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Meds CBD


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Does CBD have any adverse side effects? What about drug interactions? CBD is a very safe substance, but patients taking other medications should check with their doctor about drug interactions, which are more likely when consuming high doses of single-molecule CBD products. At sufficient dosages, CBD will temporarily deactivate cytochrome P450 enzymes, thereby altering how we metabolize a wide range of compounds, including THC. Cytochrome P450 enzymes metabolize more than 60 percent of Big Pharma meds. CBD is a more potent inhibitor of cytochrome P450 than the grapefruit compound Bergapten, so ask your doctor if grapefruit interacts with your medication. If grapefruit does, then CBD probably does, too. Patients on a CBD-rich treatment regimen should monitor changes in blood levels of prescription medications and, if need be, adjust dosage.


What is CBD?

Cannabidiol—CBD—is a cannabis compound that has significant medical benefits, but does not make people feel “stoned” and can actually counteract the psychoactivity of THC. The fact that CBD-rich cannabis is non-psychoactive or less psychoactive than THC-dominant strains makes it an appealing option for patients looking for relief from inflammation, pain, anxiety, psychosis, seizures, spasms, and other conditions without disconcerting feelings of lethargy or dysphoria.

Scientific and clinical research—much of it sponsored by the US government—underscores CBD’s potential as a treatment for a wide range of conditions, including arthritis, diabetes, alcoholism, MS, chronic pain, schizophrenia, PTSD, depression, antibiotic-resistant infections, epilepsy, and other neurological disorders. CBD has demonstrable neuroprotective and neurogenic effects, and its anti-cancer properties are currently being investigated at several academic research centers in the United States and elsewhere.

Project CBD responds to inquiries from all over the world. Almost everyone wants to know where to get CBD-rich products and how to use them for maximum benefit. After decades in which only high-THC cannabis was available in North America and beyond, CBD-rich strains and products are now available to medical users.

“CBD-rich” versus “CBD dominant:” By “CBD-rich,” we mean a cannabis strain or product that has equal amounts of CBD and THC, or more CBD than THC (usually at least 4 percent CBD by dry weight.). By “CBD-dominant,” we mean strains or products that are CBD-rich but have very little THC content.
CBD User's Manual
A Beginner's Guide to Cannabidiol & Cannabis Therapeutics
CBD User's Manual: A Beginner's Guide to Cannabis Therapeutics
By Project CBD on July 13, 2016

In 2009, a handful of CBD-rich cannabis strains were discovered serendipitously in Northern California, America’s cannabis breadbasket, where certified patients could access medical marijuana legally. Thus began a great laboratory experiment in democracy involving CBD-rich cannabis therapeutics. The advent of whole plant CBD-rich oil as a grassroots therapeutic option has changed the national conversation about cannabis. It’s no longer a question of whether medical marijuana works – today the key question is how to use cannabis for maximum therapeutic benefit. But most health professionals have little experience in this area. So Project CBD has created a CBD User’s Manual for patients that addresses key questions about cannabidiol and cannabis therapeutics.

What is CBD?

Cannabidiol or CBD is a non-intoxicating component of the cannabis plant with enormous therapeutic potential. Although CBD doesn’t make people feel high like THC does, it’s causing quite a buzz among scientists, health professionals, and medical marijuana patients who are using CBD-rich products to treat a wide range of conditions - chronic pain, cancer, Crohn’s, diabetes, rheumatoid arthritis, PTSD, cardiovascular disease, anxiety, antibiotic-resistant infections, multiple sclerosis, schizophrenia, and more. Academic research centers in the United States and elsewhere are currently studying the effects of CBD on these and other ailments. Scientists refer to CBD as a “promiscuous” compound because it confers therapeutic benefits in many different ways while tapping into how we function physiologically and biologically on a deep level. Extensive preclinical research and some clinical studies have shown that CBD has strong anti-oxidant, anti-inflammatory, anticonvulsant, anti-depressant, anti-psychotic, anti-tumoral, and neuroprotective qualities. Cannabidiol can change gene expression and remove beta amyloid plaque, the hallmark of Alzheimer’s, from brain cells.

Would these capsules negate the high I get from vaping regular flowers or dabbing?
I'm not an expert, by any means... but any time I've added CBD distillate to a dab, it has only enhanced the effects... not diminished them. By 'enhance' I do not mean that it gets me higher; rather that it helps the benefits for (in my case) pain relief.
@momofthegoons What a great thread! CBD is a game-changer, healthwise.

Anecdotal story - a few months ago a friend was about to say goodbye to her 17 year old cat. He was looking rough - sunken, watery eyes, fur falling out in clumps, not eating, looking about ready for the trip to the farm. So some goof thought 'hey, this CBD stuff is OK for pediatric epilepsy, I wonder what it'll do to the cat?'. Open the Friskies and put a drop each, then into cat dish. Cat, even sick, loves friskies And he slept for 36 hours, woke up, and was ravenous. 4 days later friend says 'I don't know whats up with the cat, but he's on the kitchen island chewing on something'. Anyways, the cat came back. And the cat continues to get a couple of drops of CBD most every day. And his eyes are normal, he's eating, he's playful, and he jumps on the counter every now and again, just to see whats there. He's a much younger cat, and quite content.

@Vicki a few months ago I saw someone 'green out' on dabs at a dispensary. One of the guys said 'here, try this CBD-rich dab' and the sweats, shakes and ashen colour were replaced by a normal person in just a minute or two. And now I take CBD drops sublingually. I still vape flower and oils and get results. So I guess the answer to your question is 'it depends'. Good luck, and bon chance :)
CBD Becoming More Popular Among Medical Marijuana Patients, Survey Finds

23 February, 2017
Findings in a new survey indicate that more registered medical marijuana patients in California are choosing to use cannabidiol (CBD)-dominant products.
Californians with medical marijuana prescriptions are opting more for cannabidiol (CBD) dominant products, according to a new report from a Bay Area-based medical marijuana delivery company.

Eaze recently published its second annual report, “State of Cannabis,” which found that the number of CBD products sold to its medical marijuana patients increased by 38 percent in 2016 compared to the year prior.

CBD is among the most prominent of the more than 85 cannabinoids found in cannabis. Unlike the well-known psychoactive cannabinoid tetrahydrocannabinol (THC), CBD is not psychoactive and therefore doesn’t cause users to experience a high.

For its report, Eaze utilized data from its more than 250,000 medical marijuana customers. In addition, at least 5,000 of those customers responded to surveys.

The medical marijuana customers that responded to the survey reported that they found CBD to help with anxiety, focus and inflammation.

Thousands of studies have been done on CBD, and the compound has also been shown in a patent by the US National Institutes of Health to have significant antioxidant and neuroprotective properties.

CBD that’s derived from marijuana remains regulated under federal law and can only be legally obtained in states that have passed medical marijuana laws. Qualified medical marijuana patients must first obtain a prescription and register with their respective state’s program.

CBD that’s derived from the stalks and seeds of hemp, however, is excluded from the federal Controlled Substances Act. CBD hemp oil is therefore legal to purchase and use in all 50 U.S. states, without a prescription and regardless of state laws.

