molecular Pharmaceutics April 29, 2014
Abstract: http://pubs.acs.org/doi/abs/10.1021/mp5001923
----------------------------------------------------------------------------------------------
CB2 Receptor Activation Inhibits Melanoma Cell Transmigration through the Blood-Brain Barrier
International Journal of Molecular Sciences May 8, 2014
Abstract: http://www.mdpi.com/1422-0067/15/5/8063
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Targeting multiple cannabinoid antitumor pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer
British Journal of Pharmacology June 2014
Abstract: http://onlinelibrary.wiley.com/doi/10.1111/bph.12803/abstract
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The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2
International Journal of Cancer June 2014
Abstract: http://onlinelibrary.wiley.com/doi/10.1002/ijc.28591/abstract
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Potential upstream regulators of cannabinoid receptor 1 signaling in prostate cancer: A Bayesian network analysis of data from a tissue microarray
The Prostate June 9, 2014
FULL TEXT: http://onlinelibrary.wiley.com/doi/10.1002/pros.22827/full
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Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling
The Journal of Biological Chemistry June 18, 2014
Abstract: http://www.jbc.org/content/early/2014/07/02/jbc.M114.561761.abstract
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Cannabinoids Inhibit angiogenic capacities of Endothelial cells via release of Tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells
Biochemical Pharmacology June 26, 2014
Abstract: http://www.sciencedirect.com/science/article/pii/S0006295214003608
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Cannabinoids as therapeutic agents in cancer: current status and future implications
Oncotarget July 17, 2014
FULL TEXT:
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B0%5D=2233&path%5B1%5D=3664
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CANNABINOIDS INCREASE LUNG CANCER CELL LYSIS BY LYMPHOKINE-ACTIVATED KILLER CELLS VIA UPREGULATION OF ICAM-1.
Biochemical Pharmacology July 25, 2014
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25069049
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Protective and therapeutic effects of cannabis plant extract on liver cancer induced by dimethylnitrosamine in mice
Alexandria Journal of Medicine September 2014
FULL TEXT: http://www.sciencedirect.com/science/article/pii/S209050681400027X
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Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid
Carcinogenesis September 30, 2014
Abstract: http://carcin.oxfordjournals.org/content/early/2014/10/22/carcin.bgu205.abstract
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Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells
The Journal of Toxicological Sciences October 2014
Abstract: https://www.jstage.jst.go.jp/article/jts/39/5/39_711/_article
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The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model
Molecular Cancer Therapeutics November 14, 2014
Abstract:
http://mct.aacrjournals.org/content/early/2014/11/12/1535-7163.MCT-14-0402.abstract
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The antitumor action of cannabinoids on glioma tumorigenesis
Histology and Histopathology December 4, 2014
FULL TEXT (Manuscript): http://www.hh.um.es/Reviews-proofs/11-569-manuscript.pdf
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New Insights into Antimetastatic and Antiangiogenic Effects of Cannabinoids
International Review of Cell and Molecular Biology Volume 314, 2015 Published on-line: December 18, 2014
Abstract: http://www.sciencedirect.com/science/article/pii/S1937644814000082
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Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: Novel anti-tumor mechanisms of Cannabidiol in breast cancer
Molecular Oncology January 19, 2015
Abstract: http://www.sciencedirect.com/science/article/pii/S1574789114002956
--------------------------------------------------------------------------------------------
Proapoptotic effect of endocannabinoids in prostate cancer cells
Oncology Reports January 21, 2015
Abstract: http://www.spandidos-publications.com/10.3892/or.2015.3746
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Association Between Cannabis Use and the Risk of Bladder Cancer: Results From the California Men's Health Study
Urology February 2015
Abstract: http://www.goldjournal.net/article/S0090-4295(14)01206-0/abstract
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Exploiting Cannabinoid-Induced Cytotoxic Autophagy to Drive Melanoma Cell Death
Journal of Investigative Dermatology February 10, 2015
Abstract: http://www.nature.com/jid/journal/vaop/naam/abs/jid201545a.html
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A selective, non-toxic CB2 cannabinoid o-quinone with in vivo activity against triple negative breast cancer
Journal of Medicinal Chemistry February 11, 2015
Abstract: http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b00078
---------------------------------------------------------------------------------------
Cannabis in Cancer Care
by Dr. Donald Abrams and Dr. Manuel Guzmán
Clinical Pharmacology & Therapeutics April 17, 2015
FULL TEXT: http://onlinelibrary.wiley.com/doi/10.1002/cpt.108/pdf
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The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids
Journal of Neuroimmune Pharmacology June 2015
Abstract: http://link.springer.com/article/10.1007%2Fs11481-015-9608-y
--------------------------------------------------------------------------------------
