This thread is a listing of all of the medicinal uses for cannabis sorted by disease (in 2012). There are also informational links regarding cannabis. While this is an older article, it has a lot of great information. The Glossary is at at the end. This first post is the latest introduction and pages 1 - 4. Prior year's introductions are at the end of the article.
Granny Storm Crow's MMJ Reference List- January 2012
Well, here I am again, staring at this blank screen, trying to figure out what to say so you will share the information I have gathered. ―Once the medical facts about cannabis become known, the need for legalization becomes obvious!‖ How many times have I said that? I need YOU to educate those around you. I can‘t do it alone!
At times, it seems so futile- this never-ending battle against ignorance about cannabis. But I can‘t give up - this simple herb has some amazing uses and people need to know what it can do.
Cannabis should be treated like any other medicinal herb, because that‘s what it is, just an herbal medicine with a rather pleasant side effect- you feel ―high‖. Unlike common aspirin, cannabis never kills by overdose. Compared to some pharmaceutical drugs‘ side effects, the ―cotton-mouth‖, ―red eye‖, ―munchies‖ and ―feeling a just bit too good‖ from using cannabis seems so trivial!
As Americans, we should be free to exercise our right to choose the type of medicines that we take. Anyone exhibiting the first signs of Alzheimer‘s should be able to choose between Aricept, Marinol, or natural cannabis to slow the deposit of mind-clogging amyloid plaque.
“When tested at double the concentration of THC, Aricept blocked plaque formation only 22% as well as THC, and Cognex blocked plaque formation only 7% as well as THC.” (Marijuana May Slow Alzheimer's - WebMD, 2006)
Marinol is just a capsule of a pure synthetic THC dissolved in sesame oil. It will work, but some people find that it causes anxiety because it lacks CBD (cannabidiol) to balance the THC high.
Natural cannabis has CBD and other cannabinoids in it, which act in a different way to slow the progress of Alzheimer‘s. (―Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer‘s disease‖ - Molecular Pharmacology, 2011) I know which I would logically choose, but in 2/3s of the US, and everywhere by federal law, that choice is forbidden to us. Our government has banned our best choice!
Then there are thousands facing the severe nausea of chemotherapy- will they be able to keep an anti- nausea pill down long enough for it to work? Wouldn‘t it be simpler to inhale some cannabis vapor, or smoke, and get almost instantaneous relief? In 16 states, you can!
And the pain from cancer? “Medical Marijuana a Success in Israel‖ – “More than two-thirds of cancer patients who were prescribed medical marijuana to combat pain are reportedly satisfied with the treatment” Are we less free than the Israelis? They are free to get legal, prescribed cannabis for cancer pain- are you? Our neighbor, Canada, has legal medical cannabis, and their government grows cannabis for patients! And surprise! The US has 4 federally legal MMJ patients and grows for them. The program is closed. No new patients allowed! Why? And why is cannabis research, all but banned in the US? This prohibitionist foolishness has to end!
2012 is supposed to be a time of change, an ―interesting‖ year. It is time for us to demand a change in the laws on cannabis! We must keep telling the truth, keep presenting the facts to our friends and our families. The facts are there in PubMed- cannabis IS medicine! Our government lies to us about cannabis! And folks- “If the truth won’t do, then something is wrong!”