The findings in the Eaze report also suggest that medical marijuana users are opting to consume cannabis to relax in the evenings rather than drink alcohol. Of the medical marijuana customers surveyed, over 82 percent of people said that marijuana caused them to reduce their alcohol intake, with 11 percent of respondents claiming they have quit drinking alcohol entirely because of their marijuana use.

“When we asked people, ‘What do you use for anxiety and stress relief?’ we see they are starting to recognize they get a lot of benefit from cannabis in the evenings,” Jamie Feaster, vice president of marketing for Eaze, told Bay Area News Group.

The report also found that baby boomers represent the fastest growing segment as a percentage of medical marijuana deliveries. The number of boomers that ordered medical marijuana grew 25 percent over the previous year.

Interest in vaporizing cannabis concentrates is also seemingly building among California medical marijuana users, according to the report. Eaze found that 31 percent of its medical marijuana customers had ordered a vaporizer cartridge by the end of 2016, up from just 7 percent the year prior. The growth in vaporizer sales marks a 429 percent year-over-year increase. The report also found 20 percent of medical marijuana deliveries in 2016 contained a vaporizer cartridge, compared to less than 5 percent of 2015 deliveries.

You can access the entire Eaze report here.

We’ve detailed what studies have so far discovered about CBD and its therapeutic properties and you can access that information here.

This article may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the Safe Harbor created by those sections. This material contains statements about expected future events and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements by definition involve risks, uncertainties.


Dr. Ethan Russo, a neurologist and psychopharmacology researcher, notes in a 2011 study that the therapeutic effects of CBD are broad, including: analgesic, anti-inflammatory, antioxidant, anti-emetic (prevents vomiting), anti-anxiety, anti-psychotic, anti-convulsant and cytotoxic in certain cancer cells.

Russo really knows his stuff by the way — in addition to being a medical doctor and researcher, he served as president of the International Cannabinoid Research Society and chairman of the International Association for Cannabinoid Medicines.

Generally, CBD products are primarily made from the concentrated extract of the flowers, leaves and possibly stalks of marijuana or hemp. Most CBD products are either oil-based tinctures or capsules that are consumed orally, or topicals applied to the skin; however, there is a growing variety of other products containing CBD, including those for pets.

To find out if CBD would show on a urine drug test, I consulted employment drug testing expert Barry Sample, who is the director of science and technology for Quest Diagnostics, one of the larger diagnostic testing firms in the U.S.

“If the product contains only CBD and has had the THC removed, then an individual being tested would not be expected to test positive for marijuana or marijuana metabolite,” Sample says via email.

For good measure, I contacted marijuana health and science researcher, Paul Armentano. Armentano says via email: “Not unless those products also contain quantities of THC. Drug tests screen for either THC or the carboxy-THC metabolite, not for CBD.”

Both experts agree: As long as there is no THC in the CBD products, then a urine test would not yield a positive result for THC metabolites.

Sounds good, but there may be minute amounts of THC in your CBD products. An aspect in cannabinoid compounds that aids efficacy is the entourage effect. Coined by venerable Israeli cannabis researcher Raphael Mechoulam in 1999, the entourage effect is the belief that the compounds in cannabis work better together than if the compounds are isolated. CBD products, in addition to the CBD cannabinoid, may contain additional cannabis compounds, including THC, to purportedly increase the effectiveness of the product.

From a regulatory standpoint, the U.S. Food and Drug Administration (FDA) has federal oversight over this nascent marketplace. In February 2015 and again in 2016, the FDA sent out warning letters to a handful of CBD companies. The letters focused on CBD content that didn’t match product labeling and improper medical claims made on websites. Lab analysis revealed some consumer products had a fraction of CBD claimed on the label. As of March 9, the FDA hadn’t yet issued any warnings for 2017.

As a consumer in this relatively new market, especially one who takes drug tests, research the products carefully. Look on the company or product website and assess the credibility and transparency of the company. Make sure you see analytical test results of the same product lot number you are consuming. It’s important to be confident in the company supplying your CBD products by knowing the potency and safety of the products.

CBD Oil: Benefits, Uses & Side Effects

CBD hemp oil has a huge range of potential health benefits and uses, including reducing pain, soothing anxiety, lowering your risk of cancer, improving mood, protecting the immune system, balancing the metabolism, aiding sleep disorders, eliminating depression, preventing arthritic inflammation and healing the skin, among others. CBD oil can also be used in many different ways and has a variety of applications for natural health. There are some side effects of using CBD oil, including low blood pressure, lightheadedness, fatigue, dry mouth, and slowed motor functions. However, in the majority of studies, these side effects have been found to be quite mild, and not fatal. In fact, these are often exaggerated versions of the desired side effects – the reasons why people use the oil in the first place.

What Is CBD Hemp Oil?
CBD hemp oil is the product derived from the hemp plant, which is high in CBD (cannabidiol) and low in THC (tetrahydrocannabinol). This oil has received a large amount of attention in recent years, due to the growing wave of marijuana legislation and debate in many countries, including the United States. While cannabis and smoking marijuana (which often has a high level of the psychotropic compound THC) is still illegal in many places, as more is being learned about CBD, and its potential effects on health, it is becoming more and more accepted as a legal and safe remedy for a wide variety of health conditions. Since it has a minimal amount of the psychotropic compound THC, use of this oil does not result in a traditional “high”, so its effects are generally considered therapeutic, not mind-altering.

There are more than 80 cannabinoids found in cannabis plants, with THC being the primary one, followed by CBD. However, in the hemp plant, which is a different strain of the species Cannabis sativa, CBD is the main active ingredient, and THC is barely present, making its use and legality more widespread. The reason that CBD is such an effective form of support for human health is due to the body’s endogenous cannabinoid system. This regulatory structure of the body has millions of cannabinoid receptors in the brain and nervous system, which react not only to plant-derived cannabinoids (such as hemp and marijuana), but also to natural cannabinoids produced within our body. When hemp oil is used and processed by the body, it is effectively boosting the function of the endocannabinoid system, helping our body regulate itself in many different ways.


Not only does true CBD hemp oil contain high levels of cannabidiol, but also vitamins, nutrients, minerals, volatile acids, and antioxidants that will further supplement your health.

Benefits Of CBD Oil
CBD oil has become very popular with people suffering from chronic pain, sleep disorders, insomnia, anxiety, stress, depression, skin conditions, inflammation, arthritis, low appetite, poor metabolic function, a weak immune system and chronic diseases, as well as people with a high risk of cancer.

Appetite: Part of the regulation of body processes that the endocannabinoid system controls is the appetite. This is largely due to the release of certain hormones in the body that control hunger and satiety. By optimizing the levels of these hormones based on the actual needs of your body, you can establish a healthy appetite, particularly following surgery, extended illness or injury.

Skin Health: Improving the appearance of the skin, especially reducing the signs and symptoms of acne and eczema, are the great benefits of regular CBD oil use. Topical application is quite popular for this, whether in a diluted or undiluted form, depending on the severity of the skin affliction. The powerful anti-inflammatory properties of the oil can also soothe redness, itchiness and swollen areas on the skin.