Differential role of cannabinoids in the pathogenesis of skin cancer
Life Sciences October 1, 2015
Abstract: http://www.sciencedirect.com/science/article/pii/S0024320515002209
----------------------------------------------------------------------------------------------
Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner
International Journal of Cancer October 15, 2015
Abstract:
http://onlinelibrary.wiley.com/doi/10.1002/ijc.29573/abstract;jsessionid=E140E1EE265F116851C70A4551D30B3B.f03t01
----------------------------------------------------------------------------------------------
The use of cannabinoids as anticancer agents
Progress in Neuro-Psychopharmacology and Biological Psychiatry January 4, 2016
FULL TEXT: http://www.sciencedirect.com/science/article/pii/S0278584615001190
----------------------------------------------------------------------------------------------
In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma
Current Oncology March 16, 2016
FULL TEXT: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791143/
-------------------------------------------------------------------------------------------
Anticancer mechanisms of cannabinoids
by Guillermo Velasco, PhD, Cristina Sánchez, PhD, and Manuel Guzmán, PhD
Current Oncology March 16, 2016
FULL TEXT: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791144/
-------------------------------------------------------------------------------------
Integrating cannabis into clinical cancer care
by Dr. Donald Abrams
Current Oncology March 16, 2016
FULL TEXT: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791148/
-------------------------------------------------------------------------------------
Cannabis and cancer: toward a new understanding
Current Oncology March 16, 2016
FULL TEXT: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791146/
-------------------------------------------------------------------------------------
Why I chose to use cannabis
Current Oncology March 16, 2016
FULL TEXT: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791147/
---------------------------------------------------------------------------------------
Medical Marijuana Use in Oncology: A Review
JAMA Oncology March 17, 2016
FULL TEXT: http://oncology.jamanetwork.com/article.aspx?articleid=2504173
---------------------------------------------------------------------------------------------
Antitumorigenic targets of cannabinoids – current status and implications
Expert Opinion on Therapeutic Targets April 12, 2016
Abstract:
http://www.tandfonline.com/doi/abs/10.1080/14728222.2016.1177512#.VylAIdIrI2w
----------------------------------------------------------------------------------------------
Using Medical Cannabis in an Oncology Practice
by Donald I. Abrams, MD
ONCOLOGY May 15, 2016
FULL TEXT:
http://www.cancernetwork.com/oncology-journal/using-medical-cannabis-oncology-practice
------------------------------------------------------------------------------------------
Endocannabinoid system: a promising therapeutic target for the treatment of haematological malignancies?
Current Medicinal Chemistry May 30, 2016
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27237820
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Endocannabinoid system as a regulator of tumor cell malignancy – biological pathways and clinical significance
OncoTargets and Therapy July 18, 2016
FULL TEXT:
https://www.dovepress.com/endocannabinoid-system-as-a-regulator-of-tumor-cell-malignancy-ndash-b-peer-reviewed-fulltext-article-OTT
-----------------------------------------------------------------------------------------------
Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents
Frontiers in Pharmacology October 7, 2016
FULL TEXT: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054289/
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Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness
Journal of Natural Medicines January 2017
Abstract: https://link.springer.com/article/10.1007%2Fs11418-016-1030-0
----------------------------------------------------------------------------------------------
Cannabinoid derivatives exert a potent anti-myeloma activity both in vitro and in vivo
International Journal of Cancer February 1, 2017
Abstract: http://onlinelibrary.wiley.com/doi/10.1002/ijc.30483/abstract
-------------------------------------------------------------------------------------------
Bladder cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism
Scientific Reports February 13, 2017
FULL TEXT: http://www.nature.com/articles/srep42157
----------------------------------------------------------------------------------------------
Emerging therapeutic targets in cancer induced bone disease: A focus on the peripheral type 2 cannabinoid receptor
Pharmacological Research March 6, 2017
Abstract: http://www.sciencedirect.com/science/article/pii/S1043661816313809
-----------------------------------------------------------------------------------------------
Cannabinoids as Modulators of Cell Death: Clinical Applications and Future Directions
Reviews of Physiology, Biochemistry and Pharmacology April 20, 2017
Abstract: https://link.springer.com/chapter/10.1007%2F112_2017_3
-----------------------------------------------------------------------------------------------
Cannabinoids as Anticancer Drugs
Advances in Pharmacology June 12, 2017
Abstract: http://www.sciencedirect.com/science/article/pii/S105435891730039X?via%3Dihub
-----------------------------------------------------------------------------------------------
Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration
International Journal of Oncology July 2017
Abstract: https://www.spandidos-publications.com/ijo/51/1/369
 