1
It Is Time for Marijuana to Be Reclassified as Something Other Than a Schedule I Drug! (2005) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1681626&tool=pmcentrez
ACEA/ ARACHIDONYL-2'-CHLOROETHYLAMIDE - synthetic, CB1 agonist
The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU- 210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice. (abst – 2002) http://www.ncbi.nlm.nih.gov/pubmed/12095655
In vivo effects of CB1 receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain of healthy and ethanol-treated rats. (full – 2006) http://www.if-pan.krakow.pl/pjp/pdf/2006/6_876.pdf
Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock- induced seizure model. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16930590
Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. (full - 2007) http://jpet.aspetjournals.org/content/322/3/1144.long
Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17870135
Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells (full - 2008) http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block
Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation. (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585399/?tool=pubmed
Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees. (full – 2008) http://onlinelibrary.wiley.com/doi/10.1002/art.23156/full
Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha- mediated ceramide de novo synthesis in colon cancer cells. (full – 2008) http://clincancerres.aacrjournals.org/content/14/23/7691.long
Endogenous cannabinoids induce fever through the activation of CB1 receptors. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765314/?tool=pubmed
2
The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats. (full – 2009) http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02098.x/full
Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19223154
Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19827302
Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19751793
Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19150453
Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation (abst - 2010) http://www.nature.com/npp/journal/vaop/ncurrent/full/npp2010214a.html
Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21764086
L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21928146
Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22079489
Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by Aβ neurotoxicity. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22172925
Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21937980
Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22233683
3
ACHILLES TENDINOSIS
Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169627/?tool=pubmed
ACNE
The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757311/?tool=pubmed
Endocannabinoid signaling and epidermal differentiation. (abst – 2011)
http://www.ncbi.nlm.nih.gov/pubmed/21628127
ADD/ ADHD
ADHD by Ryan P (anecdotal - no date)
http://www.rxmarijuana.com/shared_comments/ADHD4.htm
Marijuana and ADD Therapeutic uses of Medical Marijuana in the treatment of ADD (no date) http://www.onlinepot.org/medical/add&mmj.htm
Barba Jacob and the history of marihuana (abst – 1986)
http://www.ncbi.nlm.nih.gov/pubmed/3296662
How Cannabis Compares to other treatments (no date - 2008)
http://dcsafeaccess.org/medical/how-cannabis-compares-to-other-treatments/
Recipe For Trouble (anecdotal/ news - 2002 )
http://www.cbsnews.com/stories/2002/03/05/48hours/main503022.shtml
Association between cannabinoid receptor gene (CNR1) and childhood attention deficit/hyperactivity disorder in Spanish male alcoholic patients (full - 2003) http://www.nature.com/mp/journal/v8/n5/full/4001278a.html
Cannabinoids effective in animal model of hyperactivity disorder (abst - 2003)
http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=162#4
Cannabis 'Scrips to Calm Kids? (news - 2004)
http://www.foxnews.com/story/0,2933,117541,00.html
4
Granny Storm Crow's MMJ Reference List- January 2012
Well, here I am again, staring at this blank screen, trying to figure out what to say so you will share the information I have gathered. ―Once the medical facts about cannabis become known, the need for legalization becomes obvious!‖ How many times have I said that? I need YOU to educate those around you. I can‘t do it alone!
At times, it seems so futile- this never-ending battle against ignorance about cannabis. But I can‘t give up - this simple herb has some amazing uses and people need to know what it can do.
Cannabis should be treated like any other medicinal herb, because that‘s what it is, just an herbal medicine with a rather pleasant side effect- you feel ―high‖. Unlike common aspirin, cannabis never kills by overdose. Compared to some pharmaceutical drugs‘ side effects, the ―cotton-mouth‖, ―red eye‖, ―munchies‖ and ―feeling a just bit too good‖ from using cannabis seems so trivial!
As Americans, we should be free to exercise our right to choose the type of medicines that we take. Anyone exhibiting the first signs of Alzheimer‘s should be able to choose between Aricept, Marinol, or natural cannabis to slow the deposit of mind-clogging amyloid plaque.
“When tested at double the concentration of THC, Aricept blocked plaque formation only 22% as well as THC, and Cognex blocked plaque formation only 7% as well as THC.” (Marijuana May Slow Alzheimer's - WebMD, 2006)
Marinol is just a capsule of a pure synthetic THC dissolved in sesame oil. It will work, but some people find that it causes anxiety because it lacks CBD (cannabidiol) to balance the THC high.
Natural cannabis has CBD and other cannabinoids in it, which act in a different way to slow the progress of Alzheimer‘s. (―Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer‘s disease‖ - Molecular Pharmacology, 2011) I know which I would logically choose, but in 2/3s of the US, and everywhere by federal law, that choice is forbidden to us. Our government has banned our best choice!