Pain: Arguably the strongest reason for the legality of CBD oil, its analgesic properties have been proven thousands of times, and this oil is commonly recommended for chronic pain of all kinds, ranging from back pain to the full-body agony of cancer. It can disrupt the activity of pain receptors in the body and instead cause a release of neurotransmitters such as serotonin and dopamine – “feel good” compounds that can erase discomfort and pain, even if the pharmaceutical painkillers have no effect.

Neurodegenerative Disease: A number of studies have connected the use of cannabidiol (CBD) with decreased occurrence and severity of neurodegenerative diseases, such as Alzheimer’s and Huntington’s disease. This presents yet another exciting development for medical researchers, given the persistent challenges to finding effective solutions for these conditions.

Anxiety: Although some people claim that marijuana makes them “paranoid” or anxious, that is largely due to the psychotropic THC found in cannabis. CBD hemp oil is well known to reduce feelings of anxiety and stress, as well as reduce depressive episodes by increasing the levels of “positive” hormones and neurotransmitters in the body.

Inflammation: When it comes to inflammation, some people can only find relief with CBD oil, particularly those with advanced cases of rheumatoid arthritis, multiple sclerosis, migraines, joint disorders and pervasive muscle pain. In some cases, people have reported nearly miraculous improvement in the inflammatory symptoms of chronic disease.

Epilepsy: Highly concentrated doses of CBD oil have been successfully used to treat epilepsy in a number of research studies. While there has been limited success in medication to prevent or treat epilepsy, the physical and neurological regulatory properties of CBD oil represent an exciting new solution for people with this seizure-inducing condition.

Cancer: Another major reason why CBD oil has been positively received in some parts of the medical community is its apparent effect on cancer and tumor growth. In multiple studies, the use of CBD oil (even direct injection into tumors) has resulted in tumor reduction or elimination. The antioxidants within CBD hemp oil also provide anti-mutagenic properties and lower users’ risk of cancer.

Sleep Disorders: There is a strong sedative quality to CBD hemp oil, making it a popular remedy for people with insomnia, sleeplessness, interrupted sleep, post-traumatic stress disorder, restless leg disorder and other nighttime issues. Inhaling a small amount of CBD oil, applying it to your chest, or even putting a few drops on your pillow can help you get the good night’s sleep you’ve been seeking.

Immune System: The majority of cannabinoids have been proven to have positive effects on the body’s immune system, particularly CBD oil, as it can help regulate overactive immune systems. This means less susceptibility to allergens, and a possible application for autoimmune diseases, which are some of the most difficult-to-treat medical conditions.

Uses Of CBD Oil
CDB hemp oil has a number of uses and comes in many forms including capsules, tinctures, sublingual supplements, liquid oil, oil as a paste, sprays, salves, creams and in edible forms, such as candies or sweets. You can also inhale CBD oil from vapor-releasing pens, similar to the technology for e-cigarettes. This variety of forms also provides a lot of controlled flexibility in terms of concentration, making CBD hemp oil useful and desirable for people of all ages, economic means, and personal needs.

Side Effects Of CBD Oil
There are a number of possible side effects to using CBD oil, such as fatigue, dry mouth, lightheadedness, hypotension and impaired motor functions. However, when used in moderate amounts, most people do not experience these side effects, and none of them are known for being fatal or particularly dangerous. More than 20,000 studies have been done in the past 15 years on cannabis, hemp, and cannabinoids, and the results have been overwhelmingly supportive of the therapeutic potential and viability of CBD oil. That being said, some people should be cautious before using this powerful oil.

Blood Pressure – One of the notable soothing benefits of CBD oil is its effect on blood pressure, helping to protect heart health and promote calm in the body. However, if you are already taking medication for hypertension, combining this with CBD oil can potentially cause dangerously low blood pressure (hypotension).
Appropriate Use – Since sedation, fatigue, and lightheadedness are known effects of CBD hemp oil, particularly when consumed in large amounts, it is important that you not use heavy machinery or attempt to drive while under the effects of this therapeutic oil.
Motor Functions – The sluggishness that many people associate with being “high” can be a side effect of concentrated CBD oil use, resulting in motor function impairment. This effect is temporary and will pass in a matter of hours.
Weight Gain – Appetite stimulation, or at least regulation, is a side effect of CBD oil. So, if you are already struggling with obesity, be sure to monitor your intake of food to prevent overeating, snacking between meals and additional weight gain.
Oil Quality – The most dangerous aspect of CBD oil is potentially using low-quality oil or CBD oil that hasn’t been properly produced. With thousands of small businesses getting involved in the medicinal marijuana industry, it is more important than ever to research brands and pay attention to consumer reports concerning these oils.
Pregnancy – Research on the use of CBD oil during pregnancy is unfortunately lacking, but most experts do not recommend it. Other anecdotal reports support its use, particularly for aching muscles and anxiety or depression. Before using this oil – or any essential oil – while pregnant, always speak with a doctor about your particular condition.
CBD Oil Dosage
An appropriate dosage of CBD oil will depend on the individual, as well as the severity of the health condition a person is trying to remedy. For example, someone using CBD hemp oil to relieve chronic pain may use 5 mg per day until the pain subsides, whereas a multiple sclerosis patient may take 80 mg per day for 2-3 weeks at a time to soothe their symptoms. Generally speaking, the average amount for most medicinal applications is 25 mg, taken twice per day.

If this is not sufficient for calming your symptoms, a gradual increase of another 25 mg per day, over the course of 3-4 weeks, is recommended. While there have been no reports of more serious side effects when this oil is taken in larger concentrations, it is best to slowly increase your dose to find a comfortable and effective level, given your individual characteristics and needs.

More and more medical professionals and becoming informed about the potential benefits of CBD hemp oil, and are more commonly recommending it for their patients. Before adding this potent oil to your daily life, particularly if you have a pre-existing medical condition, speak with your doctor about any risks.

Hemp Oil
Unlike CBD oil, hemp oil is derived from the seeds of the hemp plant – typically industrial hemp. This means that the amount of cannabinoids found in hemp oil are actually quite low. The CBD content of this oil may be close to 0%, whereas the CBD content of CBD hemp oil can be as high as 15%, or more!

Hemp oil does have a number of uses and is often marketed as a cooking oil or a product that is good for moisturizing the skin. It is also used in the production of certain soaps, shampoos, and even foods, as well as being a basic ingredient for bio-fuel and even a more sustainable form of plastic. Hemp has been cultivated and used for roughly 10,000 years, and it definitely has useful purposes. However, its lack of cannabinoids, namely CBD, means that it has little therapeutic value.

Be wary of any manufacturers who try to market natural hemp oil for its anti-cancer, anti-inflammatory or other medicinal applications. You will be much better off with CBD hemp oil, which can have critical effects on human health that have been proven countless times.

Note: Use of CBD oil and Hemp oil is banned/restricted by some countries such as UAE, Dubai, and Saudi Arabia so consult your local health specialist before use.