momofthegoons

Vapor Accessory Addict
Staff member
This one is a tough one to cut and paste so I'm going to have to just give you the link....

Clinical Studies and Case Reports
On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.
 

ataxian

In a BLACK HOLE!
This one is a tough one to cut and paste so I'm going to have to just give you the link....

Clinical Studies and Case Reports
On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.

PINK is my FAVORITE COLOR!!
I saw the most well known DOCTORS for what I have?
No one mentioned the benefit of CANNABIS?
 

momofthegoons

Vapor Accessory Addict
Staff member
No one mentioned the benefit of CANNABIS?
It's interesting; isn't it? Not one of my doctors has either. In fact, the only time I've known of a doctor prescribing (other than certification doctors) was when my mom was dying of cancer and they gave her Marinol to help her eat. Now... she could have easily obtained real cannabis... but chose to use the Marinol instead. And hated it. :idon'tknow:

My MMJ certification doctor told me that no doctor will recommend cannabis until the Feds are on board. They are afraid of losing their Medicare billings.
 

ataxian

In a BLACK HOLE!
It's interesting; isn't it? Not one of my doctors has either. In fact, the only time I've known of a doctor prescribing (other than certification doctors) was when my mom was dying of cancer and they gave her Marinol to help her eat. Now... she could have easily obtained real cannabis... but chose to use the Marinol instead. And hated it. :idon'tknow:

My MMJ certification doctor told me that no doctor will recommend cannabis until the Feds are on board. They are afraid of losing their Medicare billings.
I have one of the best NERO's in the USA and said no cure or comfort?

I have no MEDICAL background and dumb me found CANNABIS the best way to cope?
 

ddave

Well-Known Member
Accessory Maker
Seriously Awesome thread!

Now if @herbivore21 could devise a method of administration and dosing regimen to treat each, I believe he'd be in for one of those Nobel Peace Prizes. :clap:
 

Baron23

Well-Known Member
I have often thought; 1) that we too often exaggerate the benefits of MMJ to the detriment of our credibility and; 2) we are too quick to embrace homeopathic type treatments while being far to quick to dismiss standard medical treatments.

I guess I have a third common thought....few of us are medical professionals but it seems that we sometimes allow ourselves to offer advise that exceeds our qualifications.

Any how, below is different POV than most commonly seen in MMJ forums.

An Open Letter to Rick Simpson by Dr. Franjo Grotenhermen

Dear Rick Simpson,

You are probably the most well-known personality when it comes to the medical use of cannabis by cancer patients. Many desperate individuals, suffering from cancer and other serious maladies, put their trust in you and place great hope in your advice.

You are aware of this responsibility when you write in your book, Rick Simpson Oil – Nature’s Answer for Cancer, “I think anyone including myself, if put in a position of public trust, should expect to have their activities while working for the public watched very closely,” (Pos. 2528, Kindle). It is my conclusion, however, that you have not taken the proper measures commensurate with such great responsibility. I hope that in the future, you can do better.

I share your view when you write, “As I have stated many times, it is our watch and is our sacred responsibility to see that mankind will survive and prosper. Doctors will begin to follow the Hippocratic Oath and governments will begin to work for the greater good of the people. This is the only path we can follow which makes any sense and, if ignored, the destruction of the human race can be the only result,” (Pos. 2517, Kindle). And you continue, “My mission is simply to provide the truth to everyone possible, so together we can effect change,” (Pos. 3460, Kindle).

But I have to state that you are not taking many important facts into consideration – much to the detriment of people. You admit that you are “not a doctor” and do not “have the qualifications necessary to become one,” (pos. 1485, Kindle), but you take the liberty of exaggerating promises of healing that do not stand up to factual examination.