Then there are thousands facing the severe nausea of chemotherapy- will they be able to keep an anti- nausea pill down long enough for it to work? Wouldn‘t it be simpler to inhale some cannabis vapor, or smoke, and get almost instantaneous relief? In 16 states, you can!
And the pain from cancer? “Medical Marijuana a Success in Israel‖ – “More than two-thirds of cancer patients who were prescribed medical marijuana to combat pain are reportedly satisfied with the treatment” Are we less free than the Israelis? They are free to get legal, prescribed cannabis for cancer pain- are you? Our neighbor, Canada, has legal medical cannabis, and their government grows cannabis for patients! And surprise! The US has 4 federally legal MMJ patients and grows for them. The program is closed. No new patients allowed! Why? And why is cannabis research, all but banned in the US? This prohibitionist foolishness has to end!
2012 is supposed to be a time of change, an ―interesting‖ year. It is time for us to demand a change in the laws on cannabis! We must keep telling the truth, keep presenting the facts to our friends and our families. The facts are there in PubMed- cannabis IS medicine! Our government lies to us about cannabis! And folks- “If the truth won’t do, then something is wrong!”
1
It Is Time for Marijuana to Be Reclassified as Something Other Than a Schedule I Drug! (2005) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1681626&tool=pmcentrez
ACEA/ ARACHIDONYL-2'-CHLOROETHYLAMIDE - synthetic, CB1 agonist
The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU- 210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice. (abst – 2002) http://www.ncbi.nlm.nih.gov/pubmed/12095655
In vivo effects of CB1 receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain of healthy and ethanol-treated rats. (full – 2006) http://www.if-pan.krakow.pl/pjp/pdf/2006/6_876.pdf
Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock- induced seizure model. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16930590
Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. (full - 2007) http://jpet.aspetjournals.org/content/322/3/1144.long
Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice. (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/17870135
Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells (full - 2008) http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block
Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation. (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585399/?tool=pubmed
Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees. (full – 2008) http://onlinelibrary.wiley.com/doi/10.1002/art.23156/full
Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha- mediated ceramide de novo synthesis in colon cancer cells. (full – 2008) http://clincancerres.aacrjournals.org/content/14/23/7691.long
Endogenous cannabinoids induce fever through the activation of CB1 receptors. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765314/?tool=pubmed
2
The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats. (full – 2009) http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02098.x/full
Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19223154
Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19827302
Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19751793
Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19150453
Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation (abst - 2010) http://www.nature.com/npp/journal/vaop/ncurrent/full/npp2010214a.html
Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21764086
L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21928146
Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22079489
Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by Aβ neurotoxicity. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22172925
Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21937980
Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22233683
3
ACHILLES TENDINOSIS
Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169627/?tool=pubmed
ACNE
The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757311/?tool=pubmed
Endocannabinoid signaling and epidermal differentiation. (abst – 2011)
http://www.ncbi.nlm.nih.gov/pubmed/21628127
ADD/ ADHD
ADHD by Ryan P (anecdotal - no date)
http://www.rxmarijuana.com/shared_comments/ADHD4.htm
Marijuana and ADD Therapeutic uses of Medical Marijuana in the treatment of ADD (no date) http://www.onlinepot.org/medical/add&mmj.htm
Barba Jacob and the history of marihuana (abst – 1986)
http://www.ncbi.nlm.nih.gov/pubmed/3296662
How Cannabis Compares to other treatments (no date - 2008)
http://dcsafeaccess.org/medical/how-cannabis-compares-to-other-treatments/
Recipe For Trouble (anecdotal/ news - 2002 )
http://www.cbsnews.com/stories/2002/03/05/48hours/main503022.shtml
Association between cannabinoid receptor gene (CNR1) and childhood attention deficit/hyperactivity disorder in Spanish male alcoholic patients (full - 2003) http://www.nature.com/mp/journal/v8/n5/full/4001278a.html
Cannabinoids effective in animal model of hyperactivity disorder (abst - 2003)
http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=162#4
Cannabis 'Scrips to Calm Kids? (news - 2004)
http://www.foxnews.com/story/0,2933,117541,00.html
4
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