CBD Misconceptions

It doesn’t get you high, but it’s causing quite a buzz among medical scientists and patients. The past year has seen a surge of interest in cannabidiol (CBD), a non-intoxicating cannabis compound with significant therapeutic properties. Numerous commercial start-ups and internet retailers have jumped on the CBD bandwagon, touting CBD derived from industrial hemp as the next big thing, a miracle oil that can shrink tumors, quell seizures, and ease chronic pain—without making people feel “stoned.” But along with a growing awareness of cannabidiol as a potential health aid there has been a proliferation of misconceptions about CBD.

  1. “CBD is medical. THC is recreational.” Project CBD receives many inquiries from around the world and oftentimes people say they are seeking “CBD, the medical part” of the plant, “not THC, the recreational part” that gets you high. Actually, THC, “The High Causer,” has awesome therapeutic properties. Scientists at the Scripps Research Center in San Diego reported that THC inhibits an enzyme implicated in the formation of beta-amyloid plaque, the hallmark of Alzheimer’s-related dementia. The federal government recognizes single-molecule THC (Marinol) as an anti-nausea compound and appetite booster, deeming it a Schedule III drug, a category reserved for medicinal substances with little abuse potential. But whole plant marijuana, the only natural source of THC, continues to be classified as a dangerous Schedule I drug with no medical value.
  2. “THC is the bad cannabinoid. CBD is the good cannabinoid.” The drug warrior’s strategic retreat: Give ground on CBD while continuing to demonize THC. Diehard marijuana prohibitionists are exploiting the good news about CBD to further stigmatize high-THC cannabis, casting tetrahydrocannabinol as the bad cannabinoid, whereas CBD is framed as the good cannabinoid. Why? Because CBD doesn’t make you high like THC does. Project CBD categorically rejects this moralistic, reefer madness dichotomy in favor of whole plant cannabis therapeutics. (Read the foundational science paper: A Tale of Two Cannabinoids.)
  3. “CBD is most effective without THC.” THC and CBD are the power couple of cannabis compounds—they work best together. Scientific studies have established that CBD and THC interact synergistically to enhance each other’s therapeutic effects. British researchers have shown that CBD potentiates THC’s anti-inflammatory properties in an animal model of colitis. Scientists at the California Pacific Medical Center in San Francisco determined that a combination of CBD and THC has a more potent anti-tumoral effect than either compound alone when tested on brain cancer and breast cancer cell lines. And extensive clinical research has demonstrated that CBD combined with THC is more beneficial for neuropathic pain than either compound as a single molecule.
  4. “Single-molecule pharmaceuticals are superior to ‘crude’ whole plant medicinals.” According to the federal government, specific components of the marijuana plant (THC, CBD) have medical value, but the plant itself does not have medical value. Uncle Sam’s single-molecule blinders reflect a cultural and political bias that privileges Big Pharma products. Single-molecule medicine is the predominant corporate way, the FDA-approved way, but it’s not the only way, and it’s not necessarily the optimal way to benefit from cannabis therapeutics. Cannabis contains several hundred compounds, including various flavonoids, aromatic terpenes, and many minor cannabinoids in addition to THC and CBD. Each of these compounds has specific healing attributes, but when combined they create what scientists refer to as a holistic “entourage effect,” so that the therapeutic impact of the whole plant is greater than the sum of its single-molecule parts. The Food and Drug Administration, however, isn’t in the business of approving plants as medicine. (See the scientific evidence.)
  5. “Psychoactivity is inherently an adverse side effect.” According to politically correct drug war catechism, the marijuana high is an unwanted side effect. Big Pharma is keen on synthesizing medically active marijuana-like molecules that don’t make people high—although it’s not obvious why mild euphoric feelings are intrinsically negative for a sick person or a healthy person, for that matter. In ancient Greece, the word euphoria meant “having health,” a state of well-being. The euphoric qualities of cannabis, far from being an unwholesome side effect, are deeply implicated in the therapeutic value of the plant. “We should be thinking of cannabis as a medicine first,” said Dr. Tod Mikuriya, “that happens to have some psychoactive properties, as many medicines do, rather than as an intoxicant that happens to have a few therapeutic properties on the side.”
  6. “CBD is legal in all 50 states.” Purveyors of imported, CBD-infused hemp oil claim it’s legal to market their wares anywhere in the United States as long as the oil contains less than 0.3 percent THC. Actually, it’s not so simple. Federal law prohibits U.S. farmers from growing hemp as a commercial crop, but the sale of imported, low-THC, industrial hemp products is permitted in the United States as long as these products are derived from the seed or stalk of the plant, not from the leaves and flowers. Here’s the catch: Cannabidiol can’t be pressed or extracted from hempseed. CBD can be extracted from the flower, leaves, and, only to a very minor extent, from the stalk of the hemp plant. Hemp oil start-ups lack credibility when they say their CBD comes from hempseed and stalk. Congress may soon vote to exempt industrial hemp and CBD from the definition of marijuana under the Controlled Substances Act. Such legislation would not be necessary if CBD derived from foreign-grown hemp was already legal throughout the United States. (Read more: Sourcing CBD: Marijuana, Industrial Hemp & the Vagaries of Federal Law)
  7. “'CBD-only’ laws adequately serve the patient population.” Fifteen U.S. state legislatures have passed “CBD only” (or, more accurately, “low THC”) laws, and other states are poised to follow suit. Some states restrict the sources of CBD-rich products and specify the diseases for which CBD can be accessed; others do not. Ostensibly these laws allow the use of CBD-infused oil derived from hemp or cannabis that measures less than 0.3 percent THC. But a CBD-rich remedy with little THC doesn’t work for everyone. Parents of epileptic children have found that adding some THC (or THCA, the raw unheated version of THC) helps with seizure control in many instances. For some epileptics, THC-dominant strains are more effective than CBD-rich products. The vast majority of patients are not well served by CBD-only laws. They need access to a broad spectrum of whole plant cannabis remedies, not just the low THC medicine. One size doesn’t fit all with respect to cannabis therapeutics, and neither does one compound or one product or one strain. (Read more: Prohibition’s Last Gasp: “CBD Only.”)
  8. “CBD is CBD—It doesn’t matter where it comes from.” Yes it does matter. The flower-tops and leaves of some industrial hemp strains may be a viable source of CBD (legal issues notwithstanding), but hemp is by no means an optimal source of cannabidiol. Industrial hemp typically contains far less cannabidiol than CBD-rich cannabis. Huge amounts of industrial hemp are required to extract a small amount of CBD, thereby raising the risk of toxic contaminants because hemp is a “bio-accumulator” that draws heavy metals from the soil. Single-molecule CBD synthesized in a lab or extracted and refined from industrial hemp lacks critical medicinal terpenes and secondary cannabinoids found in cannabis strains. These compounds interact with CBD and THC to enhance their therapeutic benefits. (See also: Sourcing CBD: Marijuana, Industrial Hemp & the Vagaries of Federal Law.)
How Is Hemp CBD Oil Different From Marijuana CBD Oil?

Understand CBD’s variations and how to obtain them.