I want to clarify what one might interpret as overly harsh criticism, however, is inevitable, by six examples:

Lack of Knowledge
You write, “Decarboxylation occurs when the molecules within the oil have been rotated to the delta 9 position with the use of heat so they become more and medicinally active,” (Pos. 717, Kindle).

It is a fact, however, prior to decarboxylation, the substance is already delta-9-THC. With regard to the corresponding double bond in the THC molecule, nothing changes through the process. Decarboxylation means removal of carbon dioxide. This reaction converts the naturally present THC acid (THCA) in the plant into phenolic THC that is responsible for most of the therapeutic effects of delta-9-THC. I read on your website that you encourage to include plant-based foods in the diet, claiming that the proteins contained in plants possess cancer-fighting properties, as well. However, it is not proteins, but the phytochemicals, such as flavonoids, which may possess such properties.

Mistaken Beliefs
You write, “I think it’s of benefit to the patient for the oil to be administered as close as possible to a tumor or whatever is being treated. Therefore, if you have bowel problems, suppositories would likely work best, but if you have something like throat or stomach cancer, etc. I would ingest the oil by mouth,” (Pos. 1012, Kindle).

The truth is, that also in cases of abdominal carcinomas, cannabinoids reach the cancer through the body’s circulatory system. One should know some basic medicine, so as to not rely on beliefs, because they may turn out to be mistaken ones.

Confusing Amount and Concentration
You write, “By volume, it would be impossible for a hemp tincture to be as potent as pure oil. A patient could ingest their doses mixed with alcohol, but what good would taking this medication with alcohol do the patient?” (Pos. 1043, Kindle).

The truth is, that a diluted cannabis oil with a 5 percent THC content, ingested orally, has the identical pharmaceutical effect as a cannabis extract or cannabis oil with a THC content of 50 percent. This is because the effect is not based on concentration; it is based on the absolute amount. One milliliter of 50 percent cannabis extract contains the same amount of THCmillilitersilitres of a 5 percent extract, which is exactly 500 milligrams of THC. Only when applied externally does concentration play a role.

Missing Data
You write that, “On average, there is about one person in ten who will freely tell the world what had healed them but the majority of patients tend to remain more or less quiet … Since most people will not come forward, it makes my tasks that much harder and many will continue to die because those who have used these extracts refuse to discuss what they have witnessed,” (Pos. 1192, Kindle). And further, “Since 2003, I have provided these extracts to roughly 5000 people who were suffering with all types of medical problems. Many of these patients had several medical issues which needed attention but most were brought under control or cured with the use of this oil,” (Pos. 1377, Kindle).

You write yourself that only about one in ten patients treated by you offers feedback on the success of the treatment, and you complain that you do not hear back from most of them. Despite this, you undauntedly claim that all cancer patients, even those you never heard back from, were healed by the use of cannabis oil. Claims based on such limited data become completely absurd when contrasted with the fact that, depending on classification, there are between 100 and 1,000 types of cancer.

THC Fixation
You write that, “I always recommend high-grade oils for internal use in the treatment of serious conditions. A high-grade extract should contain THC levels in the range of 80-90% and produce an extremely sedative, yet euphoric effect when ingested. The higher the quality of the oil, the more pronounced will be its healing effects,” (Pos. 368, Kindle).

The truth is that besides THC, other cannabinoids possess cancer-inhibiting properties – in particular, CBD (cannabidiol). There are indications that in some types of tumors, CBD may play a more important role than THC. Moreover, there are strong indications that a combination of THC and CBD is more effective than THC alone, with regard to at least certain types of cancer. Among other factors, this can be of great importance when THC is insufficiently tolerated, and higher dosages are out of the question. In such cases, a treatment with high dosages of CBD can be attempted. You developed your theory 15 years ago when CBD was not yet in focus. However, our knowledge of the effectiveness of whole cannabis and cannabinoids in the treatment of cancer are of preliminary nature. And we must always take new data into consideration, offering our patients the most up to date advice and treatments possible.

Warning Against Effective Therapies
You write, “Unfortunately, many people who come to me have been badly damaged by the medical system with their chemo and radiation, etc. The damage such treatments cause have a lasting effect in people who have suffered these so-called treatments are the hardest to cure. But don’t despair, for even if you have been badly damaged, this oil still has a 70 to 80% success rate,” (Pos. 970, Kindle).

