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Dog Boy

The takeaway I'm getting is raw hemp is a better choice ? Because of the higher percentages of cannabigerolic acid, or CBGA, and cannabidiolic acid, CBDA in raw hemp before any decarboxylation ?

Does Cannabis Use Actually Thwart Coronavirus Infection?

A new study showing cannabis can help prevent Coronavirus infection has experts urging caution.

A new study this week has potheads gloating, late night talk show hosts snickering and a pandemic-scarred public contemplating a scenario straight out of a stoner comedy: Could cannabis actually stave off Covid?

The truth is, annoyingly, less straightforward than that.

The study, published in the Journal of Natural Products, found that “cannabis compounds prevented the virus that causes Covid-19 from penetrating healthy human cells.”

According to the authors of the study, “cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by a pseudovirus expressing the SARS-CoV-2 spike protein and prevented entry of live SARS-CoV-2 into cells,” while “cannabigerolic acid and cannabidiolic acid were equally effective against the SARS-CoV-2 alpha variant B.1.1.7 and the beta variant B.1.351.”

A report by Bloomberg helped distill all that for the laymen.

“The two compounds commonly found in hemp — called cannabigerolic acid, or CBGA, and cannabidiolic acid, or CBDA — were identified during a chemical screening effort as having potential to combat coronavirus, researchers from Oregon State University said. In the study, they bound to spike proteins found on the virus and blocked a step the pathogen uses to infect people,” Bloomberg explained. “The researchers tested the compounds’ effect against alpha and beta variants of the virus in a laboratory. The study didn’t involve giving the supplements to people or comparing infection rates in those who use the compounds to those who don’t.”

“These compounds can be taken orally and have a long history of safe use in humans,” Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center said in a statement, as quoted by Bloomberg. “They have the potential to prevent as well as treat infection by SARS-CoV-2.”

There are a few details to keep in mind. The Oregon State University in vitro study hasn’t gone as far as human trials, as limits in medical cannabis research continue to be the norm. Futhermore, cannabigerolic acid and cannabidiolic acid are converted to other compounds after decarboxylation and/or smoking. So smoking, for instance, probably isn’t an efficient way of gaining these benefits.

Nesas Hemp is maker of “the world’s first living full-spectrum organic CBDA hemp extract.” The company uses living hemp and preserves the plant’s natural molecular structure and naturally occurring CBDA, and other beneficial phytonutrients.

“The recent study done by researchers at Oregon State University, underscores what we’ve known for years—CBDA has medicinal properties. The big takeaway from this study however, is that the compounds that help prevent the virus that causes COVID-19 from entering human cells are cannabigerolic acid, or CBGA, and cannabidiolic acid, CBDA, NOT the generic CBD compounds that are found in so many hemp products today,” Nesas Hemp CEO Inesa Ponomariovaite told High Times. “That’s because CBGA and CBDA are produced using raw, living hemp, which ensures the healthy compounds that naturally occur in the plant end up in the final product that is eventually consumed by people. Regular CBD products are often made by burning the plant, which is not only carcinogenic, it also damages the molecular structure of the plant and changes its medicinal properties. In fact, research shows CBDA is often 1,000 times more potent than CBD and helps reduce inflammation, improves digestion, boosts the immune system, improves sleep and stabilizes moods.”

Ponomariovaite continued, saying “currently, most CBD products use extreme temperatures and other harmful processes to extract cannabinoids from the hemp plant to produce hemp extract, also known as hemp oil. This damages the natural cannabinoid acids and the medicinal properties found in the plant.”

The study has gone viral and has also prompted laughs and notes of caution from experts. The revelations proved to be quality fodder for late night monologues.

“This would be interesting. All this time we’ve been listening to the C.D.C., we should have been eating CBD,” cracked Jimmy Kimmel on Wednesday.

“You know, it’s funny—all these crazy cures, I’m like ‘Oh, that’s ridiculous.’ Ivermectin, the horse dewormer; bleach. And then somebody says marijuana prevents Covid, I’m like ‘Oh, really? Do tell,” he said.

Stephen Colbert couldn’t resist either.

“Great news for all the teenagers whose parents find weed in their room: ‘Oh, Mom, I see you found the Covid-stopping compounds that I hid in my sock drawer. Those aren’t mine. No, no. Those aren’t mine. I’m just holding them for my friend, Tony Fauci,’” he saidWednesday.

“In other words, the pot enters the body and asks Covid, ‘Are you a cell? You have to tell me if you’re a cell,’” Colbert added.

Cannabis Use Won’t Replace Coronavirus Vaccinations​

Still, this doesn’t mean that you should swap a jab for a joint.

As Chris Roberts explained over at Forbes, what the Oregon State study does show is that “that certain cannabis-derived preparations, given in the right amount, might help people fight off Covid-19,” which he said is “exciting stuff.”

“What this research does not mean is that smoking cannabis helps protect you from the coronavirus, or that ‘weed stops Covid’ (at least in the practical sense), or that the reason why someone got sick with Covid while someone else didn’t had anything to do with cannabis,” Roberts wrote.

Forbes highlighted some other reasons to be skeptical of the study, with Dr. Mikael Sodergren, the head of Imperial College London’s medical cannabis research group, telling the outlet that the findings would still need to be “confirmed in animal models and tested on humans in clinical trials.”

Sodergren told Forbes that the study furthermore provides “no evidence to support the smoking or ingestion of cannabis products to do the same.”