Wednesday 11/16/2016
by Zoe Wilder

At 5 years old, young Charlotte Figi had been suffering roughly 300 grand mal seizures weekly for years when her father, Matt, looking for alternatives to her mostly unsuccessful traditional allopathic treatments, found a video online extolling the benefits of CBD oil in the treatment of Dravet Syndrome. Under Colorado’s fledgling medical marijuana program, Charlotte’s parents found a strain of high cannabidiol (CBD), low tetrahydrocannabinol (THC), cannabis flower named R4 being sold at a Colorado dispensary. They bought a few ounces and worked with friends to extract oil from it. High-CBD, low-THC cannabis is a desirable medicine, both for the therapeutic benefits of CBD and the low presence of THC, which minimizes psychoactivity. Charlotte responded favorably to her very first dose, bringing the frequency of her seizures down to one per week.

Her parents then met the Stanley brothers, owners of Colorado’s largest dispensary at the time and cultivators of a high-CBD strain of cannabis very few people were purchasing. Together, they developed the dormant strain into a continual harvest and constant supply of medical marijuana CBD oil to treat Charlotte, and subsequently, other patients seeking similar relief. The strain became what’s known today as Charlotte’s Web. When the news of this process, and others like it, aired on CNN medical correspondent Sanjay Gupta’s documentary Weed in 2013, people across the globe, especially parents of children suffering seizures, flocked to the Internet to find this “miracle” CBD oil. Little was to be found.

Capitalizing businesses quickly jumped in to fill the void created by the Federal Controlled Substances Act, which strictly prohibits the use and sale of marijuana because of the presence of THC, not CBD. Under the law, hemp-derived CBD is completely legal, but CBD doesn’t appear out of thin air. In order to produce CBD oil, you must first harvest high-CBD cannabis plants, legally. In the United States, this requires growers to be licensed in their state either as an industrial hemp farmer or a medical/recreational marijuana grower. Not all states provide these licenses, and where some do, each type of license has a completely different set of parameters, rules, and regulations, including whom you can sell your products to.

Needless to say, the rabid overnight demand for CBD oil combined with the intricacies of a nation involved in a drug war created a very confusing topic, and an opportunity for businesses to sell snake oil. Still today, people are discovering the wonders of CBD and yearning for information on how to obtain it. In an effort to untangle this web, here’s a go-to guide for understanding the differences between hemp-derived CBD oils and marijuana-derived CBD oils.

Hemp CBD Oil
Cannabidiol (CBD) is a cannabinoid known largely for its muscle relaxant properties. Isolated on its own, CBD is non-psychoactive and it’s been reported to be effective in treating seizures, even in young children.

CBD is found in both the drug producing Cannabis Indica and hemp producing Cannabis Sativa. Hemp CBD oil is derived from industrial hemp, the C. Sativa species of cannabis, which produces nearly no amount of the cannabinoid Delta-9-tetrahydrocannabinol (THC), but does produce some amount of the cannabinoid Cannabidiol (CBD). Industrialized hemp production is legal at the federal level, with laws and licensure varying from state-to-state.

Not All Hemp CBD Oils Are Created Equal
Not many cannabis researchers or cannabis professionals will refute the efficacy and wonders of the cannabinoid Cannabidiol. It can be a potent and powerful product with amazing therapeutic benefits. However, the ways in which cannabidiol is extracted from industrial hemp plants, then manufactured, concentrated, formulated, etc., and delivered or administered to a customer or patient, is largely suspect. Some customers have even reported becoming violently ill from poorly manufactured hemp CBD products, many of which either contain mysterious inactive chemicals or ingredients different than those listed on the label.

Hemp CBD is regulated by the FDA as a dietary supplement, and like other dietary supplements the FDA is “not authorized to review dietary supplement products for safety and effectiveness before they are marketed.” This is in direct opposition to most modern day medical and recreational marijuana markets. Both regulated medical and recreational markets typically have stringent production and testing guidelines and manufacturing regulations, and these guidlines typically exclude the sale of hemp-derived CBD through medical and recreational dispensaries.

This is from the FDA’s website:

“In late February 2015, FDA issued several warning letters to firms that market unapproved drugs for the diagnosis, cure, mitigation, treatment, or prevention of diseases. Some of these firms claim that their products contain cannabidiol (CBD). FDA has tested those products and, in some of them, did not detect any CBD. It is important to note that these products are not approved by FDA for the diagnosis, cure, mitigation, treatment, or prevention of any disease, and often they do not even contain the ingredients found on the label. Consumers should beware purchasing and using any such products.”
A list of FDA warning letters and test results for Cannabidiol related products and manufactures can be found here.

Conversely, the Stanley Brothers, creators of the original Charlotte’s Web now manufacture CBD Hemp Oil under the name CW Hemp. Because Charlotte’s Web products contain less than 0.3 percent THC, they are allowed by U.S. Federal law to ship their acclaimed Hemp CBD oil products straight to your doorstep.

Many Medical Marijuana Producers Are Producing Consistent, Top Quality CBD, Too
Charlotte’s Web is not the only high-CBD strain or CBD product out there. Strains like AC/DC, Harlequin, Cannatonic, Sour Tsunami, Ringo’s Gift, and many others exist.

Since 1996, there have been several medical marijuana markets growing in the western United States. In the region, states like California, Washington, and Oregon created an avenue for seasoned cannabis cultivators to farm cannabis medicines for their patients. Nearly two decades later, these states and several others, including Colorado, are expanding into the country’s first full-fledged recreational cannabis markets. Growers in these markets have been producing both high-THC and high-CBD strains of marijuana and merging them into edibles, concentrates, and topicals of all forms to assist customers and patients with their therapeutic needs.

These markets are now becoming known for having stricter testing standards than standard produce agriculture, and now nearly half the country’s states have some form of medical marijuana program or more. In these markets, medical marijuana cardholders can typically access CBD products containing much higher concentrations of Cannabidiol than hemp-derived CBD products, and due to stringent testing, oftentimes purer CBD products as well. When obtaining CBD products through a regulated medical or recreational marijuana marketplace, customer service representatives should be able to display and explain a product's origins, ingredients, and test results. State-certified labs provide these insights, and some even provide full cannabinoid and terpene analysis, too.

CBD Works Best Combined With Other Cannabinoids
Cannabis contains hundreds of compounds, 80 of which are currently categorized as cannabinoids. CBD and THC are the principal cannabinoids in cannabis, both commonly occurring in the relatively largest concentrations, and they are incredibly synergistic.

Embracing the full-spectrum of cannabis’ naturally occurring phytonutrients is part of a process called whole plant medicine. This practice is highly regarded in the holistic and alternative medicine communities, existing in stark contrast to the practice of fractionated medicine, a process involving the heavy use processing and chemical synthesis popularized by the pharmaceutical industry.

Long before people began hybridizing cannabis to create the highest THC strain to wow judges at cannabis competitions, naturally occurring fields of cannabis most likely contained plants with moderate concentrations of both primary cannabinoids CBD and THC along with other naturally occurring therapeutic cannabinoids like CBG, CBN, plus various terpenes, flavonoids, and all other phytonutrients found in healthy cannabis plants. Thanks to Israeli researcher Raphael Mechoulam, the synergies of all these compounds working together is now known as “The Entourage Effect.”