Now I arrive at a very serious issue. You recommend that all cancer patients avoid standard treatments because radiation therapy and chemotherapy both cause damage. Instead, all patients could be healed with your cannabis oil. We don’t know the actual success rate of your cannabis oil, and you can’t possibly know it either because you’ve had too little feedback from your clients. But we do know the success rates of standard therapies. In Germany, of the 500,000 individuals diagnosed with cancer each year, 280,000 are healed. This comes out to around 55%. As recently as 1980, two-thirds of all cancer patients succumbed to their ailment.

If the recovery rate from standard treatments continues to rise, and the rate of recovery for those treated with cannabis remains unknown, how many patients have died needlessly, following your advice?

And how many patients, who could have been healed, if they had received a combination of cannabinoids and conventional therapies, could have survived had they not solely relied on cannabis?

That you present things wrongly by not understanding chemistry, physiology, and medicine is not what I hold against you. One doesn’t necessarily need to understand all the details. However, this is a question of life and death, and such a serious issue, that you have to be accused of not living up to your responsibility and therefore your own aspirations.

This is about the wellbeing of individuals who turn to us. They have a right to the best possible and most recent information, as well the best possible advice. When it comes to medical treatment, especially when confronted with serious illness, it is not enough to treat patients by relying on good intentions and vehemently presenting a conviction.

I am convinced that your reputation among supporters would improve if you were able to revise and update your advice. I am convinced that cannabis and cannabinoid therapies are of value in the treatment of cancer. Let us address their potential with great care and consciousness!

Yours truly,

Franjo Grotenhermen

From the book: “Grotenhermen F. Cannabis gegen Krebs: Der Stand der Wissenschaft und praktische Folgerungen für die Therapie” [Cannabis against Cancer: The State of Science and Practical Conclusions for the Treatment]. Solothurn, Switzerland: Nachtschatten Verlag, 2017. With a preface by Dr Burkhard Hinz, Director of the Institute for Pharmacology and Toxicology, University of Rostock, Germany.

Website: http://www.nachtschattenverlag.ch/products/product_1624.html



Franjo Grotenhermen, M.D., born in 1957, studied medicine at the University of Cologne. He runs a medical practice, mainly devoted to the medical use of cannabis and cannabinoids. Dr. Grotenhermen is the founder and chairman of the German Association for Cannabis as Medicine (ACM), founder and executive director of the International Association for Cannabinoid Medicines (IACM) (www.cannabis-med.org) and chairman of the Medical Cannabis Declaration (MCD). He is editor of the IACM-Bulletin, which is published bi-weekly in several languages and editor of the online journal CANNABINOIDS, published on the website of the IACM. He is a principal of the nova-Institute based near Cologne and author of many articles, books, and book chapters on the therapeutic potential, pharmacology, and toxicology of cannabinoids.
 

olivianewtonjohn

New Member
I wanted to post this article here as it really opened my eyes to the problems with many of the cannabis studies showing cannabinoids "healing" cancer (the studies dont exactly say that but thats the take home message many conclude). A conclusion that people take from the studies but if I had to bet $, I would say even the researchers of the studies would be very reluctant to say it cues cancer. In my opinion the likely hood of something curing "cancer" is very low as many cancers have very little to do with one another, see cancer is a diverse set of diseases (but I would be very happy to be wrong).

Article is written by a surgical oncologist and professor of cancer biology:

https://sciencebasedmedicine.org/medical-marijuana-as-the-new-herbalism-part-2-cannabis-does-not-cure-cancer/
 