The benefits of hemp and cannabis continue to unfold. Dr. Raphael Mechoulam was ahead of the game, praising the health benefits of cannabinoid acids in 2019.
In vitro, not in vivo I believe so no telling what the effect may be from various forms of ingestion….right?

My mate has been getting various supplements from this place in USA for a while
He sent them a couple of the articles about this study and asked if they could make some without decarbing
They had it up for pre order the same week - cbga and cbda in one using cold extraction

They also have 50% off storewide each month for people with low income or on a pension or with a disability - the owner is a veteran apparently
I was approved overnight for the discount using a picture of my Ausland disability pension card

Who's to know how well this stuff will work for Rona prevention, but it can't hurt I spose and the two active ingredients are good for your health anyway

New Study Reveals Potential Benefits of Cannabis for COVID-19 Patients

Cannabis consumers with COVID-19 experienced “better outcomes and mortality” compared to similar patients who did not use cannabis.

Years now after the height of the pandemic, a new study shows evidence of the benefits of cannabis for those who had COVID-19. According to the researcher’s conclusions, cannabis consumers affected by COVID-19 experienced “better outcomes and mortality” compared to non-consumers. The study, entitled “Exploring the Relationship Between Marijuana Smoking and Covid-19,” was announced at a meeting for the American College of Chest Physicians, which was held in Honolulu, Hawaii on Oct. 11. It was also published in the October issue of CHEST Journal.

Researchers noted that they analyzed data from the National Inpatient Sample, which is the largest publicly available collection of inpatient healthcare data—recording about seven million hospital visits per year. Researchers studied 322,214 patients over 18 years of age, with only 2,603 stating that they were cannabis consumers.

Each cannabis-consuming patient was matched 1:1 with a non-consumer, as well as their “age, race, gender, and 17 other comorbidities including chronic lung disease.” The other comorbidities included obstructive sleep apnea, obesity, hypertension, and diabetes mellitus, which were more commonly found in non-users.

In these comparisons, cannabis users experienced a lowered rate of specific conditions. “On univariate analysis, marijuana users had significantly lower rates of intubation (6.8% vs 12%), acute respiratory distress syndrome (ARDS) (2.1% vs 6%), acute respiratory failure (25% vs 52.9%) and severe sepsis with multiorgan failure (5.8% vs 12%),” researchers explained. “They also had lower in-hospital cardiac arrest (1.2% vs 2.7%) and mortality (2.9% vs 13.5%).”

“Marijuana smokers had better outcomes and mortality compared to non-users,” researchers concluded. “The beneficial effect of marijuana use may be attributed to its potential to inhibit viral entry into cells and prevent the release of proinflammatory cytokines, thus mitigating cytokine release syndrome.”

These findings led researchers to add a note about these results, and the potential clinical implications. “The significant decrease in mortality and complications warrants further investigation of the association between marijuana use and COVID-19,” researchers added. “Our study highlights a topic of future research for larger trials especially considering the widespread use of marijuana.”

After the pandemic began, researchers’ inability to study cannabis freely as a way to help people suffering from COVID-19 became immediately apparent, due to the Schedule I status of cannabis. In July 2020, Dr. Laszlo Mechtler, Medical Director of the Dent Neurological Institute in Buffalo, New York, explained the need to reclassify cannabis. “It is my opinion that much of this lack of understanding stems from the lack of research that has been done on cannabis, which is rooted in marijuana’s classification as a Schedule I controlled substance by the federal government,” Mechtler said.

That same month, researchers at the University of Nebraska and Texas Biomedical Research Institute began a study to analyze how CBD could help treat deadly lung inflammation that’s often associated with COVID-19.

In July 2022, High Times interviewed Professor Richard Van Breeman from Oregon State’s College of Pharmacy and Linus Pauling Institute Global Hemp Innovation Center. Breeman shared about his research, which was initially published in January 2022, in relation to cannabis and its effects on SARS-CoV-2, which is the cause of COVID-19. “Our team discovered that cannabidiolic acid (CBDA) and cannabigerolic acid (CBGA) can bind to the spike protein of SARS-CoV-2. We also discovered that these compounds can block cell entry using live SARS-CoV-2,” Breemen said. “That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells.”

Another study published in August 2022 found that cannabis consumers experienced less severe COVID-19 symptoms, and improved clinical outcomes. “Consistent with known trends, active cannabis users were overall younger than non-users,” researchers wrote. “However, when adjusting for age these outcomes remained consistent. Even more, when adjusting for comorbid conditions, demographics and smoking history we found that cannabis users still had less severe disease progression compared to non-users.”

In that particular study, researchers reviewed the cases of 1,831 COVID-19 patients who required hospital admission. “While there was a trend toward improved survival in cannabis users, this was not statistically significant,” researchers explained. “To our knowledge, this is the first study looking at clinical outcomes of cannabis users hospitalized with COVID-19. Further studies, including prospective analyses, will help to better understand the relationship between cannabis and COVID-19 outcomes.”

In September 2022, cannabis was used by many to treat the symptoms of long COVID, although there is little research to support its efficacy. “It helps keep me focused or at least my mind off negative thoughts brought on by long COVID,” David, a patient and long COVID sufferer told High Times. For me, but much more so for my partner, it helps settle nausea. My partner literally wouldn’t be able to hold down the first meal of the day for a time without taking an edible to help settle their stomach. And sleep, oh do I enjoy actually getting to sleep again since becoming a heavier cannabis user.”

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