While not sanctioned for children because of its euphoria-producing properties, adding any amount of THC to a therapeutic dose of CBD largely enhances CBD’s effects. Medical cardholders in many states can now access CBD products with varying ratios of CBD to THC. Everything from 20:1 to 1:1 ratios, even 2 parts THC to 1 part CBD, make for an incredibly therapeutic array of options for patients seeking the benefits of Cannabidiol.

Hopefully this guide will help you better understand the intricacies and the processes involved in accessing varying forms of CBD.

Posted on August 25, 2015

While they are similar in some ways, there are important differences between hemp oil and CBD oil. As a consumer, it’s easy to get confused by phrases such as “cannabis oil” and “marijuana oil,” especially when many companies seem to use these terms interchangeably. Let’s take a closer look at hemp oil and CBD oil to learn how to distinguish the two.

Hemp oil is fabricated from the plant called hemp. In other words, it is a hemp extract taken from the seeds of the plant. While this type of oil can be extracted from all plants in the cannabis genus, industrial hemp is the only plant used for hemp oil. This type of hemp is specifically produced industrially and the amount of psychoactive substances that are contained in it is minimal.

  • Hemp oil is great for cooking and a full of nutrients. It can provide a crispy and nutty taste to foods and can be a wonderful replacement for olive oil in salads.
  • It is a great natural moisturizer that can be used after a shower.
  • Hemp oil can be the base for different forms of plastic, instead of petroleum.
  • It is used in the production of paints that are more eco-friendly than petroleum-based paints.
  • It can be used as bio-diesel fuel, like other vegetable oils.
  • Hemp oil is used for making lotions, soaps and even some foods.
CBD oil is the short form of the term cannabidiol oil. Cannabidiol is a natural component of industrial cannabis or hemp. CBD oil is cannabis oil that has a significant content of cannabidiol. It is made from the flowers, leaves and stalks of hemp and not from its seeds like hemp oil. CBD oil has become very popular in the medical marijuana industry, because it can be helpful in the treatment of various conditions without the typical intoxicating effects of marijuana use.

  • Can be used in the treatment of cancer .
  • It is used in the treatment of inflammatory disorders, anxiety, depression, seizures and neurodegenerative disorders.
  • Can be used in the treatment of epilepsy.
Hemp and marijuana are cousins in the plant world, but marijuana has a much higher THC content than hemp. Hemp oil contains low levels of CBD – typically less than 25 parts per million – while CBD oil can be up to 15% CBD. Because the plants are related, some unscrupulous sellers of hemp oil are trying to market it for its medicinal value, which is negligible.

This outlines the importance of knowing your source for your meds. Make sure you are buying Cannabis CBD and not hemp CBD!
10 Highest CBD Cannabis Strains


People who want the medical benefits of cannabis without the psychoactive buzz need to shop for the CBD (Cannabidiol) content. CBD is credited with treating alcoholism, antibiotic-resistant infections, arthritis, chronic pain, depression, diabetes, epilepsy, MS, PTSD, and neurological disorders.

It’s the CBD that relieves anxiety, inflammation, pain, psychosis, seizures, and spasms. It’s the THC (tetrahydrocannabinol) that makes you stoned enough not to care.

The Project CBD™ differentiates between CBD-rich cannabis and CBD-dominant forms: “By ‘CBD-rich,’ we mean a cannabis strain or product that has equal amounts of CBD and THC, or more CBD than THC (usually at least 4 percent CBD by dry weight.). By ‘CBD-dominant,’ we mean strains or products that are CBD-rich but have very little THC content.”

And, that is the argument that explains why many more states permit CBD products than recreational products.

10 highest CBD Cannabis Strains

  1. AC/DC: This is a legacy strain owing its origins to Cannatonic. The extremely dominant CBD content reduces anxiety, chemotherapy effects, epilepsy, MS, pain, and stress. The CBD content registers at 20%, and the very low THC shows as only 1% to 6%. That means it produces little or no psychoactive high, so it is not the first choice of recreational users.
  2. Blueberry Essence: Life Gardens of Washington produces a Blueberry Essence. Its fruity – blueberry and mango - aroma leaves an earthy taste, and it tests as relieving pain. The strain leaves patients relaxed, tingly, and sleepy. The balance shows as 9.6% THC/13.0% CBD.
  3. Cannatonic: This strain lists at Sativa/Indica (50/50). The taste has citrus and wood with an earthy smell. Its minimal high discourages recreational use, but the high CBD content (12%) treats epilepsy and pain with a relaxing and uplifting impact. Medical patients also use Cannatonic for ADD/ADHD, anxiety, arthritis, chronic pain, depression, and fibromyalgia.
  4. CBD Kush: CBD Crew and Dutch Passion developed this child of Kandy Kush as a hybrid strain with equal parts THC and CBD (7%/7%). Smokers with low tolerance for high impact effects and patients with anxiety, inflammation, and pain use CBD Kush. Its psychoactive effects offer a tame experience that relaxes muscles without too much mental cloudiness.
  5. Purple Cheese: A predominantly Indica-dominant hybrid delivers a heavy full body hit of relaxing CBD cannabinoids. Its energizing and social high moves quickly to an intense body stone. Purple Cheese works well for those seeking to relieve symptoms of ADD/ADHD, anxiety, bipolar disorder, chronic pain, depression and eye pressure. In Purple Cheese, THC (12/16%) is higher than the CBD (0.00/4.0%) explaining the major stone.
  6. Sour Tsunami: This Sativa-dominant strain was specifically developed to be CBD dominant. Smell and taste of wood and earth produce only a slight buzz. It will leave you relaxed and pain free. Sativa heavy, the THC count is 10% or less while the CBD is very high at 11% to 13%.
  7. Stephen Hawking Kush: This Indica-dominant hybrid is part of Alphakrokik Genes’ CBD+ genetics line emphasizes high-CBD strains. Smells of earth and wood mix with citrus. The high 22% CBD level serves those looking to soothe pain and relax without sacrificing functionality or falling victim to paranoia or nausea that sometimes comes with smoking a strong strain.
  8. Valentine X: Another hybrid (50/50), Valentine X treats cancer-related discomforts, epilepsy, inflammation, and seizure disorders. An offspring of AC/DC, it boasts a pungent, citrusy skunk aroma. Users experience a creative high, euphoric mood and muscle relaxation. Its analgesic effects relieve stress, depression, nausea, and cancer pain. The strain is 70/80% THC and 15/18% CBD.
  9. Warlock: Magus Genetics developed this Indica-dominant strain for its stimulating focused high. While sharpening your brain, it reduces the inattention and boredom associated with ADD/ADHD mindsets. Sweet and sour, the results relieve stress and improve engagement. Warlock is high in both THC and CBD at 18% to 13% respectively.
  10. Zen: Hints of earth and sour berries mark this hybrid with a touch of lavender. The THC (10%) and CBD (8.6%) balance is valued for treating digestion disorders, as well as anorexia, anxiety, appetite, Chron’s disease, and nausea.

Medical marijuana has clear and defined markets, so products are multiplying. The strains listed here do not exhaust the number of CBD strains available, including Charlotte’s Web, Harlequin, Pennywise, and Remedy.