CarolKing

Always in search of the perfect vaporizer
Action Center
Legal Issues
News Releases
Cannabis Derivative Provides Anti-Cancer Activity in Preclinical Model of Pancreatic Cancer
Thursday, 12 September 2019
Boston, MA: The administration of a cannabis-derived flavonoid enhances radiotherapy treatment in preclinical models of pancreatic cancer, according to findings published in the journal Frontiers in Oncology.
A team of researchers affiliated with the Dana-Farber Cancer Institute at Harvard University and the University of Massachusetts assessed the anti-cancer activity of a non-psychoactive cannabis derivative, FBL-03G, in preclinical models of metastatic pancreatic cancer.
Researchers reported that the inclusion of FBL-03G during radiotherapy "induce[d] apoptosis and inhibit[ed] cancer cell concentration" in culture. In animal models, the compound "slowed tumor growth" and was associated with a "significant increase in mice survival."
They concluded, "[T]he FBL-03G results reveal a new potential non-cannabinoid cannabis derivative with major potential for consideration in further investigations in the treatment of pancreatic cancer, where new therapy options are urgently needed." Pancreatic cancer is one of the hardest-to-treat forms of the disease, killing over 90 percent of sufferers within five years.
Preclinical studies identifying anti-cancer activity of cannabinoids date back to the mid-1970s. Far fewer studies exist assessing the therapeutic efficacy of cannabis-specific flavonoids, but recently some scientists have expressed interest in their anti-inflammatory potential.
For more information, contact Paul Armentano, NORML
 

Baron23

Well-Known Member
Action Center
Legal Issues
News Releases
Cannabis Derivative Provides Anti-Cancer Activity in Preclinical Model of Pancreatic Cancer
Thursday, 12 September 2019
Boston, MA: The administration of a cannabis-derived flavonoid enhances radiotherapy treatment in preclinical models of pancreatic cancer, according to findings published in the journal Frontiers in Oncology.
A team of researchers affiliated with the Dana-Farber Cancer Institute at Harvard University and the University of Massachusetts assessed the anti-cancer activity of a non-psychoactive cannabis derivative, FBL-03G, in preclinical models of metastatic pancreatic cancer.
Researchers reported that the inclusion of FBL-03G during radiotherapy "induce[d] apoptosis and inhibit[ed] cancer cell concentration" in culture. In animal models, the compound "slowed tumor growth" and was associated with a "significant increase in mice survival."
They concluded, "[T]he FBL-03G results reveal a new potential non-cannabinoid cannabis derivative with major potential for consideration in further investigations in the treatment of pancreatic cancer, where new therapy options are urgently needed." Pancreatic cancer is one of the hardest-to-treat forms of the disease, killing over 90 percent of sufferers within five years.
Preclinical studies identifying anti-cancer activity of cannabinoids date back to the mid-1970s. Far fewer studies exist assessing the therapeutic efficacy of cannabis-specific flavonoids, but recently some scientists have expressed interest in their anti-inflammatory potential.
For more information, contact Paul Armentano, NORML
Yeah, saw this in a number of on-line pubs the other day.

Makes you just want to carpet bomb the DEA (and Congress for that matter) for holding up any real MJ research. Just think, if they do find a magic bullet for some terrible disease (yes, and they really have already with child seizure disorders and CBD) that people have suffered with or died from and the only thing that stopped it from eing available was the DEA and the idiot drug warriors....well, this might be the scene outside of DEA HQ:

1568390572017.png
 

ataxian

In a BLACK HOLE!
Yeah, saw this in a number of on-line pubs the other day.

Makes you just want to carpet bomb the DEA (and Congress for that matter) for holding up any real MJ research. Just think, if they do find a magic bullet for some terrible disease (yes, and they really have already with child seizure disorders and CBD) that people have suffered with or died from and the only thing that stopped it from eing available was the DEA and the idiot drug warriors....well, this might be the scene outside of DEA HQ:

View attachment 13044
I alway’s bitch about DC?
2-day my wife bought me the USA Constitution 2-read!

I don’t want 2-sound like a sitcom?
Your photo is just like 2-day?
 

Baron23

Well-Known Member
I alway’s bitch about DC?
2-day my wife bought me the USA Constitution 2-read!

I don’t want 2-sound like a sitcom?
Your photo is just like 2-day?
Hi my friend - actually reading the Constitution is an eye opener. Rather than listen to a bunch of paid political hack pundits telling you what it says, you can read the plain English of it.

For example, many, many people feel that they have the right to say anything at any time and anywhere and defend this as their "First Amendment" rights.

Well, the First Amendment says not such thing and conveys no such rights.

What it does say is "Congress shall make no law.......abridging the freedom of speech" Key word underlined by me.

This means that if your boss tells you to shut the fuck up and get back to work, they have NOT violated your rights under the First Amendment.

See what I'm saying?

And further, while I enjoy many priveldges and freedoms conveyed to me by the Supreme Court when they found a right to privacy in the Constitution....I have yet to find that in there at all.
 

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