CBD works subtly and quietly. It interacts mildly with the user’s cannabinoid receptors. It works with cannabinoids to do a better job or it reduces barriers to the receptors’ performance.

This has made research into how CBD works difficult, but research into patient effects shows enough promise to encourage development of synthetic CBD.

In addition, CBD comes in many forms other than smoking strains. These include CBD Oil, Powder, Sprays, Tinctures, and Topicals.

Hemp Oil is also promoted as containing a low percentage of CBD, but it’s very low THC percentage and will not produce a high. Still, it should not be confused with CBD Oil. According to Eric Steenstra, executive director of Hemp Industries Association, “CBD is not a product or component of hemp seeds, and labeling to that effect is misleading and motivated by the desire to take advantage of the legal gray area of CBD under federal law.”

In states where CBD products are available for sale, the medical dispensary and/or retail store will gladly introduce you to products specific to your health needs.

CBD and Prescription Meds Go Head-to-Head in New Massive Study

6 June, 2017

A new study will explore the effectiveness of CBD as an alternative to traditionally used prescription medications.
The efficacy of cannabidiol (CBD) as an alternative to prescription drugs will be investigated in a new study by medical marijuana company HelloMD and market research firm Brightfield Group. The study will survey over 150,000 HelloMD community members on their consumption of CBD and perceptions of efficacy.

CBD is a primary compound found in cannabis plants like marijuana and hemp. Previous studies have indicated that CBD holds pain relieving, anti-inflammation, anti-epilepsy, anti-anxiety, antioxidant, and neuroprotective properties. The demand for CBD continues to grow as people become increasingly aware of the cannabinoid’s natural health effects. In a recent report, the Hemp Business Journal estimated that the CBD market would surge 700 percent over four years, from $202 million in 2016 to $2.1 billion by 2020.

The HelloMD and Brightfield Group study will feature the largest patient sample size to date to examine CBD patient demographics, applications, psychographics and perceived efficacy.

“There is a skepticism towards many of today’s CBD products, and a confusion over how to identify which of them actually do anything at all,” said Dr. Perry Solomon, chief medical officer of HelloMD, in a press release. “This survey offers an opportunity to establish some baselines around perceptions, concerns and successes from which we can build on going forward.”

CBD is non-psychoactive, meaning it doesn’t cause users to experience a high. When derived from marijuana, CBD is only available to legally obtain in states with medical marijuana laws. When derived from imported hemp, CBD is legal in all 50 U.S. states and in 40 countries.
Brightfield Group director of research Bethany Gomez believes the survey will offer insight on the identities and purposes of those who use CBD-based products. The survey will also gather information on CBD’s efficacy for various symptoms and conditions in comparison to traditional prescription drugs like opioids.

“Given the growing market share for CBD products, it is time to understand more about the user’s experience,” said Gomez. “Who is using CBD? Are they using Hemp or whole plant or CBD only? Are these products perceived as effective in comparison with THC dominant products, prescription drugs and opioids or over-the-counter medications? This collaboration with HelloMD will move us close to answering these critical questions.”

Previous studies have found that individuals are increasingly using cannabis products as a substitute for prescription drugs. Access to legal cannabis has been linked to a significant drop in medical prescriptions. Earlier this year, researchers from the Bastyr University Research Institute found that people are opting to use cannabis instead of prescription medications for pain, anxiety and depression. A just-published market research report suggests that nationwide legalized medical cannabis would cut into the pharmaceutical industry by $4 billion annually.

The HelloMD and Brightfield Group comprehensive report summarizing the survey’s results will be available for free around mid-June. Earlier this year, HelloMD collaborated with University of California Berkeley to survey 17,000 patients on the topic of cannabis as an alternative to opiates. That study is still pending release.
Amazing Uses of CBD

Among the cannabinoids in cannabis, the main psychoactive compound, THC, often outshines the one that provides a natural anti-anxiety, anti-epileptic and antipsychotic effect.

Cannabidiol, or CBD, lacks the colorful high commonly associated with your traditional marijuana high and doesn’t have much of a noticeable effect when isolated. When combined with THC, the relaxing effect combats any feelings of paranoia or panic that can sometimes be felt under the influence.

While lauded for it’s effect on epilepsy, recent cannabis research has identified CBD as the component responsible for a great deal of marijuana’s medical benefits. Here are 10 medical use for CBD that you might not have known about:

1. Reduces Nausea & Vomiting

CBD oil is great for reducing nausea and vomiting, which can occur as symptoms due to most of gastrointestinal disorders, as well as other (more serious) systemic diseases.

2. Multiple Sclerosis

Scientists at the Cajal Institute used animal models and cell cultures to find that CBD reversed inflammatory responses and served as durable protection from the effects of multiple sclerosis. Mice with 10 days of CBD treatment had superior motor skills and showed progression in their condition. Using this information, researchers concluded that CBD has the potential ability to reduce various aspects of MS.

3. Post Traumatic Stress Disorder

CBD is known to produce anti-anxiety and anti-inflammatory effects when ingested by slowing everything down and calming the user. Those with PTSD are often overcome with anxiety and stress, so patients frequently find relief by using cannabidiol. The antipsychotic benefits provide a stable mental environment for those that need it most.

4. Cancer Healing

We are not saying that CBD oil can “cure” cancer – but it can certainly boost the body’s capacities in fighting these cells as well as improving the quality of life while you are battling it.

5. Diabetes

In a study using CBD, the development of diabetes in non-obese diabetic mice was prevented. Although there wasn’t a direct effect of cannabidiol on glucose levels, the treatment prevented the production of IL-12 by splenocytes. Preventing this cytokine is important because it plays a huge role in many autoimmune diseases.

6. Schizophrenia

In 2012, a group of German researchers published a study in the journal Translational Psychiatry. The potent antipsychotic Amisulpride and CBD were compared between 42 schizophrenia patients. The two treatments were deemed effective, but the short side-effect profile of CBD out shined the pharmaceutical option.

7. Arthritis Treatment

Arthritis occurs due to high inflammation in the joints – and as you already know, CBD oil is one of the best anti-inflammatory agents you can consume.

8. Fibromyalgia

Common treatments for fibromyalgia are anti-inflammatory medications, opioid pain medications and corticosteroids. A 2011 study that focused on CBD treatment for fibromyalgia produced very promising results for future uses in treatment. Half of the 56 participants used CBD, while the other half used traditional methods to treat their condition. Those that used cannabis saw a great reduction in their symptoms and pain, while those using traditional methods didn’t see much of an improvement.

9. Insomnia

One of the few side effects of CBD is tiredness, but for many, it’s what they seek out in the natural herb. Since pharmaceuticals for aiding sleep pose risk for addiction and leave you feeling groggy the next day, it’s best to go the safe route with non-habit forming CBD. When searching for strains to combat insomnia, try staying with Indica and CBD-heavy strains to knock you out when you need it most.

10. Prion/Mad Cow Disease

Cannabidiol has been shown to halt prions, the proteins that cause neurodegenerative diseases like Creutzfeldt-Jakob disease and mad cow. The formation and accumulation of prions was prevented with the aide of cannabidiol during a study published in the Journal of Neuroscience in 2007. For mice that were infected, CBD increased their survival time by about a week.

11. Reducing Parkinson’s Symptoms

Because it is an effective anti-inflammatory agent, CBD oil is very effective at reducing Parkinson’s disease’ssymptoms.

12. Cigarette Addiction

In a double-blind, placebo-controlled study, 24 smokers were randomly chosen to receive either an inhaler of CBD or a placebo. Participants were asked to take a puff every time they had an urge to puff a cigarette. Over the week, those with placebo inhalers saw no change in their total number of cigarettes consumed, while those who were taking CBD saw a nearly 40 percent drop in their intake. Using the inhaler decreased the number of cigarettes without increasing their craving for nicotine, pointing towards a purpose for cannabidiol in the withdrawal process.

13. Crohn’s Disease

Some scientists say CBD could be an effective treatment for bowel diseases like Crohn’s Disease. THC and CBD interact with the system that controls gut function in the body, something that Crohn’s patients suffer issues with. The component of cannabis’ anti-inflammatory ability brings a lot of relief to those suffering from this condition.

14. Alzheimer’s Disease

Due to its similarity to Parkinson’s disease, CBD oil is also very effective in alleviating Alzheimer’s disease.

15. Acne

A study published in the Journal of Clinical Investigation and the National Institute of Health discovered that CBD can provide treatment for acne. Researchers used cannabis-derived cannabidiol on the human sebaceous glands and came to the conclusion that CBD acts as a highly effective sebostatic and anti-inflammatory agent by inhibiting lipid synthesis.

…and CBD is good For Pets As Well

If its good for humans, why wouldn’t it be good for pets as well? Try CBD oil next time your beloved companion suffers from any of these symptoms or diseases.

A groundbreaking study has documented the superior therapeutic properties of whole plant CBD-rich cannabis extract as compared to single-molecule CBD.

A groundbreaking study from Israel has documented the superior therapeutic properties of whole plant CBD-rich cannabis extract as compared to single-molecule cannabidiol (CBD).

Published in the journal Pharmacology &Pharmacy (Feb. 2015), the article directly challenges one of the sacred cows of Big Pharma and the medical-industrial complex—the notion that “crude” botanical preparations are inherently low grade and less effective than pure, single-molecule compounds.

Entitled “Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol,” the article is all the more noteworthy given the contribution of co-author Lumir Hanus, who was instrumental in the discovery of anandamide, the endogenous cannabinoid compound first identified in the mammalian brain in 1992.

Hanus and two Israeli colleagues from Hebrew University of Jerusalem surveyed the scientific literature and noted that during the past fifteen years numerous preclinical studies had focused on the anti-inflammatory effects of pure, single-molecule CBD in animal models of various pathologies, including rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and diabetes. (See preclinical data regarding CBD.)

These studies showed that administration of pure, single-molecule CBD resulted in a bell-shaped dose-response curve, meaning that when the amount of CBD exceeded a certain point its therapeutic impact declined dramatically. “Healing was only observed when CBD was given within a very limited dose range, whereas no beneficial effect was achieved at either lower or higher doses,” the authors observed. This characteristic of single-molecule CBD—manifested as a bell-shaped dose response—imposes serious obstacles that limit its usefulness in a clinical context.

hardly any THC and therefore is not intoxicating. The origins of Avidekel can be traced to Spain, where breeders developed several phenotypes of “Cannatonic” (as in “cannabis tonic”), including a strain that measures close to 20 percent CBD by dry weight with almost no intoxicating ingredients. (The same high-yielding CBD-dominant strain is known as “ACDC” in California.)

The Israeli researchers extracted CBD-rich oil from clone 202. The extract—consisting of 17.9 percent CBD, 1.1 percent THC, 1.1 percent cannabichromene (CBC), 0.2 percent cannabigerol (CBG), and “traces” of cannabinol (CBN) and cannabivarol (CBDV)—was given to mice to evaluate its anti-inflammatory and painkilling effect.

For comparative purposes, the scientists administered pure CBD to another group of mice and assessed its anti-inflammatory and analgesic properties. They also compared the extent to which single-molecule CBD and whole plant CBD inhibited the production of tumor necrosis factor alpha (TNFa), a systemic inflammatory signaling molecule. Dysregulation of TNF-alpha production has been implicated in several diseases including cancer, Alzheimer’s, clinical depression, and irritable bowel syndrome.

The pure CBD tests confirmed the findings of earlier preclinical research. Once again, single-molecule CBD administration generated a bell-shaped dose-response curve with a narrow therapeutic window.

But a different dose response pattern was observed when the clone 202 extract was administered to mice. Rather than showing a bell-shaped curve, where a therapeutic effect could only be achieved at a certain concentration of pure CBD, the whole plant CBD-rich extract caused a direct, dose-dependent inhibition of pain, inflammation, and TNFa production. “In stark contrast to purified CBD,” the Israeli team reported, “the clone extract…provided a clear correlation between the anti-inflammatory and anti-nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses.”


Moreover, the Israeli researchers found that a small amount of CBD in the clone extract was needed for significant pain relief compared to the much larger amount of pure CBD required to achieve the same analgesic effect. And whereas pure, single-molecule CBD precipitated a dramatic drop in efficacy if more than a specific dosage was administered, an “overdose” of whole plant CBD-rich extract did not undermine its therapeutic potency. When greater than an optimal dose of the clone 202 oil was administered, its effectiveness leveled off, suggesting that a medicinal plateau had been reached.

The Israeli study found that Cannabis clone 202 extract “is superior over CBD for the treatment of inflammatory conditions.” The greater efficiency of the whole plant extract might be explained by additive or synergistic interactions between CBD and dozens of minor phytocannabinoids and hundreds of non-cannabinoid plant compounds. “It is likely that other components in the extract synergize with CBDto achieve the desired anti-inflammatory action that may contribute to overcoming the bell-shaped dose-response of purified CBD,” the Israeli team surmised.


The scientists also felt it was important to examine how the CBD-rich Cannabis extract compared with commercial painkillers and anti-inflammatory drugs. They found that both pure CBD and the clone 202 extract exhibited greater anti-inflammatory potency than aspirin. Aspirin, but not tramadol, registered a slight inhibitory effect on TNFa production, which was negligible in comparison to the strong inhibitory effect of pure CBD and clone 202.

The key finding that CBD in the presence of other Cannabis components improves the dose-response is supported by recent reports documenting the anti-proliferative effect of cannabidiol on tumor cells and the inhibitory effect of CBD on bladder contractility.

“A lot of research has been made to isolate and characterize isolated single constituents of traditional herbal medicine to find their rationale for therapeutic uses,” the Israeli team concluded. “However, our data together with those of others provide legitimation to introduce a new generation of phytopharmaceuticals to treat diseases that have hitherto been treated using synthetic drugs alone. The therapeutic synergy observed with plant extracts results in the requirement for a lower amount of active components, with consequent reduced adverse effects
An old buddy was released from the military in the 90s due to MS. Last year his neurologist gave him an 'all clear, no symptoms' diagnosis. It's hard to say this hasn't helped him, given it's currently his only medication...

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